Most cited papers in Ion channel regulation and function
What are the most cited papers in Ion channel regulation and function?
The most cited paper in Ion channel regulation and function is "Calcium's Role in Mechanotransduction during Muscle Development" (Tatiana Benavides Damm, Marcel Egli, 2014), with 14,545 citations. Next come "The capsaicin receptor: a heat-activated ion channel in the pain pathway" (9,220) and "International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels" (7,147).
Showing 50 of 99 papers. Every paper with more than 1,670 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Calcium's Role in Mechanotransduction during Muscle Development Tatiana Benavides Damm, Marcel Egli · Cellular Physiology and Biochemistry | 2014 | 14,545 |
| 2 | The capsaicin receptor: a heat-activated ion channel in the pain pathway Michael J. Caterina, Mark A. Schumacher, Makoto Tominaga et al. · Nature | Oct 1997 | 9,220 |
| 3 | International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels William A. Catterall, K. George Chandy, David E. Clapham et al. · Pharmacological Reviews | Dec 2003 | 7,147 |
| 4 | The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity Declan Anthony Doyle, João Henrique Morais-Cabral, Richard A. Pfuetzner et al. · Science | 3 Apr 1998 | 6,890 |
| 5 | Cardiac excitation–contraction coupling Donald M. Bers · Nature | 2002 | 4,798 |
| 6 | Cellular and Molecular Mechanisms of Pain Allan I. Basbaum, Diana M. Bautista, Grégory Scherrer et al. · Cell | Oct 2009 | 4,393 |
| 7 | Calcium Signaling David E. Clapham · Cell | Dec 2007 | 4,195 |
| 8 | Magnesium gates glutamate-activated channels in mouse central neurones Linda M. Nowak, Piotr D. Bregestovski, Philippe Ascher et al. · Nature | Feb 1984 | 4,063 |
| 9 | Neuronal Plasticity: Increasing the Gain in Pain Clifford J. Woolf, Michael W. Salter · Science | 9 Jun 2000 | 3,780 |
| 10 | Glutamate Receptor Ion Channels: Structure, Regulation, and Function Stephen F. Traynelis, Lonnie P. Wollmuth, Chris J. McBain et al. · Pharmacological Reviews | 17 Aug 2010 | 3,615 |
| 11 | Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor Michael J. Caterina, Andreas Leffler, Annika B. Malmberg et al. · Science | 14 Apr 2000 | 3,554 |
| 12 | Developmental and regional expression in the rat brain and functional properties of four NMDA receptors Hannah Monyer, Nail Burnashev, David Laurie et al. · Neuron | Mar 1994 | 3,522 |
| 13 | Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels Bertrand Coste, Jayanti Mathur, Manuela Schmidt et al. · Science | 2 Sep 2010 | 3,398 |
| 14 | Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase. Ole Thastrup, Peter J. Cullen, Bjørn K. Drøbak et al. · Proceedings of the National Academy of Sciences | Apr 1990 | 3,301 |
| 15 | Glycine potentiates the NMDA response in cultured mouse brain neurons John William Johnson, Philippe Ascher · Nature | Feb 1987 | 3,160 |
| 16 | The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli Makoto Tominaga, Michael J. Caterina, Annika B. Malmberg et al. · Neuron | Sep 1998 | 3,109 |
| 17 | Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Luc Pellerin, Pierre Julius Magistretti · Proceedings of the National Academy of Sciences | 25 Oct 1994 | 2,935 |
| 18 | Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones Mark L. Mayer, Gary L. Westbrook, Peter B. Guthrie · Nature | May 1984 | 2,914 |
| 19 | Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension Masayoshi Uehata, Toshimasa Ishizaki, Hiroyuki Satoh et al. · Nature | Oct 1997 | 2,895 |
| 20 | Identification of a cold receptor reveals a general role for TRP channels in thermosensation David D. McKemy, Werner Neuhausser, David J. Julius · Nature | 10 Feb 2002 | 2,752 |
| 21 | Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid Edward Meigs Brown, Gerardo Gamba, Daniela Mendes dos Reis Riccardi et al. · Nature | Dec 1993 | 2,656 |
| 22 | Homeostatic plasticity in the developing nervous system Gina G. Turrigiano, Sacha B. Nelson · Nature reviews. Neuroscience | 20 Jan 2004 | 2,589 |
| 23 | A model for receptor-regulated calcium entry James W. Putney · Cell Calcium | Feb 1986 | 2,579 |
| 24 | Single-channel currents recorded from membrane of denervated frog muscle fibres Erwin Neher, Bert Sakmann · Nature | Apr 1976 | 2,576 |
| 25 | NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease Pierre Paoletti, Camilla Bellone, Qiang Zhou · Nature reviews. Neuroscience | 20 May 2013 | 2,574 |
| 26 | Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes Hannah Monyer, Rolf Sprengel, Ralf Schoepfer et al. · Science | 22 May 1992 | 2,560 |
| 27 | ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures Gina M. Story, Andrea M. Peier, Alison J. Reeve et al. · Cell | Mar 2003 | 2,510 |
| 28 | A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel Michael C. Sanguinetti, Changan Jiang, Mark E. Curran et al. · Cell | Apr 1995 | 2,455 |
| 29 | Calmodulin Plays a Pivotal Role in Cellular Regulation Wai Yiu Cheung · Science | 4 Jan 1980 | 2,444 |
| 30 | ATP-regulated K+ channels in cardiac muscle Akinori Noma · Nature | Sep 1983 | 2,348 |
| 31 | Structure and Regulation of Voltage-Gated Ca 2+ Channels William A. Catterall · Annual Review of Cell and Developmental Biology | Nov 2000 | 2,340 |
| 32 | The Intrinsic Electrophysiological Properties of Mammalian Neurons: Insights into Central Nervous System Function Rodolfó R. Llinás · Science | 23 Dec 1988 | 2,322 |
| 33 | Thyroid Hormone and the Cardiovascular System Irwin L. Klein, Kaie Ojamaa · New England Journal of Medicine | 15 Feb 2001 | 2,315 |
| 34 | A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome Mark E. Curran, Igor Splawski, Katherine W. Timothy et al. · Cell | Mar 1995 | 2,292 |
| 35 | International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels William A. Catterall, Alan L. Goldin, Stephen G. Waxman · Pharmacological Reviews | Dec 2005 | 2,284 |
| 36 | Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts Michael R. Bristow, Robert Ginsburg, Wayne A. Minobe et al. · New England Journal of Medicine | 22 Jul 1982 | 2,284 |
| 37 | Caveolin, a protein component of caveolae membrane coats Karen G. Rothberg, John E. Heuser, William C. Donzell et al. · Cell | Feb 1992 | 2,274 |
| 38 | The influence of some cations on an adenosine triphosphatase from peripheral nerves Jens Chr. Skou · Biochimica et Biophysica Acta | 1957 | 2,258 |
| 39 | Allosteric proteins and cellular control systems Jacques Monod, Jean‐Pierre Changeux, François Jacob · Journal of Molecular Biology | Apr 1963 | 2,253 |
| 40 | Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor Maria Dorota Majewska, Neil L. Harrison, Rochelle D. Schwartz et al. · Science | 23 May 1986 | 2,234 |
| 41 | Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs Ian Creese, David R. Burt, Solomon H. Snyder · Science | 30 Apr 1976 | 2,234 |
| 42 | Neuronal Calcium Signaling Michael John Berridge · Neuron | Jul 1998 | 2,216 |
| 43 | Three types of neuronal calcium channel with different calcium agonist sensitivity Martha C. Nowycky, Aaron P.D. Fox, Richard W. Tsien · Nature | Aug 1985 | 2,214 |
| 44 | Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Valina L. Dawson, Ted M. Dawson, Edythe D. London et al. · Proceedings of the National Academy of Sciences | 15 Jul 1991 | 2,187 |
| 45 | Physiological roles and properties of potassium channels in arterial smooth muscle Mark Tyler Nelson, John M. Quayle · American Journal of Physiology-Cell Physiology | Apr 1995 | 2,168 |
| 46 | EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION John E. Heuser, Thomas S. Reese · The Journal of Cell Biology | May 1973 | 2,167 |
| 47 | Evidence for a central component of post-injury pain hypersensitivity Clifford J. Woolf · Nature | Dec 1983 | 2,167 |
| 48 | The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation Claudio Rivera, Juha Voipio, John A. Payne et al. · Nature | 1999 | 2,163 |
| 49 | Crystal Structure of a Mammalian Voltage-Dependent Shaker Family K + Channel Stephen Barstow Long, Ernest B. Campbell, Roderick MacKinnon · Science | 7 Jul 2005 | 2,157 |
| 50 | STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx Jen Liou, Man Lyang Kim, Won Do Heo et al. · Current Biology | 10 Jun 2005 | 2,133 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.