Topic · Ion Channels and Receptors
Most cited papers in Ion Channels and Receptors
What are the most cited papers in Ion Channels and Receptors?
The most cited paper in Ion Channels and Receptors is "The capsaicin receptor: a heat-activated ion channel in the pain pathway" (Michael J. Caterina, Mark A. Schumacher, Makoto Tominaga et al., 1997), with 9,220 citations. Next come "Inositol trisphosphate and calcium signalling" (6,606) and "The versatility and universality of calcium signalling" (5,749).
Showing 50 of 99 papers. Every paper with more than 862 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The capsaicin receptor: a heat-activated ion channel in the pain pathway Michael J. Caterina, Mark A. Schumacher, Makoto Tominaga et al. · Nature | Oct 1997 | 9,220 |
| 2 | Inositol trisphosphate and calcium signalling Michael John Berridge · Nature | 1993 | 6,606 |
| 3 | The versatility and universality of calcium signalling Michael John Berridge, Peter Lipp, Martin D. Bootman · Nature Reviews Molecular Cell Biology | Oct 2000 | 5,749 |
| 4 | Calcium signalling: dynamics, homeostasis and remodelling Michael John Berridge, Martin D. Bootman, H. Llewelyn Roderick · Nature Reviews Molecular Cell Biology | Jul 2003 | 5,649 |
| 5 | Cellular and Molecular Mechanisms of Pain Allan I. Basbaum, Diana M. Bautista, Grégory Scherrer et al. · Cell | Oct 2009 | 4,393 |
| 6 | Calcium Signaling David E. Clapham · Cell | Dec 2007 | 4,195 |
| 7 | Inositol phosphates and cell signalling Michael John Berridge, Robin F. Irvine · Nature | Sep 1989 | 4,090 |
| 8 | Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor Michael J. Caterina, Andreas Leffler, Annika B. Malmberg et al. · Science | 14 Apr 2000 | 3,554 |
| 9 | Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels Bertrand Coste, Jayanti Mathur, Manuela Schmidt et al. · Science | 2 Sep 2010 | 3,398 |
| 10 | The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli Makoto Tominaga, Michael J. Caterina, Annika B. Malmberg et al. · Neuron | Sep 1998 | 3,109 |
| 11 | TRP channels as cellular sensors David E. Clapham · Nature | Dec 2003 | 2,798 |
| 12 | Identification of a cold receptor reveals a general role for TRP channels in thermosensation David D. McKemy, Werner Neuhausser, David J. Julius · Nature | 10 Feb 2002 | 2,752 |
| 13 | Molecular mechanisms of nociception David J. Julius, Allan I. Basbaum · Nature | Sep 2001 | 2,687 |
| 14 | ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures Gina M. Story, Andrea M. Peier, Alison J. Reeve et al. · Cell | Mar 2003 | 2,510 |
| 15 | A TRP Channel that Senses Cold Stimuli and Menthol Andrea M. Peier, Aziz Moqrich, Anne C. Hergarden et al. · Cell | Mar 2002 | 2,377 |
| 16 | A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function Stefan Feske, Yousang Gwack, Murali Prakriya et al. · Nature | 2 Apr 2006 | 2,298 |
| 17 | Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing Dmitry Usoskin, Alessandro Furlan, Saiful Islam et al. · Nature Neuroscience | 24 Nov 2014 | 2,297 |
| 18 | STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx Jen Liou, Man Lyang Kim, Won Do Heo et al. · Current Biology | 10 Jun 2005 | 2,133 |
| 19 | Store-Operated Calcium Channels Anant B. Parekh, James W. Putney · Physiological Reviews | 23 Mar 2005 | 2,102 |
| 20 | TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents Diana M. Bautista, S.E. Jordt, Tetsuro Nikai et al. · Cell | Mar 2006 | 1,950 |
| 21 | TRP Channels Kartik Venkatachalam, Craig Montell · Annual Review of Biochemistry | 9 Feb 2007 | 1,932 |
| 22 | Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 Sven‐Eric Jordt, Diana M. Bautista, Huai-hu Chuang et al. · Nature | 2004 | 1,912 |
| 23 | Vanilloid (Capsaicin) Receptors and Mechanisms ARPAD SZALLASI, Peter M. Blumberg · Pharmacological Reviews | Jun 1999 | 1,911 |
| 24 | Calcium oscillations increase the efficiency and specificity of gene expression Ricardo E. Dolmetsch, Keli Xu, Richard S. Lewis · Nature | Apr 1998 | 1,907 |
| 25 | STIM1, an essential and conserved component of store-operated Ca2 + channel function Jack Roos, Paul J. DiGregorio, Andriy V. Yeromin et al. · The Journal of Cell Biology | 2 May 2005 | 1,837 |
| 26 | Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin Michael Bandell, Gina M. Story, Sun Wook Hwang et al. · Neuron | Mar 2004 | 1,834 |
| 27 | Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Peter D. Holzer · Pharmacological Reviews | Jun 1991 | 1,789 |
| 28 | NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder Laetitia Agostini, Fabio Martinon, Kimberly Burns et al. · Immunity | Mar 2004 | 1,772 |
| 29 | Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia John B. Davis, Julie Gray, Martin J. Gunthorpe et al. · Nature | May 2000 | 1,770 |
| 30 | Structure of the TRPV1 ion channel determined by electron cryo-microscopy Maofu Liao, Erhu Cao, David J. Julius et al. · Nature | 3 Dec 2013 | 1,768 |
| 31 | Differential activation of transcription factors induced by Ca2+ response amplitude and duration Ricardo E. Dolmetsch, Richard S. Lewis, Christopher Carl Goodnow et al. · Nature | Apr 1997 | 1,718 |
| 32 | A capsaicin-receptor homologue with a high threshold for noxious heat Michael J. Caterina, Tobias A. Rosen, Makoto Tominaga et al. · Nature | Apr 1999 | 1,627 |
| 33 | An SCN9A channelopathy causes congenital inability to experience pain James J. Cox, Frank M. Reimann, Adeline K. Nicholas et al. · Nature | Dec 2006 | 1,618 |
| 34 | The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway Michael J. Caterina, David J. Julius · Annual Review of Neuroscience | Mar 2001 | 1,574 |
| 35 | AN INTRODUCTION TO TRP CHANNELS Ian Scott Ramsey, Markus Delling, David E. Clapham · Annual Review of Physiology | 14 Oct 2005 | 1,564 |
| 36 | Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol Thomas Frank Hofmann, Alexander G. Obukhov, Michael Schaefer et al. · Nature | 1999 | 1,506 |
| 37 | Nociceptors: the sensors of the pain pathway Adrienne E. Dubin, Ardem Patapoutian · Journal of Clinical Investigation | Nov 2010 | 1,450 |
| 38 | The menthol receptor TRPM8 is the principal detector of environmental cold Diana M. Bautista, Jan Siemens, Joshua M. Glazer et al. · Nature | 30 May 2007 | 1,424 |
| 39 | Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor Wolfgang Liedtke, Yong Choe, Marc A. Martı́-Renom et al. · Cell | Oct 2000 | 1,402 |
| 40 | Transient Receptor Potential Cation Channels in Disease Bernd Nilius, Grzegorz Owsianik, Thomas Voets et al. · Physiological Reviews | 2007 | 1,400 |
| 41 | STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane Shenyuan L. Zhang, Ying Yu, Jack Roos et al. · Nature | Oct 2005 | 1,399 |
| 42 | Characteristics of the Cholecystokinin-Induced Depolarization of Pacemaking Activity in Cultured Interstitial Cells of Cajal from Murine Small Intestine Jae Hwa Lee, Sung-Young Kim, Young Kyu Kwon et al. · Cellular Physiology and Biochemistry | 2013 | 1,384 |
| 43 | Orai1 is an essential pore subunit of the CRAC channel Murali Prakriya, Stefan Feske, Yousang Gwack et al. · Nature | 20 Aug 2006 | 1,358 |
| 44 | CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca 2+ Entry Monika Vig, Christine Peinelt, Andreas Beck et al. · Science | 27 Apr 2006 | 1,320 |
| 45 | TMEM16A confers receptor-activated calcium-dependent chloride conductance Young Duk Yang, Hawon Cho, Jae Yeon Koo et al. · Nature | 24 Aug 2008 | 1,301 |
| 46 | TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity Antonella Caputo, Emanuela Caci, Loretta Ferrera et al. · Science | 4 Sep 2008 | 1,284 |
| 47 | Store-Operated Calcium Channels Murali Prakriya, Richard S. Lewis · Physiological Reviews | 23 Sep 2015 | 1,275 |
| 48 | TRPA1 mediates formalin-induced pain Colleen R. McNamara, Josh Mandel-Brehm, Diana M. Bautista et al. · Proceedings of the National Academy of Sciences | 8 Aug 2007 | 1,274 |
| 49 | TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction Kelvin Y. Kwan, Andrew J. Allchorne, Melissa A. Vollrath et al. · Neuron | Apr 2006 | 1,272 |
| 50 | Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition Huai-hu Chuang, Elizabeth D. Prescott, Haeyoung Kong et al. · Nature | Jun 2001 | 1,263 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.