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Most cited papers in Leprosy Research and Treatment

What are the most cited papers in Leprosy Research and Treatment?

The most cited paper in Leprosy Research and Treatment is "Massive gene decay in the leprosy bacillus" (Stewart Thomas Cole et al., 2001), with 1,799 citations. Next come "POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN" (1,189) and "CONTROLLED TRIAL OF PREDNISOLONE IN ACUTE POLYNEUROPATHY" (1,137).

Showing 50 of 99 papers. Every paper with more than 227 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Massive gene decay in the leprosy bacillus Stewart Thomas Cole et al. · Nature Open access Feb 2001 1,799
2 POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN Abdulrahman Mahgoub, L. Graham Dring, Jeffrey R. Idle et al. · The Lancet Sep 1977 1,189
3 CONTROLLED TRIAL OF PREDNISOLONE IN ACUTE POLYNEUROPATHY Richard AC Hughes, John Newsom–Davis, G D Perkin et al. · The Lancet Oct 1978 1,137
4 Defining Protective Responses to Pathogens: Cytokine Profiles in Leprosy Lesions Masahiro Yamamura, Koichi Uyemura, Robert Deans et al. · Science 11 Oct 1991 1,130
5 Genomewide Association Study of Leprosy Furen Zhang et al. · New England Journal of Medicine Open access 17 Dec 2009 1,056
6 Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. Andre Luis Moreira, E P Sampaio, A Zmuidzinas et al. · The Journal of Experimental Medicine Open access Jun 1993 1,054
7 Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones Padmini Salgame, John S. Abrams, Carol Clayberger et al. · Science 11 Oct 1991 1,015
8 Ageing and infection G. Gavazzi, Karl‐Heinz Krause · The Lancet Infectious Diseases 28 Oct 2002 1,008
9 The complete genome sequence of Mycobacterium bovis Thierry Garnier et al. · Proceedings of the National Academy of Sciences Open access 3 Jun 2003 987
10 M. tuberculosis and M. leprae Translocate from the Phagolysosome to the Cytosol in Myeloid Cells Nicole N. van der Wel, David L. Hava, Diane Houben et al. · Cell Open access Jun 2007 980
11 The Continuing Challenges of Leprosy David M. Scollard, Linda B. Adams, Tom Gillis et al. · Clinical Microbiology Reviews Open access Apr 2006 933
12 Psoriasis prevalence among adults in the United States Tara D. Rachakonda, Clayton W. Schupp, April Wang Armstrong · Journal of the American Academy of Dermatology 2 Jan 2014 790
13 Urban epidemic of severe leptospirosis in Brazil Albert Icksang Ko, Mitermayer Galvão dos Reis, Cibele Maria Ribeiro Dourado et al. · The Lancet Sep 1999 774
14 Leprosy Warwick J. Britton, Diana N.J. Lockwood · The Lancet Apr 2004 687
15 The history of tuberculosis Thomas M. Daniel · Respiratory Medicine Open access 2 Sep 2006 680
16 THE EXPERIMENTAL DISEASE THAT FOLLOWS THE INJECTION OF HUMAN LEPROSY BACILLI INTO FOOT-PADS OF MICE Charles C. Shepard · The Journal of Experimental Medicine Open access Sep 1960 599
17 Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival. John A. Armstrong, P. D’Arcy Hart · The Journal of Experimental Medicine Open access Jul 1975 545
18 Antigen-independent activation of naive and memory resting T cells by a cytokine combination. Derya Unutmaz, Piero Pileri, Sergio Abrignani · The Journal of Experimental Medicine Open access Sep 1994 535
19 Thalidomide in the treatment of lepra reactions Jacob Sheskin · Clinical Pharmacology & Therapeutics May 1965 534
20 Leprosy now: epidemiology, progress, challenges, and research gaps Laura Cunha Rodrigues, Diana N.J. Lockwood · The Lancet Infectious Diseases 26 May 2011 517
21 The anatomy of conscious vision: an fMRI study of visual hallucinations Dominic H Ffytche, Robert Howard, Michael John Brammer et al. · Nature Neuroscience Dec 1998 511
22 On the Origin of Leprosy Marc Monot et al. · Science Open access 12 May 2005 496
23 Susceptibility to leprosy is associated with PARK2 and PACRG Marcelo Távora Mira et al. · Nature 21 Jan 2004 483
24 Bell's Palsy Donald H. Gilden · New England Journal of Medicine 22 Sep 2004 473
25 The True Nature of Bell's Palsy: Analysis af 1,000 Consecutive Patients Kedar K. Adour, Frederick M. Byl, Raymond L. Hilsinger et al. · The Laryngoscope May 1978 462
26 Thalidomide in the Treatment of the Mucocutaneous Lesions of the Behcet Syndrome Vedat Hamuryudan, Cem Mat, Sebahattin Saip et al. · Annals of Internal Medicine 15 Mar 1998 457
27 Rapid diagnostic tests compared with malaria microscopy for guiding outpatient treatment of febrile illness in Tanzania: randomised trial Hugh Reyburn, Hilda Mbakilwa, Rose Mwangi et al. · BMJ Open access 26 Jan 2007 440
28 A review of thalidomide's history and current dermatological applications Anthony J. Perri, Sylvia Hsu · Dermatology Online Journal Open access 2003 433
29 Randomised comparison of thalidomide versus placebo in toxic epidermal necrolysis P. Wolkenstein, Jacques Latarjet, Jean‐Claude Roujeau et al. · The Lancet Nov 1998 430
30 TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells Stephan R. Krutzik, Belinda H. Tan, Huiying Li et al. · Nature Medicine Open access 8 May 2005 404
31 Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects - Part 1 Joel Carlos Lastória, Marilda Aparecida Milanêz Morgado de Abreu · Anais Brasileiros de Dermatologia Open access Apr 2014 404
32 Recent developments in Bell's palsy N. Julian Holland, Graeme M. Weiner · BMJ Open access 2 Sep 2004 399
33 Disability in people affected by leprosy: the role of impairment, activity, social participation, stigma and discrimination Wim H. van Brakel, Benyamin Sihombing, Hernani Djarir et al. · Global Health Action Open access 19 Jul 2012 398
34 Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses Rosane M. B. Teles, Thomas G. Graeber, Stephan R. Krutzik et al. · Science Open access Mar 2013 396
35 Comparative genomic and phylogeographic analysis of Mycobacterium leprae Marc Monot et al. · Nature Genetics Open access Nov 2009 396
36 Defining protective responses to pathogens: cytokine profiles in leprosy lesions Masayuki Yamamura, Koichi Uyemura, RJ Deans et al. · Science 11 Oct 1991 392
37 Divergent T-cell cytokine patterns in inflammatory arthritis. Anna Katharina Simon, Eva M. Seipelt, J. Sieper · Proceedings of the National Academy of Sciences Open access 30 Aug 1994 380
38 2021 DORIS definition of remission in SLE: final recommendations from an international task force Ronald van Vollenhoven et al. · Lupus Science & Medicine Open access Nov 2021 376
39 Probable Zoonotic Leprosy in the Southern United States Richard W. Truman, Pushpendra Singh, Rahul Sharma et al. · New England Journal of Medicine Open access 27 Apr 2011 372
40 The Influence of Thalidomide on the Clinical and Immunologic Manifestation of Erythema Nodosum Leprosum Elizabeth Pereira Sampaio, Gilla Kaplan, Antônio Basílio de Miranda et al. · The Journal of Infectious Diseases Aug 1993 371
41 Rediscovering thalidomide: A review of its mechanism of action, side effects, and potential uses S S Tseng, Grace Pak, Kenneth Washenik et al. · Journal of the American Academy of Dermatology Open access Dec 1996 370
42 Cytokine patterns in the pathogenesis of human leishmaniasis. Claude Pirmez, Masayuki Yamamura, Koichi Uyemura et al. · Journal of Clinical Investigation Open access Apr 1993 366
43 Genome-Wide Comparison of Medieval and Modern Mycobacterium leprae Verena J. Schuenemann et al. · Science Open access 14 Jun 2013 363
44 Safety of doxycycline and minocycline: A systematic review K. A. Smith, James J. Leyden · Clinical Therapeutics Review Sep 2005 356
45 Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. Ian M. Orme, A. D. Roberts, J P Griffin et al. · The Journal of Immunology Jul 1993 356
46 Natural History of Bell's Palsy Erik Peitersen · Acta Oto-Laryngologica 1992 355
47 Clinical Pharmacokinetics of Doxycycline and Minocycline Sylvie Saivin, Georges Houin · Clinical Pharmacokinetics Dec 1988 355
48 Activation and regulation of Toll-like receptors 2 and 1 in human leprosy Stephan R. Krutzik, Marîa Teresa Ochoa, Peter A. Sieling et al. · Nature Medicine Open access 14 Apr 2003 355
49 Visual hallucinations in Parkinson's disease: a review and phenomenological survey James B. Barnes · Journal of Neurology Neurosurgery & Psychiatry Open access Jun 2001 348
50 Minocycline in Rheumatoid Arthritis: A 48-Week, Double-Blind, Placebo-Controlled Trial Barbara C. Tilley, Graciela S. Alarcon, Stephen P. Heyse et al. · Annals of Internal Medicine 15 Jan 1995 343

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.