Most cited papers in Lipid metabolism and biosynthesis
What are the most cited papers in Lipid metabolism and biosynthesis?
The most cited paper in Lipid metabolism and biosynthesis is "Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol" (William R. Morrison, Lloyd M. Smith, 1964), with 6,001 citations. Next come "Regulation of the mevalonate pathway" (5,449) and "Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters." (4,765).
Showing 50 of 100 papers. Every paper with more than 1,096 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol William R. Morrison, Lloyd M. Smith · Journal of Lipid Research | Oct 1964 | 6,001 |
| 2 | Regulation of the mevalonate pathway Joseph L. Goldstein, Michael S. Brown · Nature | Feb 1990 | 5,449 |
| 3 | Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. Marco T. Castagna, Yoshimi Takai, Kozo Kaibuchi et al. · Journal of Biological Chemistry | Jul 1982 | 4,765 |
| 4 | Lipid Rafts As a Membrane-Organizing Principle Daniel Lingwood, Kai Simons · Science | 31 Dec 2009 | 4,485 |
| 5 | Metabolism of Isolated Fat Cells Martin Rodbell · Journal of Biological Chemistry | Feb 1964 | 4,432 |
| 6 | SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver Jay D. Horton, Joseph L. Goldstein, Michael Scott Brown · Journal of Clinical Investigation | May 2002 | 4,078 |
| 7 | Autophagy regulates lipid metabolism Rajat Singh, Susmita Kaushik, Yongjun Wang et al. · Nature | Apr 2009 | 4,022 |
| 8 | Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains Markus Ritter, Sabine Schmidt, Martin Jakab et al. · Cellular Physiology and Biochemistry | 2013 | 3,933 |
| 9 | Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor Peter Tontonoz, Erding Hu, Bruce M. Spiegelman · Cell | Dec 1994 | 3,551 |
| 10 | Discovery and refinement of loci associated with lipid levels Cristen J. Willer et al. · Nature Genetics | 6 Oct 2013 | 3,319 |
| 11 | Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots George Rouser, Sidney Fleischer, Akira Yamamoto · Lipids | May 1970 | 3,301 |
| 12 | Quantitative Determination of Serum Triglycerides by the Use of Enzymes Giovanni Bucolo, H David · Clinical Chemistry | May 1973 | 3,206 |
| 13 | Functional Brown Adipose Tissue in Healthy Adults Kirsi A. Virtanen, Martin E. Lidell, Janne Orava et al. · New England Journal of Medicine | 8 Apr 2009 | 3,085 |
| 14 | Mechanisms of Insulin Action and Insulin Resistance Max C. Petersen, Gerald I. Shulman · Physiological Reviews | Aug 2018 | 3,051 |
| 15 | Dynamics and functions of lipid droplets James A. Olzmann, Pedro Carvalho · Nature Reviews Molecular Cell Biology | 6 Dec 2018 | 2,853 |
| 16 | Early allopolyploid evolution in the post-Neolithic Brassica napus oilseed genome Boulos Chalhoub et al. · Science | 21 Aug 2014 | 2,644 |
| 17 | Insect Fat Body: Energy, Metabolism, and Regulation Estela L. Arrese, José L. Soulages · Annual Review of Entomology | 2 Sep 2009 | 2,589 |
| 18 | Lipid extraction of tissues with a low-toxicity solvent Atsushi Hara, Norman S. Radin · Analytical Biochemistry | Oct 1978 | 2,568 |
| 19 | The plasma lecithin:cholesterol acyltransferase reaction John A. Glomset · Journal of Lipid Research | Mar 1968 | 2,420 |
| 20 | Direct transesterification of all classes of lipids in a one-step reaction. Guy Lepage, Claudie Roy · Journal of Lipid Research | Nov 1986 | 2,407 |
| 21 | PRDM16 controls a brown fat/skeletal muscle switch Patrick Seale, Bryan C. Bjork, Wenli Yang et al. · Nature | Aug 2008 | 2,369 |
| 22 | SUGAR SENSING AND SIGNALING IN PLANTS: Conserved and Novel Mechanisms Filip Rolland, Elena Baena Gonzalez, Jen Sheen · Annual Review of Plant Biology | 7 Apr 2006 | 2,354 |
| 23 | Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes Adı́lson Guilherme, Joseph V. Virbasius, Vishwajeet Puri et al. · Nature Reviews Molecular Cell Biology | 10 Apr 2008 | 2,310 |
| 24 | Mechanisms for Insulin Resistance: Common Threads and Missing Links Varman T. Samuel, Gerald I. Shulman · Cell | Mar 2012 | 2,275 |
| 25 | Omega-3 fatty acids in health and disease and in growth and development AP Simopoulos · American Journal of Clinical Nutrition | Sep 1991 | 2,172 |
| 26 | Metabolic control through the PGC-1 family of transcription coactivators Jiandie D. Lin, Christoph Handschin, Bruce M. Spiegelman · Cell Metabolism | Jun 2005 | 2,150 |
| 27 | Understanding the diversity of membrane lipid composition T. HARAYAMA, Howard Riezman · Nature Reviews Molecular Cell Biology | 7 Feb 2018 | 2,144 |
| 28 | Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase Robert Zimmermann, Juliane Gertrude Bogner‐Strauß, Guenter Haemmerle et al. · Science | 18 Nov 2004 | 2,135 |
| 29 | Triglyceride accumulation protects against fatty acid-induced lipotoxicity Laura L. Listenberger, Xianlin Han, Sarah Elizabeth Lewis et al. · Proceedings of the National Academy of Sciences | 10 Mar 2003 | 2,126 |
| 30 | Human Fatty Liver Disease: Old Questions and New Insights Jonathan C. Cohen, Jay D. Horton, Helen H. Hobbs · Science | 24 Jun 2011 | 2,097 |
| 31 | PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro Evan D. Rosen, Pasha Sarraf, Amy E. Troy et al. · Molecular Cell | Oct 1999 | 2,089 |
| 32 | Mechanisms and regulation of cholesterol homeostasis Jie Luo, Hongyuan Yang, Bao‐Liang Song · Nature Reviews Molecular Cell Biology | 17 Dec 2019 | 2,064 |
| 33 | Microtubule Assembly in the Absence of Added Nucleotides Michael L. Shelanski, Felicia Gaskin, Charles R. Cantor · Proceedings of the National Academy of Sciences | Mar 1973 | 2,062 |
| 34 | Oxidative Modifications to Cellular Components in Plants Ian Max Møller, Poul Erik Jensen, Andreas Hansson · Annual Review of Plant Biology | 16 Feb 2007 | 1,954 |
| 35 | Rapid phosphatidic acid accumulation in response to low temperature stress in Arabidopsis is generated through diacylglycerol kinase Steven A. Arisz, Ringo van Wijk, Wendy Roels et al. · Frontiers in Plant Science | 2013 | 1,938 |
| 36 | Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperature Oliver Berger, Olle Edholm, Fritz Jähnig · Biophysical Journal | May 1997 | 1,873 |
| 37 | A comprehensive classification system for lipids Eoin Fahy, Shankar Subramaniam, H. Alex Brown et al. · Journal of Lipid Research | 16 Feb 2005 | 1,865 |
| 38 | Lipid polymorphism and the functional roles of lipids in biological membranes Pieter R. Cullis, Ben de Kruijff · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes | Dec 1979 | 1,862 |
| 39 | Transcriptional control of adipocyte formation Stephen R. Farmer · Cell Metabolism | Oct 2006 | 1,835 |
| 40 | Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism Bart Staels, Jean Dallongeville, Johan H. Auwerx et al. · Circulation | 10 Nov 1998 | 1,802 |
| 41 | Trans Fatty Acids and Cardiovascular Disease Dariush Mozaffarian, Mira Katan, Alberto Ascherio et al. · New England Journal of Medicine | 12 Apr 2006 | 1,774 |
| 42 | Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum. Yukio Fujiki, A L Hubbard, Stanley Fowler et al. · The Journal of Cell Biology | Apr 1982 | 1,768 |
| 43 | Lipid Droplets and Cellular Lipid Metabolism Tobias C. Walther, Robert V. Farese · Annual Review of Biochemistry | 22 May 2012 | 1,730 |
| 44 | Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins Yuan Lin, David S.W. Protter, Michael K. Rosen et al. · Molecular Cell | 24 Sep 2015 | 1,730 |
| 45 | The multifaceted roles of fatty acid synthesis in cancer Florian Röhrig, Almut Schulze · Nature reviews. Cancer | 23 Sep 2016 | 1,718 |
| 46 | Reprogramming of fatty acid metabolism in cancer Nikos Koundouros, George Poulogiannis · British Journal of Cancer | 9 Dec 2019 | 1,680 |
| 47 | Newly identified loci that influence lipid concentrations and risk of coronary artery disease Cristen J. Willer et al. · Nature Genetics | 13 Jan 2008 | 1,609 |
| 48 | Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein Michael Ohh, Cheol Won Park, Mircea Ivan et al. · Nature Cell Biology | 9 Jun 2000 | 1,605 |
| 49 | Acyl-Lipid Metabolism Yonghua Li‐Beisson et al. · The Arabidopsis Book | 2013 | 1,575 |
| 50 | The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease Jelske N. van der Veen, John Paul Kennelly, Sereana Wan et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes | 11 Apr 2017 | 1,569 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.