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Most cited papers in melanin and skin pigmentation

What are the most cited papers in melanin and skin pigmentation?

The most cited paper in melanin and skin pigmentation is "A biomarker that identifies senescent human cells in culture and in aging skin in vivo." (Goberdhan P. Dimri, X Lee, George Basile et al., 1995), with 7,565 citations. Next come "Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains" (3,039) and "Distinct Sets of Genetic Alterations in Melanoma" (2,732).

Showing 50 of 100 papers. Every paper with more than 728 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences Open access 26 Sep 1995 7,565
2 Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains Patrick L. McGeer, Shigeru Itagaki, Barry E. Boyes et al. · Neurology Aug 1988 3,039
3 Distinct Sets of Genetic Alterations in Melanoma John A. Curtin, Jane Fridlyand, Toshiro Kageshita et al. · New England Journal of Medicine Open access 16 Nov 2005 2,732
4 Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal Stanley Cohen · Journal of Biological Chemistry Open access May 1962 2,204
5 BRAFE600-associated senescence-like cell cycle arrest of human naevi Chrysiis Michaloglou, Liesbeth C.W. Vredeveld, Marı́a S. Soengas et al. · Nature Open access Aug 2005 2,159
6 Tyrosine Hydroxylase Toshiharu Nagatsu, Morton H. Levitt, Sidney Udenfriend · Journal of Biological Chemistry Open access Sep 1964 2,062
7 Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation Andrzej T. Slominski, Desmond John Tobin, Shigeki Shibahara et al. · Physiological Reviews Review 21 Sep 2004 2,030
8 UV Radiation and the Skin John August D'Orazio, Stuart Gordon Jarrett, Alexandra Amaro-Ortiz et al. · International Journal of Molecular Sciences Open access 7 Jun 2013 1,979
9 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome Wei Fan, Bruce A. Boston, Robert A. Kesterson et al. · Nature 1997 1,922
10 Highly Recurrent TERT Promoter Mutations in Human Melanoma Franklin W. Huang, Eran Hodis, Mary Jue Xu et al. · Science Open access 24 Jan 2013 1,867
11 Calcium regulation of growth and differentiation of mouse epidermal cells in culture Henry Hennings, Delores Michael, Christina Cheng et al. · Cell 1980 1,822
12 Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans Heiko Krude, Heike Biebermann, Werner A. P. Luck et al. · Nature Genetics Jun 1998 1,741
13 The Protective Role of Melanin Against UV Damage in Human Skin † Michaela Brenner, Vincent J. Hearing · Photochemistry and Photobiology Open access 16 Nov 2007 1,722
14 Kinetic studies of pigment synthesis by non‐sulfur purple bacteria Germaine Cohen-Bazire, William R. Sistrom, Roger Y. Stanier · Journal of Cellular and Comparative Physiology Feb 1957 1,622
15 Anatomy and regulation of the central melanocortin system Roger D. Cone · Nature Neuroscience 26 Apr 2005 1,586
16 Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma Levi A. Garraway, Hans R. Widlund, Mark Andrew Rubin et al. · Nature Jul 2005 1,560
17 An Updated Review of Tyrosinase Inhibitors Te‐Sheng Chang · International Journal of Molecular Sciences Open access 26 May 2009 1,555
18 Aromatic Amino Acids and Modification of Parkinsonism George C. Cotzias, Melvin H. Van Woert, Lewis M. Schiffer · New England Journal of Medicine 16 Feb 1967 1,499
19 Melanoma biology and new targeted therapy Vanessa C. Gray‐Schopfer, Claudia Wellbrock, Richard Marais · Nature 21 Feb 2007 1,397
20 Melanocyte biology and skin pigmentation Jennifer Y. Lin, David E. Fisher · Nature Feb 2007 1,391
21 Melanoma Arlo J. Miller, Martín C. Mihm · New England Journal of Medicine 6 Jul 2006 1,347
22 The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene E N Geissler, Melanie A. Ryan, David E. Housman · Cell Oct 1988 1,326
23 Toxic effects of ultraviolet radiation on the skin Yasuhiro Matsumura, Honnavara N. Ananthaswamy · Toxicology and Applied Pharmacology 11 Dec 2003 1,274
24 Tyrosinase: a comprehensive review of its mechanism Álvaro Sánchez‐Ferrer, José Neptuno Rodríguez‐López, Francisco Garcı́a-Cánovas et al. · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology Feb 1995 1,245
25 The evolution of human skin coloration Nina G. Jablonski, George Chaplin · Journal of Human Evolution Jul 2000 1,237
26 Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma Michael O. Krauthammer et al. · Nature Genetics Open access 29 Jul 2012 1,221
27 Molecular regulation of stem cell quiescence Tom H. Cheung, Thomas A. Rando · Nature Reviews Molecular Cell Biology ReviewOpen access 23 May 2013 1,188
28 MITF: master regulator of melanocyte development and melanoma oncogene Carmit Levy, Mehdi Khaled, David E. Fisher · Trends in Molecular Medicine Review 9 Aug 2006 1,182
29 Review: Ultraviolet radiation and skin cancer Deevya L. Narayanan, Rao N. Saladi, JOSHUA L. FOX · International Journal of Dermatology 30 Aug 2010 1,182
30 Human Keratinocytes That Express hTERT and Also Bypass a p16 INK4a -Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics Mark Andrew Dickson, William C. Hahn, Yasushi Ino et al. · Molecular and Cellular Biology Open access Feb 2000 1,122
31 Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein Colin A. Hodgkinson, Karen J. Moore, Atsuo Nakayama et al. · Cell Jul 1993 1,111
32 Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis Pavida Pittayapruek, Jitlada Meephansan, Ornicha Prapapan et al. · International Journal of Molecular Sciences Open access 2 Jun 2016 1,103
33 Oxidative Pathways for Catecholamines in the Genesis of Neuromelanin and Cytotoxic Quinones Doyle G. Graham · Molecular Pharmacology Jul 1978 1,102
34 Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms Joi A. Nichols, Santosh K. Katiyar · Archives of Dermatological Research Open access 6 Nov 2009 1,100
35 Acne vulgaris Hywel C Williams, Robert Paul Dellavalle, Sarah E. Garner · The Lancet 31 Aug 2011 1,098
36 Oxidative Stress in the Pathogenesis of Skin Disease David R. Bickers, Mohammad S. Athar · Journal of Investigative Dermatology Open access 16 Nov 2006 1,093
37 The Genetic Evolution of Melanoma from Precursor Lesions Alan Hunter Shain, Iwei Yeh, Ivanka Kovalyshyn et al. · New England Journal of Medicine Open access 11 Nov 2015 1,091
38 Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor Dongsi Lu, Derril H. Willard, Indravadan R. Patel et al. · Nature Oct 1994 1,086
39 A comprehensive review on tyrosinase inhibitors Samaneh Zolghadri, Asieh Bahrami, Mahmud Tareq Hassan Khan et al. · Journal of Enzyme Inhibition and Medicinal Chemistry Open access 2019 1,081
40 Signaling Pathways in Melanogenesis Stacey Ann N. D’mello, Graeme J. Finlay, Bruce C. Baguley et al. · International Journal of Molecular Sciences Open access 15 Jul 2016 1,080
41 SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans Rebecca L. Lamason et al. · Science 15 Dec 2005 1,076
42 Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future Y.-J. Kim, Hiroshi Uyama · Cellular and Molecular Life Sciences Open access 15 May 2005 1,067
43 Oxidative Stress in Aging Human Skin Mark Rinnerthaler, Johannes Bischof, Maria Karolin Streubel et al. · Biomolecules Open access 21 Apr 2015 1,054
44 Structure of Polydopamine: A Never-Ending Story? Jürgen Liebscher, Radosław Mrówczyński, Holger A. Scheidt et al. · Langmuir 22 Jul 2013 1,054
45 The physical and chemical properties of eumelanin Paul Meredith, Tadeusz Sarna · Pigment Cell Research Open access 20 Oct 2006 1,041
46 Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin Linda R. Yaswen, Nicole L. Diehl, Miles B. Brennan et al. · Nature Medicine Sep 1999 1,028
47 Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response. Sven‐Erik Dahlén, J Björk, Per Hedqvist et al. · Proceedings of the National Academy of Sciences Open access Jun 1981 1,027
48 Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice Kiminori Hosoda, Robert E. Hammer, James A. Richardson et al. · Cell Dec 1994 1,016
49 Variants of the melanocyte–stimulating hormone receptor gene are associated with red hair and fair skin in humans Paloma Valverde, Eugene Healy, Ian J. Jackson et al. · Nature Genetics Nov 1995 1,013
50 Laccases: a never-ending story Paola Giardina, Vincenza Faraco, Cinzia Pezzella et al. · Cellular and Molecular Life Sciences Open access 21 Oct 2009 1,005

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.