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Most cited papers in Metabolomics and Mass Spectrometry Studies

Metabolomics and Mass Spectrometry Studies

What are the most cited papers in Metabolomics and Mass Spectrometry Studies?

The most cited paper in Metabolomics and Mass Spectrometry Studies is "Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction" (Hiroshi Ohkawa, Nobuko Ohishi, Kunio Yagi, 1979), with 29,425 citations. Next come "Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2" (25,165) and "Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents" (24,756).

Showing 50 of 98 papers. Every paper with more than 2,568 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Hiroshi Ohkawa, Nobuko Ohishi, Kunio Yagi · Analytical Biochemistry Jun 1979 29,425
2 Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 Evan K Bolyen et al. · Nature Biotechnology Open access112 authors 24 Jul 2019 25,165
3 Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents Vernon L. Singleton, Joseph A. Rossi · American Journal of Enology and Viticulture 1965 24,756
4 Metagenomic biomarker discovery and explanation Nicola Segata, Jacques Izard, Levi D. Waldron et al. · Genome biology Open access 24 Jun 2011 17,136
5 NMRPipe: A multidimensional spectral processing system based on UNIX pipes Frank Delaglio, Stephan Grzesiek, Geerten W. Vuister et al. · Journal of Biomolecular NMR Nov 1995 16,465
6 MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification Jürgen Cox, Matthias Mann · Nature Biotechnology 23 Nov 2008 15,998
7 Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. Laurent Excoffier, Peter E. Smouse, Joseph M. Quattro · Genetics Open access Jun 1992 14,110
8 clusterProfiler 4.0: A universal enrichment tool for interpreting omics data Tianzhi Wu, Erqiang Hu, Shuangbin Xu et al. · The Innovation Open access Jul 2021 13,194
9 The Perseus computational platform for comprehensive analysis of (prote)omics data Stefka Tyanova, Tikira Temu, Pavel G. Sinitcyn et al. · Nature Methods Open access 27 Jun 2016 9,121
10 Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels Andrej Shevchenko, Matthias S. Wilm, Ole Vorm et al. · Analytical Chemistry Mar 1996 9,120
11 DrugBank 5.0: a major update to the DrugBank database for 2018 David Scott Wishart et al. · Nucleic Acids Research Open access 4 Nov 2017 9,014
12 Protein Identification and Analysis Tools on the ExPASy Server Elisabeth Gasteiger, Christine Hoogland, Alexandre Gattiker et al. · Humana Press eBooks Book chapterOpen access 2005 8,916
13 Universal sample preparation method for proteome analysis Jacek R. Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj et al. · Nature Methods 19 Apr 2009 8,878
14 THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM Richard J. Havel, Howard A. Eder, Joseph H. Bragdon · Journal of Clinical Investigation Open access Sep 1955 8,822
15 A simplification of the protein assay method of Lowry et al. which is more generally applicable Gary L. Peterson · Analytical Biochemistry Dec 1977 8,575
16 Probability-based protein identification by searching sequence databases using mass spectrometry data David N. Perkins, Darryl Pappin, David M. Creasy et al. · Electrophoresis Dec 1999 8,335
17 The PRIDE database and related tools and resources in 2019: improving support for quantification data Yasset Pérez‐Riverol et al. · Nucleic Acids Research Open access 22 Oct 2018 7,481
18 A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY Open access Apr 1999 7,022
19 PICRUSt2 for prediction of metagenome functions Gavin M. Douglas, Vincent J. Maffei, Jesse Zaneveld et al. · Nature Biotechnology Open access Jun 2020 7,006
20 A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples Mary Ann K. Markwell, Suzanne M. Haas, LORAN L. BIEBER et al. · Analytical Biochemistry Jun 1978 6,504
21 The Human Microbiome Project Peter James Turnbaugh, Ruth E. Ley, Micah Hamady et al. · Nature Open access 17 Oct 2007 6,235
22 Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease Zeneng Wang, Elizabeth Klipfell, Brian J. Bennett et al. · Nature Open access Apr 2011 5,702
23 PubChem Substance and Compound databases Sunghwan Kim, Paul A Thiessen, Evan Bolton et al. · Nucleic Acids Research Open access 22 Sep 2015 5,614
24 Quality control and preprocessing of metagenomic datasets Robert Schmieder, Robert Alan Edwards · Bioinformatics Open access 28 Jan 2011 5,477
25 XCMS: Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment, Matching, and Identification Colin A. Smith, Elizabeth J. Want, Grace O’Maille et al. · Analytical Chemistry 7 Jan 2006 5,419
26 An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea Daniel T. McDonald, Morgan N. Price, Julia K. Goodrich et al. · The ISME Journal Open access Dec 2011 5,371
27 Proposed minimum reporting standards for chemical analysis Lloyd W. Sumner et al. · Metabolomics Open access 11 Sep 2007 5,359
28 The MaxQuant computational platform for mass spectrometry-based shotgun proteomics Stefka Tyanova, Tikira Temu, Jüergen Cox · Nature Protocols 27 Oct 2016 5,351
29 In-gel digestion for mass spectrometric characterization of proteins and proteomes Andrej Shevchenko, Henrik Tomas, J. Havli et al. · Nature Protocols Dec 2006 5,186
30 How good are my data and what is the resolution? Philip Rainsford Evans, Garib N. Murshudov · Acta Crystallographica Section D Biological Crystallography Open access 12 Jun 2013 5,147
31 Skyline: an open source document editor for creating and analyzing targeted proteomics experiments Brendan MacLean, Daniela M. Tomazela, Nicholas Shulman et al. · Bioinformatics Open access 9 Feb 2010 5,063
32 A Statistical Model for Identifying Proteins by Tandem Mass Spectrometry Alexey I. Nesvizhskii, Andrew Keller, Eugene Kolker et al. · Analytical Chemistry 15 Jul 2003 5,023
33 Empirical Statistical Model To Estimate the Accuracy of Peptide Identifications Made by MS/MS and Database Search Andrew Keller, Alexey I. Nesvizhskii, Eugene Kolker et al. · Analytical Chemistry 12 Sep 2002 5,013
34 Why do cancers have high aerobic glycolysis? Robert A. Gatenby, Robert J. Gillies · Nature reviews. Cancer Review Nov 2004 4,841
35 Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking Mingxun Wang et al. · Nature Biotechnology Open access127 authors Aug 2016 4,812
36 Metagenomic Analysis of the Human Distal Gut Microbiome Steven R. Gill, Mihai Pop, Robert T. DeBoy et al. · Science Open access Jun 2006 4,702
37 A cross-platform toolkit for mass spectrometry and proteomics Matthew Chambers et al. · Nature Biotechnology Open access Oct 2012 4,457
38 Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis Robert Koeth et al. · Nature Medicine Open access 7 Apr 2013 4,454
39 MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights Zhiqiang Pang, Jasmine Chong, Guangyan Zhou et al. · Nucleic Acids Research Open access 28 Apr 2021 4,235
40 Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry Joshua Eric Elias, Steven P. Gygi · Nature Methods 27 Feb 2007 4,142
41 PubChem in 2021: new data content and improved web interfaces Sunghwan Kim, Jie Chen, Tiejun Cheng et al. · Nucleic Acids Research Open access 12 Oct 2020 4,131
42 Functional cartography of complex metabolic networks Roger Guimerà, Luı́s A. Nunes Amaral · Nature Open access Feb 2005 4,113
43 mixOmics: An R package for ‘omics feature selection and multiple data integration Florian Rohart, Benoît Gautier, Amrit Singh et al. · PLoS Computational Biology Open access 3 Nov 2017 4,107
44 ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap Tauno Metsalu, Jaak Vilo · Nucleic Acids Research Open access 12 May 2015 4,030
45 MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data Tomáš Pluskal, Sandra D. Castillo, Alejandro Villar‐Briones et al. · BMC Bioinformatics Open access 23 Jul 2010 4,019
46 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Jeremy Kirk Nicholson, John C. Lindon, Elaine C. Holmes · Xenobiotica 1999 3,918
47 MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis Jasmine Chong, Othman Soufan, Carin Li et al. · Nucleic Acids Research Open access 13 Apr 2018 3,876
48 Estimation of metabolite concentrations from localized in vivo proton NMR spectra Stephen W. Provencher · Magnetic Resonance in Medicine Dec 1993 3,732
49 2016 update of the PRIDE database and its related tools Juan Antonio Vizcaíno, Attila Csordás, Noemí del‐Toro et al. · Nucleic Acids Research Open access 2 Nov 2015 3,695
50 HMDB 4.0: the human metabolome database for 2018 David Scott Wishart et al. · Nucleic Acids Research Open access 23 Oct 2017 3,621

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.