Most cited papers in Microbial Natural Products and Biosynthesis
What are the most cited papers in Microbial Natural Products and Biosynthesis?
The most cited paper in Microbial Natural Products and Biosynthesis is "Click Chemistry: Diverse Chemical Function from a Few Good Reactions" (Hartmuth Christian Kolb, M. G. Finn, Karl Barry Sharpless, 2001), with 13,223 citations. Next come "Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019" (7,078) and "LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery" (6,702).
Showing 50 of 99 papers. Every paper with more than 1,260 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Click Chemistry: Diverse Chemical Function from a Few Good Reactions Hartmuth Christian Kolb, M. G. Finn, Karl Barry Sharpless · Angewandte Chemie International Edition | Jun 2001 | 13,223 |
| 2 | Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019 David J. Newman, Gordon M. L. Cragg · Journal of Natural Products | 12 Mar 2020 | 7,078 |
| 3 | LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery Roman A. Laskowski, Mark Basil Swindells · Journal of Chemical Information and Modeling | 5 Oct 2011 | 6,702 |
| 4 | Natural Products as Sources of New Drugs from 1981 to 2014 David J. Newman, Gordon M. L. Cragg · Journal of Natural Products | 7 Feb 2016 | 5,967 |
| 5 | Natural Products as Sources of New Drugs over the Last 25 Years David J. Newman, Gordon M. L. Cragg · Journal of Natural Products | 20 Feb 2007 | 5,531 |
| 6 | Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study Yiyun Liu, Yang Wang, Timothy Rutland Walsh et al. · The Lancet Infectious Diseases | 18 Nov 2015 | 5,509 |
| 7 | Natural products in drug discovery: advances and opportunities Atanas G. Atanasov et al. · Nature Reviews Drug Discovery | 28 Jan 2021 | 5,395 |
| 8 | The National Center for Biotechnology Information D. A. Benson, Mark S. Boguski, David J. Lipman et al. · Genomics | Feb 1990 | 5,163 |
| 9 | Marine natural products D. J. Faulkner · Natural Product Reports | 1990 | 4,883 |
| 10 | Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010 David J. Newman, Gordon M. L. Cragg · Journal of Natural Products | 8 Feb 2012 | 4,699 |
| 11 | SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules Antoine Daina, Olivier Alain Michielin, Vincent Zoete · Nucleic Acids Research | May 2019 | 4,583 |
| 12 | ChEMBL: a large-scale bioactivity database for drug discovery Anna Gaulton, Louisa J. Bellis, A. Patrícia Bento et al. · Nucleic Acids Research | 23 Sep 2011 | 4,581 |
| 13 | Synthesis of Proteins by Native Chemical Ligation Philip E. Dawson, Tom W. Muir, Ian Clark‐Lewis et al. · Science | 4 Nov 1994 | 4,169 |
| 14 | ZINC − A Free Database of Commercially Available Compounds for Virtual Screening John J. Irwin, Brian K. Shoichet · Journal of Chemical Information and Modeling | 14 Dec 2004 | 4,130 |
| 15 | Two-Component Signal Transduction Ann Marie Stock, Victoria Robinson, Paul N. Goudreau · Annual Review of Biochemistry | Jun 2000 | 3,702 |
| 16 | ZINC 15 – Ligand Discovery for Everyone Teague Sterling, John J. Irwin · Journal of Chemical Information and Modeling | 19 Oct 2015 | 3,459 |
| 17 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) Stephen D. Bentley et al. · Nature | May 2002 | 3,297 |
| 18 | CDD: a Conserved Domain Database for the functional annotation of proteins Aron Marchler‐Bauer et al. · Nucleic Acids Research | 24 Nov 2010 | 3,277 |
| 19 | From genomics to chemical genomics: new developments in KEGG Minoru I. Kanehisa · Nucleic Acids Research | 28 Dec 2005 | 3,192 |
| 20 | antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline Kai Blin, Simon J. Shaw, Kat Steinke et al. · Nucleic Acids Research | 17 Apr 2019 | 3,159 |
| 21 | Natural Products as Sources of New Drugs over the Period 1981−2002 David J. Newman, Gordon M. L. Cragg, Kenneth M. Snader · Journal of Natural Products | 12 Jun 2003 | 3,095 |
| 22 | Discovery and resupply of pharmacologically active plant-derived natural products: A review Atanas G. Atanasov, Birgit Waltenberger, Eva‐Maria Pferschy‐Wenzig et al. · Biotechnology Advances | 15 Aug 2015 | 2,927 |
| 23 | Natural products: A continuing source of novel drug leads Gordon M. L. Cragg, David J. Newman · Biochimica et Biophysica Acta (BBA) - General Subjects | 18 Feb 2013 | 2,925 |
| 24 | CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database Baofeng Jia et al. · Nucleic Acids Research | 17 Oct 2016 | 2,884 |
| 25 | Production of the antimalarial drug precursor artemisinic acid in engineered yeast Dae‐Kyun Ro, Eric M. Paradise, Mario Ouellet et al. · Nature | 13 Apr 2006 | 2,875 |
| 26 | antiSMASH 6.0: improving cluster detection and comparison capabilities Kai Blin, Simon J. Shaw, Alexander Kloosterman et al. · Nucleic Acids Research | 19 Apr 2021 | 2,755 |
| 27 | The re-emergence of natural products for drug discovery in the genomics era Alan L. Harvey, RuAngelie Edrada‐Ebel, Ronald J. Quinn · Nature Reviews Drug Discovery | 23 Jan 2015 | 2,609 |
| 28 | The evolving role of natural products in drug discovery Frank E. Koehn, Guy T. Carter · Nature Reviews Drug Discovery | 24 Feb 2005 | 2,586 |
| 29 | Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery Stuart L. Schreiber · Science | 17 Mar 2000 | 2,579 |
| 30 | Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. Steven K. Hanks, Tony R. Hunter · PubMed | May 1995 | 2,542 |
| 31 | Drugs for bad bugs: confronting the challenges of antibacterial discovery David J Payne, Michael N. Gwynn, David J. Holmes et al. · Nature Reviews Drug Discovery | 8 Dec 2006 | 2,527 |
| 32 | Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase Tatsuya Tamaoki, Hisayo Nomoto, ISAMI TAKAHASHI et al. · Biochemical and Biophysical Research Communications | Mar 1986 | 2,475 |
| 33 | A new antibiotic kills pathogens without detectable resistance Losee Lucy Ling et al. · Nature | 5 Jan 2015 | 2,471 |
| 34 | APD3: the antimicrobial peptide database as a tool for research and education Guangshun Wang, Xia Li, Zhe Wang · Nucleic Acids Research | 23 Nov 2015 | 2,445 |
| 35 | Pyrrolidinyl‐Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents Chris V. Galliford, Karl A. Scheidt · Angewandte Chemie International Edition | 17 Oct 2007 | 2,429 |
| 36 | Antibiotics: past, present and future Matthew I. Hutchings, Andrew W. Truman, Barrie M. Wilkinson · Current Opinion in Microbiology | Oct 2019 | 2,428 |
| 37 | PLIP: fully automated protein–ligand interaction profiler Sebastian Salentin, Sven B. Schreiber, V. Joachim Haupt et al. · Nucleic Acids Research | 14 Apr 2015 | 2,422 |
| 38 | antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation Kai Blin, Simon J. Shaw, Hannah E. Augustijn et al. · Nucleic Acids Research | 4 May 2023 | 2,390 |
| 39 | Bioprospecting for Microbial Endophytes and Their Natural Products Gary Allan Strobel, Bryn Daisy · Microbiology and Molecular Biology Reviews | Dec 2003 | 2,371 |
| 40 | The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1 Steven K. Hanks, Tony Hunter · The FASEB Journal | May 1995 | 2,339 |
| 41 | Techniques for extraction and isolation of natural products: a comprehensive review Qingwen Zhang, Ligen Lin, Wen‐Cai Ye · Chinese Medicine | 17 Apr 2018 | 2,301 |
| 42 | How antibiotics kill bacteria: from targets to networks Michael A. Kohanski, Daniel J. Dwyer, James J. Collins · Nature Reviews Microbiology | 4 May 2010 | 2,297 |
| 43 | Antibacterial drug discovery in the resistance era Eric D. Brown, Gerard D. Wright · Nature | 2016 | 2,295 |
| 44 | Distribution of Menaquinones in Actinomycetes and Corynebacteria M.D. Collins, T. Pirouz, Michael Goodfellow et al. · Journal of General Microbiology | Jun 1977 | 2,293 |
| 45 | A Protein Interaction Map of Drosophila melanogaster Loïc Giot et al. · Science | 10 Nov 2003 | 2,282 |
| 46 | Taxonomy, Physiology, and Natural Products of Actinobacteria Essaïd Ait Barka, Parul Vatsa, Lisa Sanchez et al. · Microbiology and Molecular Biology Reviews | Mar 2016 | 2,267 |
| 47 | QSAR Modeling: Where Have You Been? Where Are You Going To? Artem R Cherkasov, Eugene N. Muratov, Denis Fourches et al. · Journal of Medicinal Chemistry | 18 Dec 2013 | 2,178 |
| 48 | Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature Paul G. Arnison et al. · Natural Product Reports | 20 Nov 2012 | 2,136 |
| 49 | antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences Marnix H. Medema, Kai Blin, Peter Cimermančič et al. · Nucleic Acids Research | 14 Jun 2011 | 2,083 |
| 50 | Drug Discovery and Natural Products: End of an Era or an Endless Frontier? Jesse W.-H. Li, John C. Vederas · Science | 9 Jul 2009 | 2,077 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.