Most cited papers in Nigella sativa pharmacological applications
What are the most cited papers in Nigella sativa pharmacological applications?
The most cited paper in Nigella sativa pharmacological applications is "A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol" (Ronald J.W. Lambert, Panagiotis N. Skandamis, Peter John Coote et al., 2001), with 2,452 citations. Next come "Antioxidant activity of Nigella sativa essential oil" (1,862) and "A review on therapeutic potential of Nigella sativa: A miracle herb" (1,437).
Showing 50 of 99 papers. Every paper with more than 246 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol Ronald J.W. Lambert, Panagiotis N. Skandamis, Peter John Coote et al. · Journal of Applied Microbiology | 12 Sep 2001 | 2,452 |
| 2 | Antioxidant activity of Nigella sativa essential oil M. Burits, Franz Bučar · Phytotherapy Research | 2000 | 1,862 |
| 3 | A review on therapeutic potential of Nigella sativa: A miracle herb Aftab Ahmad, Asif Husain, Mohd Abdul Mujeeb et al. · Asian Pacific Journal of Tropical Biomedicine | 28 Feb 2013 | 1,437 |
| 4 | Pharmacological and toxicological properties of Nigella sativa Badreldin H. Ali, Gerald Blunden · Phytotherapy Research | Apr 2003 | 1,126 |
| 5 | Discovery of curcumin, a component of golden spice, and its miraculous biological activities Subash C. Gupta, Sridevi Patchva, Wonil Koh et al. · Clinical and Experimental Pharmacology and Physiology | 24 Nov 2011 | 859 |
| 6 | Immunomodulatory and therapeutic properties of the Nigella sativa L. seed Mohamed Labib Salem · International Immunopharmacology | 2 Jul 2005 | 857 |
| 7 | Fixed Oil ofNigella sativaand Derived Thymoquinone Inhibit Eicosanoid Generation in Leukocytes and Membrane Lipid Peroxidation Peter J. Houghton, Rema Zarka, Beatriz de las Heras et al. · Planta Medica | Feb 1995 | 789 |
| 8 | The role of oxidative stress in the pathogenesis of multiple sclerosis: The need for effective antioxidant therapy Daniel Offen, Yossi Gilgun‐Sherki, Eldad Melamed · Journal of Neurology | Mar 2004 | 640 |
| 9 | Applications of novel drug delivery system for herbal formulations M. Ajazuddin, Shailendra Saraf · Fitoterapia | 13 May 2010 | 622 |
| 10 | Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action F.J. Álvarez-Martínez, Enrique Barrajón‐Catalán, María Herranz‐López et al. · Phytomedicine | 9 Jul 2021 | 557 |
| 11 | A Review on Anti-Inflammatory Activity of Monoterpenes Rita de Cássia da Silveira e Sá, Luciana Dantas Farias de Andrade, Damião Pergentino de Sousa · Molecules | 18 Jan 2013 | 554 |
| 12 | Thymoquinone: Potential cure for inflammatory disorders and cancer Chern Chiuh Woo, Alan Prem Kumar, Gautam Sethi et al. · Biochemical Pharmacology | 17 Oct 2011 | 543 |
| 13 | Thymoquinone and its therapeutic potentials Sara Darakhshan, Ali Bidmeshki Pour, Abasalt Hosseinzadeh Colagar et al. · Pharmacological Research | 5 Apr 2015 | 510 |
| 14 | Bioavailability enhancers of herbal origin: An overview Kritika Kesarwani, Rajiv Gupta · Asian Pacific Journal of Tropical Biomedicine | 26 Feb 2013 | 497 |
| 15 | The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa Mastour S. Al‐Ghamdi · Journal of Ethnopharmacology | Jun 2001 | 494 |
| 16 | Thymoquinone Is a Potent Superoxide Anion Scavenger Osama Ahmed Badary, Ragia A. Taha, Ayman M. Gamal El-Din et al. · Drug and Chemical Toxicology | 2003 | 453 |
| 17 | Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials Fikrat I. Abdullaev, Jesús Javier Espinosa-Aguirre · Cancer Detection and Prevention | 2004 | 434 |
| 18 | Thymoquinone: A promising anti-cancer drug from natural sources Hala U. Gali‐Muhtasib, Albert Roessner, Regine Schneider‐Stock · The International Journal of Biochemistry & Cell Biology | 9 Nov 2005 | 420 |
| 19 | Studies on the antimicrobial activity of Nigella sativa seed (black cumin) M. S. Hanafy, M.E. Hatem · Journal of Ethnopharmacology | Sep 1991 | 414 |
| 20 | Lead Phytochemicals for Anticancer Drug Development Sukhdev Singh, Bhupender Sharma, Shamsher S. Kanwar et al. · Frontiers in Plant Science | 8 Nov 2016 | 411 |
| 21 | Bioavailability of phytochemicals and its enhancement by drug delivery systems Farrukh Aqil, Radha Munagala, Jeyaprakash Jeyabalan et al. · Cancer Letters | 19 Feb 2013 | 400 |
| 22 | Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation Kamel Chaieb, Bochra Kouidhi, Hanene Jrah et al. · BMC Complementary and Alternative Medicine | 13 Apr 2011 | 397 |
| 23 | Natural product-based nanoformulations for cancer therapy: Opportunities and challenges Dharambir Kashyap, Hardeep Singh Tuli, Mükerrem Betül Yerer et al. · Seminars in Cancer Biology | 14 Aug 2019 | 391 |
| 24 | Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects Noriko Otsuki, Nam Hoang Dang, Emi Kumagai et al. · Journal of Ethnopharmacology | 7 Dec 2009 | 391 |
| 25 | Antioxidant therapy for treatment of inflammatory bowel disease: Does it work? Fabiana Andréa Moura, Kívia Queiroz de Andrade, Juliana Célia Farias dos Santos et al. · Redox Biology | 25 Oct 2015 | 388 |
| 26 | Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: A review Happy Agarwal, Amatullah Mustafa Nakara, Venkat Kumar Shanmugam · Biomedicine & Pharmacotherapy | 7 Dec 2018 | 381 |
| 27 | High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.) Omar A. Ghosheh, Abdulghani A. Houdi, Peter Anthony Crooks · Journal of Pharmaceutical and Biomedical Analysis | Apr 1999 | 379 |
| 28 | Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses Ebrahim M Yimer, Kald Beshir Tuem, Aman Karim et al. · Evidence-based Complementary and Alternative Medicine | 12 May 2019 | 377 |
| 29 | Review on Pharmacology of Cisplatin: Clinical Use, Toxicity and Mechanism of Resistance of Cisplatin Sara A. Aldossary · Biomedical & Pharmacology Journal | 7 Feb 2019 | 370 |
| 30 | Nigella sativa L.: Chemical composition and physicochemical characteristics of lipid fraction Salma Cheikh-Rouhou, Souhail Besbes, Basma Hentati et al. · Food Chemistry | 5 Apr 2006 | 370 |
| 31 | Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin Azam Hosseinzadeh, Seyed Kamran Kamrava, Mohammad Taghi Joghataei et al. · Journal of Pineal Research | 24 Aug 2016 | 364 |
| 32 | Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug Valiollah Hajhashemi, Alireza Ghannadi, Hadi Jafarabadi · Phytotherapy Research | Mar 2004 | 363 |
| 33 | Chemical Composition of the Fixed and Volatile Oils of Nigella sativa L. from Iran Bahman Nickavar, Faraz Mojab, Katayoun Javidnia et al. · Zeitschrift für Naturforschung C | Oct 2003 | 361 |
| 34 | Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways Tingfang Yi, Sung‐Gook Cho, Zhengfang Yi et al. · Molecular Cancer Therapeutics | Jul 2008 | 354 |
| 35 | The fractional inhibitory concentration (FIC) index as a measure of synergy Michael J. Hall, R.F. Middleton, Donald Westmacott · Journal of Antimicrobial Chemotherapy | 1983 | 352 |
| 36 | Moroccan Medicinal plants as inhibitors against SARS-CoV-2 main protease: Computational investigations Ilham Aanouz, Assia Belhassan, K. El-Khatabi et al. · Journal of Biomolecular Structure and Dynamics | 20 Apr 2020 | 348 |
| 37 | The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice M. R. Mahmoud, Hanan S. El‐Abhar, S. A. Saleh · Journal of Ethnopharmacology | Feb 2002 | 340 |
| 38 | PROTECTIVE EFFECT OF THYMOQUINONE AGAINST DOXORUBICIN–INDUCED CARDIOTOXICITY IN RATS: A POSSIBLE MECHANISM OF PROTECTION Mahmoud N. Nagi, Mahmoud Ahmed Mansour · Pharmacological Research | Mar 2000 | 335 |
| 39 | Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety Md. Abdul Hannan et al. · Nutrients | 24 May 2021 | 334 |
| 40 | Spices for Prevention and Treatment of Cancers Jie Zheng, Yue Zhou, Ya Li et al. · Nutrients | 12 Aug 2016 | 332 |
| 41 | Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT‐diaphorase in different tissues of mice: a possible mechanism of action Mahmoud Ahmed Mansour, Mahmoud N. Nagi, Aiman Saad El-Khatib et al. · Cell Biochemistry and Function | 18 Jan 2002 | 331 |
| 42 | Acute and chronic toxicity of Nigella sativa fixed oil A Zaoui, Yahia Cherrah, N. Mahassini et al. · Phytomedicine | 2002 | 330 |
| 43 | Radical Scavenging Activity of Black Cumin ( Nigella sativa L.), Coriander ( Coriandrum sativum L.), and Niger ( Guizotia abyssinica Cass.) Crude Seed Oils and Oil Fractions Mohamed Fawzy Ramadan, Lothar W. Kroh, Jörg-T. Mörsel · Journal of Agricultural and Food Chemistry | 24 Oct 2003 | 328 |
| 44 | Immune-Boosting, Antioxidant and Anti-inflammatory Food Supplements Targeting Pathogenesis of COVID-19 M. Mrityunjaya, V. Pavithra, R. Neelam et al. · Frontiers in Immunology | 7 Oct 2020 | 326 |
| 45 | Antimicrobial activity and chemical composition of Mentha pulegium L. essential oil Mohaddese Mahboubi, Ghasem Haghi · Journal of Ethnopharmacology | 28 Jul 2008 | 325 |
| 46 | Antimicrobial activity of essential oils and structurally related synthetic food additives towards selected pathogenic and beneficial gut bacteria Wenjin Si, Joshua Gong, Rong Tsao et al. · Journal of Applied Microbiology | 12 Dec 2005 | 321 |
| 47 | Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine Thirumurugan Gunasekaran, Tedesse Haile, Tedele Nigusse et al. · Asian Pacific Journal of Tropical Biomedicine | May 2014 | 317 |
| 48 | Targeting Nuclear Factor-κB Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis Gautam Sethi, Kwang Seok Ahn, Bharat Bhushan Aggarwal · Molecular Cancer Research | Jun 2008 | 316 |
| 49 | Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells Navdeep Chehl, Galina I. Chipitsyna, Qiaoke Gong et al. · HPB | Aug 2009 | 316 |
| 50 | Phytochemistry, pharmacology, and therapeutic uses of black seed ( Nigella sativa ) Wesam Kooti, Zahra Hasanzadeh-Noohi, Naim Sharafi-Ahvazi et al. · Chinese Journal of Natural Medicines | Oct 2016 | 312 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.