Most cited papers in Pharmacological Effects and Assays
What are the most cited papers in Pharmacological Effects and Assays?
The most cited paper in Pharmacological Effects and Assays is "The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review" (Laetitia Prut, Catherine Belzung, 2003), with 3,236 citations. Next come "Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts" (2,284) and "The Mechanism of Muscular Contraction" (1,970).
Showing 50 of 100 papers. Every paper with more than 532 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review Laetitia Prut, Catherine Belzung · European Journal of Pharmacology | Feb 2003 | 3,236 |
| 2 | Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts Michael R. Bristow, Robert Ginsburg, Wayne A. Minobe et al. · New England Journal of Medicine | 22 Jul 1982 | 2,284 |
| 3 | The Mechanism of Muscular Contraction Hugh Esmor Huxley · Science | 20 Jun 1969 | 1,970 |
| 4 | Genetics of Mouse Behavior: Interactions with Laboratory Environment John C. Crabbe, Douglas Wahłsten, Bruce C. Dudek · Science | 4 Jun 1999 | 1,704 |
| 5 | Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma ROMAIN A. PAUWELS, Claes-Göran Löfdahl, Dirkje Sjoukje Postma et al. · New England Journal of Medicine | 13 Nov 1997 | 1,524 |
| 6 | Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood Norman Orentreich∥, JOEL L. BRIND, Ronald L. Rizer et al. · The Journal of Clinical Endocrinology & Metabolism | Sep 1984 | 1,364 |
| 7 | GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function Daniel M. Rosenbaum, Vadim Cherezov, Michael A. Hanson et al. · Science | 25 Oct 2007 | 1,348 |
| 8 | Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Michael R. Bristow, Robert Ginsburg, Victor A.W.M. Umans et al. · Circulation Research | Sep 1986 | 1,330 |
| 9 | 3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists Arvid Carlsson, Margit Lindqvist, Tor Magnusson · Nature | 30 Nov 1957 | 1,277 |
| 10 | Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin Richard A. F. Dixon, Brian K. Kobilka, David J. Strader et al. · Nature | May 1986 | 1,275 |
| 11 | A Review of Antibiotic Use in Food Animals: Perspective, Policy, and Potential Timothy Landers, Bevin Cohen, Thomas E. Wittum et al. · Public Health Reports | 2012 | 1,273 |
| 12 | History of the Use of Antibiotic as Growth Promoters in European Poultry Feeds Jose I.R. Castanon · Poultry Science | Nov 2007 | 1,264 |
| 13 | Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor T J Murphy, R. Wayne Alexander, Kathy K. Griendling et al. · Nature | May 1991 | 1,258 |
| 14 | The Use of β-Agonists and the Risk of Death and near Death from Asthma Walter O. Spitzer, Samy Suissa, Pierre Ernst et al. · New England Journal of Medicine | 20 Feb 1992 | 1,229 |
| 15 | Journal of Sports Science and Medicine Matthew Stewart · Wilderness and Environmental Medicine | 22 Aug 2014 | 1,228 |
| 16 | Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range Mose Da Prada, Gerhard Zürcher · Life Sciences | Oct 1976 | 1,183 |
| 17 | Determination of titanium dioxide added as an inert marker in chicken digestibility studies F. Short, P. Gorton, Julian Wiseman et al. · Animal Feed Science and Technology | Jun 1996 | 1,139 |
| 18 | SEX‐HORMONE‐BINDING GLOBULIN David C. Anderson · Clinical Endocrinology | 1974 | 1,137 |
| 19 | The Salmeterol Multicenter Asthma Research Trial Harold S. Nelson, Scott T. Weiss, Eugene R. Bleecker et al. · CHEST Journal | 2006 | 1,117 |
| 20 | The beta adrenergic theory of the atopic abnormality in bronchial asthma Andor Szentivanyi · Journal of Allergy | Oct 1968 | 1,104 |
| 21 | Calculation of free and bound fractions of testosterone and estradiol-17β to human plasma proteins at body temperature Ragnar Södergård, Torbjörn Carl Bäckström, Vasant Shanbhag et al. · Journal of Steroid Biochemistry | Jun 1982 | 1,102 |
| 22 | Molecular Characterization of the Human β 3 -Adrenergic Receptor Laurent Jean Emorine, Stéfano Marullo, Marie‐M. BRIEND‐SUTREN et al. · Science | 8 Sep 1989 | 1,087 |
| 23 | A Method for the Fluorimetric Determination of Adrenaline and Noradrenaline in Tissues.1 Åke Bertler, Arvid Carlsson, Evald Rosengren · Acta Physiologica Scandinavica | Aug 1958 | 1,031 |
| 24 | The Conversion of Testosterone to 5α-Androstan-17β-ol-3-one by Rat Prostate in Vivo and in Vitro Nicholas Bruchovsky, Jean D. Wilson · Journal of Biological Chemistry | Apr 1968 | 1,026 |
| 25 | Methods to detect nitric oxide and its metabolites in biological samples Nathan S. Bryan, Matthew B. Grisham · Free Radical Biology and Medicine | 30 Apr 2007 | 1,003 |
| 26 | Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells Terence F. McDonald, Siegried Pelzer, W. Trautwein et al. · Physiological Reviews | Apr 1994 | 1,002 |
| 27 | Occurrence, partition and removal of pharmaceuticals in sewage water and sludge during wastewater treatment Aleksandra Jelić, Meritxell Gros, Antoni Ginebreda et al. · Water Research | 14 Nov 2010 | 993 |
| 28 | Administration of substances to laboratory animals: routes of administration and factors to consider. Patricia V. Turner, Thea Brabb, Cynthia A. Pekow et al. · PubMed | Sep 2011 | 991 |
| 29 | The use and control of nitrate and nitrite for the processing of meat products Karl‐Otto Honikel · Meat Science | 28 Jun 2007 | 962 |
| 30 | Two dopamine receptors: Biochemistry, physiology and pharmacology J.C. Stoof, John W. Kebabian · Life Sciences | Dec 1984 | 943 |
| 31 | Multicenter, Placebo-Controlled Trial of Lorcaserin for Weight Management Steven R. Smith, Neil J. Weissman, Christen M. Anderson et al. · New England Journal of Medicine | 14 Jul 2010 | 912 |
| 32 | Effects of Androgenic-Anabolic Steroids in Athletes Fred Hartgens, Harm Kuipers · Sports Medicine | 2004 | 875 |
| 33 | Transdermal Testosterone Gel Improves Sexual Function, Mood, Muscle Strength, and Body Composition Parameters in Hypogonadal Men1 Christina Wang, Ronald S. Swerdloff, Ali Iranmanesh et al. · The Journal of Clinical Endocrinology & Metabolism | Aug 2000 | 851 |
| 34 | Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors Jos�e E. Leysen, Frans H. L. Awouters, Ludo E. J. Kennis et al. · Life Sciences | Mar 1981 | 846 |
| 35 | A national reconnaissance for pharmaceuticals and other organic wastewater contaminants in the United States — II) Untreated drinking water sources Michael J. Focazio, Dana W. Kolpin, Kimberlee K. Barnes et al. · The Science of The Total Environment | 24 Apr 2008 | 843 |
| 36 | An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein Gianni Biolo, Kevin D. Tipton, Samuel Klein et al. · American Journal of Physiology-Endocrinology and Metabolism | Jul 1997 | 826 |
| 37 | Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor Katsutoshi Sasaki, Yoshiaki Yamano, Smriti Bardhan et al. · Nature | May 1991 | 814 |
| 38 | A functional basis for classification of α-adrenergic receptors Spencer Berthelsen, William A. Pettinger · Life Sciences | Sep 1977 | 802 |
| 39 | Progressive hypertrophy and heart failure in β 1 -adrenergic receptor transgenic mice Stefan Hanns Engelhardt, Lutz Hein, Frank Wiesmann et al. · Proceedings of the National Academy of Sciences | 8 Jun 1999 | 790 |
| 40 | Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses Erin E. Chambers, Diane M. Diehl, Ziling Lu et al. · Journal of Chromatography B | 8 Jan 2007 | 775 |
| 41 | Validation of bioanalytical LC–MS/MS assays: Evaluation of matrix effects Ann Van Eeckhaut, Katrien Lanckmans, Sophie Sarre et al. · Journal of Chromatography B | 14 Jan 2009 | 762 |
| 42 | The Heart and the Atrial Natriuretic Factor* M.-F. Cantin, Jacques J. Genest · Endocrine Reviews | Apr 1985 | 753 |
| 43 | Effects of Reducing or Discontinuing Inhaled Budesonide in Patients with Mild Asthma Tari Haahtela, Markku Järvinen, Tuomo Kava et al. · New England Journal of Medicine | 15 Sep 1994 | 748 |
| 44 | Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs Jonathan R.S. Arch, A. T. Ainsworth, Michael Anthony Cawthorne et al. · Nature | May 1984 | 731 |
| 45 | DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility Daniel J. Urban, Bryan L. Roth · The Annual Review of Pharmacology and Toxicology | 8 Oct 2014 | 710 |
| 46 | The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea‐pig ileum longitudinal muscle strip W. D. M. Paton, E. S. Vizi · British Journal of Pharmacology | 1969 | 710 |
| 47 | Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. Owen W. Griffith · Journal of Biological Chemistry | Nov 1982 | 706 |
| 48 | The pattern of energy metabolism in the mouse oöcyte and zygote. J. D. Biggers, D. G. Whittingham, Roger P. Donahue · Proceedings of the National Academy of Sciences | Aug 1967 | 703 |
| 49 | Marked Decline in Serum Concentrations of Adrenal C19 Sex Steroid Precursors and Conjugated Androgen Metabolites During Aging Fernand Labrie, Alain Bélanger, Lionel Cusan et al. · The Journal of Clinical Endocrinology & Metabolism | Aug 1997 | 701 |
| 50 | ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR* G. Alan Robison, Reginald W. Butcher, Earl W. Sutherland · Annals of the New York Academy of Sciences | Feb 1967 | 676 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.