Most cited papers in Phytochemical compounds biological activities
What are the most cited papers in Phytochemical compounds biological activities?
The most cited paper in Phytochemical compounds biological activities is "Natural Products as Sources of New Drugs from 1981 to 2014" (David J. Newman, Gordon M. L. Cragg, 2016), with 5,967 citations. Next come "Natural products in drug discovery: advances and opportunities" (5,395) and "Natural products: A continuing source of novel drug leads" (2,925).
Showing 50 of 100 papers. Every paper with more than 379 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Natural Products as Sources of New Drugs from 1981 to 2014 David J. Newman, Gordon M. L. Cragg · Journal of Natural Products | 7 Feb 2016 | 5,967 |
| 2 | Natural products in drug discovery: advances and opportunities Atanas G. Atanasov et al. · Nature Reviews Drug Discovery | 28 Jan 2021 | 5,395 |
| 3 | Natural products: A continuing source of novel drug leads Gordon M. L. Cragg, David J. Newman · Biochimica et Biophysica Acta (BBA) - General Subjects | 18 Feb 2013 | 2,925 |
| 4 | Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. Minoru Yoshida, Masako Kijima, Motomu Akita et al. · Journal of Biological Chemistry | Oct 1990 | 1,869 |
| 5 | Drug discovery from medicinal plants Marcy J. Balunas, Alan Douglas Kinghorn · Life Sciences | 30 Sep 2005 | 1,823 |
| 6 | Polyketide biosynthesis: a millennium review James Staunton, Kira J. Weissman · Natural Product Reports | 2001 | 1,652 |
| 7 | The Biosynthetic Logic of Polyketide Diversity Christian Hertweck · Angewandte Chemie International Edition | 9 Jun 2009 | 1,367 |
| 8 | Biology and biochemistry of proteinases in tumor invasion Paolo Mignatti, D. B. Rifkin · Physiological Reviews | 1993 | 1,256 |
| 9 | Antimicrobial properties of allicin from garlic Serge Ankri, David Mirelman · Microbes and Infection | Feb 1999 | 1,175 |
| 10 | Natural products to drugs: natural product-derived compounds in clinical trials Mark S. Butler · Natural Product Reports | 2008 | 1,080 |
| 11 | K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases Hiroshi Kase, Kazuyuki Iwahashi, Satoshi Nakanishi et al. · Biochemical and Biophysical Research Communications | 1987 | 944 |
| 12 | Allicin: Chemistry and Biological Properties Jan Borlinghaus, Frank Albrecht, Martin C. H. Gruhlke et al. · Molecules | 19 Aug 2014 | 894 |
| 13 | Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis Emily Pisha, Heebyung Chai, Ik‐Soo Lee et al. · Nature Medicine | Oct 1995 | 891 |
| 14 | Natural products: An evolving role in future drug discovery Bhuwan B. Mishra, Vinod K. Tiwari · European Journal of Medicinal Chemistry | 2 Sep 2011 | 868 |
| 15 | Chemistry and pharmacology of the citrus bioflavonoid hesperidin Alka B. Garg, Sanjay Garg, Lourens J. D. Zaneveld et al. · Phytotherapy Research | 23 Oct 2001 | 859 |
| 16 | Triterpene Biosynthesis in Plants Ramesha B. Thimmappa, Katrin Geisler, Thomas Louveau et al. · Annual Review of Plant Biology | 6 Feb 2014 | 829 |
| 17 | Biological properties of onions and garlic Marta Corzo-Martínez, Nieves Corzo, Mar Villamiel · Trends in Food Science & Technology | 3 Aug 2007 | 818 |
| 18 | Phase II Multi-Institutional Trial of the Histone Deacetylase Inhibitor Romidepsin As Monotherapy for Patients With Cutaneous T-Cell Lymphoma Richard Piekarz, Robin Frye, Maria L Chanco Turner et al. · Journal of Clinical Oncology | 14 Oct 2009 | 744 |
| 19 | Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin Patrick J. Westfall, Douglas J. Pitera, Jacob R. Lenihan et al. · Proceedings of the National Academy of Sciences | 12 Jan 2012 | 739 |
| 20 | Natural products for cancer chemotherapy Arnold L. Demain, Preeti Vaishnav · Microbial Biotechnology | 18 Nov 2010 | 734 |
| 21 | Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. HAMAO UMEZAWA, TAKAAKI AOYAGI, Suda Hiroyuki et al. · The Journal of Antibiotics | 1976 | 725 |
| 22 | Natural products as leads to anticancer drugs Marina Gordaliza · Clinical & Translational Oncology | Dec 2007 | 715 |
| 23 | The Use of Biological Assays to Evaluate Botanicals Jerry L. McLaughlin, Lingling L. Rogers, Jon E. Anderson · Drug Information Journal | Apr 1998 | 709 |
| 24 | Bromelain: biochemistry, pharmacology and medical use H. Rainer MAURER · Cellular and Molecular Life Sciences | Aug 2001 | 682 |
| 25 | Flavonoid Composition of Fruit Tissues of Citrus Species Yoichi Nogata, Koji Sakamoto, Hiroyuki Shiratsuchi et al. · Bioscience Biotechnology and Biochemistry | 2006 | 681 |
| 26 | Clarifying the Real Bioactive Constituents of Garlic Harunobu Amagase · Journal of Nutrition | Mar 2006 | 677 |
| 27 | Novel antiviral agents: a medicinal plant perspective Sabah Jassim, Meena Akeel Naji · Journal of Applied Microbiology | 12 Aug 2003 | 675 |
| 28 | Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications Nicholas Mitsiades, Constantine S. Mitsiades, Vassiliki Poulaki et al. · Blood | 15 Jun 2002 | 669 |
| 29 | Inhibition of Mouse Sarcoma 180 by Polysaccharides from Lentinus edodes (Berk.) Sing. Goro Chihara, YUKIKO Y. MAEDA, Junji Hamuro et al. · Nature | May 1969 | 667 |
| 30 | Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck André Veillette, Michael A. Bookman, Eva M Horak et al. · Nature | Mar 1989 | 665 |
| 31 | PHOTOCHEMISTRY AND PHOTOBIOLOGY OF PSORALENS Pill‐Soon Song, Kenneth J. Tapley · Photochemistry and Photobiology | Jun 1979 | 653 |
| 32 | Pharmacological properties of the ubiquitous natural product betulin Sami Alakurtti, Taru Mäkelä, Salme Koskimies et al. · European Journal of Pharmaceutical Sciences | 2 May 2006 | 653 |
| 33 | Natural Products in Cancer Therapy: Past, Present and Future Min Huang, Jin‐Jian Lu, Jian Ding · Natural Products and Bioprospecting | 3 Jan 2021 | 650 |
| 34 | Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene Mohammad Saleem · Cancer Letters | 23 May 2009 | 640 |
| 35 | Prevention and Therapy of Cancer by Dietary Monoterpenes Pamela L. Crowell · Journal of Nutrition | Mar 1999 | 637 |
| 36 | Evaluation of the Use of Different Solvents for Phytochemical Constituents, Antioxidants, and In Vitro Anti-Inflammatory Activities of Severinia buxifolia Dieu‐Hien Truong, Dinh Hieu Nguyen, Nhat Thuy Anh Ta et al. · Journal of Food Quality | 3 Feb 2019 | 632 |
| 37 | Converting citrus wastes into value-added products: Economic and environmently friendly approaches Kavita Sharma, Neelima Mahato, Moo Hwan Cho et al. · Nutrition | 5 Oct 2016 | 618 |
| 38 | Plant Glandular Trichomes as Targets for Breeding or Engineering of Resistance to Herbivores Joris J. Glas, Bernardus C. J. Schimmel, Juan Manuel Alba et al. · International Journal of Molecular Sciences | 12 Dec 2012 | 618 |
| 39 | Antibacterial activity of extracts from some edible plants commonly consumed in Asia Najeeb S. Al-zoreky, Kazuhiko Nakahara · International Journal of Food Microbiology | Feb 2003 | 616 |
| 40 | A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles Jörn Piel · Proceedings of the National Academy of Sciences | 14 Oct 2002 | 612 |
| 41 | Multiple pathways control protein kinase C phosphorylation Davey B. Parekh, Wolfgang H. Ziegler, Peter J. Parker · The EMBO Journal | 15 Feb 2000 | 607 |
| 42 | Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork Christian Hertweck, Andriy N. Luzhetskyy, Yuriy V. Rebets et al. · Natural Product Reports | 22 Nov 2006 | 604 |
| 43 | Antimicrobial activity of essential oil extracts of various onions (Allium cepa) and garlic (Allium sativum) Noureddine Benkeblia · LWT | 27 Oct 2003 | 602 |
| 44 | Zur Kenntnis der Triterpene. 190. Mitteilung. Eine stereochemische Interpretation der biogenetischen Isoprenregel bei den Triterpenen Albert Eschenmoser, L. Růžička, Oskar Jeger et al. · Helvetica Chimica Acta | 1955 | 602 |
| 45 | Natural Products as Anticancer Agents: Current Status and Future Perspectives Abid Naeem, Pengyi Hu, Ming Yu Yang et al. · Molecules | 30 Nov 2022 | 597 |
| 46 | Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes Ramesh Kumar Saini, Arina Ranjit, Kavita Sharma et al. · Antioxidants | 26 Jan 2022 | 576 |
| 47 | Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom Amit Kumar Roy, Shailendra Saraf · Biological and Pharmaceutical Bulletin | 2006 | 573 |
| 48 | Metabolic and functional diversity of saponins, biosynthetic intermediates and semi-synthetic derivatives Tessa Moses, Kalliope K. Papadopoulou, Anne Osbourn · Critical Reviews in Biochemistry and Molecular Biology | 6 Oct 2014 | 556 |
| 49 | Traditional and medicinal uses of mangroves Wickramasinghe M. Bandaranayake · Mangroves and Salt Marshes | Sep 1998 | 556 |
| 50 | HIV inhibitory natural products. Part 7. The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum Yoel Kashman, Kirk R. Gustafson, Richard W. Fuller et al. · Journal of Medicinal Chemistry | Jul 1992 | 550 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.