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Most cited papers in Radiopharmaceutical Chemistry and Applications

Radiopharmaceutical Chemistry and Applications

What are the most cited papers in Radiopharmaceutical Chemistry and Applications?

The most cited paper in Radiopharmaceutical Chemistry and Applications is "The nuclear receptor superfamily: The second decade" (David J. Mangelsdorf, Carl S. Thummel, Miguel Beato et al., 1995), with 7,017 citations. Next come "Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ" (4,662) and "Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67." (4,236).

Showing 50 of 100 papers. Every paper with more than 846 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 The nuclear receptor superfamily: The second decade David J. Mangelsdorf, Carl S. Thummel, Miguel Beato et al. · Cell Open access Dec 1995 7,017
2 Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ W. David Benton, Ronald W. Davis · Science 8 Apr 1977 4,662
3 Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. Johannes Gerdes, Hilmar Lemke, Heinz Baisch et al. · The Journal of Immunology Oct 1984 4,236
4 Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer Scott Arthur Tomlins, Daniel R. Rhodes, Sven Perner et al. · Science 27 Oct 2005 3,908
5 Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer Chris C. Parker et al. · New England Journal of Medicine 17 Jul 2013 3,410
6 The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassay Anthony E. Bolton, W. M. Hunter · Biochemical Journal Open access Jul 1973 3,267
7 Studies on Prostatic Cancer: I. The Effect of Castration, of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate Charles Huggins, Clarence V. Hodges · The Journal of Urology Jul 2002 3,204
8 Natural History of Progression After PSA Elevation Following Radical Prostatectomy Charles R. Pound · JAMA 5 May 1999 3,112
9 Rapid Isolation of Antigens from Cells with A Staphylococcal Protein A-Antibody Adsorbent: Parameters of the Interaction of Antibody-Antigen Complexes with Protein A Steven Kessler · The Journal of Immunology Dec 1975 2,949
10 Precision Measurement of Half-Lives and Specific Activities of U 235 and U 238 Arthur H. Jaffey, Kian Flynn, L.E. Glendenin et al. · Physical Review C Nov 1971 2,874
11 Lutetium-177–PSMA-617 for Metastatic Castration-Resistant Prostate Cancer Oliver A. Sartor, Johann Sebastian De Bono, Kim N. Chi et al. · New England Journal of Medicine Open access 23 Jun 2021 2,834
12 Metastasis to bone: causes, consequences and therapeutic opportunities Gregory R. Mundy · Nature reviews. Cancer Review Aug 2002 2,802
13 Mechanisms of Bone Metastasis Garson David Roodman · New England Journal of Medicine 14 Apr 2004 2,764
14 AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer Emmanuel S. Antonarakis et al. · New England Journal of Medicine Open access 3 Sep 2014 2,744
15 Efficient Trace-labelling of Proteins with Iodine Arthur Sproul McFarlane · Nature 5 Jul 1958 2,560
16 Bortezomib or High-Dose Dexamethasone for Relapsed Multiple Myeloma Paul Gerard Guy Richardson et al. · New England Journal of Medicine Open access 15 Jun 2005 2,514
17 A rapid radiochemical method for the determination of choline acetyltransferase Frode Fonnum · Journal of Neurochemistry Feb 1975 2,403
18 Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study Michael S. Hofman et al. · The Lancet 22 Mar 2020 2,053
19 Radioimmunoassay for Cyclic Nucleotides Alton L. Steiner, Charles W. Parker, DAVID M. KIPNIS · Journal of Biological Chemistry Open access Feb 1972 2,032
20 Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands Robert B. Innis et al. · Journal of Cerebral Blood Flow & Metabolism 23 May 2007 2,002
21 Metastatic bone disease: clinical features, pathophysiology and treatment strategies Robert Edward Coleman · Cancer Treatment Reviews Jun 2001 1,942
22 Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer Himisha Beltran, Davide Prandi, Juan Miguel Mosquera et al. · Nature Medicine Open access 8 Feb 2016 1,786
23 Trial Design and Objectives for Castration-Resistant Prostate Cancer: Updated Recommendations From the Prostate Cancer Clinical Trials Working Group 3 Howard I. Scher et al. · Journal of Clinical Oncology Open access 22 Feb 2016 1,667
24 A Comparative Study of the Peroxidase-antiperoxidase Method and an Avidin-Biotin Complex Method for Studying Polypeptide Hormones with Radioimmunoassay Antibodies Su-Ming Hsu, Laurence Raine, Herbert Fanger · American Journal of Clinical Pathology May 1981 1,655
25 Bisphosphonates: Mechanism of Action and Role in Clinical Practice Matthew T. Drake, Bart Lyman Clarke, Sundeep Khosla · Mayo Clinic Proceedings Open access Sep 2008 1,648
26 Somatostatin receptor scintigraphy with [111In-DTPA-d-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients E. P. Krenning, Dik J. Kwekkeboom, Willem H. Bakker et al. · European Journal of Nuclear Medicine and Molecular Imaging Open access Aug 1993 1,572
27 Prostate-specific membrane antigen expression in normal and malignant human tissues. Donald Silver, Inmaculada Pellicer, W R Fair et al. · PubMed 1997 1,552
28 Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [ N - 11 C-Methyl]-(−)-Cocaine PET Studies in Human Subjects Jean Logan, Joanna S. Fowler, Nora D. Volkow et al. · Journal of Cerebral Blood Flow & Metabolism Sep 1990 1,528
29 Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial Eugene D. Kwon et al. · The Lancet Oncology Open access 12 May 2014 1,518
30 In vivo amplification of the androgen receptor gene and progression of human prostate cancer Tapio Visakorpi, Eija Hyytinen, Pasi A. Koivisto et al. · Nature Genetics Apr 1995 1,500
31 Treatment With the Radiolabeled Somatostatin Analog [ 177 Lu-DOTA 0 ,Tyr 3 ]Octreotate: Toxicity, Efficacy, and Survival Dik J. Kwekkeboom, Wouter W. de Herder, Boen L.R. Kam et al. · Journal of Clinical Oncology Open access 29 Apr 2008 1,459
32 Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study Karim S. Fizazi, Howard I. Scher, Arturo Molina et al. · The Lancet Oncology 17 Sep 2012 1,402
33 Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study Charles J. Ryan et al. · The Lancet Oncology 15 Jan 2015 1,378
34 Surveillance or Metastasis-Directed Therapy for Oligometastatic Prostate Cancer Recurrence: A Prospective, Randomized, Multicenter Phase II Trial Piet Ost, Dries Reynders, Karel Decaestecker et al. · Journal of Clinical Oncology 14 Dec 2017 1,375
35 Selection of Successive Tumour Lines for Metastasis Isaiah J. Fidler · Nature New Biology Apr 1973 1,368
36 A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity Thomas Decker, Marie‐Luise Lohmann‐Matthes · Journal of Immunological Methods Nov 1988 1,367
37 Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. Masashi Mukoyama, Kazuwa Nakao, Kiminori Hosoda et al. · Journal of Clinical Investigation Open access Apr 1991 1,363
38 OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. Michael G. Stabin, Richard B. Sparks, Eric A. Crowe · PubMed Jun 2005 1,356
39 Biodegradable polymers for use in surgery—polyglycolic/poly(actic acid) homo- and copolymers: 1 D.K. Gilding, Andrew M. Reed · Polymer Dec 1979 1,341
40 Use of Polyethylene Glycol to Separate Free and Antibody-Bound Peptide Hormones in Radioimmunoassays† Bernard Desbuquois, G D Aurbach · The Journal of Clinical Endocrinology & Metabolism Nov 1971 1,302
41 Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial Christopher Parker et al. · The Lancet Open access 21 Oct 2018 1,289
42 Molecular Imaging with PET Simon Mensah Ametamey, Michael Honer, Pius August Schubiger · Chemical Reviews Review 22 Apr 2008 1,274
43 Long-Term Results of the M. D. Anderson Randomized Dose-Escalation Trial for Prostate Cancer Deborah Ann Kuban, Susan L. Tucker, Lei Dong et al. · International Journal of Radiation Oncology*Biology*Physics 4 Sep 2007 1,248
44 Monoclonal antibody therapy of cancer Gregory Paul Adams, Louis M. Weiner · Nature Biotechnology Sep 2005 1,246
45 Positron emission tomography provides molecular imaging of biological processes Michael E. Phelps · Proceedings of the National Academy of Sciences Open access Aug 2000 1,243
46 Long-Term Efficacy of Zoledronic Acid for the Prevention of Skeletal Complications in Patients With Metastatic Hormone-Refractory Prostate Cancer F. Saad, D. M. Gleason, R. Murray et al. · JNCI Journal of the National Cancer Institute Jun 2004 1,215
47 Imaging proliferation in vivo with [F-18]FLT and positron emission tomography Anthony Frank Shields, John R. Grierson, Bernhard Matthias Dohmen et al. · Nature Medicine Nov 1998 1,212
48 Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Chantale T. Guy, Marc A. Webster, Michael D. Schaller et al. · Proceedings of the National Academy of Sciences Open access 15 Nov 1992 1,212
49 Outcomes of Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer Ryan Phillips et al. · JAMA Oncology Open access 26 Mar 2020 1,178
50 [177Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study Michael S. Hofman, John A. Violet, Rodney John Hicks et al. · The Lancet Oncology 8 May 2018 1,178

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.