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Most cited papers in Renal cell carcinoma treatment

What are the most cited papers in Renal cell carcinoma treatment?

The most cited paper in Renal cell carcinoma treatment is "Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review" (Rimda Wanchoo, Sabine Karam, Nupur N. Uppal et al., 2017), with 15,286 citations. Next come "Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing" (7,931) and "Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma" (5,972).

Showing 50 of 98 papers. Every paper with more than 1,044 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review Rimda Wanchoo, Sabine Karam, Nupur N. Uppal et al. · American Journal of Nephrology ReviewOpen access 2017 15,286
2 Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing Marco Gerlinger et al. · New England Journal of Medicine Open access 7 Mar 2012 7,931
3 Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma Robert John Motzer et al. · New England Journal of Medicine Open access 25 Sep 2015 5,972
4 Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma Robert John Motzer, Thomas E. Hutson, Piotr Tomczak et al. · New England Journal of Medicine Open access 10 Jan 2007 5,801
5 Sorafenib in Advanced Clear-Cell Renal-Cell Carcinoma Bernard J. Escudier, Tim G Eisen, Walter Michael Stadler et al. · New England Journal of Medicine Open access 10 Jan 2007 4,813
6 Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma Robert John Motzer et al. · New England Journal of Medicine Open access 21 Mar 2018 4,756
7 Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial Jonathan E. Rosenberg et al. · The Lancet Open access 5 Mar 2016 3,762
8 Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma Gary R. Hudes, Michael Anthony Carducci, Piotr Tomczak et al. · New England Journal of Medicine 30 May 2007 3,671
9 Comprehensive molecular characterization of clear cell renal cell carcinoma Chad J. Creighton et al. · Nature Open access292 authors 23 Jun 2013 3,603
10 Pembrolizumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma Brian I. Rini et al. · New England Journal of Medicine Open access 16 Feb 2019 3,488
11 EAU Guidelines on Renal Cell Carcinoma: 2014 Update Börje Ljungberg, Karim Bensalah, Steven E. Canfield et al. · European Urology Open access 21 Jan 2015 3,474
12 Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial Robert John Motzer, Bernard J. Escudier, Stéphane Marie. Oudard et al. · The Lancet 23 Jul 2008 3,036
13 Everolimus for Advanced Pancreatic Neuroendocrine Tumors James C. Yao, Manisha H. Shah, Tetsuhide Ito et al. · New England Journal of Medicine Open access 9 Feb 2011 2,877
14 Renal cell carcinoma James J.-D. Hsieh, Mark P. Purdue, Sabina Signoretti et al. · Nature Reviews Disease Primers ReviewOpen access 9 Mar 2017 2,857
15 A Randomized Trial of Bevacizumab, an Anti–Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer James Chih‐Hsin Yang, Leah R. Haworth, Richard Mark Sherry et al. · New England Journal of Medicine Open access 30 Jul 2003 2,707
16 Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma Robert John Motzer et al. · New England Journal of Medicine Open access 16 Feb 2019 2,590
17 Distant metastasis occurs late during the genetic evolution of pancreatic cancer Shinichi Yachida, Siân Jones, Ivana Božić et al. · Nature Open access Oct 2010 2,563
18 The R.E.N.A.L. Nephrometry Score: A Comprehensive Standardized System for Quantitating Renal Tumor Size, Location and Depth Alexander Kutikov, Robert G. Uzzo · The Journal of Urology 18 Jul 2009 2,426
19 Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up Bernard J. Escudier, Camillo Porta, Manuela Schmidinger et al. · Annals of Oncology Open access Sep 2014 2,263
20 Renal-Cell Carcinoma Robert John Motzer, Neil Harrison Bander, David M. Nanus · New England Journal of Medicine 19 Sep 1996 2,251
21 Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial Bernard J. Escudier, Anna Pluzanska, P. Koralewski et al. · The Lancet Dec 2007 2,234
22 Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial Arjun Vasant Balar et al. · The Lancet Open access 7 Dec 2016 2,230
23 Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma Robert John Motzer, Thomas E. Hutson, Piotr Tomczak et al. · Journal of Clinical Oncology Open access Jun 2009 2,196
24 Prognostic Factors for Overall Survival in Patients With Metastatic Renal Cell Carcinoma Treated With Vascular Endothelial Growth Factor–Targeted Agents: Results From a Large, Multicenter Study Daniel Y.C. Heng, Wanling Xie, Meredith M. Regan et al. · Journal of Clinical Oncology 14 Oct 2009 2,159
25 WT-1 is required for early kidney development Jordan A. Kreidberg, Hannu V. Sariola, Janet M. Loring et al. · Cell Aug 1993 2,019
26 Pazopanib versus Sunitinib in Metastatic Renal-Cell Carcinoma Robert John Motzer et al. · New England Journal of Medicine Open access 21 Aug 2013 1,936
27 Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets Kornelius Schulze et al. · Nature Genetics Open access 30 Mar 2015 1,896
28 Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial Brian I. Rini et al. · The Lancet 4 Nov 2011 1,861
29 Guideline for Management of the Clinical T1 Renal Mass Steven C. Campbell, Andrew C. Novick, Arie S. Belldegrun et al. · The Journal of Urology 27 Aug 2009 1,844
30 Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma Robert John Motzer, Madhu Mazumdar, Jennifer Bacik et al. · Journal of Clinical Oncology Aug 1999 1,812
31 Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma Robert John Motzer et al. · New England Journal of Medicine Open access 13 Feb 2021 1,811
32 Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma Toni K. Choueiri et al. · New England Journal of Medicine Open access 3 Mar 2021 1,801
33 Mutations of the VHL tumour suppressor gene in renal carcinoma James R. Gnarra et al. · Nature Genetics May 1994 1,752
34 Nephrectomy Followed by Interferon Alfa-2b Compared with Interferon Alfa-2b Alone for Metastatic Renal-Cell Cancer Robert Charles Flanigan, Sydney E. Salmon, Brent A. Blumenstein et al. · New England Journal of Medicine 6 Dec 2001 1,742
35 Epidemiology of Renal Cell Carcinoma Umberto Capitanio, Karim Bensalah, Axel Bex et al. · European Urology Open access 20 Sep 2018 1,699
36 Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis Minoru Takasato, Pei Xuan Er, Han Sheng Chiu et al. · Nature 7 Oct 2015 1,661
37 Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer Ian P. M. Tomlinson et al. · Nature Genetics 25 Feb 2002 1,650
38 Renal cell carcinoma Brian I. Rini, Steven C. Campbell, Bernard J. Escudier · The Lancet Mar 2009 1,649
39 Activity of SU11248, a Multitargeted Inhibitor of Vascular Endothelial Growth Factor Receptor and Platelet-Derived Growth Factor Receptor, in Patients With Metastatic Renal Cell Carcinoma Robert John Motzer, Marc Dror Michaelson, Bruce G. Redman et al. · Journal of Clinical Oncology Open access 5 Dec 2005 1,637
40 Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study William C. W. Huang, Andrew S. Levey, Angel M. Serio et al. · The Lancet Oncology Open access 18 Aug 2006 1,618
41 Rising Incidence of Renal Cell Cancer in the United States Wong Ho Chow · JAMA 5 May 1999 1,600
42 The World Health Organization/International Society of Urological Pathology Consensus Classification of Urothelial (Transitional Cell) Neoplasms of the Urinary Bladder Jonathan I. Epstein, Mahul B. Amin, Victor R. Reuter et al. · The American Journal of Surgical Pathology Dec 1998 1,595
43 Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development Hyun Mi Kang, Seon Ho Ahn, Peter S. Choi et al. · Nature Medicine Open access 24 Nov 2014 1,580
44 Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III Trial Samuel A. Wells, Bruce G. Robinson, Robert F. Gagel et al. · Journal of Clinical Oncology Open access 25 Oct 2011 1,569
45 Renal-Cell Carcinoma Herbert T. Cohen, Francis J. McGovern · New England Journal of Medicine 7 Dec 2005 1,566
46 Prospective Randomized Study of Doxorubicin-Eluting-Bead Embolization in the Treatment of Hepatocellular Carcinoma: Results of the PRECISION V Study Johannes Lämmer et al. · CardioVascular and Interventional Radiology Open access 11 Nov 2009 1,563
47 European Association of Urology Guidelines on Renal Cell Carcinoma: The 2022 Update Börje Ljungberg, Laurence K. Albiges, Yasmin Abu‐Ghanem et al. · European Urology Open access 25 Mar 2022 1,549
48 Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas Laura S. Schmidt et al. · Nature Genetics May 1997 1,542
49 European Association of Urology Guidelines on Renal Cell Carcinoma: The 2019 Update Börje Ljungberg, Laurance Albiges, Yasmin Abu‐Ghanem et al. · European Urology 25 Feb 2019 1,529
50 Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma Thomas B. Powles et al. · New England Journal of Medicine Open access 18 Sep 2020 1,526

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.