Topic · Selenium in Biological Systems
Most cited papers in Selenium in Biological Systems
What are the most cited papers in Selenium in Biological Systems?
The most cited paper in Selenium in Biological Systems is "Selenium: Biochemical Role as a Component of Glutathione Peroxidase" (John T. Rotruck, Alun Lloyd Pope, Howard E. Ganther et al., 1973), with 7,831 citations. Next come "The importance of selenium to human health" (4,171) and "Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain" (3,637).
Showing 50 of 100 papers. Every paper with more than 686 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Selenium: Biochemical Role as a Component of Glutathione Peroxidase John T. Rotruck, Alun Lloyd Pope, Howard E. Ganther et al. · Science | 9 Feb 1973 | 7,831 |
| 2 | The importance of selenium to human health Margaret P. Rayman · The Lancet | Jul 2000 | 4,171 |
| 3 | Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development | 1999 | 3,637 |
| 4 | Selenium and human health Margaret P. Rayman · The Lancet | 28 Feb 2012 | 3,542 |
| 5 | Glutathione peroxidase activity in selenium-deficient rat liver Richard A Lawrence, Raymond F. Burk · Biochemical and Biophysical Research Communications | Aug 1976 | 3,541 |
| 6 | Free radicals, antioxidants, and nutrition Yun-Zhong Fang, Sheng Yang, Guoyao Wu · Nutrition | Oct 2002 | 2,574 |
| 7 | Characterization of Mammalian Selenoproteomes Gregory V. Kryukov, Sergi Castellano, Sergey V. Novoselov et al. · Science | 29 May 2003 | 2,385 |
| 8 | Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis Gina M. DeNicola, Florian A. Karreth, Timothy J. Humpton et al. · Nature | Jul 2011 | 2,302 |
| 9 | Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers Scott Michael Lippman et al. · JAMA | 9 Dec 2008 | 2,136 |
| 10 | The thioredoxin antioxidant system Jun Lu, Arne Holmgren · Free Radical Biology and Medicine | 27 Jul 2013 | 2,078 |
| 11 | Effects of cytochalasin and phalloidin on actin. John A. Cooper · The Journal of Cell Biology | Oct 1987 | 2,034 |
| 12 | Glutathione metabolism and its selective modification. A Meister · Journal of Biological Chemistry | Nov 1988 | 2,026 |
| 13 | Strategies of antioxidant defense Helmut Sies · European Journal of Biochemistry | Jul 1993 | 1,950 |
| 14 | Glutathione peroxidases Regina Brigelius‐Flohé, Matilde Maiorino · Biochimica et Biophysica Acta (BBA) - General Subjects | 29 Nov 2012 | 1,909 |
| 15 | Biochemistry, Cellular and Molecular Biology, and Physiological Roles of the Iodothyronine Selenodeiodinases Antonio Carlos Bianco, Domenico Salvatore, Balázs Gereben et al. · Endocrine Reviews | Feb 2002 | 1,804 |
| 16 | Vitamin E and the Risk of Prostate Cancer Eric A. Klein et al. · JAMA | 12 Oct 2011 | 1,772 |
| 17 | Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis Irina Ingold et al. · Cell | 28 Dec 2017 | 1,693 |
| 18 | Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR) does not differ between normo- and hypomotile human sperm samples Federica Tramer, Luisa Caponecchia, Paolo Sgrò et al. · International Journal of Andrology | Apr 2004 | 1,686 |
| 19 | Oxidative stress and male infertility—a clinical perspective Kelton P. Tremellen · Human Reproduction Update | 14 Feb 2008 | 1,520 |
| 20 | Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings Philippe Jean Guerin · Human Reproduction Update | Mar 2001 | 1,440 |
| 21 | Selenoproteins: Molecular Pathways and Physiological Roles Vyacheslav M. Labunskyy, Dolph Lee Hatfield, Vadim N. Gladyshev · Physiological Reviews | Jul 2014 | 1,429 |
| 22 | Glutathione peroxidase: A selenoenzyme Leopold Flohé, Wolfgang A. Günzler, Hans Hartmut Schock · FEBS Letters | 15 May 1973 | 1,388 |
| 23 | Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants Klaudia Jomová, Suliman Yousef Alomar, Saleh Hamad Alwasel et al. · Archives of Toxicology | 14 Mar 2024 | 1,365 |
| 24 | From Selenium to Selenoproteins: Synthesis, Identity, and Their Role in Human Health Laura V. Papp, Jun Lu, Arne Holmgren et al. · Antioxidants and Redox Signaling | 18 May 2007 | 1,344 |
| 25 | S ELENIUM IN H IGHER P LANTS Norman Terry, Adel M. Zayed, Mark P. de Souza et al. · Annual Review of Plant Physiology and Plant Molecular Biology | Jun 2000 | 1,328 |
| 26 | Selenium in Human Health and Disease Susan Jane Fairweather‐Tait, Yongping Bao, Martin R. Broadley et al. · Antioxidants and Redox Signaling | 2 Sep 2010 | 1,324 |
| 27 | Effect of Oxidative Stress on Male Reproduction Ashok Kumar Agarwal, Gurpriya Virk, Chloe Shu Hui Ong et al. · The World Journal of Men s Health | 2014 | 1,301 |
| 28 | Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities Edith Lubos, Joseph Loscalzo, Diane E. Handy · Antioxidants and Redox Signaling | 18 Nov 2010 | 1,288 |
| 29 | In Vitro Cytotoxicity of Nanoparticles in Mammalian Germline Stem Cells Laura K. Braydich‐Stolle, Saber M. Hussain, John J. Schlager et al. · Toxicological Sciences | 13 Jul 2005 | 1,249 |
| 30 | Effect of Dietary Selenium on Erythrocyte and Liver Glutathione Peroxidase in the Rat Dean G. Hafeman, Roger A. Sunde, William G. Hoekstra · Journal of Nutrition | May 1974 | 1,241 |
| 31 | Generation of Reactive Oxygen Species, Lipid Peroxidation, and Human Sperm Function R. John Aitken, Jane S. Clarkson, Simon B. Fishel · Biology of Reproduction | Jul 1989 | 1,235 |
| 32 | Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants Arif Tasleem Jan, Mudsser Azam, Kehkashan Siddiqui et al. · International Journal of Molecular Sciences | 10 Dec 2015 | 1,228 |
| 33 | The Glutathione Status of Cells Nechama S. Kosower, Edward M. Kosower · International review of cytology | 1978 | 1,221 |
| 34 | Importance of SE-glutathione peroxidase, catalase, and CU/ZN-SOD for cell survival against oxidative stress Carine Michiels, Martine Raes, Olivier Toussaint et al. · Free Radical Biology and Medicine | Sep 1994 | 1,196 |
| 35 | Environmental Mercury and Its Toxic Effects Kevin M. Rice, Ernest M. Walker, Miaozong Wu et al. · Journal of Preventive Medicine and Public Health | 31 Mar 2014 | 1,149 |
| 36 | Selenium in global food systems Gerald F. Combs · British Journal Of Nutrition | May 2001 | 1,142 |
| 37 | Tissue-specific functions of individual glutathione peroxidases Regina Brigelius‐Flohé · Free Radical Biology and Medicine | Nov 1999 | 1,116 |
| 38 | Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation Makoto Kobayashi, Masayuki P. Yamamoto · Antioxidants and Redox Signaling | 11 Feb 2005 | 1,077 |
| 39 | The physicochemical basis of cholesterol gallstone formation in man William H. Admirand, DONALD M. SMALL · Journal of Clinical Investigation | May 1968 | 1,069 |
| 40 | Molecular Mechanism of Heavy Metal Toxicity and Tolerance in Plants: Central Role of Glutathione in Detoxification of Reactive Oxygen Species and Methylglyoxal and in Heavy Metal Chelation Mohammad Anwar Hossain, Piyatida Pukclai, Jaime A. Teixeira da Silva et al. · Journal of Botany | 2 Apr 2012 | 1,042 |
| 41 | The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation Holly K. Bryan, Adedamola Olayanju, Christopher E. Goldring et al. · Biochemical Pharmacology | 5 Dec 2012 | 1,030 |
| 42 | Selenomethionyl proteins produced for analysis by multiwavelength anomalous diffraction (MAD): a vehicle for direct determination of three‐dimensional structure. Wayne A. Hendrickson, John R. Horton, David M. LeMaster · The EMBO Journal | May 1990 | 1,018 |
| 43 | Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans Annie Pfohl‐Leszkowicz, Richard A. Manderville · Molecular Nutrition & Food Research | 29 Dec 2006 | 1,009 |
| 44 | The selenoenzyme phospholipid hydroperoxide glutathione peroxidase Fulvio Ursini, Matilde Maiorino, Carlo Gregolin · Biochimica et Biophysica Acta (BBA) - General Subjects | Mar 1985 | 996 |
| 45 | Role of reactive oxygen species in male infertility Rakesh Kumar Sharma, Ashok Kumar Agarwal · Urology | Dec 1996 | 986 |
| 46 | Physical–Chemical Properties of Biogenic Selenium Nanostructures Produced by Stenotrophomonas maltophilia SeITE02 and Ochrobactrum sp. MPV1 Elena Piacenza, Alessandro Presentato, Emmanuele Ambrosi et al. · Frontiers in Microbiology | 19 Dec 2018 | 961 |
| 47 | Spontaneous Lipid Peroxidation and Production of Hydrogen Peroxide and Superoxide in Human Spermatozoa Superoxide Dismutase as Major Enzyme Protectant Against Oxygen Toxicity Juan G. Álvarez, Joseph C. Touchstone, Luis Blasco et al. · Journal of Andrology | 10 Sep 1987 | 935 |
| 48 | Selenium, selenoproteins and human health: a review K.M. Brown, J R Arthur · Public Health Nutrition | Apr 2001 | 930 |
| 49 | Glutathione in plants: biosynthesis and physiological role in environmental stress tolerance Mirza Hasanuzzaman, Kamrun Nahar, Taufika Islam Anee et al. · Physiology and Molecular Biology of Plants | 10 Mar 2017 | 924 |
| 50 | Why Nature Chose Selenium Hans J. Reich, Robert J. Hondal · ACS Chemical Biology | 7 Mar 2016 | 924 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.