Topic · Spaceflight effects on biology
Most cited papers in Spaceflight effects on biology
What are the most cited papers in Spaceflight effects on biology?
The most cited paper in Spaceflight effects on biology is "A simple technique for quantitation of low levels of DNA damage in individual cells" (Narendra Prasad Singh, Michael T. McCoy, Raymond R. Tice et al., 1988), with 10,851 citations. Next come "Oxidants, oxidative stress and the biology of ageing" (9,446) and "The structure of the nervous system of the nematode Caenorhabditis elegans" (5,884).
Showing 50 of 99 papers. Every paper with more than 763 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | A simple technique for quantitation of low levels of DNA damage in individual cells Narendra Prasad Singh, Michael T. McCoy, Raymond R. Tice et al. · Experimental Cell Research | Mar 1988 | 10,851 |
| 2 | Oxidants, oxidative stress and the biology of ageing Toren Finkel, Nikki J. Holbrook · Nature | Nov 2000 | 9,446 |
| 3 | The structure of the nervous system of the nematode Caenorhabditis elegans JG White, Eileen Southgate, J. Nichol Thomson et al. · Philosophical transactions of the Royal Society of London. Series B, Biological sciences | 12 Nov 1986 | 5,884 |
| 4 | Kinetics and Kinematics for Translational Motions in Microgravity During Parabolic Flight Leia A. Stirling, Karen E. Willcox, Philip A. Ferguson et al. · Aviation Space and Environmental Medicine | Jun 2009 | 5,266 |
| 5 | Coordination of circadian timing in mammals Steven M. Reppert, David R. Weaver · Nature | Aug 2002 | 4,422 |
| 6 | Post-embryonic cell lineages of the nematode, Caenorhabditis elegans J.E. Sulston, H. Robert Horvitz · Developmental Biology | Mar 1977 | 3,621 |
| 7 | C. elegans : des neurones et des gènes Christelle Gally, Jean‐Louis Bessereau · médecine/sciences | Jun 2003 | 3,405 |
| 8 | Physiological Parameters in Laboratory Animals and Humans Brian E. Davies, Tim Morris · Pharmaceutical Research | Jul 1993 | 2,937 |
| 9 | The genetics of ageing Cynthia J. Kenyon · Nature | 23 Mar 2010 | 2,774 |
| 10 | Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus Francesca Damiola, Nguyet Le Minh, Nicolas Preitner et al. · Genes & Development | Dec 2000 | 2,428 |
| 11 | PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues Seung Hee Yoo, Shin Yamazaki, Phillip L. Lowrey et al. · Proceedings of the National Academy of Sciences | 12 Feb 2004 | 2,399 |
| 12 | Rejuvenation of aged progenitor cells by exposure to a young systemic environment Irina M. Conboy, Michael J. Conboy, Amy J. Wagers et al. · Nature | Feb 2005 | 2,311 |
| 13 | Life in extreme environments Lynn J. Rothschild, Rocco L. Mancinelli · Nature | Feb 2001 | 2,266 |
| 14 | IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice Martin Holzenberger, Joëlle Dupont, Bertrand Ducos et al. · Nature | 4 Dec 2002 | 2,140 |
| 15 | A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells Aurélio Balsalobre, Francesca Damiola, Ueli Schibler · Cell | Jun 1998 | 2,022 |
| 16 | Ageing as a Risk Factor for Disease Teresa Niccoli, Linda Partridge · Current Biology | Sep 2012 | 1,931 |
| 17 | Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats Shin Yamazaki, Rika Numano, Michikazu Abe et al. · Science | 28 Apr 2000 | 1,926 |
| 18 | The aging process. Denham Harman · Proceedings of the National Academy of Sciences | Nov 1981 | 1,918 |
| 19 | Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling Aurélio Balsalobre, Steven A. Brown, Lysiane Marcacci et al. · Science | 29 Sep 2000 | 1,895 |
| 20 | Entrainment of the Circadian Clock in the Liver by Feeding Karl‐Arne Stokkan, Shin Yamazaki, Hajime Tei et al. · Science | 19 Jan 2001 | 1,821 |
| 21 | Senescence in Health and Disease Shenghui He, Norman E. Sharpless · Cell | Jun 2017 | 1,801 |
| 22 | Why do we age? Thomas B. L. Kirkwood, Steven N. Austad · Nature | Nov 2000 | 1,800 |
| 23 | Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker Charles Andrew Czeisler, Jeanne F. Duffy, Theresa L. Shanahan et al. · Science | 25 Jun 1999 | 1,719 |
| 24 | Molecular components of the mammalian circadian clock Caroline H. Ko, Joseph S. Takahashi · Human Molecular Genetics | 20 Sep 2006 | 1,684 |
| 25 | A functional analysis of circadian pacemakers in nocturnal rodents Colin S. Pittendrigh, Serge Daan · Journal of Comparative Physiology A | Oct 1976 | 1,652 |
| 26 | Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals Maureen K. Bunger, Lisa D. Wilsbacher, Susan M. Moran et al. · Cell | Dec 2000 | 1,650 |
| 27 | TENSEGRITY: THE ARCHITECTURAL BASIS OF CELLULAR MECHANOTRANSDUCTION Donald E. Ingber · Annual Review of Physiology | Oct 1997 | 1,569 |
| 28 | Micro/nanorobots for biomedicine: Delivery, surgery, sensing, and detoxification Jinxing Li, Berta Esteban‐Fernández de Ávila, Wei Feng Gao et al. · Science Robotics | Mar 2017 | 1,566 |
| 29 | Molecular architecture of the mammalian circadian clock Carrie L. Partch, Carla B. Green, Joseph S. Takahashi · Trends in Cell Biology | Aug 2013 | 1,497 |
| 30 | Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: Part 1. Structure, gelation rate and mechanical properties Catherine K. Kuo, Peter Ma · Biomaterials | Mar 2001 | 1,492 |
| 31 | Heat shock factors: integrators of cell stress, development and lifespan Malin Åkerfelt, Richard I. Morimoto, Lea Sistonen · Nature Reviews Molecular Cell Biology | 14 Jul 2010 | 1,490 |
| 32 | Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein David J. Clancy, David Gems, Lawrence G. Harshman et al. · Science | 6 Apr 2001 | 1,461 |
| 33 | Stem Cell Function, Self-Renewal, and Behavioral Heterogeneity of Cells from the Adult Muscle Satellite Cell Niche Charlotte A. Collins, Irwin Olsen, Peter S. Zammit et al. · Cell | Jul 2005 | 1,441 |
| 34 | Asymmetric Self-Renewal and Commitment of Satellite Stem Cells in Muscle Shihuan Kuang, Kazuki Kuroda, Fabien Le Grand et al. · Cell | Jun 2007 | 1,440 |
| 35 | Stress and the General Adaptation Syndrome Hans Selye · BMJ | 17 Jun 1950 | 1,439 |
| 36 | A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo Thomas J. Farrell, Michael S. Patterson, Brian C. Wilson · Medical Physics | Jul 1992 | 1,382 |
| 37 | Optogenetics: 10 years of microbial opsins in neuroscience Karl Deisseroth · Nature Neuroscience | 26 Aug 2015 | 1,339 |
| 38 | Haematopoietic stem cell release is regulated by circadian oscillations Simón Méndez‐Ferrer, Daniel Lucas, Michela Battista et al. · Nature | 6 Feb 2008 | 1,317 |
| 39 | Stresses at the Cell-to-Substrate Interface during Locomotion of Fibroblasts Micah Dembo, Yu‐li Wang · Biophysical Journal | Apr 1999 | 1,315 |
| 40 | Physical forces during collective cell migration Xavier Trepat, Michael R. Wasserman, Thomas E. Angelini et al. · Nature Physics | 3 May 2009 | 1,270 |
| 41 | Anhydrobiosis J.H. Crowe, Folkert A. Hoekstra, Lois M. Crowe · Annual Review of Physiology | Oct 1992 | 1,269 |
| 42 | Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans Laura A. Herndon, Peter J. Schmeissner, Justyna M. Dudaronek et al. · Nature | Oct 2002 | 1,249 |
| 43 | Desiccation tolerance of prokaryotes Malcolm Potts · Microbiological Reviews | Dec 1994 | 1,234 |
| 44 | Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock Roman V. Kondratov, Anna A. Kondratova, Victoria Gorbacheva et al. · Genes & Development | 15 Jul 2006 | 1,219 |
| 45 | JTK_CYCLE: An Efficient Nonparametric Algorithm for Detecting Rhythmic Components in Genome-Scale Data Sets Michael E. Hughes, John B. Hogenesch, Karl Kornacker · Journal of Biological Rhythms | 28 Sep 2010 | 1,198 |
| 46 | A Model for Photoreceptor-Based Magnetoreception in Birds Thorsten Ritz, Salih Adem, Klaus J. Schulten · Biophysical Journal | Feb 2000 | 1,195 |
| 47 | Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression Jamie Marc Zeitzer, Derk‐Jan Dijk, Richard E. Kronauer et al. · The Journal of Physiology | Aug 2000 | 1,190 |
| 48 | Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels Paul E. Hardin, Jeffrey C. Hall, Michael Rosbash · Nature | Feb 1990 | 1,171 |
| 49 | Psychrophilic enzymes: hot topics in cold adaptation Georges Feller, Charles Gerday · Nature Reviews Microbiology | Dec 2003 | 1,169 |
| 50 | The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight Francine E. Garrett-Bakelman et al. · Science | 12 Apr 2019 | 1,157 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.