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Most cited papers in Sulfur Compounds in Biology

What are the most cited papers in Sulfur Compounds in Biology?

The most cited paper in Sulfur Compounds in Biology is "Tissue sulfhydryl groups" (George L. Ellman, 1959), with 26,451 citations. Next come "Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids" (12,147) and "Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues" (6,083).

Showing 50 of 100 papers. Every paper with more than 993 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Tissue sulfhydryl groups George L. Ellman · Archives of Biochemistry and Biophysics May 1959 26,451
2 Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids Laura C. Green, David A. Wagner, Joseph A. Glogowski et al. · Analytical Biochemistry Oct 1982 12,147
3 Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues Frank Tietze · Analytical Biochemistry Mar 1969 6,083
4 Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine Owen W. Griffith · Analytical Biochemistry Jul 1980 4,625
5 Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver M MORON, Joseph William DePierre, Bengt Mannervik · Biochimica et Biophysica Acta (BBA) - General Subjects 4 Jan 1979 4,221
6 A fluorometric method for determination of oxidized and reduced glutathione in tissues Paul J. Hissin, Russell Hilf · Analytical Biochemistry Jul 1976 4,127
7 Glutathione Metabolism and Its Implications for Health Guoyao Wu, Joanne R. Lupton, Nancy D. Turner et al. · Journal of Nutrition Open access Mar 2004 3,876
8 A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation Özcan Erel · Clinical Biochemistry 6 Mar 2004 2,933
9 Oxidative Stress in Cancer John David Hayes, Albena T. Dinkova‐Kostova, Kenneth D. Tew · Cancer Cell Open access 9 Jul 2020 2,652
10 Glutathione: Overview of its protective roles, measurement, and biosynthesis Henry Jay Forman, Hongqiao Zhang, Alessandra Rinna · Molecular Aspects of Medicine Open access 31 Aug 2008 2,644
11 Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi et al. · Nature Medicine 7 May 2007 2,586
12 Structure, mechanism and regulation of peroxiredoxins Zachary A. Wood, Ewald Schröder, J. Robin Harris et al. · Trends in Biochemical Sciences Review 2003 2,553
13 Physiological functions of thioredoxin and thioredoxin reductase Elias S.J. Arnér, Arne Holmgren · European Journal of Biochemistry Open access Oct 2000 2,553
14 Peroxynitrite oxidation of sulfhydryls. Rafael Radí, Joseph S. Beckman, Ken Bush et al. · Journal of Biological Chemistry Open access Mar 1991 2,493
15 A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds Stuart A. Lipton, Yun‐Beom Choi, Zhuo‐Hua Pan et al. · Nature Aug 1993 2,449
16 H 2 S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase Guangdong Yang, Lingyun Wu, Bo Jiang et al. · Science Open access 23 Oct 2008 2,317
17 Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method Irfan Rahman, Aruna Kode, Saibal K. Biswas · Nature Protocols Dec 2006 2,277
18 The possible role of hydrogen sulfide as an endogenous neuromodulator K. Abe, Hideo Kimura · Journal of Neuroscience Open access Feb 1996 2,252
19 Glutathione synthesis Shelly Chi-Loo Lu · Biochimica et Biophysica Acta (BBA) - General Subjects Open access 17 Sep 2012 2,197
20 Hyperhomocysteinemia: An Independent Risk Factor for Vascular Disease Robert Clarke, Leslie Daly, Killian Robinson et al. · New England Journal of Medicine Open access 25 Apr 1991 2,180
21 Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis L. Joseph Su, Jiahao Zhang, Hernando Gómez et al. · Oxidative Medicine and Cellular Longevity Open access 13 Oct 2019 2,176
22 The thioredoxin antioxidant system Jun Lu, Arne Holmgren · Free Radical Biology and Medicine 27 Jul 2013 2,078
23 Purification and characterization of the flavoenzyme glutathione reductase from rat liver. Inger Carlberg, Bengt Mannervik · Journal of Biological Chemistry Open access Jul 1975 2,027
24 Glutathione metabolism and its selective modification. A Meister · Journal of Biological Chemistry Open access Nov 1988 2,026
25 The importance of glutathione in human disease Danyelle M. Townsend, Kenneth D. Tew, Haïm Tapiero · Biomedicine & Pharmacotherapy Open access May 2003 2,015
26 DNA Damage and Oxygen Radical Toxicity James A. Imlay, Stuart Linn · Science 3 Jun 1988 1,977
27 Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed Rui Ting Wang · Physiological Reviews Review Apr 2012 1,948
28 The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener Weimin Zhao, Jing Zhang, Yanjie Lu et al. · The EMBO Journal Open access Nov 2001 1,937
29 Two's company, three's a crowd: can H 2 S be the third endogenous gaseous transmitter? Rui Ting Wang · The FASEB Journal 30 Oct 2002 1,807
30 Reactive oxygen species in living systems: Source, biochemistry, and role in human disease Barry B. Halliwell · The American Journal of Medicine Sep 1991 1,807
31 Colorimetric determination of phospholipids with ammonium ferrothiocyanate John C. Stewart · Analytical Biochemistry May 1980 1,791
32 The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid Okezie I. Aruoma, Barry B. Halliwell, Brigid M. Hoey et al. · Free Radical Biology and Medicine 1989 1,780
33 A novel automated method to measure total antioxidant response against potent free radical reactions Özcan Erel · Clinical Biochemistry 2 Dec 2003 1,772
34 Glutathione and its role in cellular functions Helmut Sies · Free Radical Biology and Medicine Nov 1999 1,737
35 Redefining Oxidative Stress Dean P. Jones · Antioxidants and Redox Signaling Sep 2006 1,721
36 Metabolism and functions of glutathione in brain Ralf Dringen · Progress in Neurobiology Dec 2000 1,710
37 Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). Owen W. Griffith, A Meister · Journal of Biological Chemistry Open access Aug 1979 1,698
38 Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules Min Hee Lee, Jong Seung Kim, Jonathan L. Sessler · Chemical Society Reviews ReviewOpen access 6 Oct 2014 1,663
39 Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate Michael A. Marletta, Poksyn S. Yoon, Radha Iyengar et al. · Biochemistry Nov 1988 1,610
40 Hydrogen Peroxide Sensing and Signaling Elizabeth A. Veal, Alison M. Day, Brian A. Morgan · Molecular Cell Open access Apr 2007 1,608
41 Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide David A. Wink, James B. Mitchell · Free Radical Biology and Medicine Sep 1998 1,604
42 Drinking Water Nitrate and Human Health: An Updated Review Mary H. Ward, Rena R. Jones, Jean D. Brender et al. · International Journal of Environmental Research and Public Health Open access 23 Jul 2018 1,577
43 Fluorescent and colorimetric probes for detection of thiols Xiaoqiang Chen, Ying Mei Zhou, Xiaojun Peng et al. · Chemical Society Reviews Review 2010 1,576
44 Role of nitric oxide synthesis in macrophage antimicrobial activity Carl Nathan, John B. Hibbs · Current Opinion in Immunology Review 1991 1,541
45 Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress John David Hayes, Lesley I. McLellan · Free Radical Research 1999 1,534
46 Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations William Perry Arnold, Chandra K. Mittal, Shoji Katsuki et al. · Proceedings of the National Academy of Sciences Open access Aug 1977 1,460
47 The changing faces of glutathione, a cellular protagonist Alfonso Pompella, Athanase Visvikis, Aldo Paolicchi et al. · Biochemical Pharmacology Open access 11 Sep 2003 1,375
48 iNOS-mediated nitric oxide production and its regulation Fügen Aktan · Life Sciences 8 May 2004 1,372
49 Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten H. Druckrey, R. Preußmann, Stan Ivankovic et al. · Journal of Cancer Research and Clinical Oncology 1967 1,355
50 Assay of glutathione reductase in crude tissue homogenates using 5,5′-dithiobis(2-nitrobenzoic acid) Ivan K. Smith, Thomas L. Vierheller, Carol A. Thorne · Analytical Biochemistry Dec 1988 1,351

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.