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Most cited papers in Synthesis of Organic Compounds

What are the most cited papers in Synthesis of Organic Compounds?

The most cited paper in Synthesis of Organic Compounds is "The specificities of protein kinase inhibitors: an update" (Jenny Bain, Hilary McLauchlan, Matthew Elliott et al., 2003), with 1,369 citations. Next come "Biologically active dihydropyrimidones of the Biginelli-type — a literature survey" (1,332) and "Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation" (1,108).

Showing 50 of 100 papers. Every paper with more than 279 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 The specificities of protein kinase inhibitors: an update Jenny Bain, Hilary McLauchlan, Matthew Elliott et al. · Biochemical Journal Open access 26 Mar 2003 1,369
2 Biologically active dihydropyrimidones of the Biginelli-type — a literature survey Christian Oliver Kappe · European Journal of Medicinal Chemistry Dec 2000 1,332
3 Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation Mariappan Premanathan, Karthikeyan Krishnamoorthy, Kadarkaraithangam Jeyasubramanian et al. · Nanomedicine Nanotechnology Biology and Medicine 28 Oct 2010 1,108
4 Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity Fernanda Borges, Fernanda M.F. Roleira, Nuno Milhazes et al. · Current Medicinal Chemistry 29 Mar 2005 998
5 Phosphorus-containing flame retardant epoxy thermosets: Recent advances and future perspectives Siqi Huo, Pingan Song, Bin Yu et al. · Progress in Polymer Science 21 Jan 2021 901
6 Medicinal properties of mangosteen (Garcinia mangostana) José Pedraza‐Chaverrí, Noemí Cárdenas‐Rodríguez, Marisol Orozco‐Ibarra et al. · Food and Chemical Toxicology 7 Aug 2008 765
7 Chromone: A Valid Scaffold in Medicinal Chemistry Alexandra Gaspar, María João Matos, Jorge Garrido et al. · Chemical Reviews ReviewOpen access 21 Feb 2014 757
8 Effect of Plant Flavonoids on Immune and Inflammatory Cell Function Elliott Middleton · Advances in experimental medicine and biology Book chapter 1998 740
9 Antioxidant properties of hydroxy-flavones Nicole Cotelle, Jean‐Luc Bernier, Jean‐Pierre Catteau et al. · Free Radical Biology and Medicine 1996 705
10 Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus Hironori Tsuchiya, Masaru Satô, Takashi Miyazaki et al. · Journal of Ethnopharmacology Open access 1996 699
11 Synthesis and pharmacological activity of 2-oxo-(2H) 1-benzopyran-3-carboxamide derivatives Leonardo Bonsignore, Gianni Loy, Daniela Secci et al. · European Journal of Medicinal Chemistry 1993 695
12 A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone Sung‐Wuk Jang, Xia Liu, Manuel A Yepes et al. · Proceedings of the National Academy of Sciences Open access 25 Jan 2010 689
13 Medicinal natural products. A biosynthetic approach Michael Heinrich · Journal of Ethnopharmacology Jun 2002 669
14 PHOTOCHEMISTRY AND PHOTOBIOLOGY OF PSORALENS Pill‐Soon Song, Kenneth J. Tapley · Photochemistry and Photobiology Jun 1979 653
15 Evaluation of the Antioxidant Potential of Natural Products Sang Kook Lee, Zakaria H. Mbwambo, HaSook Chung et al. · Combinatorial Chemistry & High Throughput Screening Apr 1998 637
16 Studies on Coumarins and Coumarin-Related Compounds to Determine their Therapeutic Role in the Treatment of Cancer Aoife Lacy · Current Pharmaceutical Design Nov 2004 634
17 New Developments in the Chemistry of N-Acyliminium Ions and Related Intermediates W. Nico Speckamp, Marinus J. Moolenaar · Tetrahedron Jun 2000 613
18 Natural and Synthetic Chromenes, Fused Chromenes, and Versatility of Dihydrobenzo[h]chromenes in Organic Synthesis Ramendra Pratap, Vishnu Ji Ram · Chemical Reviews Review 10 Oct 2014 603
19 The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products Vassilios P. Papageorgiou, Andreana N. Assimopoulou, Elias A. Couladouros et al. · Angewandte Chemie International Edition Feb 1999 595
20 Exploring Pharmacological Significance of Chalcone Scaffold: A Review Nilanchala Sahu, S. S. Balbhadra, Jaswantsingh Nathuram Choudhary et al. · Current Medicinal Chemistry 2012 585
21 Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Mou‐Tuan Huang, Thomas W. Lysz, Thomas Ferraro et al. · PubMed Feb 1991 574
22 Multicomponent domino reactions for the synthesis of biologically active natural products and drugs Lutz Friedjan Tietze, Andrea Modi · Medicinal Research Reviews 2000 561
23 Bioactive Benzofuran derivatives: A review Hena Khanam, Shamsuzzaman · European Journal of Medicinal Chemistry 22 Nov 2014 557
24 Traditional and medicinal uses of mangroves Wickramasinghe M. Bandaranayake · Mangroves and Salt Marshes Sep 1998 556
25 Phloroglucinol compounds of natural origin Inder Pal Singh, Sandip Bibishan Bharate · Natural Product Reports 2006 550
26 Antibacterial Activity of Turmeric Oil: A Byproduct from Curcumin Manufacture Pradeep Singh Negi, Guddadarangavvanahally K. Jayaprakasha, Li Rao et al. · Journal of Agricultural and Food Chemistry 24 Sep 1999 543
27 Flavones: An important scaffold for medicinal chemistry Manjinder Singh, Maninder Kaur, Om Silakari · European Journal of Medicinal Chemistry Open access 5 Jul 2014 543
28 Studies on antioxidants: Their carcinogenic and modifying effects on chemical carcinogenesis N. Ito, Masamichi Hirose, Shoji Fukushima et al. · Food and Chemical Toxicology Oct 1986 522
29 Two Distinct Sources of Elicited Reactive Oxygen Species in Tobacco Epidermal Cells. Andrew C. Allan, Robert Fluhr · The Plant Cell Open access Sep 1997 521
30 The Synthesis of 1-Phenyl-3-methyl-4-acyl-pyrazolones-5. Bror Skytte Jensen, Hans Meier, Knut Lundquist et al. · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry Open access 1959 515
31 Antioxidant Xanthones from the Pericarp of Garcinia mangostana (Mangosteen) Hyun‐Ah Jung, Bao‐Ning Su, William J. Keller et al. · Journal of Agricultural and Food Chemistry 18 Feb 2006 513
32 Synthetic and Natural Coumarins as Cytotoxic Agents Irena P. Kostova · Anti-Cancer Agents in Medicinal Chemistry 2005 502
33 Chromones as a privileged scaffold in drug discovery: A review Rangappa Sangappa Keri, Srinivasa Budagumpi, Ranjith Krishna Pai et al. · European Journal of Medicinal Chemistry 21 Mar 2014 501
34 Current Developments of Coumarin Compounds in Medicinal Chemistry Xin-Mei Peng, Guri L. V. Damu, Cheng He Zhou · Current Pharmaceutical Design Apr 2013 501
35 Physiochemical, Optical and Biological Activity of Chitosan-Chromone Derivative for Biomedical Applications Santosh Kumar, Joonseok Koh · International Journal of Molecular Sciences Open access 18 May 2012 478
36 Fluorescent chemosensors of carbohydrates. A means of chemically communicating the binding of polyols in water based on chelation-enhanced quenching Juyoung Yoon, Anthony W. Czarnik · Journal of the American Chemical Society Jul 1992 476
37 Kojic Acid, a Cosmetic Skin Whitening Agent, is a Slow-binding Inhibitor of Catecholase Activity of Tyrosinase Juana Cabanes, Soledad Chazarra, Francisco García‐Carmona · Journal of Pharmacy and Pharmacology Dec 1994 458
38 Synthesis of halogen derivatives of benzo[h]chromene and benzo[a]anthracene with promising antimicrobial activities Mostafa M. Khafagy, Ashraf Hassan Fekry Abd El‐Wahab, Fathy A. Eid et al. · Il Farmaco Sep 2002 456
39 Controlled microwave heating in modern organic synthesis: highlights from the 2004–2008 literature Christian Oliver Kappe, Doris Dallinger · Molecular Diversity 20 Apr 2009 450
40 Synthesis of methyl 2,3-dideoxy-DL-alk-2-enopyranosides from furan compounds OSMAN JUN. ACHMATOWICZ, Pawel Bukowski, Barbara Szechner et al. · Tetrahedron 1971 447
41 Coumarins as Antioxidants Irena P. Kostova, Sumati Bhatia, Petar Grigorov et al. · Current Medicinal Chemistry Sep 2011 438
42 5-lipoxygenase inhibitory activity of zileuton. G W Carter, Patrick Young, Daniel H. Albert et al. · Journal of Pharmacology and Experimental Therapeutics Mar 1990 421
43 AN EFFICIENT METHOD FOR GLUCOSYLATION OF HYDROXY COMPOUNDS USING GLUCOPYRANOSYL FLUORIDE Teruaki Mukaiyama, Yoshiyuki Murai, Shin‐ichiro Shoda · Chemistry Letters Mar 1981 418
44 Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances Joana Reis, Alexandra Gaspar, Nuno Milhazes et al. · Journal of Medicinal Chemistry Open access 24 May 2017 416
45 Plant-Derived Leading Compounds for Chemotherapy of Human Immunodeficiency Virus (HIV) Infection A.J. Vlietinck, Tess De Bruyne, Sandra Apers et al. · Planta Medica Open access Mar 1998 416
46 Unsaturated O- and N-Heterocycles from Carbohydrate Feedstocks Frieder W. Lichtenthaler · Accounts of Chemical Research 7 May 2002 413
47 Notch signaling: An emerging therapeutic target for cancer treatment Xun Yuan, Hua Kang Wu, Hanxiao Xu et al. · Cancer Letters Open access Sep 2015 412
48 An overview of some recent advances in DOPO-derivatives: Chemistry and flame retardant applications Khalifah A. Salmeia, Sabyasachi Gaan · Polymer Degradation and Stability 23 Dec 2014 410
49 Plant Natural Flavonoids Against Multidrug Resistant Pathogens Meirong Song, Ying Liu, Tingting Li et al. · Advanced Science Open access 26 May 2021 401
50 Cellular pharmacology studies of shikonin derivatives Xin Chen, Lu Yang, Joost J. Oppenheim et al. · Phytotherapy Research May 2002 401

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.