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Most cited papers in Trace Elements in Health

What are the most cited papers in Trace Elements in Health?

The most cited paper in Trace Elements in Health is "Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death" (Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al., 2012), with 19,018 citations. Next come "Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation." (9,552) and "Selenium: Biochemical Role as a Component of Glutathione Peroxidase" (7,831).

Showing 50 of 99 papers. Every paper with more than 1,367 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al. · Cell Open access May 2012 19,018
2 Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Yael Gavrieli, Yoav Sherman, Shmuel A. Ben‐Sasson · The Journal of Cell Biology Open access Nov 1992 9,552
3 Selenium: Biochemical Role as a Component of Glutathione Peroxidase John T. Rotruck, Alun Lloyd Pope, Howard E. Ganther et al. · Science 9 Feb 1973 7,831
4 Adult sibling experience, roles, relationshhips and future concerns - a review of the literature in learning disabilities C Catassi et al. · Institutional Research Information System University of Turin (University of Turin) Open access 1996 5,515
5 Prions Stanley Ben Prusiner · Proceedings of the National Academy of Sciences Open access 10 Nov 1998 5,428
6 Metals, Toxicity and Oxidative Stress Marián Valko, Harry Morris, M Cronin · Current Medicinal Chemistry 29 Apr 2005 5,027
7 Copper induces cell death by targeting lipoylated TCA cycle proteins Peter Tsvetkov, Shannon Coy, Boryana Petrova et al. · Science Open access 17 Mar 2022 5,017
8 Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization Elizabeta Nemeth, Marie S. Tuttle, Julie Powelson et al. · Science 28 Oct 2004 4,836
9 Caspases: the executioners of apoptosis Gerald M. Cohen · Biochemical Journal Open access 15 Aug 1997 4,755
10 The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor Jie Kang, Hans-Georg Lemaire, Axel Unterbeck et al. · Nature Feb 1987 4,640
11 Oxidative mechanisms in the toxicity of metal ions SIDNEY J. STOHS, D. Bagchi · Free Radical Biology and Medicine Feb 1995 4,225
12 The importance of selenium to human health Margaret P. Rayman · The Lancet Jul 2000 4,171
13 Emerging roles of caspase-3 in apoptosis Alan George Porter, Reiner U. Jänicke · Cell Death and Differentiation 28 Jan 1999 3,932
14 Selenium and human health Margaret P. Rayman · The Lancet 28 Feb 2012 3,542
15 Glutathione peroxidase activity in selenium-deficient rat liver Richard A Lawrence, Raymond F. Burk · Biochemical and Biophysical Research Communications Aug 1976 3,541
16 Advances in metal-induced oxidative stress and human disease Klaudia Jomová, Marián Valko · Toxicology 16 Mar 2011 3,223
17 Cloning and characterization of a mammalian proton-coupled metal-ion transporter Hiromi Gunshin, Bryan Mackenzie, Urs V. Berger et al. · Nature 31 Jul 1997 3,203
18 The biochemical basis of zinc physiology Bert L. Vallée, Kenneth H. Falchuk · Physiological Reviews 1993 3,019
19 Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis William C. Earnshaw, Luis Miguel Martins, Scott H. Kaufmann · Annual Review of Biochemistry Review Jun 1999 2,776
20 The Effects of Cadmium Toxicity Giuseppe Genchi, Maria Stefania Sinicropi, Graziantonio Lauria et al. · International Journal of Environmental Research and Public Health Open access 26 May 2020 2,707
21 The ferritins: molecular properties, iron storage function and cellular regulation Pauline M. Harrison, Paolo Arosio · Biochimica et Biophysica Acta (BBA) - Bioenergetics Open access Jul 1996 2,698
22 Structural and Functional Aspects of Metal Sites in Biology R. H. Holm, Pierre Kennepohl, Edward I. Solomon · Chemical Reviews Review 1996 2,548
23 P HYTOCHELATINS AND M ETALLOTHIONEINS : Roles in Heavy Metal Detoxification and Homeostasis Christopher S. Cobbett, Peter B. Goldsbrough · Annual Review of Plant Biology Review Jun 2002 2,509
24 The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme Yuan Ji · Cell Open access 19 Nov 1993 2,501
25 The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases Michael Karin · Journal of Biological Chemistry Open access Jul 1995 2,458
26 The role of iron and reactive oxygen species in cell death Scott J. Dixon, Brent R. Stockwell · Nature Chemical Biology 17 Dec 2013 2,410
27 Oxidative Stress Hypothesis in Alzheimer's Disease William R. Markesbery · Free Radical Biology and Medicine 1997 2,390
28 Characterization of Mammalian Selenoproteomes Gregory V. Kryukov, Sergi Castellano, Sergey V. Novoselov et al. · Science 29 May 2003 2,385
29 A multidrug resistance transporter from human MCF-7 breast cancer cells L. Austin Doyle, Weidong Yang, Lynne V. Abruzzo et al. · Proceedings of the National Academy of Sciences Open access 22 Dec 1998 2,333
30 Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. K M Pan, M. A. Baldwin, Jack T Nguyen et al. · Proceedings of the National Academy of Sciences Open access Dec 1993 2,280
31 IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin Elizabeta Nemeth, Seth Rivera, Victoria R. Gabayan et al. · Journal of Clinical Investigation May 2004 2,242
32 Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie? Joseph T. Jarrett, Peter T. Lansbury · Cell Jun 1993 2,194
33 Enrichment of cereal grains with zinc: Agronomic or genetic biofortification? İsmail Çakmak · Plant and Soil 27 Nov 2007 2,183
34 Copper toxicity, oxidative stress, and antioxidant nutrients Lisa M. Gaetke · Toxicology 2 Jun 2003 2,176
35 Toxicity of lead: a review with recent updates Gagan D. Flora, Deepesh Gupta, Archana Tiwari · Interdisciplinary Toxicology Open access 9 Nov 2012 2,172
36 Two to Tango: Regulation of Mammalian Iron Metabolism Matthias W. Hentze, Martina Ulrike Muckenthaler, Bruno Galy et al. · Cell Open access Jul 2010 2,142
37 Copper, iron and zinc in Alzheimer's disease senile plaques Mark A. Lovell, J. David Robertson, William J. Teesdale et al. · Journal of the Neurological Sciences Jun 1998 2,128
38 Disorders of Iron Metabolism Nancy C. Andrews · New England Journal of Medicine 23 Dec 1999 2,127
39 Mice devoid of PrP are resistant to scrapie Hansruedi Büeler, Adriano Aguzzi, Andreas W. Sailer et al. · Cell Open access Jul 1993 2,107
40 Intellectual Impairment in Children with Blood Lead Concentrations below 10 μg per Deciliter Richard L. Canfield, Charles Henderson, Deborah A. Cory‐Slechta et al. · New England Journal of Medicine Open access 16 Apr 2003 2,089
41 Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging Emily L. Que, Dylan Wythe Domaille, Christopher J. Chang · Chemical Reviews Review 22 Apr 2008 2,072
42 Mechanisms and Functions of Cell Death Ronald E. Ellis, Junying Yuan, H. Robert Horvitz · Annual Review of Cell Biology Nov 1991 2,067
43 The Epidemiology of Global Micronutrient Deficiencies Regan Lucas Bailey, Keith P. West, Robert E. Black · Annals of Nutrition and Metabolism 2015 2,053
44 Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements Wes Lee, Pamela J. Mitchell, Robert Tjian · Cell Jun 1987 2,047
45 Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO) Sharon M. Moe, Tilman Bernhard Drüeke, John Alastair Cunningham et al. · Kidney International Open access 26 Apr 2006 1,997
46 Developmental neurotoxicity of industrial chemicals Philippe Grandjean, PJ Landrigan · The Lancet 14 Nov 2006 1,978
47 The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene Peter C. Bull, Gordon R. Thomas, Johanna M. Rommens et al. · Nature Genetics Dec 1993 1,966
48 The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc Jeremy M Berg, Yigong Shi · Science 23 Feb 1996 1,956
49 Lead toxicity: a review Ab Latif Wani, Anjum Ara, Jawed Ahmad Usmani · Interdisciplinary Toxicology Open access Jun 2015 1,945
50 Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells Wan Seok Yang, Brent R. Stockwell · Chemistry & Biology Open access Mar 2008 1,916

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.