Topic · Tryptophan and brain disorders
Most cited papers in Tryptophan and brain disorders
What are the most cited papers in Tryptophan and brain disorders?
The most cited paper in Tryptophan and brain disorders is "The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia" (Stanley R. Kay, Abraham Fiszbein, Lewis A. Opler, 1987), with 21,651 citations. Next come "Structure, function and diversity of the healthy human microbiome" (12,195) and "Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies" (8,499).
Showing 50 of 100 papers. Every paper with more than 1,888 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia Stanley R. Kay, Abraham Fiszbein, Lewis A. Opler · Schizophrenia Bulletin | 1987 | 21,651 |
| 2 | Structure, function and diversity of the healthy human microbiome Curtis Huttenhower et al. · Nature | Jun 2012 | 12,195 |
| 3 | Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies Undine Emmi Lang, Stefan Borgwardt · Cellular Physiology and Biochemistry | 2013 | 8,499 |
| 4 | Biological insights from 108 schizophrenia-associated genetic loci Stephan Ripke et al. · Nature | Jul 2014 | 8,181 |
| 5 | From inflammation to sickness and depression: when the immune system subjugates the brain Robert Dantzer, Jason C. O’Connor, Gregory G. Freund et al. · Nature reviews. Neuroscience | 12 Dec 2007 | 7,434 |
| 6 | The amyloid hypothesis of Alzheimer's disease at 25 years Dennis J. Selkoe, John Hardy · EMBO Molecular Medicine | 29 Mar 2016 | 6,336 |
| 7 | The ‘Trier Social Stress Test’ – A Tool for Investigating Psychobiological Stress Responses in a Laboratory Setting Clemens Kirschbaum, Karl‐Martin Pirke, Dirk Helmut Hellhammer · Neuropsychobiology | 22 Feb 2008 | 6,194 |
| 8 | Lecanemab in Early Alzheimer’s Disease Christopher H. van Dyck, Chad J. Swanson, Paul S. S. Aisen et al. · New England Journal of Medicine | 30 Nov 2022 | 5,691 |
| 9 | Inflamm‐aging: An Evolutionary Perspective on Immunosenescence Claudio Franceschi, Massimiliano Bonafè, Silvana Valensin et al. · Annals of the New York Academy of Sciences | Jun 2000 | 5,391 |
| 10 | The Microbiota-Gut-Brain Axis John F. Cryan et al. · Physiological Reviews | 28 Aug 2019 | 5,217 |
| 11 | Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain Bruce S. McEwen · Physiological Reviews | Jul 2007 | 4,968 |
| 12 | Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation Nicholas Arpaia, Clarissa Campbell, Xiying Fan et al. · Nature | 13 Nov 2013 | 4,892 |
| 13 | A Meta-Analysis of Cytokines in Major Depression Yekta Dowlati, Nathan Herrmann, Walter Swardfager et al. · Biological Psychiatry | 17 Dec 2009 | 4,780 |
| 14 | Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour John F. Cryan, Timothy G. Dinan · Nature reviews. Neuroscience | 12 Sep 2012 | 4,624 |
| 15 | Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity Amandine Everard, Clara Belzer, Lucie Geurts et al. · Proceedings of the National Academy of Sciences | 13 May 2013 | 4,539 |
| 16 | Alzheimer's Disease Henry W. Querfurth, Frank M. LaFerla · New England Journal of Medicine | 27 Jan 2010 | 4,526 |
| 17 | Network Analysis: An Integrative Approach to the Structure of Psychopathology Denny Borsboom, Angélique O. J. Cramer · Annual Review of Clinical Psychology | 28 Mar 2013 | 4,457 |
| 18 | Clozapine for the Treatment-Resistant Schizophrenic John Michael Kane · Archives of General Psychiatry | Sep 1988 | 4,159 |
| 19 | The role of inflammation in depression: from evolutionary imperative to modern treatment target Andrew H. Miller, Charles L. Raison · Nature reviews. Immunology | 29 Dec 2015 | 3,963 |
| 20 | Antidepressant effects of ketamine in depressed patients Robert Berman, Angela Cappiello, Amit N. Anand et al. · Biological Psychiatry | Feb 2000 | 3,904 |
| 21 | Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression Andrew H. Miller, Vladimir Maletic, Charles L. Raison · Biological Psychiatry | 16 Jan 2009 | 3,889 |
| 22 | Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve Javier A. Bravo, Paul Forsythe, Marianne V. Chew et al. · Proceedings of the National Academy of Sciences | 29 Aug 2011 | 3,886 |
| 23 | A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Carlos A. Zarate, Jaskaran B. Singh, Paul J. Carlson et al. · Archives of General Psychiatry | Aug 2006 | 3,806 |
| 24 | Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty Luigi Ferrucci, Elisa Fabbri · Nature Reviews Cardiology | 31 Jul 2018 | 3,731 |
| 25 | Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis Jessica M. Yano, Kristie B. Yu, Gregory P. Donaldson et al. · Cell | Apr 2015 | 3,664 |
| 26 | Mechanisms Underlying Inflammation in Neurodegeneration Christopher K. Glass, Kaoru Saijo, Beate Winner et al. · Cell | Mar 2010 | 3,593 |
| 27 | The Neuroendocrinology of Stress: A Never Ending Story Stafford Louis Lightman · Journal of Neuroendocrinology | Jun 2008 | 3,574 |
| 28 | A network theory of mental disorders Denny Borsboom · World Psychiatry | 26 Jan 2017 | 3,547 |
| 29 | Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies Josep O. Dalmau, Amy J. Gleichman, Ethan G. Hughes et al. · The Lancet Neurology | 15 Oct 2008 | 3,513 |
| 30 | Complement and microglia mediate early synapse loss in Alzheimer mouse models Soyon Hong, Victoria F. Beja-Glasser, Bianca M. Nfonoyim et al. · Science | 31 Mar 2016 | 3,511 |
| 31 | Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota Marie Vétizou et al. · Science | 5 Nov 2015 | 3,498 |
| 32 | Gut microbiota, metabolites and host immunity Michelle G. Rooks, Wendy S. Garrett · Nature reviews. Immunology | 27 May 2016 | 3,491 |
| 33 | The role of short-chain fatty acids in microbiota–gut–brain communication Boushra Dalile, Lukas Van Oudenhove, Bram Vervliet et al. · Nature Reviews Gastroenterology & Hepatology | 23 May 2019 | 3,399 |
| 34 | Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans John Harrison Krystal · Archives of General Psychiatry | Mar 1994 | 3,359 |
| 35 | Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry. Suzanne C. Segerstrom, Gregory E. Miller · Psychological Bulletin | 2004 | 3,353 |
| 36 | Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders Elaine Y. Hsiao, Sara W. McBride, Sophia Hsien et al. · Cell | Dec 2013 | 3,352 |
| 37 | Stress signalling pathways that impair prefrontal cortex structure and function Amy F.T. Arnsten · Nature reviews. Neuroscience | 20 May 2009 | 3,306 |
| 38 | Normal gut microbiota modulates brain development and behavior Rochellys Diaz Heijtz, Shugui Wang, Farhana Anuar et al. · Proceedings of the National Academy of Sciences | 31 Jan 2011 | 3,280 |
| 39 | Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic-Pituitary-Adrenal Responses to Stress Dong Liu, Josie C. Diorio, Beth M. Tannenbaum et al. · Science | 12 Sep 1997 | 3,185 |
| 40 | Microbiota in health and diseases Kejun Hou, Zhuo‐Xun Wu, Xuan-Yu Chen et al. · Signal Transduction and Targeted Therapy | 23 Apr 2022 | 3,178 |
| 41 | Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease Allison Agus, Julien Planchais, Harry Sokol · Cell Host & Microbe | Jun 2018 | 3,176 |
| 42 | Cytokines sing the blues: inflammation and the pathogenesis of depression Charles L. Raison, Lucile Capuron, Andrew H. Miller · Trends in Immunology | 29 Nov 2005 | 3,023 |
| 43 | The ecology of the microbiome: Networks, competition, and stability Katharine Z. Coyte, Jonas Schlüter, Kevin R. Foster · Science | 5 Nov 2015 | 2,956 |
| 44 | mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Nanxin Li, Boyoung Lee, Rongjian Liu et al. · Science | 19 Aug 2010 | 2,929 |
| 45 | The molecular neurobiology of depression Vaishnav Krishnan, Eric J. Nestler · Nature | Oct 2008 | 2,859 |
| 46 | Psychosis as a State of Aberrant Salience: A Framework Linking Biology, Phenomenology, and Pharmacology in Schizophrenia Shitij Kapur · American Journal of Psychiatry | 27 Dec 2002 | 2,858 |
| 47 | Single-cell transcriptomic analysis of Alzheimer’s disease Hansruedi Mathys, José Dávila-Velderrain, Zhuyu Peng et al. · Nature | May 2019 | 2,838 |
| 48 | Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis Matthew Bryant Howren, Donald M. Lamkin, Jerry M. Suls · Psychosomatic Medicine | Feb 2009 | 2,786 |
| 49 | Subgenual prefrontal cortex abnormalities in mood disorders Wayne Curtis Drevets, Joseph L. Price, Joseph R. Simpson et al. · Nature | Apr 1997 | 2,718 |
| 50 | Prevalence and Correlates of Bipolar Spectrum Disorder in the World Mental Health Survey Initiative Kathleen Ries Merikangas, Robert Jin, Jianping He et al. · Archives of General Psychiatry | 7 Mar 2011 | 2,670 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.