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Most cited papers in Vitamin K Research Studies

What are the most cited papers in Vitamin K Research Studies?

The most cited paper in Vitamin K Research Studies is "Apixaban versus Warfarin in Patients with Atrial Fibrillation" (Christopher B. Granger et al., 2011), with 9,001 citations. Next come "Edoxaban versus Warfarin in Patients with Atrial Fibrillation" (5,195) and "An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels." (3,820).

Showing 50 of 100 papers. Every paper with more than 641 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Apixaban versus Warfarin in Patients with Atrial Fibrillation Christopher B. Granger et al. · New England Journal of Medicine Open access 28 Aug 2011 9,001
2 Edoxaban versus Warfarin in Patients with Atrial Fibrillation Robert Patrick Giugliano et al. · New England Journal of Medicine Open access 19 Nov 2013 5,195
3 An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. Brigitte A. Rigat, Catherine Hubert, F Alhenc‐Gelas et al. · Journal of Clinical Investigation Open access Oct 1990 3,820
4 A Quantitative Assessment of Plasma Homocysteine as a Risk Factor for Vascular Disease Carol J. Boushey · JAMA 4 Oct 1995 3,609
5 Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. Aihao H. Ding, Carl Nathan, Dennis J. Stuehr · The Journal of Immunology Oct 1988 2,847
6 Apixaban in Patients with Atrial Fibrillation Stuart J. Connolly et al. · New England Journal of Medicine Open access 10 Feb 2011 2,433
7 Pharmacology and Management of the Vitamin K Antagonists Jack Ansell, Jack Hirsh, Elaine M. Hylek et al. · CHEST Journal Jun 2008 2,121
8 A Human Homolog of Angiotensin-converting Enzyme Sarah R. Tipnis, Nigel M. Hooper, Ralph Hyde et al. · Journal of Biological Chemistry Open access Oct 2000 2,047
9 Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients The Heart Outcomes Prevention Evaluation Study Investigators · New England Journal of Medicine Open access 20 Jan 2000 1,964
10 Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention Sebastian J. Padayatty, Arie Katz, Yaohui Wang et al. · Journal of the American College of Nutrition Feb 2003 1,957
11 Guide to Receptors and Channels (GRAC), 5th edition SPH Alexander, Alistair A. Mathie, JA Peters · British Journal of Pharmacology Open access Nov 2011 1,944
12 2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary Arthur Papaioannou, Suzanne N. Morin, Angela Man-Wei Cheung et al. · Canadian Medical Association Journal Open access 12 Oct 2010 1,756
13 Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease The Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators · New England Journal of Medicine Open access 12 Mar 2006 1,736
14 A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice**College of Pharmacy, University of Nebraska, Lincoln 8. Norris W. Dunham, T.S. Miya · Journal of the American Pharmaceutical Association (Scientific ed ) Mar 1957 1,721
15 Cachectin and tumour necrosis factor as two sides of the same biological coin Bruce Beutler, Anthony Cerami · Nature Apr 1986 1,657
16 The Effects of Strontium Ranelate on the Risk of Vertebral Fracture in Women with Postmenopausal Osteoporosis Pierre Jean Meunier, Christian Roux, Ego Seeman et al. · New England Journal of Medicine Open access 28 Jan 2004 1,641
17 S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles Rosario Donato · The International Journal of Biochemistry & Cell Biology Jul 2001 1,590
18 The Pharmacology and Management of the Vitamin K Antagonists Jack Ansell, Jack Hirsh, Leon Poller et al. · CHEST Journal Sep 2004 1,536
19 Dabigatran versus Warfarin in Patients with Mechanical Heart Valves John W. Eikelboom, Stuart J. Connolly, Martina Brueckmann et al. · New England Journal of Medicine Sep 2013 1,514
20 Global vitamin D status and determinants of hypovitaminosis D Ambrish Mithal, Denys A. Wahl, J.‐P. Bonjour et al. · Osteoporosis International Open access 18 Jun 2009 1,478
21 Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol Robert P. Heaney, K. Michael Davies, Tai C. Chen et al. · American Journal of Clinical Nutrition Open access 2003 1,413
22 Antioxidants and Atherosclerotic Heart Disease María José Ferreira Díaz, Balz Frei, Joseph A. Vita et al. · New England Journal of Medicine 7 Aug 1997 1,358
23 Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Mark N. Levine, Cathy Conry‐Cantilena, Y Wang et al. · Proceedings of the National Academy of Sciences Open access 16 Apr 1996 1,322
24 Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone Peter V. Hauschka, Jane B. Lian, David E.C. Cole et al. · Physiological Reviews Jul 1989 1,287
25 The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1 Daniel Picot, Patrick J. Loll, R. Michael Garavito · Nature 1994 1,265
26 Deficiency of protein C in congenital thrombotic disease. John H. Griffin, B. L. Evatt, Theodore S. Zimmerman et al. · Journal of Clinical Investigation Open access Nov 1981 1,264
27 The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene Lluís Fajas, Didier Auboeuf, Eric Raspé et al. · Journal of Biological Chemistry Open access Jul 1997 1,183
28 Warfarin in the Prevention of Stroke Associated with Nonrheumatic Atrial Fibrillation Michael D. Ezekowitz, Samuel L. Bridgers, K James et al. · New England Journal of Medicine Open access 12 Nov 1992 1,170
29 Global Consensus Recommendations on Prevention and Management of Nutritional Rickets Craig Frank Munns et al. · The Journal of Clinical Endocrinology & Metabolism Open access 8 Jan 2016 1,153
30 Function and Mechanism of Zinc Metalloenzymes Keith A. McCall, Chih-chin Huang, Carol A. Fierke · Journal of Nutrition Open access May 2000 1,148
31 Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2 Simone Rost, Andreas Fregin, Vytautas Ivaškevičius et al. · Nature Feb 2004 1,141
32 The Effect of Folic Acid Fortification on Plasma Folate and Total Homocysteine Concentrations Paul F. Jacques, Jacob Selhub, Andrew G. Bostom et al. · New England Journal of Medicine Open access 13 May 1999 1,135
33 Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis Mark J Bolland, A Avenell, John A. Baron et al. · BMJ Open access 29 Jul 2010 1,101
34 Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials Deepak P. Vivekananthan, Marc S. Penn, Shelly K Sapp et al. · The Lancet Review Jun 2003 1,086
35 Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells. Shoji Kagami, Wayne A. Border, Diane E. Miller et al. · Journal of Clinical Investigation Open access Jun 1994 1,084
36 Cyclic Administration of Pamidronate in Children with Severe Osteogenesis Imperfecta Francis H. Glorieux, Nicholas J. Bishop, Horacio Plotkin et al. · New England Journal of Medicine Open access Oct 1998 1,030
37 Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988–1994, Shanna Nesby-O’Dell, Kelley S. Scanlon, Mary E. Cogswell et al. · American Journal of Clinical Nutrition Open access Jul 2002 1,007
38 Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use Sebastian J. Padayatty, He Sun, Yaohui Wang et al. · Annals of Internal Medicine 6 Apr 2004 986
39 Association Between Omega-3 Fatty Acid Supplementation and Risk of Major Cardiovascular Disease Events Evangelos C. Rizos, Evangelia Ntzani, Eftychia Bika et al. · JAMA 11 Sep 2012 968
40 A Comparison of Six Weeks with Six Months of Oral Anticoagulant Therapy after a First Episode of Venous Thromboembolism Sam Schulman, Ann-Sofie Rhedin, Per Lindmarker et al. · New England Journal of Medicine 22 Jun 1995 947
41 Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans Anitra C. Carr, Balz Frei · American Journal of Clinical Nutrition Open access Jun 1999 947
42 The S100 protein family: History, function, and expression Danna B. Zimmer, Emily H. Cornwall, Aimee L. Landar et al. · Brain Research Bulletin 1995 934
43 Phospholipase A2 structure/function, mechanism, and signaling John E. Burke, Edward A. Dennis · Journal of Lipid Research Open access 14 Nov 2008 930
44 Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH Jihye Yun, Edouard Mullarky, Changyuan Lu et al. · Science Open access 5 Nov 2015 927
45 Separation of Bacterial Menaquinones by HPLC Using Reverse Phase (RP18) and a Silver Loaded Ion Exchanger as Stationary Phases Reiner Michael Kroppenstedt · Journal of Liquid Chromatography 1982 927
46 Procalcitonin increase after endotoxin injection in normal subjects. Paresh Dandona, David E. Nix, Michael F. Wilson et al. · The Journal of Clinical Endocrinology & Metabolism Dec 1994 922
47 Poorer Behavioral and Developmental Outcome More Than 10 Years After Treatment for Iron Deficiency in Infancy Betsy Lozoff, Elías Jiménez, John William Hagen et al. · PEDIATRICS Apr 2000 916
48 Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock Paul Ellis Marik, Vikramjit S. Khangoora, Racquel Rivera et al. · CHEST Journal Open access 6 Dec 2016 896
49 A family of mammalian Na+-dependent L-ascorbic acid transporters Hiroyasu Tsukaguchi, Taro Tokui, Bryan Mackenzie et al. · Nature May 1999 885
50 The lipocalin protein family: structural and sequence overview Darren R. Flower, Anthony C.T. North, Clare Sansom · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology Oct 2000 877

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.