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Most cited papers in Medicine

What are the most cited papers in Medicine?

The most cited paper in Medicine is "Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries" (Hyuna Sung, Adalberto M. Filho, Mathieu Laversanne et al., 2021), with 114,522 citations. Next come "The PRISMA 2020 statement: an updated guideline for reporting systematic reviews" (105,915) and "Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries" (88,280).

Showing 50 of 100 papers. Every paper with more than 16,152 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries Hyuna Sung, Adalberto M. Filho, Mathieu Laversanne et al. · CA A Cancer Journal for Clinicians Open access 4 Feb 2021 114,522
2 The PRISMA 2020 statement: an updated guideline for reporting systematic reviews Matthew James Page et al. · BMJ ReviewOpen access 29 Mar 2021 105,915
3 Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram et al. · CA A Cancer Journal for Clinicians Open access 12 Sep 2018 88,280
4 “Mini-mental state” Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh · Journal of Psychiatric Research Nov 1975 87,598
5 Hallmarks of Cancer: The Next Generation Douglas Hanahan, Robert A. Weinberg · Cell Open access Mar 2011 67,836
6 Mutation of the mouse klotho gene leads to a syndrome resembling ageing. M Kuro-o, Y Matsumura, H Aizawa et al. · PubMed 6 Nov 1997 66,570
7 Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement David Moher, Alessandro Liberati, Jennifer Tetzlaff et al. · PLoS Medicine ReviewOpen access 20 Jul 2009 65,199
8 Measuring inconsistency in meta-analyses Julian P. T. Higgins, Simon G. Thompson, Jonathan J Deeks et al. · BMJ Open access 4 Sep 2003 64,184
9 Global cancer statistics Ahmedin Jemal, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians Open access 4 Feb 2011 55,108
10 Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Chaolin Huang et al. · The Lancet Open access 24 Jan 2020 52,028
11 A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation Mary E. Charlson, Peter Pompei, Kathy L. Aleš et al. · Journal of Chronic Diseases 1987 50,676
12 STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT J Martin Bland, DouglasG. Altman · The Lancet Feb 1986 48,188
13 The Hospital Anxiety and Depression Scale A. S. Zigmond, R Philip Snaith · Acta Psychiatrica Scandinavica Jun 1983 47,341
14 Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues Haider Raza, Annie John, Abderrahim Nemmar · Cellular Physiology and Biochemistry Open access 2013 47,289
15 The PHQ-9 Kurt Kroenke, Robert L. Spitzer, Janet B. W. Williams · Journal of General Internal Medicine Open access Sep 2001 45,744
16 An Inventory for Measuring Depression Aaron T. Beck · Archives of General Psychiatry Jun 1961 38,441
17 Quantifying heterogeneity in a meta‐analysis Julian P. T. Higgins, Simon G. Thompson · Statistics in Medicine 21 May 2002 37,545
18 The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research Daniel J. Buysse, Charles F. Reynolds, T. H. Monk et al. · Psychiatry Research May 1989 35,692
19 A new mathematical model for relative quantification in real-time RT-PCR Michael Walter Pfaffl · Nucleic Acids Research Open access May 2001 35,329
20 The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. John E. Ware, Cathy Donald Sherbourne · PubMed Jun 1992 33,990
21 Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge William T. Friedewald, Robert I. Levy, Donald S. Fredrickson · Clinical Chemistry Jun 1972 32,670
22 Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man David Richard Matthews, J P Hosker, A. Rudenski et al. · Diabetologia Open access Jul 1985 31,761
23 Classification of Surgical Complications Daniel R. Dindo, Nicolas Demartines, Pierre-Alain Clavien · Annals of Surgery Open access 22 Jul 2004 31,598
24 Clinical Characteristics of Coronavirus Disease 2019 in China Wei‐jie Guan et al. · New England Journal of Medicine Open access 28 Feb 2020 31,256
25 PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer Andreas Daniel Hartkopf, Florin‐Andrei Taran, Markus Wallwiener et al. · Breast Care Open access 2016 30,915
26 A Novel Coronavirus from Patients with Pneumonia in China, 2019 Na Zhu, Dingyu Zhang, Wenling Wang et al. · New England Journal of Medicine Open access 24 Jan 2020 30,499
27 The MOS 36-ltem Short-Form Health Survey (SF-36) John E. Ware, Cathy Donald Sherbourne · Medical Care Jun 1992 30,226
28 New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) E. A. Eisenhauer, P. Therasse, Jan Bogaerts et al. · European Journal of Cancer 27 Dec 2008 30,125
29 Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study Ömer Toprak, Hüseyin Kurt, Yasin Sarı et al. · Kidney & Blood Pressure Research Open access 2017 29,690
30 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Hiroshi Ohkawa, Nobuko Ohishi, Kunio Yagi · Analytical Biochemistry Jun 1979 29,425
31 Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 Jacques Ferlay, Isabelle Soerjomataram, Rajesh Prabhakar Dikshit et al. · International Journal of Cancer Open access 13 Sep 2014 29,250
32 Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Fei Zhou, Ting Yu, Ronghui Du et al. · The Lancet Open access Mar 2020 29,236
33 The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Mervyn Singer, Clifford Scott Deutschman, Christopher W. Seymour et al. · JAMA Open access 22 Feb 2016 29,012
34 The Hallmarks of Cancer Douglas Hanahan, Robert A. Weinberg · Cell Open access 2000 28,893
35 The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration Alessandro Liberati, Douglas G. Altman, Jennifer Tetzlaff et al. · PLoS Medicine ReviewOpen access 20 Jul 2009 28,074
36 Global cancer statistics, 2012 Lindsey A. Torre, Freddie Bray, Rebecca L. Siegel et al. · CA A Cancer Journal for Clinicians Open access 4 Feb 2015 27,467
37 A new and rapid colorimetric determination of acetylcholinesterase activity George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology Jul 1961 27,264
38 Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement PRISMA-P Group, David Moher, Larissa Shamseer et al. · Systematic Reviews ReviewOpen access 2015 27,092
39 The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment Ziad Samir Nasreddine, Natalie A. Phillips, Valérie Bédirian et al. · Journal of the American Geriatrics Society 30 Mar 2005 26,231
40 Antioxidant activity applying an improved ABTS radical cation decolorization assay Roberta Re, Nicoletta Pellegrini, Anna R. Proteggente et al. · Free Radical Biology and Medicine May 1999 26,207
41 A New Equation to Estimate Glomerular Filtration Rate Andrew S. Levey, Lesley A. Stevens, Christopher H. Schmid et al. · Annals of Internal Medicine Open access 5 May 2009 26,119
42 Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries Freddie Bray, Mathieu Laversanne, Hyuna Sung et al. · CA A Cancer Journal for Clinicians Open access 4 Apr 2024 25,936
43 AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility Garrett M. Morris, Ruth Huey, William Lindstrom et al. · Journal of Computational Chemistry Open access 27 Apr 2009 25,864
44 Use of a free radical method to evaluate antioxidant activity Wendy Brand-Williams, Marie‐Elisabeth Cuvelier, Claudette Berset · LWT Open access 1995 25,846
45 The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure The JNC 7 Report Aram V. Chobanian · JAMA 20 May 2003 25,591
46 Geant4—a simulation toolkit Stefano Agostinelli et al. · Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment Open access127 authors 21 Jun 2003 25,572
47 Frailty in Older Adults: Evidence for a Phenotype Linda P. Fried, Catherine M. Tangen, Jeremy D Walston et al. · The Journals of Gerontology Series A Mar 2001 25,162
48 The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants Elda Dermyshi, Yizhong Wang, Chongbing Yan et al. · Neonatology Review 2017 24,491
49 Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal Ndiaye, Matar, Lespez, Laurent, Tribolo, Chantal et al. · Monash University Research Portal (Monash University) Open access 28 Mar 2024 24,104
50 A pneumonia outbreak associated with a new coronavirus of probable bat origin Peng Zhou et al. · Nature Open access 3 Feb 2020 23,429

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.