Most cited papers from Acucela (United States)

Acucela (United States)

What are the most cited papers from Acucela (United States)?

The most cited paper from Acucela (United States) is "Emixustat Hydrochloride for Geographic Atrophy Secondary to Age-Related Macular Degeneration" (Philip J. Rosenfeld, Pravin U. Dugel, Frank Gerhard Holz et al., 2018), with 124 citations. Next come "SAFETY AND EFFECT ON ROD FUNCTION OF ACU-4429, A NOVEL SMALL-MOLECULE VISUAL CYCLE MODULATOR" (97) and "Effects of Potent Inhibitors of the Retinoid Cycle on Visual Function and Photoreceptor Protection from Light Damage in Mice" (80).

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Showing 44 of 44 papers. Every paper is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Emixustat Hydrochloride for Geographic Atrophy Secondary to Age-Related Macular Degeneration Philip J. Rosenfeld, Pravin U. Dugel, Frank Gerhard Holz et al. · Ophthalmology Open access	30 Apr 2018	124
2	SAFETY AND EFFECT ON ROD FUNCTION OF ACU-4429, A NOVEL SMALL-MOLECULE VISUAL CYCLE MODULATOR Ryo Kubota, Nancy L. Boman, Robert David et al. · Retina	26 Apr 2011	97
3	Effects of Potent Inhibitors of the Retinoid Cycle on Visual Function and Photoreceptor Protection from Light Damage in Mice Akiko Maeda, Tadao Maeda, Marcin Golczak et al. · Molecular Pharmacology Open access	12 Jul 2006	80
4	Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity Claes Båvik, Susan Henry, Yan Zhang et al. · PLoS ONE Open access	13 May 2015	74
5	PHASE 1, DOSE-RANGING STUDY OF EMIXUSTAT HYDROCHLORIDE (ACU-4429), A NOVEL VISUAL CYCLE MODULATOR, IN HEALTHY VOLUNTEERS Ryo Kubota, Suliman Al‐Fayoumi, Suresh Mallikaarjun et al. · Retina	20 Sep 2013	73
6	Protective Effect of Crocin against Blue Light– and White Light–Mediated Photoreceptor Cell Death in Bovine and Primate Retinal Primary Cell Culture Aïcha Laabich, Ganesh P. Vissvesvaran, Kuo Lee Lieu et al. · Investigative Ophthalmology & Visual Science Open access	23 Jun 2006	66
7	PHASE II, RANDOMIZED, PLACEBO-CONTROLLED, 90-DAY STUDY OF EMIXUSTAT HYDROCHLORIDE IN GEOGRAPHIC ATROPHY ASSOCIATED WITH DRY AGE-RELATED MACULAR DEGENERATION Pravin U. Dugel, Roger L. Novack, Karl G. Csaky et al. · Retina Open access	May 2015	64
8	Lecithin:Retinol Acyltransferase Is Responsible for Amidation of Retinylamine, a Potent Inhibitor of the Retinoid Cycle Marcin Golczak, Yoshikazu Imanishi, Vladimir Kuksa et al. · Journal of Biological Chemistry Open access	11 Oct 2005	61
9	Effects of Strain and Treatment with Inhaled All-Trans-Retinoic Acid on Cigarette Smoke-Induced Pulmonary Emphysema in Mice Thomas H. March, Larry E. Bowen, Gregory L. Finch et al. · COPD Journal of Chronic Obstructive Pulmonary Disease	Jul 2005	45
10	A multi-centre, blinded, randomised, placebo-controlled, laboratory-based study of MQX-503, a novel topical gel formulation of nitroglycerine, in patients with Raynaud phenomenon Laura Kathleen Hummers, Carin E. Dugowson, Frederick J. Dechow et al. · Annals of the Rheumatic Diseases	26 Dec 2012	39
11	Protective effects of myricetin and related flavonols against A2E and light mediated-cell death in bovine retinal primary cell culture Aïcha Laabich, Corinne C. Manmoto, Vladimir Kuksa et al. · Experimental Eye Research	30 Apr 2007	35
12	Visual cycle modulation in neurovascular retinopathy James D. Akula, Ronald M. Hansen, Radouil T. Tzekov et al. · Experimental Eye Research	28 Apr 2010	34
13	Bioanalysis of Emixustat (Acu-4429) in Whole Blood Collected with Volumetric Absorptive Microsampling by LC–MS/MS Zhixin Miao, James Farnham, Glenn D. Hanson et al. · Bioanalysis	Sep 2015	32
14	A RANDOMIZED, PLACEBO-CONTROLLED STUDY OF INTRAVITREAL OCRIPLASMIN IN PEDIATRIC PATIENTS SCHEDULED FOR VITRECTOMY Kimberly A. Drenser, Aniz Girach, Antonio Capone · Retina	23 Sep 2015	29
15	The relationship between neurotrophic factors and CaMKII in the death and survival of retinal ganglion cells Nigel G. F. Cooper, Aïcha Laabich, W. Fan et al. · Progress in brain research Book chapter	2008	20
16	Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets β-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide Δ4-desaturase 1 Eugenia Poliakov, William Samuel, Todd E Duncan et al. · PLoS ONE Open access	27 Apr 2017	19
17	Effects of emixustat hydrochloride in patients with proliferative diabetic retinopathy: a randomized, placebo-controlled phase 2 study Ryo Kubota, Chirag D. Jhaveri, John M Koester et al. · Graefe s Archive for Clinical and Experimental Ophthalmology Open access	27 Aug 2020	18
18	Emixustat Reduces Metabolic Demand of Dark Activity in the Retina Ryo Kubota, David John Calkins, Susan Henry et al. · Investigative Ophthalmology & Visual Science Open access	26 Nov 2019	18
19	Pharmacotherapy for metabolic and cellular stress in degenerative retinal diseases Ryo Kubota, Jeff K. Gregory, Susan Henry et al. · Drug Discovery Today	3 Dec 2019	17
20	Minocycline Protects Photoreceptors from Light and Oxidative Stress in Primary Bovine Retinal Cell Culture David W. M. Leung, L. Lindlief, Aïcha Laabich et al. · Investigative Ophthalmology & Visual Science	29 Dec 2006	14
21	Disposition, profiling and identification of emixustat and its metabolites in humans Michael E. Fitzsimmons, Gang Sun, Vladimir Kuksa et al. · Xenobiotica	5 Jul 2017	10
22	Single doses of all-trans-N-retinylacetamide slow down the ERG amplitude recovery after bleaching in rats André Marcio Vieira Messias, Eberhart Zrenner, Radouil T. Tzekov et al. · Documenta Ophthalmologica	10 Dec 2009	10
23	Oxidative Deamination of Emixustat by Human Vascular Adhesion Protein-1/Semicarbazide-Sensitive Amine Oxidase Michael J. A. Reid, Russell J. Eyre, Terry Podoll · Drug Metabolism and Disposition Open access	20 Feb 2019	9
24	Comparison of Inhibitor and Substrate Selectivity between Rodent and Human Vascular Adhesion Protein-1 Ryo Kubota, Michael J. A. Reid, Kuo Lee Lieu et al. · Mediators of Inflammation Open access	20 Jan 2020	7
25	Phase 1, Dose-Escalating Study of the Safety, Tolerability, and Pharmacokinetics of ACU-4429 in Healthy Volunteers Ryo Kubota, David G. Birch, Richard V David · Investigative Ophthalmology & Visual Science	28 Apr 2009	7
26	Validation and Reproducibility of an LC–MS/MS Method for Emixustat and Its Three Deaminated Metabolites in Human Plasma Terry Podoll, Lisa Geisler, Michael Van Parys et al. · Bioanalysis	16 Oct 2018	2
27	Effects of a Vitamin-A Derivative (AG-787-14-2) on Retinal Function in Oxygen-Induced Retinopathy James D. Akula, Ryo Kubota, Ronald M. Hansen et al. · Investigative Ophthalmology & Visual Science	14 May 2008	2
28	Novel Therapy for Non-Exudative AMD Claes Båvik, K. Murata, Tim E. McGinn et al. · Investigative Ophthalmology & Visual Science	28 Apr 2009	1
29	Ocular Distribution of the Visual Cycle Modulator (VCM) 14C-ACU-4429 in Beagle Dogs Terry Podoll, Suliman Al‐Fayoumi, Elizabeth Prescott et al. · Investigative Ophthalmology & Visual Science	26 Mar 2012	1
30	Characterizing the Metabolism and Physiological Functions of Dihydroretinoids, Charting a Novel Pathway in the Metabolism of Vitamin A Alexander R. Moise, Vladimir Kuksa, Krzysztof Palczewski · The FASEB Journal	Mar 2006	1
31	Positive Diabetic Retinopathy Outcomes with Emixustat in a Pilot Study Chirag D. Jhaveri, John M Koester, Jeffrey K. Gregory et al. · Investigative Ophthalmology & Visual Science Open access	22 Jul 2019	0
32	Randomized clinical trial evaluating the pharmacodynamics of emixustat in subjects with macular atrophy secondary to Stargardt disease Jeff K. Gregory, David G. Birch, Ryo Kubota · Investigative Ophthalmology & Visual Science Open access	10 Jun 2020	0
33	Low luminance deficit as a predictor of visual acuity changes in subjects with geographic atrophy secondary to age-related macular degeneration John M Koester, Jeffrey K. Gregory, Lukas Scheibler et al. · Investigative Ophthalmology & Visual Science Open access	23 Jun 2017	0
34	Effect of the Aroylhydrazone Class of Iron Chelators on Photoreceptor and Retinal Pigment Epithelial Cells Against Light, A2E or Oxidative Stress David W. M. Leung, Ganesh P. Vissvesvaran, L. Lindlief et al. · Investigative Ophthalmology & Visual Science	10 May 2007	0
35	Dimethylthiourea Protects Retinal Photoreceptors Against Blue Light Stress in Bovine and Primate Primary Cultures Ganesh P. Vissvesvaran, Aïcha Laabich, John Sinclair et al. · Investigative Ophthalmology & Visual Science	May 2006	0
36	Protective Effect of Myricetin and Related Flavonols Against Light-Induced Retinal Damage in Mice Liang Zhu, Aïcha Laabich, David W. M. Leung et al. · Investigative Ophthalmology & Visual Science	10 May 2007	0
37	OcuScreenTM, ex vivo Screen, for Drug Discovery and Detection of Retinal Toxins Shannon Hayes, Kuo Lee Lieu, Claes Båvik et al. · Investigative Ophthalmology & Visual Science	28 Apr 2009	0
38	Visual Cycle Modulators (VCMs) as Inhibitors of Retinal Neovascularization Susan Henry, Ewa Budzynski, Christine Diamond et al. · Investigative Ophthalmology & Visual Science	26 Mar 2012	0
39	Within-visit And Between-visit Repeatability Of The Diagnosys Full-field Stimulus Threshold (D-FST) When Measuring Rod Sensitivity In Patients With Atrophic Age-related Macular Degeneration (ARMD) Martin L. Klein, David G. Birch, John Chandler et al. · Investigative Ophthalmology & Visual Science	26 Mar 2012	0
40	Protective Activity of Myricetin-Like Flavones and Cyanidins in Light-Induced Retinal Damage Liang Zhu, David W. M. Leung, L. Lindlief et al. · Investigative Ophthalmology & Visual Science	14 May 2008	0
41	Prolonged Rod Visual Cycle Suppression with ACU-4429 in Patients with Geographic Atrophy David G. Birch, John Chandler, Al Reaves et al. · Investigative Ophthalmology & Visual Science	26 Mar 2012	0
42	Dark- and Light-Adapted Intensity-Response Function ERG Characteristics in Rodents and Monkeys Radouil T. Tzekov, Michelle Gibson, Liang Zhu et al. · Investigative Ophthalmology & Visual Science	14 May 2008	0
43	Electroretinographic (ERG) and Psychophysical Testing of Normal Subjects Given a Single Dose of a Visual Cycle Modulator (All-Trans-N-Retinylacetamide) Kirsten G. Locke, G. Caniano, Radouil T. Tzekov et al. · Investigative Ophthalmology & Visual Science	28 Apr 2009	0
44	Prostaglandin EP4 Increases Outflow Facility in Calf Eyes Using a Whole Eye Organ Perfusion (WEOP) Model Lindsey Millard, Andriy Pashko, Claes Båvik et al. · Investigative Ophthalmology & Visual Science	30 Apr 2014	0

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.