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Most cited papers from Addgene

Addgene

What are the most cited papers from Addgene?

The most cited paper from Addgene is "Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components" (Keith Pardee, Alexander A. Green, Melissa K. Takahashi et al., 2016), with 1,513 citations. Next come "Conserved pan-cancer microenvironment subtypes predict response to immunotherapy" (1,384) and "A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications" (1,194).

Showing 50 of 61 papers. Every paper with more than 37 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components Keith Pardee, Alexander A. Green, Melissa K. Takahashi et al. · Cell Open access May 2016 1,513
2 Conserved pan-cancer microenvironment subtypes predict response to immunotherapy Alexander Bagaev, Nikita Kotlov, Krystle J. Nomie et al. · Cancer Cell Open access 20 May 2021 1,384
3 A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications George W. Wright, Da Wei Huang, James D. Phelan et al. · Cancer Cell Open access Apr 2020 1,194
4 Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells Clarissa Campbell, Peter T. McKenney, Daniel M. Konstantinovsky et al. · Nature Open access 15 Apr 2020 900
5 Tisagenlecleucel in adult relapsed or refractory follicular lymphoma: the phase 2 ELARA trial Nathan Hale Fowler et al. · Nature Medicine Open access 17 Dec 2021 556
6 The khmer software package: enabling efficient nucleotide sequence analysis Michael Robin Crusoe et al. · F1000Research Open access 25 Sep 2015 429
7 AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies Sean Caenepeel et al. · Cancer Discovery Open access 25 Sep 2018 427
8 Antigen receptor repertoire profiling from RNA-seq data Dmitriy A. Bolotin, Stanislav Poslavsky, Alexey N. Davydov et al. · Nature Biotechnology Open access Oct 2017 364
9 Physical and functional interaction between WT1 and p53 proteins. Shyamala Maheswaran, Soon‐Jung Park, Amy Bernard et al. · Proceedings of the National Academy of Sciences Open access Jun 1993 308
10 Clinical trial links oncolytic immunoactivation to survival in glioblastoma Alexander Ling et al. · Nature Open access 18 Oct 2023 278
11 Expression of the APC tumor suppressor protein in oligodendroglia Ratan V. Bhat, Karen J. Axt, Jennifer S. Fosnaugh et al. · Glia Jun 1996 244
12 Adeno-Associated Virus Technologies and Methods for Targeted Neuronal Manipulation Leila Haery, Benjamin E. Deverman, Katherine S. Matho et al. · Frontiers in Neuroanatomy Open access 26 Nov 2019 212
13 Utilization of Oriented Peptide Libraries to Identify Substrate Motifs Selected by ATM Ted B. O'Neill, Alison J. Dwyer, Yael Haberman Ziv et al. · Journal of Biological Chemistry Open access Jul 2000 194
14 Precise reconstruction of the TME using bulk RNA-seq and a machine learning algorithm trained on artificial transcriptomes Aleksandr Zaitsev et al. · Cancer Cell Open access Aug 2022 141
15 The Addgene repository: an international nonprofit plasmid and data resource Joanne Kamens · Nucleic Acids Research Open access 11 Nov 2014 127
16 Regulatory Aspects of Artificial Intelligence and Machine Learning Liron Pantanowitz, Matthew G. Hanna, Joshua Pantanowitz et al. · Modern Pathology Open access 12 Sep 2024 126
17 Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance. Jyotirmoy Kusari, Kathleen A. Kenner, K I Suh et al. · Journal of Clinical Investigation Open access Mar 1994 123
18 Multi-View Neural Human Rendering Minye Wu, Yuehao Wang, Qiang Hu et al. Conference paper Jun 2020 115
19 Telomeric Protein Pin2/TRF1 as an Important ATM Target in Response to Double Strand DNA Breaks Shuji Kishi, Xiao Zhen Zhou, Yael Haberman Ziv et al. · Journal of Biological Chemistry Open access Aug 2001 110
20 Radiation-induced circulating myeloid-derived suppressor cells induce systemic lymphopenia after chemoradiotherapy in patients with glioblastoma Subhajit Ghosh, Jiayi Huang, Matthew J. Inkman et al. · Science Translational Medicine Open access 25 Jan 2023 108
21 Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes Olga I. Isaeva, George Vladimirovich Sharonov, Ekaterina O. Serebrovskaya et al. · Journal for ImmunoTherapy of Cancer Open access 29 Oct 2019 107
22 Dual inhibition of renin-angiotensin-aldosterone system and endothelin-1 in treatment of chronic kidney disease Radko Komers, Horacio Plotkin · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology Open access 24 Mar 2016 105
23 Durable response after tisagenlecleucel in adults with relapsed/refractory follicular lymphoma: ELARA trial update Martin H. Dreyling et al. · Blood Open access 9 Jan 2024 97
24 Epidermal‐growth‐factor‐receptor expression is associated with rapid tumor proliferation in bladder cancer Guido Sauter, John D. Haley, Karen Chew et al. · International Journal of Cancer 15 May 1994 94
25 p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest Patricia M. Flatt, Kornélia Polyák, Luo Jia Tang et al. · Cancer Letters Aug 2000 89
26 Comprehensive peripheral blood immunoprofiling reveals five immunotypes with immunotherapy response characteristics in patients with cancer Daniiar Dyikanov et al. · Cancer Cell Open access May 2024 88
27 Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene Dario Valenzuela, John Groffen · Nucleic Acids Research Open access 26 Jan 1986 88
28 Cloning and characterization of the gene for an additional extracellular serine protease of Bacillus subtilis Alan Sloma, G A Rufo, Kelly Theriault et al. · Journal of Bacteriology Open access Nov 1991 88
29 Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma Marta Larráyoz et al. · Nature Medicine Open access Mar 2023 86
30 Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents Yuval Shaked, Terence Tang, Jill R. Woloszynek et al. · Cancer Research Open access 8 Sep 2009 81
31 Automated Assay for HER-2/neu in Serum Robert C. Payne, Jeffrey W Allard, Linda Anderson-Mauser et al. · Clinical Chemistry Feb 2000 80
32 Molecular analysis of both translocation products of a Philadelphia-positive CML patient Annelies de Klein, Ton van Agthoven, Cora Groffen et al. · Nucleic Acids Research Open access 1986 77
33 Lack of intrafollicular memory CD4 + T cells is predictive of early clinical failure in newly diagnosed follicular lymphoma Patrizia Mondello et al. · Blood Cancer Journal Open access 15 Jul 2021 69
34 Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients Andrea J. Radtke et al. · Cancer Cell Open access 29 Feb 2024 66
35 Next-Generation Sequencing for Typing and Detection of Resistance Genes: Performance of a New Commercial Method during an Outbreak of Extended-Spectrum-Beta-Lactamase-Producing Escherichia coli Jacobien Veenemans, I. T. M. A. Overdevest, Eveline Snelders et al. · Journal of Clinical Microbiology Open access May 2014 66
36 Intracellular Targeting of the Oncogenic MUC1-C Protein with a Novel GO-203 Nanoparticle Formulation Masanori Hasegawa, Raj Kumar Sinha, Manoj Kumar et al. · Clinical Cancer Research Open access 26 Feb 2015 66
37 The Detection of Increased Amounts of the Extracellular Domain of the Epidermal Growth Factor Receptor in Serum During Carcinogenesis in Asbestosis Patients Riitta Partanen, Kari Hemminki, Heikki Koskinen et al. · Journal of Occupational and Environmental Medicine Dec 1994 66
38 Cloning and characterization of the Bacillus subtilis birA gene encoding a repressor of the biotin operon S G Bower, John B. Perkins, R. Rogers Yocum et al. · Journal of Bacteriology Open access May 1995 61
39 Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic Dianne Nicol et al. · Genome Medicine Open access 25 Sep 2017 57
40 Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations M. Elise Lauterbur et al. · eLife Open access 3 Mar 2023 55
41 Fatty Acid Hydroperoxide Lyase in Tomato Fruits: Cloning and Properties of a Recombinant Enzyme Expressed inEscherichia coli Kenji Matsui, Chinatsu MIYAHARA, Jack Dale Wilkinson et al. · Bioscience Biotechnology and Biochemistry 2000 54
42 Molecular Epidemiology of p53 Protein Mutations in Workers Exposed to Vinyl Chloride Steven J. Smith, Yongliang Li, Richard J. Whitley et al. · American Journal of Epidemiology Feb 1998 54
43 Mutant c-Ki-ras p21 protein in chemical carcinogenesis in humans exposed to vinyl chloride Immaculata De Vivo, Marie‐Jeanne Marion, Steven J. Smith et al. · Cancer Causes & Control May 1994 51
44 A vision to the future: value-based laboratory medicine Mario Plebani et al. · Clinical Chemistry and Laboratory Medicine (CCLM) Open access 11 Sep 2024 49
45 Artificial Seeds — Encapsulated Somatic Embryos Keith Redenbaugh, Joann A. Fujii, David Slade et al. · Biotechnology in agriculture and forestry Book chapter 1991 49
46 Duvelisib plus romidepsin in relapsed/refractory T cell lymphomas: a phase 1b/2a trial Steven M. Horwitz et al. · Nature Medicine Open access 17 Jun 2024 48
47 Multicenter Phase 2 Study of Oral azacitidine (CC-486) plus CHOP as initial treatment for peripheral T-cell lymphoma Jia Ruan et al. · Blood Open access 16 Feb 2023 48
48 Immunodetection of Parkin protein in vertebrate and invertebrate brains: a comparative study using specific antibodies Judith M. Horowitz, Vita A. Vernace, Jason M. Myers et al. · Journal of Chemical Neuroanatomy 2001 48
49 A Neural Rendering Framework for Free-Viewpoint Relighting Zhang Chen, Anpei Chen, Guli Zhang et al. Conference paper Jun 2020 47
50 Technology and Future of Multi-Cancer Early Detection Danny A. Milner, Jochen K. Lennerz · Life Open access 29 Jun 2024 45

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.