| 1 |
Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications
John Löfblom, Joachim Feldwisch, Vladimir Tolmachev et al. · FEBS Letters
Open access |
11 Apr 2010 |
657 |
| 2 |
Tumor Imaging Using a Picomolar Affinity HER2 Binding Affibody Molecule
Anna Orlova, Mikaela Magnusson, Tove Lisa Jenny Eriksson et al. · Cancer Research
Open access |
15 Apr 2006 |
574 |
| 3 |
Protein A chromatography for antibody purification
Sophia Hober, Karin Nord, Martin Linhult · Journal of Chromatography B
|
10 Oct 2006 |
561 |
| 4 |
Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation
Wolfgang Hoyer, Caroline Grönwall, Andreas Jonsson et al. · Proceedings of the National Academy of Sciences
Open access |
29 Mar 2008 |
418 |
| 5 |
Affibody Molecules in Biotechnological and Medical Applications
Stefan Ståhl, Torbjörn Gräslund, Amelie Eriksson Karlström et al. · Trends in biotechnology
Review |
14 May 2017 |
394 |
| 6 |
Molecular Imaging of HER2-Expressing Malignant Tumors in Breast Cancer Patients Using Synthetic 111In- or 68Ga-Labeled Affibody Molecules
Richard Paul Baum, Vikas Prasad, Dirk Müller et al. · Journal of Nuclear Medicine
Open access |
19 May 2010 |
310 |
| 7 |
Measuring HER2-Receptor Expression In Metastatic Breast Cancer Using [ 68 Ga]ABY-025 Affibody PET/CT
Jens Nørkær Sørensen, Irina Velikyan, Dan Sandberg et al. · Theranostics
Open access |
31 Dec 2015 |
272 |
| 8 |
First-in-Human Molecular Imaging of HER2 Expression in Breast Cancer Metastases Using the 111In-ABY-025 Affibody Molecule
Jens Sørensen, Dan Sandberg, Mattias Sandström et al. · Journal of Nuclear Medicine
Open access |
24 Mar 2014 |
263 |
| 9 |
Structural basis for high-affinity HER2 receptor binding by an engineered protein
Charles W. Eigenbrot, Mark H. Ultsch, Anatoly P. Dubnovitsky et al. · Proceedings of the National Academy of Sciences
Open access |
9 Aug 2010 |
238 |
| 10 |
Engineering of a femtomolar affinity binding protein to human serum albumin
Anders P. Jonsson, Jakob Dogan, Nina Herne et al. · Protein Engineering Design and Selection
|
13 May 2008 |
236 |
| 11 |
Affibody molecules as engineered protein drugs
Fredrik Y. Frejd, Kyu‐Tae Kim · Experimental & Molecular Medicine
Open access |
24 Mar 2017 |
230 |
| 12 |
Radionuclide Therapy of HER2-Positive Microxenografts Using a 177Lu-Labeled HER2-Specific Affibody Molecule
Vladimir Tolmachev, Anna Orlova, Rikard Pehrson et al. · Cancer Research
|
15 Mar 2007 |
219 |
| 13 |
Synthetic Affibody Molecules: A Novel Class of Affinity Ligands for Molecular Imaging of HER2-Expressing Malignant Tumors
Anna Orlova, Vladimir Tolmachev, Rikard Pehrson et al. · Cancer Research
Open access |
Mar 2007 |
193 |
| 14 |
Design of an Optimized Scaffold for Affibody Molecules
Joachim Feldwisch, Vladimir Tolmachev, Christofer Lendel et al. · Journal of Molecular Biology
|
11 Mar 2010 |
188 |
| 15 |
Directed Evolution to Low Nanomolar Affinity of a Tumor-Targeting Epidermal Growth Factor Receptor-Binding Affibody Molecule
Mikaela Friedman, Anna Orlova, Eva Johansson et al. · Journal of Molecular Biology
|
7 Jan 2008 |
176 |
| 16 |
Extending Half-life by Indirect Targeting of the Neonatal Fc Receptor (FcRn) Using a Minimal Albumin Binding Domain
Jan Terje Andersen, Rikard Pehrson, Vladimir Tolmachev et al. · Journal of Biological Chemistry
Open access |
7 Dec 2010 |
175 |
| 17 |
Non-immunoglobulin based protein scaffolds
John Löfblom, Fredrik Y. Frejd, Stefan Ståhl · Current Opinion in Biotechnology
Review |
5 Jul 2011 |
149 |
| 18 |
On the Selection of a Tracer for PET Imaging of HER2-Expressing Tumors: Direct Comparison of a 124I-Labeled Affibody Molecule and Trastuzumab in a Murine Xenograft Model
Anna Orlova, Helena Wållberg, Sharon Stone‐Elander et al. · Journal of Nuclear Medicine
Open access |
17 Feb 2009 |
146 |
| 19 |
Slow Internalization of Anti-HER2 Synthetic Affibody Monomer 111 In-DOTA-Z HER2:342-pep2 : Implications for Development of Labeled Tracers
Helena Wållberg, Anna Orlova · Cancer Biotherapy and Radiopharmaceuticals
|
Aug 2008 |
138 |
| 20 |
Same-Day Imaging Using Small Proteins: Clinical Experience and Translational Prospects in Oncology
Ahmet Krasniqi, Matthias D’Huyvetter, Nick Devoogdt et al. · Journal of Nuclear Medicine
Open access |
15 Mar 2018 |
134 |
| 21 |
Affibody molecules: potential forin vivoimaging of molecular targets for cancer therapy
Vladimir Tolmachev, Anna Orlova, Fredrik Y. Nilsson et al. · Expert Opinion on Biological Therapy
|
21 Mar 2007 |
131 |
| 22 |
Phage display selection of Affibody molecules with specific binding to the extracellular domain of the epidermal growth factor receptor
Mikaela Friedman, Erika Nordberg, Ingmarie Höidén‐Guthenberg et al. · Protein Engineering Design and Selection
Open access |
2007 |
130 |
| 23 |
Selection and characterization of Affibody ligands binding to Alzheimer amyloid β peptides
Caroline Grönwall, Andreas Jonsson, Sara Lindström et al. · Journal of Biotechnology
|
28 Sep 2006 |
127 |
| 24 |
Affinity Proteomics for Systematic Protein Profiling of Chromosome 21 Gene Products in Human Tissues
Charlotta Agaton, Joakim Galli, Ingmarie Höidén Guthenberg et al. · Molecular & Cellular Proteomics
Open access |
Jun 2003 |
125 |
| 25 |
Improving the tolerance of a protein a analogue to repeated alkaline exposures using a bypass mutagenesis approach
Martin Linhult, Susanne Gülich, Torbjörn Gräslund et al. · Proteins Structure Function and Bioinformatics
|
27 Feb 2004 |
122 |
| 26 |
Imaging of EGFR expression in murine xenografts using site-specifically labelled anti-EGFR 111In-DOTA-ZEGFR:2377 Affibody molecule: aspect of the injected tracer amount
Vladimir Tolmachev, Daniel Rosik, Helena Wållberg et al. · European Journal of Nuclear Medicine and Molecular Imaging
|
16 Oct 2009 |
119 |
| 27 |
Biodistribution and Radiation Dosimetry of the Anti-HER2 Affibody Molecule 68Ga-ABY-025 in Breast Cancer Patients
Mattias Sandström, K. Lindskog, Irina Velikyan et al. · Journal of Nuclear Medicine
Open access |
9 Feb 2016 |
114 |
| 28 |
Affibody Molecules for Epidermal Growth Factor Receptor Targeting In Vivo: Aspects of Dimerization and Labeling Chemistry
Vladimir Tolmachev, Mikaela Friedman, Mattias Sandström et al. · Journal of Nuclear Medicine
Open access |
21 Jan 2009 |
114 |
| 29 |
Targeting of HER2-Expressing Tumors with a Site-Specifically 99mTc-Labeled Recombinant Affibody Molecule, ZHER2:2395, with C-Terminally Engineered Cysteine
Sara C. Ahlgren, Helena Wållberg, Thuy Tran et al. · Journal of Nuclear Medicine
Open access |
16 Apr 2009 |
114 |
| 30 |
99mTc-maEEE-ZHER2:342, an Affibody Molecule-Based Tracer for the Detection of HER2 Expression in Malignant Tumors
Thuy Tran, Torun Engfeldt, Anna Orlova et al. · Bioconjugate Chemistry
|
19 Oct 2007 |
108 |
| 31 |
Affibody molecules: new protein domains for molecular imaging and targeted tumor therapy.
Fredrik Y. Nilsson, Vladimir Tolmachev · PubMed
|
Mar 2007 |
107 |
| 32 |
In Vitro Characterization of a Bivalent Anti-HER-2 Affibody with Potential for Radionuclide-Based Diagnostics
Ann-Charlott Steffen, Maria Wikman, Vladimir Tolmachev et al. · Cancer Biotherapy and Radiopharmaceuticals
|
Jun 2005 |
102 |
| 33 |
In Vivo Imaging of the Programmed Death Ligand 1 by 18F PET
D. E. González Trotter, Xiangjun Meng, Paul S. Mcquade et al. · Journal of Nuclear Medicine
|
6 Jun 2017 |
101 |
| 34 |
Targeting of HER2-Expressing Tumors Using 111In-ABY-025, a Second-Generation Affibody Molecule with a Fundamentally Reengineered Scaffold
Sara C. Ahlgren, Anna Orlova, Helena Wållberg et al. · Journal of Nuclear Medicine
Open access |
16 Jun 2010 |
100 |
| 35 |
Evaluation of Maleimide Derivative of DOTA for Site-Specific Labeling of Recombinant Affibody Molecules
Sara C. Ahlgren, Anna Orlova, Daniel Rosik et al. · Bioconjugate Chemistry
|
29 Dec 2007 |
99 |
| 36 |
Imaging of HER2-expressing tumours using a synthetic Affibody molecule containing the 99mTc-chelating mercaptoacetyl-glycyl-glycyl-glycyl (MAG3) sequence
Torun Engfeldt, Anna Orlova, Thuy Tran et al. · European Journal of Nuclear Medicine and Molecular Imaging
|
4 Dec 2006 |
99 |
| 37 |
99mTc-chelator engineering to improve tumour targeting properties of a HER2-specific Affibody molecule
Torun Engfeldt, Thuy Tran, Anna Orlova et al. · European Journal of Nuclear Medicine and Molecular Imaging
|
12 Jun 2007 |
97 |
| 38 |
Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule–Albumin-Binding Domain Fusion Protein
Anna Orlova, Andreas Jonsson, Daniel Rosik et al. · Journal of Nuclear Medicine
Open access |
25 Mar 2013 |
91 |
| 39 |
Comparative in vivo evaluation of technetium and iodine labels on an anti-HER2 affibody for single-photon imaging of HER2 expression in tumors.
Anna Orlova, Fredrik Y. Nilsson, Maria Wikman et al. · PubMed
|
Mar 2006 |
90 |
| 40 |
Engineering of Affibody Molecules for Therapy and Diagnostics
Joachim Feldwisch, Vladimir Tolmachev · Methods in molecular biology
Book chapter |
2012 |
90 |
| 41 |
Engineered High-Affinity Affibody Molecules Targeting Platelet-Derived Growth Factor Receptor β In Vivo
Malin Lindborg, Eliane Cortez, Ingmarie Höidén‐Guthenberg et al. · Journal of Molecular Biology
|
29 Jan 2011 |
88 |
| 42 |
Toxicity and Pharmacokinetic Profile for Single-Dose Injection of ABY-029: a Fluorescent Anti-EGFR Synthetic Affibody Molecule for Human Use
Kimberley S. Samkoe, Jason R. Gunn, Kayla A. Marra et al. · Molecular Imaging and Biology
Open access |
Dec 2016 |
87 |
| 43 |
A novel affinity protein selection system based on staphylococcal cell surface display and flow cytometry
Nina Kronqvist, John Löfblom, Anders P. Jonsson et al. · Protein Engineering Design and Selection
|
31 Jan 2008 |
87 |
| 44 |
HEHEHE-Tagged Affibody Molecule May Be Purified by IMAC, Is Conveniently Labeled with [99mTc(CO)3]+, and Shows Improved Biodistribution with Reduced Hepatic Radioactivity Accumulation
Vladimir Tolmachev, Camilla Hofström, Jennie Malmberg et al. · Bioconjugate Chemistry
|
22 Oct 2010 |
84 |
| 45 |
Development and preclinical characterisation of 99mTc-labelled Affibody molecules with reduced renal uptake
Torun Ekblad, Thuy Tran, Anna Orlova et al. · European Journal of Nuclear Medicine and Molecular Imaging
|
Jul 2008 |
81 |
| 46 |
Combining phage and staphylococcal surface display for generation of ErbB3-specific Affibody molecules
Nina Kronqvist, Magdalena Malm, Lovisa Göstring et al. · Protein Engineering Design and Selection
|
21 Dec 2010 |
80 |
| 47 |
Cellular studies of binding, internalization and retention of a radiolabeled EGFR-binding affibody molecule
Erika Nordberg, Mikaela Friedman, Lovisa Göstring et al. · Nuclear Medicine and Biology
|
Aug 2007 |
78 |
| 48 |
Inhibiting HER3-Mediated Tumor Cell Growth with Affibody Molecules Engineered to Low Picomolar Affinity by Position-Directed Error-Prone PCR-Like Diversification
Magdalena Malm, Nina Kronqvist, Hanna Lindberg et al. · PLoS ONE
Open access |
10 May 2013 |
73 |
| 49 |
Engineering streptococcal protein G for increased alkaline stability
Susanne Gülich, Martin Linhult, Stefan Ståhl et al. · Protein Engineering Design and Selection
|
Oct 2002 |
72 |
| 50 |
Update: Affibody Molecules for Molecular Imaging and Therapy for Cancer
Anna Orlova, Joachim Feldwisch, Lars Abrahmsén et al. · Cancer Biotherapy and Radiopharmaceuticals
|
Oct 2007 |
69 |