Most cited papers from Agouron Institute

Agouron Institute

What are the most cited papers from Agouron Institute?

The most cited paper from Agouron Institute is "Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase‐trimethoprim, a drug‐receptor system" (Pnina Dauber‐Osguthorpe, Victoria A. Roberts, David J. Osguthorpe et al., 1988), with 2,083 citations. Next come "Bacterial bioluminescence: Isolation and genetic analysis of functions from Vibrio fischeri" (915) and "Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex" (765).

Published TypeFieldAccessCitations

Showing 50 of 60 papers. Every paper with more than 157 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase‐trimethoprim, a drug‐receptor system Pnina Dauber‐Osguthorpe, Victoria A. Roberts, David J. Osguthorpe et al. · Proteins Structure Function and Bioinformatics	1988	2,083
2	Bacterial bioluminescence: Isolation and genetic analysis of functions from Vibrio fischeri JoAnne Engebrecht, Kenneth H. Nealson, Michael R. Silverman · Cell	Mar 1983	915
3	Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex Charles R. Kissinger, Hans E. Parge, Daniel R. Knighton et al. · Nature	Dec 1995	765
4	Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence Bonnie L. Bassler, Miriam E. Wright, Richard E. Showalter et al. · Molecular Microbiology	Aug 1993	763
5	Multiple signalling systems controlling expression of luminescence in Vibrio harveyi : sequence and function of genes encoding a second sensory pathway Bonnie L. Bassler, Miriam E. Wright, Michael R. Silverman · Molecular Microbiology	Jul 1994	709
6	Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programming Daniel K. Gehlhaar, Gennady M. Verkhivker, Paul A. Rejto et al. · Chemistry & Biology Open access	May 1995	690
7	Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema Marika J. Karkkainen, Robert E. Ferrell, Elizabeth Lawrence et al. · Nature Genetics	Jun 2000	659
8	Crystal Structure of the Ribonuclease H Domain of HIV-1 Reverse Transcriptase Jay F. Davies, Zuzana Hostomska, Zdeněk Hostomský et al. · Science	5 Apr 1991	570
9	The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals a Trypsin-like Fold and a Structural Zinc Binding Site Robert A. Love, Hans E. Parge, John A Wickersham et al. · Cell Open access	Oct 1996	509
10	Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives Anubhab Mukherjee, Ariana K. Waters, Pranav Kalyan et al. · International Journal of Nanomedicine Open access	Mar 2019	492
11	HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway Philippe A. Gallay, Thomas J. Hope, Daniel J. Chin et al. · Proceedings of the National Academy of Sciences Open access	2 Sep 1997	486
12	Peroxisome Proliferator Activated Receptor-α Expression in Human Liver Colin N.A. Palmer, Mei-H. Hsu, Keith J. Griffin et al. · Molecular Pharmacology	1998	417
13	De Novo Design, Expression, and Characterization of Felix: a Four-Helix Bundle Protein of Native-Like Sequence Michael H. Hecht, Jane S. Richardson, David C. Richardson et al. · Science	24 Aug 1990	395
14	The three-dimensional structure of ricin at 2.8 A. W.R. Montfort, J. Ernest Villafranca, Arthur F. Monzingo et al. · Journal of Biological Chemistry Open access	Apr 1987	382
15	Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein David A. Matthews, Ward W. Smith, Rose Ann Ferre et al. · Cell	Jun 1994	360
16	Comparison of Sequential Three-Drug Regimens as Initial Therapy for HIV-1 Infection Gregory K. Robbins, Victor De Gruttola, Robert W. Shafer et al. · New England Journal of Medicine Open access	10 Dec 2003	355
17	The Relation between Baseline HIV Drug Resistance and Response to Antiretroviral Therapy: Re-Analysis of Retrospective and Prospective Studies Using a Standardized Data Analysis Plan Victor DeGruttola et al. · Antiviral Therapy Open access	2000	330
18	Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase Alex W. White, Robert J. Almassy, A. Hilary Calvert et al. · Journal of Medicinal Chemistry Open access	19 Oct 2000	289
19	Flagellar dynamometer controls swarmer cell differentiation of V. parahaemolyticus Linda L. McCarter, Marcia Hilmen, Michael R. Silverman · Cell	Jul 1988	282
20	Precise excision of intervening sequences from precursor tRNAs by a membrane-associated yeast endonuclease Craig L. Peebles, Peter A. Gegenheimer, John N Abelson · Cell	Feb 1983	279
21	Isolation and Characterization of Strains CVO and FWKO B, Two Novel Nitrate-Reducing, Sulfide-Oxidizing Bacteria Isolated from Oil Field Brine Diane Gevertz, Anita J. Telang, Gerrit Voordouw et al. · Applied and Environmental Microbiology Open access	Jun 2000	268
22	Evolution and organization of the fibrinogen locus on chromosome 4: gene duplication accompanied by transposition and inversion. J A Kant, Albert J. Fornace, Debra Saxe et al. · Proceedings of the National Academy of Sciences Open access	Apr 1985	266
23	Deciphering common failures in molecular docking of ligand-protein complexes Gennady M. Verkhivker, Djamal Bouzida, Daniel K. Gehlhaar et al. · Journal of Computer-Aided Molecular Design	Nov 2000	244
24	Identifying disordered regions in proteins from amino acid sequence Pedro R Romero, Zoran Obradović, Charles R. Kissinger et al. · Proceedings of International Conference on Neural Networks (ICNN'97) Conference paper	22 Nov 2002	243
25	Broad Antitumor and Antiangiogenic Activities of AG3340, a Potent and Selective MMP Inhibitor Undergoing Advanced Oncology Clinical Trials David R. Shalinsky, John Brekken, Helen Y. Zou et al. · Annals of the New York Academy of Sciences	Jun 1999	242
26	Occurrence of a transposition from the X-chromosome long arm to the Y-chromosome short arm during human evolution David C. Page, Mary‐Ellen Harper, Jamie Love et al. · Nature	Sep 1984	239
27	Polar and lateral flagellar motors of marine Vibrio are driven by different ion-motive forces Tatsuo Atsumi, Linda McCartert, Yasuo Imae · Nature	1992	238
28	Phase II, Randomized, Double-Blind, Placebo-Controlled Studies of Ruprintrivir Nasal Spray 2-Percent Suspension for Prevention and Treatment of Experimentally Induced Rhinovirus Colds in Healthy Volunteers Frederick G. Hayden, Ronald B. Turner, Jack M. Gwaltney et al. · Antimicrobial Agents and Chemotherapy Open access	24 Nov 2003	237
29	Protease Inhibitors as Antiviral Agents Amy K. Patick, K. E. Potts · Clinical Microbiology Reviews Open access	Oct 1998	232
30	Design of enzyme inhibitors using iterative protein crystallographic analysis Krzysztof Appelt, Russell J. Bacquet, Charlotte A. Bartlett et al. · Journal of Medicinal Chemistry Open access	Jul 1991	231
31	Functional Role of Aspartic Acid-27 in Dihydrofolate Reductase Revealed by Mutagenesis Elizabeth Ehrhardt Howell, J. Ernest Villafranca, Mark S. Warren et al. · Science	7 Mar 1986	230
32	In Vitro Antiviral Activity of AG7088, a Potent Inhibitor of Human Rhinovirus 3C Protease Amy K. Patick, Susan L. Binford, M. A. Brothers et al. · Antimicrobial Agents and Chemotherapy Open access	Oct 1999	227
33	Isolation and characterization of the Escherichia coli mutH gene product. Katherine M. Welsh, A-Lien Lu, Suzanne Clark et al. · Journal of Biological Chemistry Open access	Nov 1987	225
34	Regulation of lateral flagella gene transcription in Vibrio parahaemolyticus Robert Belas, Melvin I. Simon, Michael R. Silverman · Journal of Bacteriology Open access	Jul 1986	220
35	Stromal Matrix Metalloproteinase-9 Regulates the Vascular Architecture in Neuroblastoma by Promoting Pericyte Recruitment Christophe F. Chantrain, Hiroyuki Shimada, Sonata Jodele et al. · Cancer Research Open access	Mar 2004	214
36	Combination Therapy with Efavirenz, Nelfinavir, and Nucleoside Reverse-Transcriptase Inhibitors in Children Infected with Human Immunodeficiency Virus Type 1 Stuart E. Starr et al. · New England Journal of Medicine Open access	16 Dec 1999	211
37	Dicaffeoylquinic and Dicaffeoyltartaric Acids Are Selective Inhibitors of Human Immunodeficiency Virus Type 1 Integrase Brenda R. McDougall, Peter King, Bor Wen Wu et al. · Antimicrobial Agents and Chemotherapy Open access	1998	211
38	Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease Amy K. Patick, Hongmei Mo, Martin H. Markowitz et al. · Antimicrobial Agents and Chemotherapy Open access	Feb 1996	210
39	Directed Mutagenesis of Dihydrofolate Reductase J. Ernest Villafranca, Elizabeth Ehrhardt Howell, Donald H. Voet et al. · Science	18 Nov 1983	209
40	Genotypic and Phenotypic Characterization of Human Immunodeficiency Virus Type 1 Variants Isolated from Patients Treated with the Protease Inhibitor Nelfinavir Amy K. Patick, M. Duran, Yaming Cao et al. · Antimicrobial Agents and Chemotherapy Open access	Oct 1998	203
41	The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans Nicolette C. Caccia, Mitchell Kronenberg, Debra Saxe et al. · Cell	Jul 1984	202
42	Surface‐induced swarmer cell differentiation of Vibrio parahaemoiyticus Linda L. McCarter, Michael R. Silverman · Molecular Microbiology Open access	Jul 1990	199
43	Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase Daniel R. Knighton, Chen‐Chen Kan, Eleanor F. Howland et al. · Nature Structural Biology	Mar 1994	198
44	Implications for Chk1 Regulation: The 1.7 Å Crystal Structure of Human Cell Cycle Checkpoint Kinase Chk1 Ping Chen, Chun Luo, Yali Deng et al. · Cell Open access	Mar 2000	195
45	Phase Variation: Evolution of a Controlling Element Melvin I. Simon, Janine Zieg, Michael R. Silverman et al. · Science	19 Sep 1980	186
46	Structure and dynamics of ion transport through gramicidin A D. H. Mackay, Peter H. Berens, Kent R. Wilson et al. · Biophysical Journal Open access	Aug 1984	180
47	Structure of Haemophilus influenzae Fe+3-binding protein reveals convergent evolution within a superfamily Christopher M. Bruns, Andrew J. Nowalk, Andrew S. Arvai et al. · Nature Structural & Molecular Biology	Nov 1997	178
48	Sequence and function of LuxO, a negative regulator of luminescence in Vibrio harveyi Bonnie L. Bassler, Miriam E. Wright, Michael R. Silverman · Molecular Microbiology	May 1994	176
49	Nucleotide sequence of the luxA gene of Vibrio harveyi and the complete amino acid sequence of the alpha subunit of bacterial luciferase. Daniel H. Cohn, Alan J. Mileham, Melvin I. Simon et al. · Journal of Biological Chemistry Open access	May 1985	169
50	2.3 Å crystal structure of the catalytic domain of DNA polymerase β Jay F. Davies, Robert J. Almassy, Zuzana Hostomska et al. · Cell	Mar 1994	168

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.