| 1 |
Phase I study of the heparanase inhibitor roneparstat: an innovative approach for ultiple myeloma therapy
Mónica Galli, Manik Chatterjee, Mariella Grasso et al. · Haematologica
Open access |
26 Apr 2018 |
117 |
| 2 |
Metal-organic frameworks (MOFs) as biomolecules drug delivery systems for anticancer purposes
Michele Coluccia, Valeria Parisse, Paolo Guglielmi et al. · European Journal of Medicinal Chemistry
Open access |
3 Oct 2022 |
92 |
| 3 |
Pathophysiology of NSAID-Associated Intestinal Lesions in the Rat: Luminal Bacteria and Mucosal Inflammation as Targets for Prevention
Rocchina Colucci, Carolina Pellegrini, Matteo Fornai et al. · Frontiers in Pharmacology
Open access |
29 Nov 2018 |
53 |
| 4 |
Depression disorder in patients with cerebellar damage: Awareness of the mood state.
Silvia Clausi, Michela Lupo, Giusy Olivito et al. · Journal of Affective Disorders
|
6 Nov 2018 |
53 |
| 5 |
Comparison of the Antithrombotic and Haemorrhagic Effects of Heparin and a New Low Molecular Weight Heparin in Rats
G. Andriuoli, Roberto Mastacchi, Marco Barbanti et al. · Haemostasis
|
21 Apr 2009 |
50 |
| 6 |
The Relationship Between Endoscopic and Clinical Recurrence in Postoperative Crohn’s Disease: A Systematic Review and Meta-analysis
Alessandro Blè, Cecilia Renzulli, Fabio Cenci et al. · Journal of Crohn s and Colitis
ReviewOpen access |
10 Sep 2021 |
48 |
| 7 |
Factors affecting the electrocardiographic QT interval in malaria: A systematic review and meta-analysis of individual patient data
Xin Hui S Chan et al. · PLoS Medicine
ReviewOpen access |
5 Mar 2020 |
41 |
| 8 |
Antibody drug conjugates (ADCs) charged with HDAC inhibitor for targeted epigenetic modulation
Elena Cini, Valentina Faltoni, Elena Petricci et al. · Chemical Science
Open access |
2018 |
38 |
| 9 |
Sulodexide promotes arterial relaxation via endothelium-dependent nitric oxide-mediated pathway
J.D. Raffetto, Fiorella Calanni, Paolo Mattana et al. · Biochemical Pharmacology
Open access |
20 Apr 2019 |
37 |
| 10 |
Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity
Valentina Noemi Madia, Antonella Messore, Luca Pescatori et al. · Journal of Medicinal Chemistry
Open access |
16 Jul 2018 |
36 |
| 11 |
Velusetrag accelerates gastric emptying in subjects with gastroparesis: a multicentre, double‐blind, randomised, placebo‐controlled, phase 2 study
Braden Kuo, Chris N. Barnes, Deanna D. Nguyen et al. · Alimentary Pharmacology & Therapeutics
|
3 Apr 2021 |
33 |
| 12 |
Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth
Luisa Maresca, Enrica Crivaro, Francesca Migliorini et al. · Pharmacological Research
Open access |
19 Jul 2023 |
31 |
| 13 |
Anti-ErbB2 immunotherapeutics: struggling to make better antibodies for cancer therapy
Rita De Santis · mAbs
Open access |
2020 |
31 |
| 14 |
Novel Symmetrical Benzazolyl Derivatives Endowed with Potent Anti-Heparanase Activity
Antonella Messore et al. · Journal of Medicinal Chemistry
Open access |
9 Nov 2018 |
26 |
| 15 |
Long-term follow up of metastatic melanoma patients treated with Thymosin alpha-1: investigating immune checkpoints synergy
Riccardo Danielli, F. Cisternino, Diana Giannarelli et al. · Expert Opinion on Biological Therapy
|
31 May 2018 |
26 |
| 16 |
Human inhalable antibody fragments neutralizing SARS-CoV-2 variants for COVID-19 therapy
Olga Minenkova et al. · BOA (University of Milano-Bicocca)
|
2022 |
25 |
| 17 |
Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain
Margherita Brindisi, Giuseppe Borrelli, Simone Brogi et al. · ChemMedChem
Open access |
7 Aug 2018 |
25 |
| 18 |
Morphological and biochemical effects of intrahepatic alcohol injection in the rabbit
Davide Festi, Francesco Monti, S. Casanova et al. · Journal of Gastroenterology and Hepatology
|
Aug 1990 |
25 |
| 19 |
Rheological Behavior of a New Mucoadhesive Oral Formulation Based on Sodium Chondroitin Sulfate, Xyloglucan and Glycerol
Tiziana M. G. Pecora, Barbara Ragazzo, Walter Bertin et al. · Journal of Functional Biomaterials
Open access |
28 Apr 2021 |
23 |
| 20 |
Increasing trend in admission rates and costs for acute diverticulitis during 2005–2015: real-life data from the Abruzzo Region
Simona Cammarota, Martina Cargiolli, Paolo Andreozzi et al. · Therapeutic Advances in Gastroenterology
Open access |
2018 |
22 |
| 21 |
Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents
Fabrizio Manetti, Barbara A. Stecca, Roberta Santini et al. · ACS Medicinal Chemistry Letters
Open access |
25 Mar 2020 |
20 |
| 22 |
ErbB2 Targeted Epigenetic Modulation: Anti-tumor Efficacy of the ADC Trastuzumab-HDACi ST8176AA1
Ferdinando Maria Milazzo, Loredana Vesci, Anna Maria Anastasi et al. · Frontiers in Oncology
Open access |
23 Jan 2020 |
19 |
| 23 |
A randomized, double‐blind, placebo‐controlled, phase 2b study of the efficacy and safety of velusetrag in subjects with diabetic or idiopathic gastroparesis
Thomas L. Abell, Braden Kuo, Tuba Esfandyari et al. · Neurogastroenterology & Motility
|
9 Jan 2023 |
18 |
| 24 |
Sulodexide Improves Contraction and Decreases Matrix Metalloproteinase-2 and -9 in Veins Under Prolonged Stretch
J.D. Raffetto, Wentao Yu, Xi Wang et al. · Journal of Cardiovascular Pharmacology
Open access |
17 Nov 2019 |
17 |
| 25 |
Probiotics‐Containing Mucoadhesive Gel for Targeting the Dysbiosis Associated with Periodontal Diseases
Giuseppe Giannini, Irene Ragusa, Giulia Nerina Nardone et al. · International Journal of Dentistry
Open access |
2022 |
16 |
| 26 |
New classes of potent heparanase inhibitors from ligand-based virtual screening
Daniele Pala, Laura Scalvini, Gian Marco Elisi et al. · Journal of Enzyme Inhibition and Medicinal Chemistry
Open access |
2020 |
16 |
| 27 |
ERCP during the pandemic of COVID-19 in Wuhan, China
Ping An, Xu Huang, Xinyue Wan et al. · Gastrointestinal Endoscopy
Open access |
16 Apr 2020 |
16 |
| 28 |
Improving solubility and storage stability of rifaximin via solid-state solvation with Transcutol®
Fabrizia Grepioni, Dario Braga, Laura Chelazzi et al. · CrystEngComm
|
2019 |
16 |
| 29 |
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo
Loredana Vesci, Ferdinando Maria Milazzo, Maria Antonietta Stasi et al. · European Journal of Medicinal Chemistry
Open access |
26 Jul 2018 |
16 |
| 30 |
Arylamidonaphtalene sulfonate compounds as a novel class of heparanase inhibitors
Riccardo Rondanin, Sara Fochi, Riccardo Baruchello et al. · Bioorganic & Medicinal Chemistry Letters
Open access |
8 Aug 2017 |
16 |
| 31 |
Residual Disease Burden Among European Patients With Inflammatory Bowel Disease: A Real-World Survey
Johan M. Burisch, Ailsa L Hart, Andreas Sturm et al. · Inflammatory Bowel Diseases
Open access |
9 May 2024 |
15 |
| 32 |
A novel bioresponsive self-immolative spacer based on aza-quinone methide reactivity for the controlled release of thiols, phenols, amines, sulfonamides or amides
Elena Ermini, Annalaura Brai, Elena Cini et al. · Chemical Science
Open access |
2024 |
15 |
| 33 |
Antibody drug conjugates with hydroxamic acid cargos for histone deacetylase (HDAC) inhibition
Claudio Cianferotti, Valentina Faltoni, Elena Cini et al. · Chemical Communications
Open access |
2021 |
15 |
| 34 |
Multi-scale structural analysis of xyloglucan colloidal dispersions and hydro-alcoholic gels
Clelia Dispenza, Simona Todaro, Maria Antonietta Sabatino et al. · Cellulose
|
23 Jan 2020 |
14 |
| 35 |
Velusetrag rescues GI dysfunction, gut inflammation and dysbiosis in a mouse model of Parkinson’s disease
Jéssica Grigoletto, Fabiana Miraglia, Laura Benvenuti et al. · npj Parkinson s Disease
Open access |
2 Oct 2023 |
13 |
| 36 |
L-Acetylcarnitine causes analgesia in mice modeling Fabry disease by up-regulating type-2 metabotropic glutamate receptors
Francesco Formaggio, Roberto Rimondini, Cecilia Delprete et al. · Molecular Pain
Open access |
8 Mar 2022 |
12 |
| 37 |
Novel N-acetyl-Glycol-split heparin biotin-conjugates endowed with anti-heparanase activity
Emiliano Esposito, Israël Vlodavsky, Uri Barash et al. · European Journal of Medicinal Chemistry
|
2 Nov 2019 |
12 |
| 38 |
Early treatment with rifaximin during epileptogenesis reverses gut alterations and reduces seizure duration in a mouse model of acquired epilepsy
Valentina Kebede, Teresa Ravizza, Silvia Balosso et al. · Brain Behavior and Immunity
Open access |
10 Apr 2024 |
11 |
| 39 |
The Control of Heparanase Through the Use of Small Molecules
Giuseppe Giannini, Gianfranco Battistuzzi, Silvia Rivara · Advances in experimental medicine and biology
Book chapter |
2020 |
11 |
| 40 |
Synthesis and preliminary in vitro evaluation of DOTA-Tenatumomab conjugates for theranostic applications in tenascin expressing tumors
Giuseppe Giannini, Ferdinando Maria Milazzo, Gianfranco Battistuzzi et al. · Bioorganic & Medicinal Chemistry
Open access |
31 May 2019 |
11 |
| 41 |
A Novel Lactobacillus brevis Fermented with a Vegetable Substrate (AL0035) Counteracts TNBS-Induced Colitis by Modulating the Gut Microbiota Composition and Intestinal Barrier
Loredana Vesci, Grazia Raffaella Tundo, Sara Soldi et al. · Nutrients
Open access |
24 Mar 2024 |
10 |
| 42 |
Quinolines and Oxazino-quinoline Derivatives as Small Molecule GLI1 Inhibitors Identified by Virtual Screening
Fabrizio Manetti, Luisa Maresca, Enrica Crivaro et al. · ACS Medicinal Chemistry Letters
Open access |
22 Jul 2022 |
9 |
| 43 |
The New Phytocomplex AL0042 Extracted from Red Orange By-Products Inhibits the Minimal Hepatic Encephalopathy in Mice Induced by Thioacetamide
Loredana Vesci, Giulia Benedetta Martinelli, Yongqiang Liu et al. · Biomedicines
Open access |
11 Mar 2025 |
8 |
| 44 |
The possibilities of improving the treatment of chronic heart failure according to the results of a multicenter observational study BYHEART
Sergey N. Tereshchenko, I. A. Cheremisina, Alfiya A. Safiullina · Terapevticheskii arkhiv
Open access |
26 May 2022 |
8 |
| 45 |
Combined systemic (fluconazole) and topical (metronidazole + clotrimazole) therapy for a new approach to the treatment and prophylaxis of recurrent candidiasis
Carlo Genovese, Antonio Cianci, Salvatore Corsello et al. · Minerva Obstetrics and Gynecology
|
Jul 2019 |
8 |
| 46 |
Multicentre, 26-week, open-label phase 2 trial of the JAK inhibitor filgotinib in Behçet’s disease, idiopathic inflammatory myopathies and IgG4-related disease: DRIMID study protocol
Bettina C Geertsema-Hoeve, Jan A. M. van Laar, Joost Raaphorst et al. · BMJ Open
Open access |
Feb 2025 |
7 |
| 47 |
Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor
Giusy Tassone, Marco Mazzorana, Stefano Mangani et al. · International Journal of Molecular Sciences
Open access |
21 Aug 2022 |
7 |
| 48 |
New protocol for dissociating visuospatial working memory ability in reaching space and in navigational space
Michela Lupo, Fabio Ferlazzo, Fabio Aloise et al. · Behavior Research Methods
Open access |
27 Apr 2018 |
7 |
| 49 |
Genetic and phenotypic stability of Lacticaseibacillus paracasei DG (DSM 34154) over 10 years of industrial production
Laura Brunelli, Susanna Perotti, Giorgio Gargari et al. · Applied and Environmental Microbiology
Open access |
24 Apr 2025 |
6 |
| 50 |
Filgotinib Radiographic and Clinical Efficacy Versus Other JAK Inhibitors and Adalimumab in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate: A Systematic Review and Network Meta-Analysis
Yoshiya Tanaka, René Westhovens, Hong Sun et al. · Rheumatology and Therapy
ReviewOpen access |
10 Apr 2025 |
6 |