| 1 |
Targeted disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate oligosaccharides
Lydia C. Powell, M. Pritchard, Elaine L. Ferguson et al. · npj Biofilms and Microbiomes
Open access |
25 Jun 2018 |
188 |
| 2 |
Overcoming Drug Resistance with Alginate Oligosaccharides Able To Potentiate the Action of Selected Antibiotics
Saira Saeed Khan, Anne Tøndervik, Håvard Sletta et al. · Antimicrobial Agents and Chemotherapy
Open access |
24 Jul 2012 |
172 |
| 3 |
A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness
M. Pritchard, Lydia C. Powell, Alison A. Jack et al. · Antimicrobial Agents and Chemotherapy
Open access |
20 Jun 2017 |
89 |
| 4 |
Alginate Oligosaccharides Inhibit Fungal Cell Growth and Potentiate the Activity of Antifungals against Candida and Aspergillus spp
Anne Tøndervik, Håvard Sletta, Geir Klinkenberg et al. · PLoS ONE
Open access |
19 Nov 2014 |
89 |
| 5 |
A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease
M. Pritchard, Lydia C. Powell, Georgina Elizabeth Menzies et al. · Molecular Pharmaceutics
Open access |
Feb 2016 |
85 |
| 6 |
The effect of alginate oligosaccharides on the mechanical properties of Gram-negative biofilms
Lydia C. Powell, Ahmed Sowedan, Saira Saeed Khan et al. · Biofouling
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Apr 2013 |
85 |
| 7 |
OligoG CF-5/20 Disruption of Mucoid Pseudomonas aeruginosa Biofilm in a Murine Lung Infection Model
Wang Hengzhuang, Zhijun Song, Oana Ciofu et al. · Antimicrobial Agents and Chemotherapy
Open access |
2 Feb 2016 |
71 |
| 8 |
A Nanoscale Characterization of the Interaction of a Novel Alginate Oligomer with the Cell Surface and Motility of Pseudomonas aeruginosa
Lydia C. Powell, M. Pritchard, Charlotte Emanuel et al. · American Journal of Respiratory Cell and Molecular Biology
|
27 Sep 2013 |
68 |
| 9 |
Alginate Oligosaccharide-Induced Modification of the lasI-lasR and rhlI-rhlR Quorum-Sensing Systems in Pseudomonas aeruginosa
Alison A. Jack, Saira Saeed Khan, Lydia C. Powell et al. · Antimicrobial Agents and Chemotherapy
Open access |
15 Feb 2018 |
59 |
| 10 |
Bi-Functional Alginate Oligosaccharide–Polymyxin Conjugates for Improved Treatment of Multidrug-Resistant Gram-Negative Bacterial Infections
Joana Stokniene, Lydia C. Powell, Olav Andreas Aarstad et al. · Pharmaceutics
Open access |
11 Nov 2020 |
38 |
| 11 |
An in vitro study of alginate oligomer therapies on oral biofilms
Jessica Louise Roberts, Saira Khan, Charlotte Emanuel et al. · Journal of Dentistry
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30 Jul 2013 |
37 |
| 12 |
OligoG CF ‐5/20 normalizes cystic fibrosis mucus by chelating calcium
Anna Ermund, Christian V. Recktenwald, Gudmund Skjåk‐Bræk et al. · Clinical and Experimental Pharmacology and Physiology
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6 Mar 2017 |
35 |
| 13 |
Alginate oligosaccharides modify hyphal infiltration ofCandida albicansin anin vitromodel of invasive human candidosis
M. Pritchard, A.A. Jack, Lydia C. Powell et al. · Journal of Applied Microbiology
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21 Jun 2017 |
32 |
| 14 |
Inhaled dry powder alginate oligosaccharide in cystic fibrosis: a randomised, double-blind, placebo-controlled, crossover phase 2b study
Silke V. Koningsbruggen-Rietschel, Jane Carolyn Davies, Tacjana Pressler et al. · ERJ Open Research
Open access |
Oct 2020 |
29 |
| 15 |
The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption
M. Pritchard, Lydia C. Powell, Saira Saeed Khan et al. · Scientific Reports
Open access |
31 Mar 2017 |
29 |
| 16 |
A novel guluronate oligomer improves intestinal transit and survival in cystic fibrosis mice
Megan Vitko, Dana M. Valerio, Philip D. Rye et al. · Journal of Cystic Fibrosis
Open access |
27 Jun 2016 |
24 |
| 17 |
Exploiting Mannuronan C-5 Epimerases in Commercial Alginate Production
Anne Tøndervik, Olav Andreas Aarstad, Randi Aune et al. · Marine Drugs
Open access |
18 Nov 2020 |
22 |
| 18 |
Cellulose Nanofibril Formulations Incorporating a Low-Molecular-Weight Alginate Oligosaccharide Modify Bacterial Biofilm Development
Alison A. Jack, Henriette Rogstad Nordli, Lydia C. Powell et al. · Biomacromolecules
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28 Jun 2019 |
21 |
| 19 |
Alginate oligosaccharides enhance the antifungal activity of nystatin against candidal biofilms
Lydia C. Powell, Jennifer Y. M. Adams, Sadik Quoraishi et al. · Frontiers in Cellular and Infection Microbiology
Open access |
31 Jan 2023 |
19 |
| 20 |
Mucin structural interactions with an alginate oligomer mucolytic in cystic fibrosis sputum
M. Pritchard, Juliette L. Oakley, Charles D. Brilliant et al. · Vibrational Spectroscopy
Open access |
12 Jun 2019 |
18 |
| 21 |
Evaluating the alginate oligosaccharide (OligoG) as a therapy for Burkholderia cepacia complex cystic fibrosis lung infection
R Fischer, C. Schwarz, Rebecca Weiser et al. · Journal of Cystic Fibrosis
Open access |
24 Jan 2022 |
16 |
| 22 |
Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy
Juliette L. Oakley, Rebecca Weiser, Lydia C. Powell et al. · mSphere
Open access |
19 Jan 2021 |
15 |
| 23 |
A chemo-enzymatic method for preparation of saturated oligosaccharides from alginate and other uronic acid-containing polysaccharides
Mina Gravdahl, Olav Andreas Aarstad, Agnes Beenfeldt Petersen et al. · Carbohydrate Polymers
Open access |
11 Jul 2024 |
13 |
| 24 |
Structure–Activity Relationships of Low Molecular Weight Alginate Oligosaccharide Therapy against Pseudomonas aeruginosa
M. Pritchard, Lydia C. Powell, Jennifer Y. M. Adams et al. · Biomolecules
Open access |
8 Sep 2023 |
10 |
| 25 |
Alginate oligosaccharides enhance diffusion and activity of colistin in a mucin-rich environment
Joana Stokniene, Mathieu Varache, Philip D. Rye et al. · Scientific Reports
Open access |
23 Mar 2022 |
9 |
| 26 |
Implementation of microbiota analysis in clinical trials for cystic fibrosis lung infection: Experience from the OligoG phase 2b clinical trials
Rebecca Weiser, Philip D. Rye, Eshwar Mahenthiralingam · Journal of Microbiological Methods
Open access |
7 Jan 2021 |
8 |
| 27 |
Alginate Oligomers and Their Use as Active Pharmaceutical Drugs
Philip D. Rye, Anne Tøndervik, Håvard Sletta et al. · Springer series in biomaterials science and engineering
Book chapter |
29 Nov 2017 |
8 |
| 28 |
Low Molecular Weight Alginate Oligosaccharides as Alternatives to PEG for Enhancement of the Diffusion of Cationic Nanoparticles Through Cystic Fibrosis Mucus
Ruhina Maeshima, Aristides D. Tagalakis, Dafni Gyftaki‐Venieri et al. · Advanced Healthcare Materials
Open access |
12 Nov 2024 |
5 |
| 29 |
WS1.5 Restoration of the CFTR function by antisense oligonucleotide splicing modulation
Michal Irony‐Tur Sinai, Steve Donald Wilton, Batsheva Kerem · Journal of Cystic Fibrosis
Open access |
Jun 2014 |
4 |
| 30 |
46 Ex vivo efficacy of Lynovex®, a next generation tri-functional candidate cystic fibrosis therapy
Derry K. Mercer, Céline Charrier, James Robertson et al. · Journal of Cystic Fibrosis
Open access |
Jun 2014 |
1 |
| 31 |
44 An alginate oligomer (OligoG) developed as a dry powder for inhalation in cystic fibrosis demonstrates an excellent safety profile, similar to a nebulised solution used in a phase 2a trial
Astrid Hilde Myrset, Larry Phillips, Simon Moore et al. · Journal of Cystic Fibrosis
Open access |
Jun 2014 |
1 |
| 32 |
139 OligoG fluorescent conjugation for localisation in a mucoid pseudomonal biofilm
M. Pritchard, Elaine L. Ferguson, Lydia C. Powell et al. · Journal of Cystic Fibrosis
Open access |
Jun 2015 |
1 |
| 33 |
Alginate-Amphotericin B bifunctional conjugates have improved solubility and reduced toxicity
Mina Gravdahl, Peter Patrick Molesworth, Andreas Åslund et al. · Carbohydrate Polymers
Open access |
13 Feb 2026 |
0 |
| 34 |
WS1.6 OligoG normalizes the CF mucus phenotype
Anna Ermund, Lauren N. Meiss, Edvar Onsøyen et al. · Journal of Cystic Fibrosis
Open access |
Jun 2014 |
0 |