| 1 |
The Insula: A Brain Stimulation Target for the Treatment of Addiction
Christine Ibrahim, Dafna Sara Rubin-Kahana, Abhiram P. Pushparaj et al. · Frontiers in Pharmacology
Open access |
2 Jul 2019 |
134 |
| 2 |
Licogliflozin for nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a study
Stephen A. Harrison et al. · Nature Medicine
Open access |
20 Jun 2022 |
72 |
| 3 |
Randomized, placebo-controlled, 28-day safety and pharmacokinetics evaluation of repeated oral cannabidiol administration in healthy dogs
Dana M. Vaughn, Lina Paulionis, Justyna Kulpa · American Journal of Veterinary Research
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27 Apr 2021 |
64 |
| 4 |
Pharmacokinetic bioequivalence, safety and acceptability of Ornibel ® , a new polymer composition contraceptive vaginal ring (etonogestrel/ethinylestradiol 11.00/3.474 mg) compared with Nuvaring ® (etonogestrel/ethinylestradiol 11.7/2.7 mg)
Jaime Algorta, María Sanguino Díaz, Raquel de Benito et al. · The European Journal of Contraception & Reproductive Health Care
Open access |
2 Nov 2017 |
39 |
| 5 |
A Novel Hybridization LC-MS/MS Methodology for Quantification of siRNA in Plasma, CSF and Tissue Samples
Long Yuan, Jean-François Dupuis, Kevork Mekhssian · Molecules
Open access |
8 Feb 2023 |
37 |
| 6 |
Effect of difelikefalin, a selective kappa opioid receptor agonist, on respiratory depression:A randomized, double‐blind, placebo‐controlled trial
Eugene R. Viscusi, Marc C. Torjman, Catherine L. Munera et al. · Clinical and Translational Science
Open access |
13 May 2021 |
35 |
| 7 |
Validation and Application of Hybridization Liquid Chromatography-Tandem Mass Spectrometry Methods for Quantitative Bioanalysis of Antisense Oligonucleotides
Pei Li, Jean-François Dupuis, Valerie Vrionis et al. · Bioanalysis
|
May 2022 |
34 |
| 8 |
GCC Consolidated Feedback to ICH on the 2019 ICH M10 Bioanalytical Method Validation Draft Guideline
Corey Nehls et al. · Bioanalysis
Open access |
Sep 2019 |
30 |
| 9 |
Abuse Potential of Lemborexant, a Dual Orexin Receptor Antagonist, Compared With Zolpidem and Suvorexant in Recreational Sedative Users
Ishani Savant Landry, Nancy Hall, Jagadeesh Aluri et al. · Journal of Clinical Psychopharmacology
Open access |
24 Jun 2022 |
28 |
| 10 |
Volumetric Absorptive Microsampling Combined with Impact-Assisted Extraction for Hematocrit Effect Free Assays
Nikolay Youhnovski, Laurence Mayrand-Provencher, Eugénie-Raphaëlle Bérubé et al. · Bioanalysis
|
Nov 2017 |
25 |
| 11 |
A Growth Differentiation Factor 15 Receptor Agonist in Randomized Placebo-Controlled Trials in Healthy or Obese Persons
William Burton Smith, D. Le Nguyen, Timothy M. Clough et al. · The Journal of Clinical Endocrinology & Metabolism
Open access |
14 Aug 2024 |
24 |
| 12 |
The abuse potential of lemborexant, a dual orexin receptor antagonist, according to the 8 factors of the Controlled Substances Act
Margaret L. Moline, Shoji Asakura, Carsten Beuckman et al. · Psychopharmacology
Open access |
7 Feb 2023 |
23 |
| 13 |
Human Abuse Liability Assessment of Tobacco and Nicotine Products: Approaches for Meeting Current Regulatory Recommendations
Andrea Rae Vansickel, Sarah A. Baxter, Neil Sherwood et al. · Nicotine & Tobacco Research
|
8 Sep 2021 |
23 |
| 14 |
2022 White Paper on Recent Issues in Bioanalysis: ICH M10 BMV Guideline & Global Harmonization; Hybrid Assays; Oligonucleotides & ADC; Non-Liquid & Rare Matrices; Regulatory Inputs ( Part 1A – Recommendations on Mass Spectrometry, Chromatography and Sample Preparation, Novel Technologies, Novel Modalities, and Novel Challenges, ICH M10 BMV Guideline & Global Harmonization Part 1B - Regulatory Agen
Matt Szapacs et al. · Bioanalysis
|
Aug 2023 |
21 |
| 15 |
Recommendations for Classification of Commercial LBA Kits for Biomarkers in Drug Development From the GCC for Bioanalysis
Rafiq Islam et al. · Bioanalysis
Open access |
Apr 2019 |
15 |
| 16 |
The effects of dopamine D4 receptor ligands on operant alcohol self-administration and cue- and stress-induced reinstatement in rats
Aaron Kim, Patricia Di Ciano, Abhiram P. Pushparaj et al. · European Journal of Pharmacology
|
2 Dec 2019 |
14 |
| 17 |
12th GCC Closed Forum: Critical Reagents; Oligonucleotides; CoA; Method Transfer; HRMS; Flow Cytometry; Regulatory Findings; Stability and Immunogenicity
Chad J. Briscoe et al. · Bioanalysis
Open access |
Jun 2019 |
14 |
| 18 |
A Validated Capillary Microsampling Liquid Chromatography–Tandem Mass Spectrometry Method for Quantification of Antisense Oligonucleotides in Mouse Serum
Long Yuan, Jean-François Dupuis, Valerie Vrionis et al. · Bioanalysis
Open access |
Jun 2023 |
13 |
| 19 |
Orthogonal Analysis of Dystrophin Protein and Mrna As A Surrogate Outcome for Drug Development
Kitipong Uaesoontrachoon et al. · Biomarkers in Medicine
Open access |
5 Aug 2019 |
13 |
| 20 |
Efficacy, safety, pharmacokinetics, and associated microbiome changes of ibezapolstat compared with vancomycin in adults with Clostridioides difficile infection: a phase 2b, randomised, double-blind, active-controlled, multicentre study
Taryn A Eubank et al. · The Lancet Microbe
Open access |
11 Jun 2025 |
12 |
| 21 |
Oral, intranasal, and intravenous abuse potential of serdexmethylphenidate, a novel prodrug of d-methylphenidate
Megan J. Shram, Beatrice Setnik, Lynn Roy Webster et al. · Current Medical Research and Opinion
Open access |
16 May 2022 |
12 |
| 22 |
The safety and acceptability of twice‐daily deferiprone for transfusional iron overload: A multicentre, open‐label, phase 2 study
Sherif M. Badawy, Antonis Kattamis, Hatoon M. Ezzat et al. · British Journal of Haematology
Open access |
21 Dec 2021 |
12 |
| 23 |
Pharmacokinetics and Pharmacodynamics of Etripamil, an Intranasally Administered, Fast‐Acting, Nondihydropyridine Calcium Channel Blocker
James E. Ip, Douglas Wight, Corinne Seng Yue et al. · Clinical Pharmacology in Drug Development
Open access |
5 Feb 2024 |
11 |
| 24 |
A randomized phase 1b trial of the active site polymerase inhibitor nucleotide ATI ‐2173 in patients with chronic hepatitis B virus infection
Katherine E. Squires, Lauren Ogilvie, Alina Jucov et al. · Journal of Viral Hepatitis
Open access |
6 Oct 2022 |
11 |
| 25 |
Acute Cognitive Effects of the Dual Orexin Receptor Antagonist Lemborexant Compared With Suvorexant and Zolpidem in Recreational Sedative Users
Ishani Savant Landry, Nancy Hall, Jagadeesh Alur et al. · Journal of Clinical Psychopharmacology
Open access |
24 Jun 2022 |
10 |
| 26 |
Fresh-cheesemilk formulation fermented by a combination of freeze-dried citrate-positive cultures and exopolysaccharide-producing lactobacilli with liquid lactococcal starters
Claude P. Champagne, Julie Barrette, Denis Roy et al. · Food Research International
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24 Feb 2006 |
10 |
| 27 |
A Bioequivalence Study of Two Formulations of Oral Semaglutide in Healthy Participants
Mette S. Nielsen, Lise Brøndsted, Martin K. Kankam et al. · Diabetes Therapy
Open access |
21 Dec 2024 |
9 |
| 28 |
Anticancer effect of minor phytocannabinoids in preclinical models of multiple myeloma
Cristina Aguzzi, Laura Zeppa, Maria Beatrice Morelli et al. · BioFactors
Open access |
17 May 2024 |
9 |
| 29 |
Comparison of two carbohydrate intake strategies to improve glucose control during exercise in adolescents and adults with type 1 diabetes
Lucas Goulet-Gélinas, Marie‐Béatrice Saade, Corinne Suppère et al. · Nutrition Metabolism and Cardiovascular Diseases
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17 Dec 2020 |
8 |
| 30 |
Safety, pharmacokinetics, and pharmacodynamics of MK-6194, an IL-2 mutein designed to selectively activate regulatory T cells: single ascending dose and multiple ascending dose trial data
J. E. SCHEID et al. · ImmunoHorizons
Open access |
26 Mar 2025 |
7 |
| 31 |
RLS-0071, a dual-targeting anti-inflammatory peptide - biomarker findings from a first in human clinical trial
Jessica Goss, Pamela S. Hair, Parvathi S. Kumar et al. · Translational Medicine Communications
Open access |
6 Jan 2023 |
6 |
| 32 |
Computational Modeling of Ophthalmic Procedures
William Joseph Foster, Brian Berg, Steven N. Luminais et al. · American Journal of Ophthalmology
Open access |
28 Mar 2022 |
6 |
| 33 |
Blood Pressure Lowering Effects of a Novel Long-Acting NPR1 Agonist, XXB750, in Healthy Participants: A Randomized, First-in-Human Clinical Study
Yanling He, Wu Xueping, André Serra‐Roma et al. · Circulation
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27 May 2025 |
5 |
| 34 |
Intravenous vs. Oral Dose Comparison of Ibuprofen and Tramadol Combinations—Enantiomers, Metabolite, Linearity, and Sex-Related Effects: A Pharmacokinetics Randomized Clinical Trial
Carmen Portolés-Díez, María Rosario Salas-Butrón, Ana Ascaso et al. · Pharmaceuticals
Open access |
26 Feb 2025 |
5 |
| 35 |
Volumetric Absorptive Microsampling Coupled with Hybridization LC–MS/MS for Quantitation of Antisense Oligonucleotides
Ming-Luan Chen, Kevork Mekhssian, Muskaan Dutt et al. · Bioanalysis
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Sep 2023 |
5 |
| 36 |
The bioequivalence of fixed‐dose combination tablets of bisoprolol and ramipril and its drug‐drug interaction potential
Jan Sus, Jade Huguet, Jan Bosák et al. · Clinical and Translational Science
Open access |
8 Sep 2021 |
5 |
| 37 |
Clinical Evaluation of Potential Interaction Between Bemnifosbuvir and Ruzasvir With an Assessment of Food Effect: Results of a Phase 1 Study in Healthy Participants
Xiao‐Jian Zhou, Gaetano Morelli, Maureen Montrond et al. · Clinical Pharmacology in Drug Development
Open access |
24 Apr 2025 |
4 |
| 38 |
982. Effect of Hepatic Impairment on the Safety and Pharmacokinetics of Rezafungin
Jade Huguet, Voon S. Ong, Taylor Sandison et al. · Open Forum Infectious Diseases
Open access |
Nov 2021 |
4 |
| 39 |
Similar immunogenicity profiles between the proposed biosimilar MYL-1501D and reference insulin glargine in patients with diabetes mellitus: the phase 3 INSTRIDE 1 and INSTRIDE 2 studies
Bin Sun, Nilanjan Sengupta, Anita Rao et al. · BMC Endocrine Disorders
Open access |
26 Jun 2021 |
4 |
| 40 |
A pilot, Placebo controlled, dose-Finding, Pharmacodynamic and Pharmacokinetic Study of Orally Administered Botanical Kratom in non-Dependent, Recreational Polydrug Users with Opioid Experience under Fed Conditions.
Chad J. Reissig, Beatrice Setnik, Denise L. Milovan et al. · Drug and Alcohol Dependence
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Feb 2025 |
3 |
| 41 |
Effects of zuranolone on next-day simulated driving in healthy adults
Joi Dunbar, Gaetano Morelli, Rakesh Jain et al. · Psychopharmacology
Open access |
20 Sep 2024 |
3 |
| 42 |
Characterization of host immune cell infiltrate in human CAR T cell-mediated xenogeneic graft versus host disease in NSG mice
Elinor Willis, Esha Banerjee, Jillian Verrelle et al. · Veterinary Pathology
Open access |
19 Nov 2025 |
2 |
| 43 |
In Vivo Characterization of ONL1204, a Small Peptide Inhibitor of the Fas Receptor, as a Potential Neuroprotective Therapy for Geographic Atrophy and Dry Age-Related Macular Degeneration
Andrew J. Kocab, Marisol Cano, Marianna Bacellar‐Galdino et al. · Biomedicines
Open access |
22 Aug 2025 |
2 |
| 44 |
Pharmacokinetics and Pharmacodynamics of Nomlabofusp in Non-clinical Studies of Friedreich’s Ataxia
Flavia Toni, Vanessa Ragaglia, Devin Schecter et al. · The AAPS Journal
Open access |
25 Jun 2025 |
2 |
| 45 |
679: Effect of Moderate Hepatic Impairment on the Safety and Pharmacokinetics of Rezafungin
Voon S. Ong, Taylor Sandison, Rebeca Melara et al. · Critical Care Medicine
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11 Dec 2020 |
2 |
| 46 |
Polyvalent Human Immune Globulin: A Prospective, Open-Label Study Assessing Anti-Hepatitis A Virus (HAV) Antibody Levels, Pharmacokinetics, and Safety in HAV-Seronegative Healthy Subjects
Martin K. Kankam, Rhonda Griffin, Jeffrey Price et al. · Advances in Therapy
Open access |
16 Apr 2020 |
2 |
| 47 |
Intradermal delivery of lipophilic siRNAs enables prolonged skin retention and sustained gene silencing in a porcine model
Hassan H. Fakih et al. · Nature Communications
Open access |
3 Feb 2026 |
1 |
| 48 |
Pathology associated with human CAR T cell administration in NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ (NSG) mice: A retrospective analysis
Renata M. Mammone, Elinor Willis, Pedro Ruivo et al. · Veterinary Pathology
Open access |
27 Jan 2026 |
1 |
| 49 |
Techniques to study chimerism at the tissue level in humanized mice
Arin C. Cox, Esha Banerjee, Jillian Verrelle et al. · Veterinary Pathology
Open access |
21 Nov 2025 |
1 |
| 50 |
Ocular Pharmacokinetic Studies: Challenges and Best Practices
Marianna Bacellar‐Galdino, Sandeep Kumar Jain, Simon Kaja · Pharmaceutical science.
Book chapterOpen access |
18 Jul 2025 |
1 |