| 1 |
Neurotrophin-targeted therapeutics: A gateway to cognition and more?
Gunnar Nordvall, Pontus K. A. Larsson Forsell, Johan Sandin · Drug Discovery Today
Open access |
16 Jul 2022 |
50 |
| 2 |
Topical levocabastine versus sodium cromoglycate in allergic conjunctivitis
Hannes Odelram, Bengt Björkstén, T. AF KLERCKER et al. · Allergy
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Aug 1989 |
46 |
| 3 |
Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice
Beatriz Merino, Cristina M. Fernández-Díaz, Cristina Parrado‐Fernández et al. · Metabolism
Open access |
9 Sep 2020 |
45 |
| 4 |
Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease
Gunnar Nordvall, Johan Lundkvist, Johan Sandin · Frontiers in Molecular Neuroscience
Open access |
16 Oct 2023 |
39 |
| 5 |
Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling
Luana Naia et al. · BMC Biology
Open access |
24 Mar 2021 |
39 |
| 6 |
Identification of Novel Positive Allosteric Modulators of Neurotrophin Receptors for the Treatment of Cognitive Dysfunction
Märta Dahlström, Nather Madjid, Gunnar Nordvall et al. · Cells
Open access |
23 Jul 2021 |
35 |
| 7 |
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
Daniel V. Oliveira, Kirsten Coupland, Wenchao Shao et al. · EMBO Molecular Medicine
Open access |
16 Dec 2022 |
29 |
| 8 |
Antidepressant effects of novel positive allosteric modulators of Trk-receptor mediated signaling – a potential therapeutic concept?
Nather Madjid, Veronica Lidell, Gunnar Nordvall et al. · Psychopharmacology
Open access |
3 Jul 2023 |
21 |
| 9 |
Neuroprotective and Disease-Modifying Effects of the Triazinetrione ACD856, a Positive Allosteric Modulator of Trk-Receptors for the Treatment of Cognitive Dysfunction in Alzheimer’s Disease
Cristina Parrado Fernández, Sanja Juric, Maria Backlund et al. · International Journal of Molecular Sciences
Open access |
6 Jul 2023 |
16 |
| 10 |
Sex difference in flux of 27‐hydroxycholesterol into the brain
Cristina Parrado‐Fernández, Valerio Leoni, Ahmed Saeed et al. · British Journal of Pharmacology
Open access |
21 Dec 2020 |
15 |
| 11 |
Positive Allosteric Modulators of Trk Receptors for the Treatment of Alzheimer’s Disease
Pontus K. A. Larsson Forsell, Cristina Parrado Fernández, Boel Nilsson et al. · Pharmaceuticals
Open access |
28 Jul 2024 |
14 |
| 12 |
Topically applied novel TRPV1 receptor antagonist, ACD440 Gel, reduces evoked pain in healthy volunteers, a randomized, double‐blind, placebo‐controlled, crossover study
Märta Segerdahl, M. Rother, Magnus M. Halldin et al. · European Journal of Pain
Open access |
12 Jun 2024 |
13 |
| 13 |
Safety, Tolerability, Pharmacokinetics and Quantitative Electroencephalography Assessment of ACD856, a Novel Positive Allosteric Modulator of Trk-Receptors Following Multiple Doses in Healthy Subjects
Kristin Önnestam, Björn Mikael Nilsson, M. Rother et al. · The Journal of Prevention of Alzheimer s Disease
Open access |
6 Jul 2023 |
11 |
| 14 |
γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
Tobias A. Weber, Johan Lundkvist, Johanna Wanngren et al. · Journal of Cellular and Molecular Medicine
Open access |
20 Dec 2021 |
9 |
| 15 |
Identification and In Vitro and In Vivo Characterization of KAC-50.1 as a Potential α-Synuclein PET Radioligand
Dinahlee Saturnino Guarino, Patrícia Miranda-Azpiazu, Dan Sunnemark et al. · ACS Chemical Neuroscience
Open access |
11 Nov 2024 |
8 |
| 16 |
Identification of amino acid residues of nerve growth factor important for neurite outgrowth in human dorsal root ganglion neurons
Märta Dahlström, Gunnar Nordvall, Erik Sundström et al. · European Journal of Neuroscience
Open access |
13 Jul 2019 |
7 |
| 17 |
ACD856, a novel positive allosteric modulator of Trk receptors, single ascending doses in healthy subjects: Safety and pharmacokinetics
Boel Nilsson, Johan Bylund, Magnus M. Halldin et al. · European Journal of Clinical Pharmacology
Open access |
14 Feb 2024 |
6 |
| 18 |
Topically applied novel TRPV1 receptor antagonist, ACD440 Gel, reduces temperature-evoked pain in patients with peripheral neuropathic pain with sensory hypersensitivity, a randomized, double-blind, placebo-controlled, crossover study
Adriana Ana Miclescu, Rolf Karlsten, Ingrid Lönnstedt et al. · Scandinavian Journal of Pain
Open access |
2025 |
3 |
| 19 |
Development and In Vitro Characterization of [3H]GMC-058 as Radioligand for Imaging Parkinsonian-Related Proteinopathies
Andrea Varrone, Vasco C. Sousa, Manolo Mugnaini et al. · Cells
Open access |
9 Jun 2025 |
1 |
| 20 |
Modulation of the NGF – TRKA pathway for treatment of joint pain: preclinical in vivo evaluation in mice
Kristina Ängeby Möller, Pontus K. A. Larsson Forsell, Gunnar Nordvall et al. · Osteoarthritis and Cartilage
Open access |
Apr 2018 |
1 |
| 21 |
Analgesic, anti-inflammatory and joint protective effects of ACD137, a selective negative allosteric modulator of TrkA, in models of chemotherapy-induced peripheral neuropathy and osteoarthritis
Pontus K. A. Larsson Forsell, Maria Backlund, Veronica Lidell et al. · Scandinavian Journal of Pain
Open access |
2026 |
0 |
| 22 |
Gene therapy device-based delivery of progranulin, prosaposin, and GDNF as a combined precision and neurorestorative therapy in the rat 6-OHDA model of parkinsonism
Chiara Bertasini, Marco Rossini, Jacopo Grisotto et al. · Experimental Neurology
Open access |
23 Sep 2025 |
0 |
| 23 |
Results From a Multiple Ascending Dose Study in Healthy Volunteers of ACD856, a Positive Modulator of Neurotrophin Trk‐Receptors
Kristin Önnestam, Boel Nilsson, M. Rother et al. · Alzheimer s & Dementia
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Dec 2022 |
0 |
| 24 |
NOTCH3 active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
Daniel V. Oliveira, Kirsten Coupland, Shaobo Jin et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
12 Jul 2022 |
0 |
| 25 |
P.0229 Characterization of positive allosteric modulators of trkb for the treatment of depression
Johan Sandin, Gunnar Nordvall, Märta Dahlström et al. · European Neuropsychopharmacology
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Dec 2021 |
0 |