| 1 |
The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
Carles Cantó, Riekelt H. Houtkooper, Eija Pirinen et al. · Cell Metabolism
Open access |
Jun 2012 |
1,262 |
| 2 |
Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
Dongryeol Ryu, Laurent Mouchiroud, Pénélope A. Andreux et al. · Nature Medicine
Open access |
11 Jul 2016 |
1,116 |
| 3 |
Mitophagy in human health, ageing and disease
Anna Picca, Julie Faitg, Johan H. Auwerx et al. · Nature Metabolism
Open access |
30 Nov 2023 |
605 |
| 4 |
The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans
Pénélope A. Andreux, William E. Blanco-Bose, Dongryeol Ryu et al. · Nature Metabolism
Open access |
14 Jun 2019 |
582 |
| 5 |
Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
Davide Francesco D'Amico, Pénélope A. Andreux, Pamela Valdés et al. · Trends in Molecular Medicine
ReviewOpen access |
21 May 2021 |
417 |
| 6 |
Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults
Anurag Singh, Davide Francesco D'Amico, Pénélope A. Andreux et al. · Cell Reports Medicine
Open access |
May 2022 |
264 |
| 7 |
Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults
Sophia Z. Liu, Davide Francesco D'Amico, Eric G. Shankland et al. · JAMA Network Open
Open access |
20 Jan 2022 |
205 |
| 8 |
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis
Davide Francesco D'Amico, Merissa Olmer, Andréane M. Fouassier et al. · Aging Cell
Open access |
Jul 2022 |
169 |
| 9 |
Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy
Dominic Denk, Valentina Petrocelli, Claire Conche et al. · Immunity
Open access |
18 Oct 2022 |
155 |
| 10 |
Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid
Jacqueline M. Heilman, Pénélope A. Andreux, Nga L. Tran et al. · Food and Chemical Toxicology
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27 Jul 2017 |
122 |
| 11 |
Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population
Anurag Singh, Davide Francesco D'Amico, Pénélope A. Andreux et al. · European Journal of Clinical Nutrition
Open access |
11 Jun 2021 |
121 |
| 12 |
Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly
Pénélope A. Andreux, Marcus P.J. van Diemen, Maxime R. Heezen et al. · Scientific Reports
Open access |
29 May 2018 |
109 |
| 13 |
ARDD 2020: from aging mechanisms to interventions
Garik V. Mkrtchyan et al. · Aging
Open access |
30 Dec 2020 |
57 |
| 14 |
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
Dominic Denk, Anurag Singh, Herbert G. Kasler et al. · Nature Aging
Open access |
31 Oct 2025 |
42 |
| 15 |
Urolithin A provides cardioprotection and mitochondrial quality enhancement preclinically and improves human cardiovascular health biomarkers
Sophia Liu, Julie Faitg, Charlotte Tissot et al. · iScience
Open access |
14 Jan 2025 |
29 |
| 16 |
Mitophagy Activation by Urolithin A to Target Muscle Aging
Julie Faitg, Davide Francesco D'Amico, Chris Rinsch et al. · Calcified Tissue International
Open access |
5 Nov 2023 |
28 |
| 17 |
SMA-miRs (miR-181a-5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples
Emanuela Abiusi et al. · eLife
Open access |
20 Sep 2021 |
28 |
| 18 |
Autophagy ablation in skeletal muscles worsens sepsis-induced muscle wasting, impairs whole-body metabolism, and decreases survival
Jean‐Philippe Leduc‐Gaudet, Kayla Míguez, Marina Cefis et al. · iScience
Open access |
25 Jul 2023 |
24 |
| 19 |
Regional differences in progenitor metabolism shape brain growth during development
Natalia Baumann, Robin Jan Wagener, Awais Javed et al. · Cell
Open access |
28 Apr 2025 |
22 |
| 20 |
ORALLY ADMINISTERED UROLITHIN A IS SAFE AND MODULATES MUSCLE AND MITOCHONDRIAL BIOMARKERS IN ELDERLY
Anurag Singh, Pénélope A. Andreux, William E. Blanco-Bose et al. · Innovation in Aging
Open access |
30 Jun 2017 |
11 |
| 21 |
Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners
Jamie Whitfield, Alannah K. A. McKay, Nicolin Tee et al. · Sports Medicine
Open access |
21 Aug 2025 |
9 |
| 22 |
Nutritional Mediators of Cellular Decline and Mitochondrial Dysfunction in Older Adults
Jack M. Guralnik, Jérôme N. Feige, Anurag Singh et al. · Geriatrics
Open access |
6 Apr 2021 |
7 |
| 23 |
Urolithin A Abolishes High Anxiety and Rescues the Associated Mitochondria-Related Transcriptomic Signatures and Synaptic Function
David Mallet, Doğukan Hazar Ülgen, Jocelyn Grosse et al. · Biological Psychiatry
Open access |
31 Jul 2025 |
6 |
| 24 |
The polyphenol metabolite urolithin A suppresses myostatin expression and augments glucose uptake in human skeletal muscle cells
Andrew Wilhelmsen, Leonidas G. Karagounis, Andrew J. Bennett et al. · Nutrition & Metabolism
Open access |
17 Feb 2025 |
5 |
| 25 |
Urolithin A induces cardioprotection and enhanced mitochondrial quality during natural aging and heart failure
Shuguang Liu, Julie Faitg, Cécile Tissot et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
24 Aug 2023 |
3 |
| 26 |
Novel Potential Targets for Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-inflammatory Drugs, Troponin Activators, Mas Receptor Agonists, and Urolithin A
Waly Dioh, Vihang A. Narkar, Anurag Singh et al. · The Journals of Gerontology Series A
Open access |
Jun 2023 |
3 |
| 27 |
Urolithin A, a Gut Microbiome Derived Metabolite Improves Mitochondrial and Cellular Health: Results from a Randomized, Placebo-controlled, Double-blind Clinical Trial (FS09-06-19)
Anurag Singh, Pénélope A. Andreux, William Genaro Trujillo Blanco et al. · Current Developments in Nutrition
Open access |
Jun 2019 |
3 |
| 28 |
TRANSLATING UROLITHIN A BENEFITS ON MUSCLE MITOCHONDRIA TO HUMANS
Anurag Singh, Pénélope A. Andreux, William E. Blanco-Bose et al. · Innovation in Aging
Open access |
Nov 2018 |
3 |
| 29 |
Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials
Davide Francesco D'Amico, A. Fouassier, Julie Faitg et al. · medRxiv
PreprintOpen access |
20 Jun 2023 |
2 |
| 30 |
Potential of Urolithin A to improve joint health
Davide Francesco D'Amico, Martin Lotz · Aging
Open access |
28 Mar 2023 |
1 |