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Institution · C4 Therapeutics (United States)

Most cited papers from C4 Therapeutics (United States)

C4 Therapeutics (United States)

What are the most cited papers from C4 Therapeutics (United States)?

The most cited paper from C4 Therapeutics (United States) is "BI-3406, a Potent and Selective SOS1–KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition" (Marco H. Hofmann et al., 2020), with 432 citations. Next come "Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis" (364) and "CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells" (256).

Showing 50 of 61 papers. Every paper with more than 13 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 BI-3406, a Potent and Selective SOS1–KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition Marco H. Hofmann et al. · Cancer Discovery Open access 19 Aug 2020 432
2 Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis Pei‐Yu Chen et al. · Nature Metabolism Open access 26 Aug 2019 364
3 CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells Yi-Li Min, Hui zi Li, Cristina Rodríguez-Caycedo et al. · Science Advances Open access Mar 2019 256
4 Pharmacologic Activation of p53 Triggers Viral Mimicry Response Thereby Abolishing Tumor Immune Evasion and Promoting Antitumor Immunity Xiaolei Zhou, Madhurendra Singh, Gema Sanz et al. · Cancer Discovery Open access 6 Jul 2021 178
5 Fundamental aspects of DMPK optimization of targeted protein degraders Carina Cantrill, Prasoon Chaturvedi, Caroline Rynn et al. · Drug Discovery Today 13 Apr 2020 168
6 Phase 1 Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-type TP53 Mansoor Noorali Saleh, Manish R. Patel, Todd Michael Bauer et al. · Clinical Cancer Research Open access 22 Jul 2021 154
7 In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer Alessandro Carugo et al. · Cell Reports Open access Jun 2016 153
8 In vivo chimeric antigen receptor (CAR)-T cell therapy Adrian Bot, Andrew M. Scharenberg, Kevin M. Friedman et al. · Nature Reviews Drug Discovery Review 30 Sep 2025 118
9 A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization David Dilworth et al. · Nature Chemical Biology Open access 15 Nov 2021 110
10 OnTAD: hierarchical domain structure reveals the divergence of activity among TADs and boundaries Lin An, Tao Yang, Jiahao Yang et al. · Genome biology Open access Dec 2019 103
11 Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome Malgorzata Ewa Rogalska, Estefanía Mancini, Sophie Bonnal et al. · Science 31 Oct 2024 99
12 A1 Adenosine Receptor: Role in Diabetes and Obesity Arvinder K. Dhalla, Jeffrey W. Chisholm, Gerald M. Reaven et al. · Handbook of experimental pharmacology Book chapter 2009 92
13 Cholesterol transport function of pancreatic cholesterol esterase: Directed sterol uptake and esterification in enterocytes Angel López‐Candales, Matthew S. Bosner, Curtis A. Spilburg et al. · Biochemistry Nov 1993 81
14 A double-blind, placebo-controlled trial of two dose ranges of nefazodone in the treatment of depressed outpatients. J Mendels, Fred W. Reimherr, Ronald N. Marcus et al. · PubMed 1995 76
15 Correlation of Inhibitory Effects of Polymers on Indomethacin Precipitation in Solution and Amorphous Solid Crystallization Based on Molecular Interaction Harsh Chauhan, Anuj Kuldipkumar, Timothy E. Barder et al. · Pharmaceutical Research 11 Oct 2013 71
16 Synthetic glycans control gut microbiome structure and mitigate colitis in mice Andrew C. Tolonen, Nicholas Beauchemin, Charlie F. Bayne et al. · Nature Communications Open access 10 Mar 2022 68
17 Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design Scott J. Eron, Hongwei Huang, Roman V. Agafonov et al. · ACS Chemical Biology Open access 28 Sep 2021 63
18 Recruitment of FBXO22 for targeted degradation of NSD2 Yan Nie et al. · Nature Chemical Biology Open access 4 Jul 2024 62
19 Progress in the discovery of selective, high affinity A2B adenosine receptor antagonists as clinical candidates Rao V. Kalla, Jeff A. Zablocki · Purinergic Signalling Open access 20 Jun 2008 54
20 Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain Cindy H. Wen et al. · Science Open access227 authors 23 May 2024 52
21 Characterizing patient compliance over six months in remote digital trials of Parkinson’s and Huntington disease Shani Attias Cohen, Zeev Waks, Jordan J. Elm et al. · BMC Medical Informatics and Decision Making Open access Dec 2018 45
22 Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms Matthew A. Ciorba, Liza Konnikova, Simon Andrew Hirota et al. · Inflammatory Bowel Diseases Open access May 2024 44
23 In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse Leonela Amoasii, Hui zi Li, Yu Zhang et al. · Nature Communications Open access 4 Oct 2019 44
24 Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH Settings Brian E. Schwartz, Vaishnavi Rajagopal, Cynthia J. Smith et al. · Cells Open access 7 Oct 2020 42
25 Protein design using structure-based residue preferences David Ding, Ada Y. Shaw, Sam Sinai et al. · Nature Communications Open access 22 Feb 2024 40
26 A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy Fereidoon Daryaee, Zhuo Zhang, Kayla R. Gogarty et al. · Chemical Science Open access 2017 38
27 High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics Jeffrey R. Simard, Linda Lee, Ellen F. Vieux et al. · SLAS DISCOVERY Open access 14 Jan 2021 37
28 Orthogonal Cas9–Cas9 chimeras provide a versatile platform for genome editing Mehmet Fatih Bolukbasi, Pengpeng Liu, Kevin Luk et al. · Nature Communications Open access 13 Nov 2018 36
29 Caffeine intake induces an alteration in human neutrophil A2A adenosine receptors Katia Varani, Francesco Portaluppi, Stefania Gessi et al. · Cellular and Molecular Life Sciences Open access 5 Sep 2005 35
30 Inhibition of ENT1 relieves intracellular adenosine-mediated T cell suppression in cancer Theodore J. Sanders, Christopher S. Nabel, Margreet Brouwer et al. · Nature Immunology Open access 12 May 2025 34
31 Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity Simone Punt et al. · Cancer Immunology Immunotherapy Open access 29 Oct 2020 34
32 AKT/mTORC2 Inhibition Activates FOXO1 Function in CLL Cells Reducing B-Cell Receptor-Mediated Survival Emilio Cosimo, Anuradha Tarafdar, Michael W. Moles et al. · Clinical Cancer Research Open access 17 Dec 2018 34
33 High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer Keith H. Jansson et al. · Scientific Reports Open access 16 Nov 2018 34
34 Simultaneous enhancement of multiple functional properties using evolution-informed protein design Benjamin J. Fram, Yang Su, Ian Truebridge et al. · Nature Communications Open access 20 Jun 2024 31
35 AAA+ protease-adaptor structures reveal altered conformations and ring specialization Sora Kim, Fei Xue, Robert T. Sauer et al. · Nature Structural & Molecular Biology Open access Nov 2022 30
36 Advancing personalized medicine in brain cancer: exploring the role of mRNA vaccines Feng Lin, Emma Z. Lin, Misa Anekoji et al. · Journal of Translational Medicine Open access 18 Nov 2023 28
37 Lipid Deposition Profiles Influence Foreign Body Responses Christian C. Schreib, Maria Jarvis, Tanguy Terlier et al. · Advanced Materials Open access 5 Mar 2023 28
38 Single Cell Explorer, collaboration-driven tools to leverage large-scale single cell RNA-seq data Di Feng, Charles E. Whitehurst, Dechao Shan et al. · BMC Genomics Open access 27 Aug 2019 28
39 Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension Yi‐Yin Tai et al. · Science Translational Medicine Open access 10 Jan 2024 27
40 Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments Sina Haftchenary, Shawn D. Nelson, Laura Furst et al. · ACS Combinatorial Science Open access 12 Aug 2016 25
41 mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity Christopher J. Nirschl, Heather R. Brodkin, Celesztina Domonkos et al. · Cancer Immunology Research Open access 18 Apr 2023 24
42 A benchmark of expert-level academic questions to assess AI capabilities Long Phan et al. · Nature Open access1,101 authors 28 Jan 2026 23
43 PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer Anran Chen et al. · Molecular Cancer Therapeutics Open access 23 May 2024 23
44 CD19 directed CAR T cell therapy in diffuse large B-cell lymphoma Alfonso Quintás‐Cardama · Oncotarget Open access 6 Jul 2018 23
45 Development of an AchillesTAG degradation system and its application to control CAR-T activity Gesine K. Veits et al. · Current Research in Chemical Biology Open access 2021 22
46 Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET‐BRET Luke W. Koblan, Dennis L. Buckley, Christopher J. Ott et al. · ChemMedChem 15 Nov 2016 22
47 A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination Ellen F. Vieux, Roman V. Agafonov, Lydia M. Emerson et al. · SLAS DISCOVERY Open access 29 Mar 2021 21
48 Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review Alessandra Cesano et al. · Journal for ImmunoTherapy of Cancer Open access 2025 19
49 Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy Mari Aikio et al. · Cell Reports Open access 2025 18
50 Learning the shape of protein microenvironments with a holographic convolutional neural network Michael N. Pun, A. Ivanov, Quinn Bellamy et al. · Proceedings of the National Academy of Sciences Open access Feb 2024 17

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.