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Company · Watertown · United States

C4 Therapeutics (United States)

c4therapeutics.comROR OpenAlex
Research works
78
▲ 205% vs 2018-21
Citations
1.1k
14.6 per fractional work
Top-10% rate
12.1%
all institutions 10.0%
Open access
49%
world 40%
International
20%
world 18%
C4 Therapeutics (United States)

Not ranked overall: C4 Therapeutics (United States) is under the volume floor below which a citation excellence rate is noise. Not ranked is not the same as ranked last.

Which fields of science does C4 Therapeutics (United States) work in?

In 2022-now, 52% of research at C4 Therapeutics (United States) is in Life Sciences, 42% in Health Sciences. Its largest fields are Medicine (42%), Biochemistry, Genetics and Molecular Biology (41%), Immunology and Microbiology (8%). It does 3.1× the world's share of Life Sciences.

Life Sciences: 28 fractional works · 51.9% of its workBiochemistry, Genetics and Molecular Biology: 22 fractional works · 41.0% of its workMolecular Biology: 17 fractional works · 31.3% of its workGenetics: 2 fractional works · 3.4% of its workCancer Research: 1 fractional works · 2.4% of its workBiotechnology: 1 fractional works · 1.2% of its workCell Biology: 1 fractional works · 1.0% of its workClinical Biochemistry: 0 fractional works · 0.6% of its workPhysiology: 0 fractional works · 0.3% of its workMolecular Medicine: 0 fractional works · 0.3% of its workBiochemistry: 0 fractional works · 0.2% of its workBiophysics: 0 fractional works · 0.2% of its workImmunology and Microbiology: 4 fractional works · 7.9% of its workImmunology: 4 fractional works · 7.7% of its workSmaller subfields together: 0 fractional works · 0.1% of its workNeuroscience: 1 fractional works · 2.6% of its workNeurology: 0 fractional works · 0.9% of its workCognitive Neuroscience: 0 fractional works · 0.8% of its workCellular and Molecular Neuroscience: 0 fractional works · 0.8% of its workSmaller subfields together: 0 fractional works · 0.1% of its workAgricultural and Biological Sciences: 0 fractional works · 0.4% of its workPharmacology, Toxicology and Pharmaceutics: 0 fractional works · 0.1% of its workHealth Sciences: 23 fractional works · 42.4% of its workMedicine: 23 fractional works · 42.2% of its workOncology: 8 fractional works · 14.9% of its workHematology: 3 fractional works · 4.9% of its workRadiology, Nuclear Medicine and Imaging: 2 fractional works · 4.1% of its workPharmacology: 2 fractional works · 3.0% of its workPulmonary and Respiratory Medicine: 2 fractional works · 2.8% of its workNeurology: 1 fractional works · 2.5% of its workComplementary and alternative medicine: 1 fractional works · 1.9% of its workGenetics: 1 fractional works · 1.9% of its workEpidemiology: 1 fractional works · 1.2% of its workTransplantation: 1 fractional works · 1.0% of its workCardiology and Cardiovascular Medicine: 0 fractional works · 0.7% of its workSurgery: 0 fractional works · 0.6% of its workPhysiology: 0 fractional works · 0.5% of its workInfectious Diseases: 0 fractional works · 0.5% of its workEmergency Medicine: 0 fractional works · 0.4% of its workDermatology: 0 fractional works · 0.2% of its workPathology and Forensic Medicine: 0 fractional works · 0.2% of its workPsychiatry and Mental health: 0 fractional works · 0.2% of its workRheumatology: 0 fractional works · 0.2% of its workSmaller subfields together: 0 fractional works · 0.6% of its workNursing: 0 fractional works · 0.2% of its workPhysical Sciences: 2 fractional works · 4.6% of its workMaterials Science: 1 fractional works · 2.2% of its workMaterials Chemistry: 1 fractional works · 1.5% of its workBiomaterials: 0 fractional works · 0.7% of its workChemistry: 1 fractional works · 1.1% of its workOrganic Chemistry: 1 fractional works · 1.1% of its workMathematics: 0 fractional works · 0.6% of its workStatistics and Probability: 0 fractional works · 0.6% of its workEnvironmental Science: 0 fractional works · 0.4% of its workEcology: 0 fractional works · 0.3% of its workSmaller subfields together: 0 fractional works · 0.1% of its workChemical Engineering: 0 fractional works · 0.2% of its workBioengineering: 0 fractional works · 0.2% of its workEngineering: 0 fractional works · 0.1% of its workSocial Sciences: 1 fractional works · 1.1% of its workPsychology: 0 fractional works · 0.6% of its workClinical Psychology: 0 fractional works · 0.6% of its workSocial Sciences: 0 fractional works · 0.3% of its workHealth: 0 fractional works · 0.3% of its workBusiness, Management and Accounting: 0 fractional works · 0.2% of its workMarketing: 0 fractional works · 0.2% of its workALL ITS WORKC4 Therapeutics(United States)54fractional works, 2022-now
Life Sciences52%Physical Sciences5%Health Sciences42%Social Sciences1%

Each ring splits the one inside it: the four domains of science, their fields, their subfields. Size is fractional works in 2022-now. Every slice is a page; the interactive view zooms down to single topics and colours each by how much more of it this institution does than the world.

Its 4 domains and 16 fields, with their numbers
    1. Biochemistry, Genetics and Molecular Biology2241.0%
    2. Immunology and Microbiology47.9%
    3. Neuroscience12.6%
    4. Agricultural and Biological Sciences00.4%
    5. Pharmacology, Toxicology and Pharmaceutics00.1%
    1. Medicine2342.2%
    2. Nursing00.2%
    1. Materials Science12.2%
    2. Chemistry11.1%
    3. Mathematics00.6%
    4. Environmental Science00.4%
    5. Chemical Engineering00.2%
    6. Engineering00.1%
    1. Psychology00.6%
    2. Social Sciences00.3%
    3. Business, Management and Accounting00.2%
All of science, and how each field's share has moved since 1950: the Science domain explorer

What does C4 Therapeutics (United States) specialise in?

Where its research is concentrated relative to its size: Biochemistry, Genetics and Molecular Biology takes 7.7× the share of its output that it takes of world research.

  1. Biochemistry, Genetics and Molecular BiologyField · 22.0 works7.7×
← less than its size predicts1×more →

Location quotient, a volume reading rather than an impact one. It surfaces small, lopsided specialities.

Field profile

Location quotient across every field it publishes in: outside the ring is more than an institution of this size would be expected to publish, inside it is less.

Agricultural and Biological Sciences: 0.07× its world share, 0 worksAgricultural and Bio…Biochemistry, Genetics and Molecular Biology: 7.68× its world share, 22 worksBiochemistry, Geneti…Immunology and Microbiology: 7.82× its world share, 4 worksImmunology and Micro…Neuroscience: 1.60× its world share, 1 worksNeurosciencePharmacology, Toxicology and Pharmaceutics: 0.20× its world share, 0 worksPharmacology, Toxico…Chemical Engineering: 0.59× its world share, 0 worksChemical EngineeringChemistry: 0.69× its world share, 1 worksChemistryEngineering: 0.01× its world share, 0 worksEngineeringEnvironmental Science: 0.07× its world share, 0 worksEnvironmental ScienceMaterials Science: 0.63× its world share, 1 worksMaterials ScienceMathematics: 0.53× its world share, 0 worksMathematicsMedicine: 2.20× its world share, 23 worksMedicineNursing: 0.39× its world share, 0 worksNursingBusiness, Management and Accounting: 0.06× its world share, 0 worksBusiness, Management…Psychology: 0.20× its world share, 0 worksPsychologySocial Sciences: 0.02× its world share, 0 worksSocial Sciences1×world share
more than its size predictsabout as predictedless

Rings at 0.5×, 1× and 2×. Widest outward: Immunology and Microbiology, 7.8×. Every wedge is a field page.

All 16 fields, with their numbers
  1. Immunology and Microbiology7.82×4 works
  2. Biochemistry, Genetics and Molecular Biology7.68×22 works
  3. Medicine2.20×23 works
  4. Neuroscience1.60×1 works
  5. Chemistry0.69×1 works
  6. Materials Science0.63×1 works
  7. Chemical Engineering0.59×0 works
  8. Mathematics0.53×0 works
  9. Nursing0.39×0 works
  10. Pharmacology, Toxicology and Pharmaceutics0.20×0 works
  11. Psychology0.20×0 works
  12. Agricultural and Biological Sciences0.07×0 works
  13. Environmental Science0.07×0 works
  14. Business, Management and Accounting0.06×0 works
  15. Social Sciences0.02×0 works
  16. Engineering0.01×0 works

Who are the top researchers at C4 Therapeutics (United States)?

Ranked on the quality score, Stewart L. Fisher and Mark E. Fitzgerald lead among researchers whose main affiliation is C4 Therapeutics (United States).

  1. 1 Stewart L. Fisher United States · #242,217 worldwide 5.6k citations · 90 works
  2. 2 Mark E. Fitzgerald United States · #1,912,105 worldwide 1.1k citations · 32 works
All ranked researchers at C4 Therapeutics (United States)

What are the most cited papers from C4 Therapeutics (United States)?

The most cited paper from C4 Therapeutics (United States) is "BI-3406, a Potent and Selective SOS1–KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition" (Marco H. Hofmann et al., 2020), with 432 citations. Next come "Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis" (364) and "CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells" (256).

Most cited papers
#PaperReleasedCitations
1 BI-3406, a Potent and Selective SOS1–KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition Marco H. Hofmann et al. · Cancer Discovery Open access 19 Aug 2020 432
2 Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis Pei‐Yu Chen et al. · Nature Metabolism Open access 26 Aug 2019 364
3 CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells Yi-Li Min, Hui zi Li, Cristina Rodríguez-Caycedo et al. · Science Advances Open access Mar 2019 256
4 Pharmacologic Activation of p53 Triggers Viral Mimicry Response Thereby Abolishing Tumor Immune Evasion and Promoting Antitumor Immunity Xiaolei Zhou, Madhurendra Singh, Gema Sanz et al. · Cancer Discovery Open access 6 Jul 2021 178
5 Fundamental aspects of DMPK optimization of targeted protein degraders Carina Cantrill, Prasoon Chaturvedi, Caroline Rynn et al. · Drug Discovery Today 13 Apr 2020 168
All 61 most cited papers, with filters and sorting

Which keywords describe research at C4 Therapeutics (United States)?

By fractional works in 2022-now, weighted toward what it does more of than the world: Cancer Therapy, Tumor Microenvironment, Cancer, Transcriptional Regulation, BET Bromodomains, PROTACs, Cancer Immunotherapy and Immunotherapy.

▲ more of its work than of the world's◆ about the world's share▼ less than the world's

Size is fractional works in 2022-now in the topics tagged with each word; colour is the word's share of this institution's work against its share of the world's. The 40 words are chosen for being large and distinctive. Each links to the topic it comes from most.

All 40 words, with their numbers
  1. Cancer Therapy5▲ 18×11 topics
  2. Cancer5▲ 7.0×15 topics
  3. Tumor Microenvironment5▲ 20×7 topics
  4. Transcriptional Regulation4▲ 49×5 topics
  5. BET Bromodomains4▲ 233×1 topic
  6. PROTACs4▲ 233×1 topic
  7. Inflammation4▲ 3.3×13 topics
  8. Cancer Immunotherapy4▲ 44×2 topics
  9. Immunotherapy4▲ 9.2×6 topics
  10. Proteasome Inhibitors4▲ 96×2 topics
  11. Tumor Regression3▲ 54×2 topics
  12. Immune Checkpoint Blockade3▲ 45×1 topic
  13. PD-1 and PD-L13▲ 45×1 topic
  14. Lymphoma3▲ 31×2 topics
  15. CAR T Cells3▲ 66×1 topic
  16. Chimeric Antigen Receptor3▲ 66×1 topic
  17. Innate Immunity3▲ 15×5 topics
  18. Gene Therapy2▲ 24×4 topics
  19. Proteasome2▲ 124×1 topic
  20. Ubiquitin2▲ 124×1 topic
  21. Immune Response2▲ 6.6×4 topics
  22. Cancer Progression2▲ 18×4 topics
  23. Immunity2▲ 7.5×6 topics
  24. Genomic Analysis1▲ 10.0×3 topics
  25. Minimal Residual Disease1▲ 38×2 topics
  26. Prognostic Factors1▲ 5.8×5 topics
  27. Diagnosis Criteria1▲ 68×1 topic
  28. Drug Discovery1▲ 11×5 topics
  29. Fc Receptors1▲ 45×1 topic
  30. International Myeloma Working Group1▲ 68×1 topic
  31. Therapeutic Antibodies1▲ 35×1 topic
  32. Antigen Presentation1▲ 25×2 topics
  33. Mutation1▲ 12×5 topics
  34. Neurodegeneration1▲ 7.3×6 topics
  35. RNA methylation1▲ 27×1 topic
  36. Targeted Therapy1▲ 10×3 topics
  37. m6A-seq1▲ 27×1 topic
  38. IL-61▲ 97×1 topic
  39. Pattern Recognition Receptors1▲ 16×2 topics
  40. STAT31▲ 97×1 topic

Which research topics does C4 Therapeutics (United States) publish most on?

By volume in 2022-now: Protein Degradation and Inhibitors, Cancer Immunotherapy and Biomarkers, CAR-T cell therapy research and Ubiquitin and proteasome pathways.

Protein Degradation and …4Protein Degradation and Inhibitors: 4 fractional worksCancer Immunotherapy and Biomarkers: 3 fractional worksCAR-T cell therapy resea…3CAR-T cell therapy research: 3 fractional worksUbiquitin and proteasome…2Ubiquitin and proteasome pathways: 2 fractional worksMultiple Myeloma Research and Treatments: 1 fractional worksMonoclonal and Polyclonal Antibodies Research: 1 fractional worksRNA modifications and cancer: 1 fractional worksImmunotherapy and Immune Responses: 1 fractional worksCytokine Signaling Pathways and Interactions: 1 fractional worksTraditional Chinese Medicine Studies: 1 fractional works
Molecular BiologyOncologyHematologyRadiology, Nuclear Medicine and Imaging2 others

Area is fractional works; colour is the subfield each topic belongs to.

  1. 1 Protein Degradation and Inhibitors Molecular Biology 4 works
  2. 2 Cancer Immunotherapy and Biomarkers Oncology 3 works
  3. 3 CAR-T cell therapy research Oncology 3 works
  4. 4 Ubiquitin and proteasome pathways Molecular Biology 2 works
  5. 5 Multiple Myeloma Research and Treatments Hematology 1 works
  6. 6 Monoclonal and Polyclonal Antibodies Research Radiology, Nuclear Medicine and Imaging 1 works
  7. 7 RNA modifications and cancer Molecular Biology 1 works
  8. 8 Immunotherapy and Immune Responses Immunology 1 works
  9. 9 Cytokine Signaling Pathways and Interactions Oncology 1 works
  10. 10 Traditional Chinese Medicine Studies Complementary and alternative medicine 1 works

How open and international is its research?

Against the world's own shares: the tick on each track. Both are shares of its output, so they sit on one scale and can be read against each other as well as against the world.

openly available49.2%not open50.8%

World: 40% of research is openly available.

with international co-authors19.7%domestic only80.3%

World: 18% is written across borders.

How has C4 Therapeutics (United States)'s research output changed?

Output in 2022-2025 was 205% higher than in 2018-2021.

still counting200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is C4 Therapeutics (United States) as a percentage of every work published that year, 0.00019% in 2024.

still counting0.00020%0.00040%C4 Therapeutics (United States)0.00031% in 2025200020102020

Fractional works of C4 Therapeutics (United States) over all fractional works that year. How the balance of science has shifted.

Other research institutions in Watertown

All research institutions in Watertown

Research measures only: rankings here say nothing about teaching, admissions or student experience. Comparable institutions and collaboration partners have tabs of their own, above.

Discussion

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