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Topic · Oncology

Cytokine Signaling Pathways and Interactions

Cytokine Signaling Pathways and Interactions is a research topic within Oncology. Science Explorer counts 36k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the role of STAT3 in cancer inflammation and immunity, with a particular emphasis on its involvement in cytokine signaling, regulation of the JAK/STAT pathway, modulation of the immune response, and its impact on the tumor microenvironment. The cluster also explores the interplay between STAT3, IL-6, and SOCS proteins in transcriptional control, inflammation, and cancer progression.

  • STAT3
  • IL-6
  • JAK/STAT pathway
  • inflammation
  • cancer
  • cytokine signaling
  • immune response
  • SOCS proteins
  • tumor microenvironment
  • transcriptional control
Research works
36k
fractional, since 1950
In the world top 10%
3.7k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+1%
the tick is no change
Largest producer
China
45% of the 10 largest, 2022-now
Cytokine Signaling Pathways and Interactions

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Cytokine Signaling Pathways and Interactions research?

By volume, China and the United States publish the most (1.8k and 982 works in 2022-now).

By volume, 2022-now

  1. 1 China 1.8k works
  2. 2 United States 982 works
  3. 3 India 205 works
  4. 4 Japan 199 works
  5. 5 Germany 185 works
  6. 6 South Korea 138 works
  7. 7 United Kingdom 134 works
  8. 8 Italy 133 works
  9. 9 Egypt 112 works
  10. 10 Russia 106 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 45.1%United States: 24.6%India: 5.1%Japan: 5.0%6 others listed: 20.3%45%largest
China1,802 · 45.1%United States982 · 24.6%India205 · 5.1%Japan199 · 5.0%6 others listed810 · 20.3%

Shares of the rows listed above, not of the whole node.

Which institutions lead Cytokine Signaling Pathways and Interactions research?

By volume in 2022-now, Harvard University publishes the most Cytokine Signaling Pathways and Interactions research, followed by Sun Yat-sen University and Nanjing Medical University.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 40 works
  2. 2 Sun Yat-sen UniversityChina 38 works
  3. 3 Nanjing Medical UniversityChina 37 works
  4. 4 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 35 works
  5. 5 Shanghai Jiao Tong UniversityChina 35 works
  6. 6 Sichuan UniversityChina 35 works
  7. 7 National Institutes of HealthUnited States 30 works
  8. 8 Central South UniversityChina 30 works
  9. 9 Zhejiang UniversityChina 28 works
  10. 10 Fudan UniversityChina 28 works

Who are the leading researchers in Cytokine Signaling Pathways and Interactions?

The most-cited researchers publishing on Cytokine Signaling Pathways and Interactions include Eric S. Lander, George Davey Smith and Mark J. Daly.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 George Davey Smith United Kingdom 435k citations
  3. 3 Mark J. Daly United States 403k citations
  4. 4 Robert John Tibshirani United States 396k citations
  5. 5 Guido Kroemer France 386k citations
  6. 6 Bert Vogelstein United States 373k citations
  7. 7 Gad A. Getz United States 364k citations
  8. 8 John J.V. McMurray United Kingdom 349k citations
  9. 9 Elaine R. Mardis United States 346k citations
  10. 10 Hermann Brenner Germany 343k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Cytokine Signaling Pathways and Interactions?

The most cited paper in Cytokine Signaling Pathways and Interactions is "Inflammation and cancer" (Lisa M. Coussens, Zena Werb, 2002), with 15,251 citations. Next come "Cell Signaling by Receptor Tyrosine Kinases" (8,012) and "Osteoclast differentiation and activation" (6,707).

Most cited papers
#PaperReleasedCitations
1 Inflammation and cancer Lisa M. Coussens, Zena Werb · Nature Open access Dec 2002 15,251
2 Cell Signaling by Receptor Tyrosine Kinases Mark A. Lemmon, Joseph Schlessinger · Cell Open access Jun 2010 8,012
3 Osteoclast differentiation and activation William J. Boyle, W. Scott Simonet, David L. Lacey · Nature May 2003 6,707
4 Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 Lena Alexopoulou, Agnieszka Czopik Holt, Ruslan M. Medzhitov et al. · Nature Oct 2001 6,152
5 Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins James E. Darnell Jr., lan M. Kerr, George Robert Stark · Science 3 Jun 1994 6,151
All 100 most cited papers, with filters and sorting

Where is Cytokine Signaling Pathways and Interactions research done?

The largest centres of Cytokine Signaling Pathways and Interactions research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Nanjing (China). Among places with at least 20 works in it, it is an unusually large share of all research in Wenzhou.

Largest cities, 2022-now

  1. 1 BeijingChina 170 works
  2. 2 ShanghaiChina 146 works
  3. 3 GuangzhouChina 119 works
  4. 4 NanjingChina 79 works
  5. 5 WuhanChina 65 works
  6. 6 New YorkUnited States 65 works
  7. 7 HangzhouChina 64 works
  8. 8 SeoulSouth Korea 64 works
  9. 9 ChengduChina 59 works
  10. 10 ChangshaChina 55 works

Where it is the local speciality

  1. WenzhouCN · 24.3 works5.4×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Cytokine Signaling Pathways and Interactions than the world average.

See Cytokine Signaling Pathways and Interactions on the map

Where is the best place to study Cytokine Signaling Pathways and Interactions?

Among universities, judged by research, Harvard University, Sichuan University and Chinese Academy of Medical Sciences & Peking Union Medical College score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 15.2%fractional works in this field (log) →share of work in the world top 10% →Harvard UniversitySichuan UniversitySun Yat-sen UniversityChinese Academy of M…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 82.718.6%2.8×40 +0.6%
2Sichuan UniversityChina 71.118.1%3.4×34 +30.4%
3Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 70.815.4%7.4×35 +40.2%
4Sun Yat-sen UniversityChina 65.117.0%4.1×38 -14.0%
5Fudan UniversityChina 62.918.6%3.9×28 -3.7%
6Nanjing Medical UniversityChina 61.08.7%9.2×37 +11.9%
7Southern Medical UniversityChina 60.413.7%8.3×23 +16.7%
8Anhui Medical UniversityChina 58.613.0%12.2×26 +11.6%
9Central South UniversityChina 57.113.7%3.4×30 +4.2%
10Chengdu University of Traditional Chinese MedicineChina 57.115.2%10.8×12 +201.6%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Cytokine Signaling Pathways and Interactions, country by country

Is Cytokine Signaling Pathways and Interactions research growing?

Output in 2022-2025 was 1% higher than in 2018-2021, peaking in 2015. The fastest-growing topics are Cytokine Signaling Pathways and Interactions.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Cytokine Signaling Pathways and Interactions as a percentage of every work published that year, 0.023% in 2024.

still counting0.025%0.050%0.075%Cytokine Signaling Pathways and Interactions0.023% in 202519801990200020102020

Fractional works of Cytokine Signaling Pathways and Interactions over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Cytokine Signaling Pathways and Interactions10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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