Most cited papers in Cytokine Signaling Pathways and Interactions
What are the most cited papers in Cytokine Signaling Pathways and Interactions?
The most cited paper in Cytokine Signaling Pathways and Interactions is "Inflammation and cancer" (Lisa M. Coussens, Zena Werb, 2002), with 15,251 citations. Next come "Cell Signaling by Receptor Tyrosine Kinases" (8,012) and "Osteoclast differentiation and activation" (6,707).
Showing 50 of 100 papers. Every paper with more than 1,903 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Inflammation and cancer Lisa M. Coussens, Zena Werb · Nature | Dec 2002 | 15,251 |
| 2 | Cell Signaling by Receptor Tyrosine Kinases Mark A. Lemmon, Joseph Schlessinger · Cell | Jun 2010 | 8,012 |
| 3 | Osteoclast differentiation and activation William J. Boyle, W. Scott Simonet, David L. Lacey · Nature | May 2003 | 6,707 |
| 4 | Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 Lena Alexopoulou, Agnieszka Czopik Holt, Ruslan M. Medzhitov et al. · Nature | Oct 2001 | 6,152 |
| 5 | Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins James E. Darnell Jr., lan M. Kerr, George Robert Stark · Science | 3 Jun 1994 | 6,151 |
| 6 | THE NF-κB AND IκB PROTEINS: New Discoveries and Insights Albert S. Baldwin · Annual Review of Immunology | Apr 1996 | 5,979 |
| 7 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation David L. Lacey et al. · Cell | Apr 1998 | 5,491 |
| 8 | IL-6 in Inflammation, Immunity, and Disease Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto · Cold Spring Harbor Perspectives in Biology | 4 Sep 2014 | 5,134 |
| 9 | The Nuclear Factor NF- B Pathway in Inflammation Toby Lawrence · Cold Spring Harbor Perspectives in Biology | 7 Oct 2009 | 4,962 |
| 10 | Shared Principles in NF-κB Signaling Matthew S. Hayden, Sankar Ghosh · Cell | Feb 2008 | 4,836 |
| 11 | Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases Peter John Barnes, Michael Karin · New England Journal of Medicine | 10 Apr 1997 | 4,699 |
| 12 | Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation C. J. Marshall · Cell | 1995 | 4,623 |
| 13 | STATs in cancer inflammation and immunity: a leading role for STAT3 Hua Yu, Drew M. Pardoll, Richard Jove · Nature reviews. Cancer | 23 Oct 2009 | 4,442 |
| 14 | Interferon-γ: an overview of signals, mechanisms and functions Kate Schroder, Paul J. Hertzog, Timothy Ravasi et al. · Journal of Leukocyte Biology | 2 Oct 2003 | 4,131 |
| 15 | BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis Scott M. Wilhelm et al. · Cancer Research | Oct 2004 | 4,060 |
| 16 | Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions* Gray W. Pearson, Fred L. Robinson, Tara Beers Gibson et al. · Endocrine Reviews | Apr 2001 | 4,053 |
| 17 | NF-κB regulation in the immune system Qiutang Li, Inder M. Verma · Nature reviews. Immunology | Oct 2002 | 4,031 |
| 18 | STATs and Gene Regulation James E. Darnell Jr. · Science | 12 Sep 1997 | 4,030 |
| 19 | HOW CELLS RESPOND TO INTERFERONS George Robert Stark, Ian Macpherson Kerr, Bryan Williams et al. · Annual Review of Biochemistry | Jun 1998 | 3,971 |
| 20 | NF-κB: a key role in inflammatory diseases Paul Peter Tak, Gary S. Firestein · Journal of Clinical Investigation | 2001 | 3,919 |
| 21 | Cell Signaling by Receptor Tyrosine Kinases Joseph Schlessinger · Cell | Oct 2000 | 3,783 |
| 22 | Oncogenic kinase signalling Peter Blume‐Jensen, Tony R. Hunter · Nature | May 2001 | 3,742 |
| 23 | Activators and target genes of Rel/NF-κB transcription factors Heike Luise Pahl · Oncogene | 22 Nov 1999 | 3,715 |
| 24 | The TNF and TNF Receptor Superfamilies Richard M. Locksley, Nigel P. Killeen, Michael J. Lenardo · Cell | Feb 2001 | 3,648 |
| 25 | Missing Pieces in the NF-κB Puzzle Sankar Ghosh, Michael Karin · Cell | Apr 2002 | 3,643 |
| 26 | Mechanisms of type-I- and type-II-interferon-mediated signalling Leonidas C. Platanias · Nature reviews. Immunology | 29 Apr 2005 | 3,534 |
| 27 | Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders E. Joanna Baxter, Linda M. Scott, Peter J. Campbell et al. · The Lancet | Mar 2005 | 3,485 |
| 28 | Regulation of type I interferon responses Lionel B. Ivashkiv, Laura T. Donlin · Nature reviews. Immunology | 23 Dec 2013 | 3,394 |
| 29 | Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 Rashu B. Seth, Lijun Sun, Chee-Kwee Ea et al. · Cell | 26 Aug 2005 | 3,352 |
| 30 | A protein kinase involved in the regulation of inflammatory cytokine biosynthesis John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature | Dec 1994 | 3,317 |
| 31 | Principles of interleukin (IL)-6-type cytokine signalling and its regulation Peter Claus Heinrich, Iris Behrmann, Serge Haan et al. · Biochemical Journal | 15 Aug 2003 | 3,293 |
| 32 | Targeting the IL-6/JAK/STAT3 signalling axis in cancer Daniel E. Johnson, Rachel A. O’Keefe, Jennifer Rubin Grandis · Nature Reviews Clinical Oncology | 6 Feb 2018 | 3,257 |
| 33 | The pro- and anti-inflammatory properties of the cytokine interleukin-6 Jürgen Scheller, Athena Chalaris, Dirk Schmidt‐Arras et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 5 Feb 2011 | 3,248 |
| 34 | The complexity of NF-κB signaling in inflammation and cancer Bastian Hoesel, Johannes A. Schmid · Molecular Cancer | 2013 | 3,232 |
| 35 | STATs: transcriptional control and biological impact David E. Levy, James E. Darnell Jr. · Nature Reviews Molecular Cell Biology | Sep 2002 | 3,228 |
| 36 | Defining the clinical course of multiple sclerosis FRED D. LUBLIN et al. · Neurology | 28 May 2014 | 3,202 |
| 37 | Interferon-Stimulated Genes: A Complex Web of Host Defenses William M. Schneider, Meike Dittmann, Charles M. Rice · Annual Review of Immunology | 20 Feb 2014 | 3,196 |
| 38 | Activators and Target Genes of Rel/NF-кB Transcription Factors Torsten Loop, Heike Luise Pahl | 2003 | 3,183 |
| 39 | NF-κB: linking inflammation and immunity to cancer development and progression Michael Karin, Florian R. Greten · Nature reviews. Immunology | 20 Sep 2005 | 3,088 |
| 40 | Genomic responses in mouse models poorly mimic human inflammatory diseases Junhee Seok et al. · Proceedings of the National Academy of Sciences | 11 Feb 2013 | 3,062 |
| 41 | NF-κB: Ten Years After Patrick A. Baeuerle, David Baltimore · Cell | Oct 1996 | 3,019 |
| 42 | MAPK signal pathways in the regulation of cell proliferation in mammalian cells Wei Zhang, Hui-Tu Liu · Cell Research | Mar 2002 | 2,941 |
| 43 | Inflammation and tumor progression: signaling pathways and targeted intervention Huakan Zhao, Lei Wu, Guifang Yan et al. · Signal Transduction and Targeted Therapy | 11 Jul 2021 | 2,854 |
| 44 | Stat3 as an Oncogene Jacqueline Bromberg, Melissa H Wrzeszczynska, Geeta Devgan et al. · Cell | Aug 1999 | 2,805 |
| 45 | Interleukin-6 and the acute phase response Peter Claus Heinrich, José Vicente Castell, Tilo Andus · Biochemical Journal | Feb 1990 | 2,777 |
| 46 | Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis Stephen J. Sawcer et al. · Nature | Aug 2011 | 2,772 |
| 47 | NF-κB, inflammation, immunity and cancer: coming of age Koji Taniguchi, Michael Karin · Nature reviews. Immunology | 22 Jan 2018 | 2,765 |
| 48 | Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. David Franklin Fiorentino, M W Bond, Timothy R. Mosmann · The Journal of Experimental Medicine | Dec 1989 | 2,759 |
| 49 | The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen Andrew K. Shiau, Danielle Barstad, Paula M. Loria et al. · Cell | Dec 1998 | 2,750 |
| 50 | The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling Luke A.J. O'Neill, Andrew G. Bowie · Nature reviews. Immunology | 25 Apr 2007 | 2,679 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.