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Topic · Oncology

Cancer Cells and Metastasis

Cancer Cells and Metastasis is a research topic within Oncology. Science Explorer counts 47k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the role of cancer stem cells, epithelial-mesenchymal transition, and the tumor microenvironment in tumor metastasis, drug resistance, and cell plasticity. It explores the identification, regulation, and behavior of cancer stem cells, as well as their interactions with the microenvironment and implications for metastatic colonization. Additionally, it delves into the use of organoid models to study cancer stem cells and tumor progression.

  • Cancer Stem Cells
  • Tumor Metastasis
  • Epithelial-Mesenchymal Transition
  • Stem Cell Niches
  • Tumorigenic Cells
  • Metastatic Colonization
  • Microenvironment Regulation
  • Drug Resistance
  • Cell Plasticity
  • Organoid Models
Research works
47k
fractional, since 1950
In the world top 10%
4.8k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-1%
the tick is no change
Largest producer
China
35% of the 10 largest, 2022-now
Cancer Cells and Metastasis

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Cancer Cells and Metastasis research?

By volume, China and the United States publish the most (3k and 2.5k works in 2022-now).

By volume, 2022-now

  1. 1 China 3k works
  2. 2 United States 2.5k works
  3. 3 Japan 517 works
  4. 4 India 492 works
  5. 5 Germany 467 works
  6. 6 South Korea 343 works
  7. 7 Italy 335 works
  8. 8 United Kingdom 329 works
  9. 9 France 265 works
  10. 10 Spain 216 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 35.2%United States: 29.4%Japan: 6.2%India: 5.9%6 others listed: 23.3%35%largest
China2,957 · 35.2%United States2,470 · 29.4%Japan517 · 6.2%India492 · 5.9%6 others listed1,954 · 23.3%

Shares of the rows listed above, not of the whole node.

Which institutions lead Cancer Cells and Metastasis research?

By volume in 2022-now, Sun Yat-sen University publishes the most Cancer Cells and Metastasis research, followed by Harvard University and Shanghai Jiao Tong University.

By volume, 2022-now

  1. 1 Sun Yat-sen UniversityChina 103 works
  2. 2 Harvard UniversityUnited States 102 works
  3. 3 Shanghai Jiao Tong UniversityChina 89 works
  4. 4 The University of Texas MD Anderson Cancer CenterUnited States 77 works
  5. 5 Sichuan UniversityChina 68 works
  6. 6 Centre National de la Recherche ScientifiqueFrance 65 works
  7. 7 Russian Academy of SciencesRussia 62 works
  8. 8 Peking UniversityChina 62 works
  9. 9 Zhejiang UniversityChina 62 works
  10. 10 Fudan UniversityChina 61 works

Who are the leading researchers in Cancer Cells and Metastasis?

The most-cited researchers publishing on Cancer Cells and Metastasis include Eric S. Lander, Rob Knight and Stacey L. Gabriel.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Rob Knight United States 468k citations
  3. 3 Stacey L. Gabriel United States 402k citations
  4. 4 Robert John Tibshirani United States 396k citations
  5. 5 Guido Kroemer France 386k citations
  6. 6 Bert Vogelstein United States 373k citations
  7. 7 Gad A. Getz United States 364k citations
  8. 8 Elaine R. Mardis United States 346k citations
  9. 9 Hermann Brenner Germany 343k citations
  10. 10 Jun Wang China 340k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Cancer Cells and Metastasis?

The most cited paper in Cancer Cells and Metastasis is "Hallmarks of Cancer: The Next Generation" (Douglas Hanahan, Robert A. Weinberg, 2011), with 67,836 citations. Next come "The Hallmarks of Cancer" (28,893) and "Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement" (18,014).

Most cited papers
#PaperReleasedCitations
1 Hallmarks of Cancer: The Next Generation Douglas Hanahan, Robert A. Weinberg · Cell Open access Mar 2011 67,836
2 The Hallmarks of Cancer Douglas Hanahan, Robert A. Weinberg · Cell Open access 2000 28,893
3 Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement Massimo Dominici, Katarina Le Blanc, Ingo Mueller et al. · Cytotherapy 2006 18,014
4 Inferring tumour purity and stromal and immune cell admixture from expression data Kosuke Yoshihara, Maria Shahmoradgoli, Emmanuel Martínez et al. · Nature Communications Open access 11 Oct 2013 10,966
5 Prospective identification of tumorigenic breast cancer cells Muhammad Al‐Hajj, Max S. Wicha, Adalberto Benito‐Hernández et al. · Proceedings of the National Academy of Sciences Open access 10 Mar 2003 10,455
All 100 most cited papers, with filters and sorting

Where is Cancer Cells and Metastasis research done?

The largest centres of Cancer Cells and Metastasis research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Seoul (South Korea).

Largest cities, 2022-now

  1. 1 BeijingChina 329 works
  2. 2 ShanghaiChina 295 works
  3. 3 GuangzhouChina 223 works
  4. 4 SeoulSouth Korea 178 works
  5. 5 TokyoJapan 145 works
  6. 6 NanjingChina 131 works
  7. 7 HoustonUnited States 131 works
  8. 8 HangzhouChina 129 works
  9. 9 New YorkUnited States 125 works
  10. 10 LondonUnited Kingdom 114 works
See Cancer Cells and Metastasis on the map

Where is the best place to study Cancer Cells and Metastasis?

Among universities, judged by research, Harvard University, Sun Yat-sen University and Sichuan University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 17.58%fractional works in this field (log) →share of work in the world top 10% →Sichuan UniversityHarvard UniversitySun Yat-sen UniversityUniversity of Hong K…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 68.316.7%3.4×102 -19.5%
2Sun Yat-sen UniversityChina 67.016.0%5.3×103 +14.4%
3Sichuan UniversityChina 64.619.4%3.2×68 +29.0%
4University of Hong KongChina 60.515.9%2.9×26 +70.8%
5ETH ZurichSwitzerland 60.426.6%1.8×12 +50.5%
6Oncode InstituteNetherlands 59.822.0%46.7×12 -11.0%
7Shanghai Jiao Tong UniversityChina 59.014.6%3.3×89 +9.1%
8Nanjing Medical UniversityChina 58.015.8%7.1×60 +13.1%
9Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 57.212.9%5.8×57 +38.2%
10Zhejiang UniversityChina 57.115.9%2.4×62 +11.4%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Cancer Cells and Metastasis, country by country

Is Cancer Cells and Metastasis research growing?

Output in 2022-2025 was 1% lower than in 2018-2021, peaking in 2022.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Cancer Cells and Metastasis as a percentage of every work published that year, 0.041% in 2024.

still counting0.025%0.050%0.075%Cancer Cells and Metastasis0.042% in 202519801990200020102020

Fractional works of Cancer Cells and Metastasis over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Cancer Cells and Metastasis10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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