Bone health and treatments

Bone health and treatments is a research topic within Oncology. Science Explorer counts 43k research works in it since 1950. 10.0% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the use of bisphosphonates in the treatment of bone metastases and associated complications, particularly osteonecrosis of the jaw. It explores the mechanisms of action, clinical features, and therapeutic opportunities for bisphosphonates in cancer treatment, with a specific emphasis on prostate and breast cancer. The papers also discuss the role of bisphosphonates in maintaining bone health and preventing skeletal complications in cancer patients.

Bisphosphonates
Osteonecrosis of the Jaw
Bone Metastasis
Cancer Treatment
Skeletal Complications
Mechanism of Action
Metastatic Bone Disease
Clinical Practice Guidelines
Prostate Cancer
Breast Cancer

Research works: 43k
In the world top 10%: 4.3k
Top-10% rate: 10.0%
Growth, 2018-21 → 2022-25: -7%
Largest producer: United States

Bone health and treatments

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Bone health and treatments research?

By volume, the United States and China publish the most (1.1k and 938 works in 2022-now).

By volume, 2022-now

1 United States 1.1k works
2 China 938 works
3 Japan 418 works
4 India 302 works
5 Italy 238 works
6 United Kingdom 217 works
7 Germany 205 works
8 Brazil 183 works
9 South Korea 177 works
10 Türkiye 164 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States1,068 · 27.3%China938 · 24.0%Japan418 · 10.7%India302 · 7.7%6 others listed1,185 · 30.3%

Shares of the rows listed above, not of the whole node.

Which institutions lead Bone health and treatments research?

By volume in 2022-now, Harvard University publishes the most Bone health and treatments research, followed by Shanghai Jiao Tong University and Sichuan University.

By volume, 2022-now

1 Harvard UniversityUnited States 46 works
2 Shanghai Jiao Tong UniversityChina 29 works
3 Sichuan UniversityChina 29 works
4 Peking UniversityChina 27 works
5 All India Institute of Medical SciencesIndia 27 works
6 Seoul National UniversitySouth Korea 22 works
7 InsermFrance 21 works
8 Zhejiang UniversityChina 21 works
9 Mayo ClinicUnited States 20 works
10 Yonsei UniversitySouth Korea 19 works

Who are the leading researchers in Bone health and treatments?

The most-cited researchers publishing on Bone health and treatments include Freddie Bray, George Davey Smith and Walter Churchill Willett.

1 Freddie Bray France 550k citations
2 George Davey Smith United Kingdom 435k citations
3 Walter Churchill Willett United States 411k citations
4 Hermann Brenner Germany 343k citations
5 Shizuo Akira Japan 342k citations
6 Cyrus Cooper United Kingdom 342k citations
7 Jun Wang China 340k citations
8 Giuseppe Remuzzi Italy 328k citations
9 John P. A. Ioannidis United States 317k citations
10 Graeme J. Hankey Australia 316k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Bone health and treatments?

The most cited paper in Bone health and treatments is "Osteoclast differentiation and activation" (William J. Boyle, W. Scott Simonet, David L. Lacey, 2003), with 6,707 citations. Next come "Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation" (5,491) and "Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy" (4,645).

Most cited papers
#	Paper	Released	Citations
1	Osteoclast differentiation and activation William J. Boyle, W. Scott Simonet, David L. Lacey · Nature	May 2003	6,707
2	Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation David L. Lacey et al. · Cell Open access	Apr 1998	5,491
3	Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy Howard I. Scher, Karim S. Fizazi, Fred Saad et al. · New England Journal of Medicine Open access	15 Aug 2012	4,645
4	Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women with Osteoporosis Robert M. Neer, Claude D. Arnaud, José Zanchetta et al. · New England Journal of Medicine	10 May 2001	4,604
5	Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL Hisataka Yasuda, Nobuyuki Shima, Nobuaki NAKAGAWA et al. · Proceedings of the National Academy of Sciences Open access	31 Mar 1998	4,281

All 100 most cited papers, with filters and sorting

Where is Bone health and treatments research done?

The largest centres of Bone health and treatments research in 2022-now are Beijing (China), Tokyo (Japan), Seoul (South Korea) and Shanghai (China).

Largest cities, 2022-now

1 BeijingChina 112 works
2 TokyoJapan 100 works
3 SeoulSouth Korea 86 works
4 ShanghaiChina 83 works
5 MoscowRussia 62 works
6 GuangzhouChina 57 works
7 São PauloBrazil 55 works
8 New YorkUnited States 55 works
9 LondonUnited Kingdom 55 works
10 ParisFrance 53 works

See Bone health and treatments on the map

Where is the best place to study Bone health and treatments?

Among universities, judged by research, Harvard University, Zhejiang University and Soochow University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged

40%

Specialisationhow much of its work is in this field, counted up to 10× the world share

10%

Sizeits output in this field, on a log scale

30%

Growthoutput growth, counted from -20% to +20%

10%

Internationalshare of its work with a co-author abroad

10%

Each slider sets a weight; the share it gets of the score is beside it.

#	University	Score	Top 10%	Specialisation	Works	Growth
1	Harvard UniversityUnited States	69.7	15.8%	2.9×	46	-9.7%
2	Zhejiang UniversityChina	63.1	25.2%	1.6×	21	+14.0%
3	Soochow UniversityChina	58.7	22.1%	3.4×	16	+18.9%
4	Sichuan UniversityChina	58.4	23.7%	2.6×	29	-14.2%
5	Central South UniversityChina	53.9	31.6%	1.6×	15	-3.1%
6	Shanghai Jiao Tong UniversityChina	53.4	19.4%	2.0×	29	-28.7%
7	Xi'an Jiaotong UniversityChina	52.6	32.0%	1.1×	10	+55.0%
8	Peking UniversityChina	51.6	13.5%	2.7×	27	+3.5%
9	University of Arkansas for Medical SciencesUnited States	51.5	15.9%	11.2×	8	+10.0%
10	University of SheffieldUnited Kingdom	49.7	21.5%	4.8×	12	-57.1%
11	Nanjing Medical UniversityChina	49.3	14.0%	4.3×	19	+21.3%
12	Wuhan UniversityChina	49.0	34.7%	1.3×	9	-7.0%
13	Aarhus UniversityDenmark	47.0	19.6%	2.8×	12	-45.3%
14	University of Hong KongChina	46.5	16.5%	2.2×	10	+87.9%
15	Seoul National UniversitySouth Korea	46.4	7.2%	3.9×	22	+6.5%
16	Southern Medical UniversityChina	46.1	26.5%	4.0×	12	-19.1%
17	Indiana UniversityUnited States	45.9	17.5%	3.3×	16	-61.5%
18	Yonsei UniversitySouth Korea	45.5	10.1%	4.3×	19	+10.9%
19	Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina	44.9	17.5%	3.4×	18	-11.0%
20	University of PennsylvaniaUnited States	44.6	9.8%	3.2×	17	-2.5%
21	Washington University in St. LouisUnited States	44.1	17.7%	2.9×	10	-11.5%
22	Wenzhou Medical UniversityChina	43.5	16.3%	4.6×	11	+4.9%
23	Huazhong University of Science and TechnologyChina	43.4	19.8%	1.5×	13	+8.7%
24	University of VeronaItaly	42.9	19.4%	7.5×	8	-10.2%
25	University of CopenhagenDenmark	42.8	10.3%	2.7×	12	+10.1%
26	Columbia UniversityUnited States	42.4	16.2%	1.9×	11	-51.4%
27	Fudan UniversityChina	42.2	22.0%	1.6×	13	+2.3%
28	The University of SydneyAustralia	41.8	19.1%	2.1×	13	-2.4%
29	All India Institute of Medical SciencesIndia	41.3	2.0%	4.9×	27	+79.5%
30	Vanderbilt UniversityUnited States	40.8	11.5%	3.6×	13	-8.6%
31	Tianjin Medical UniversityChina	40.7	16.1%	6.0×	11	+5.5%
32	University of California, Los AngelesUnited States	40.3	9.9%	2.7×	16	-7.5%
33	University of California, San FranciscoUnited States	40.1	16.8%	2.7×	9	-40.7%
34	University College LondonUnited Kingdom	39.4	12.2%	1.4×	11	+3.0%
35	Cornell UniversityUnited States	39.0	24.0%	1.4×	9	-18.9%
36	University of TorontoCanada	38.6	7.4%	1.8×	18	-18.0%
37	McGill UniversityCanada	38.6	14.3%	2.3×	12	-44.9%
38	Karolinska InstitutetSweden	38.1	17.7%	3.3×	9	-24.3%
39	Baylor College of MedicineUnited States	37.4	19.2%	3.2×	8	-14.1%
40	University of MichiganUnited States	37.3	12.0%	1.7×	13	-35.2%
41	Sun Yat-sen UniversityChina	37.2	12.3%	1.9×	19	-25.6%
42	Qingdao UniversityChina	37.2	14.1%	2.7×	9	+58.0%
43	Nagasaki UniversityJapan	37.0	16.3%	15.6×	10	-31.9%
44	Fujian Medical UniversityChina	35.4	6.5%	4.7×	13	+69.8%
45	Catholic University of KoreaSouth Korea	35.0	20.1%	5.9×	10	-20.8%
46	Università Cattolica del Sacro CuoreItaly	34.2	9.0%	4.0×	9	+77.9%
47	New York Medical CollegeUnited States	34.2	10.0%	7.5×	8	+84.7%
48	Erasmus University RotterdamNetherlands	33.9	7.6%	3.2×	8	+0.2%
49	Chonnam National UniversitySouth Korea	33.5	9.4%	6.3×	9	+13.9%
50	Guangxi Medical UniversityChina	33.4	10.6%	8.0×	10	-10.1%
51	Semmelweis UniversityHungary	31.8	6.2%	9.1×	8	+15.2%
52	Istanbul UniversityTürkiye	29.0	7.7%	4.8×	9	+28.6%
53	Heidelberg UniversityGermany	28.9	8.4%	2.8×	11	-29.5%
54	Sorbonne UniversitéFrance	27.3	4.5%	2.6×	9	+16.8%
55	King's College LondonUnited Kingdom	26.6	13.2%	1.9×	8	-23.5%
56	Post Graduate Institute of Medical Education and ResearchIndia	22.8	3.6%	7.3×	12	-10.2%
57	Mohammed V UniversityMorocco	19.8	0.1%	4.3×	8	+85.5%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Bone health and treatments, country by country

Is Bone health and treatments research growing?

Output in 2022-2025 was 7% lower than in 2018-2021, peaking in 2013.

grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Bone health and treatments as a percentage of every work published that year, 0.024% in 2024.

Fractional works of Bone health and treatments over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Discussion

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Which countries lead Bone health and treatments research?

By volume, 2022-now

How concentrated that is

Which institutions lead Bone health and treatments research?

By volume, 2022-now

Who are the leading researchers in Bone health and treatments?

What are the most cited papers in Bone health and treatments?

Where is Bone health and treatments research done?

Largest cities, 2022-now

Where is the best place to study Bone health and treatments?

Is Bone health and treatments research growing?

Its share of all research

How much of it reaches the world top 10%

Which topics inside it are moving

Related research

Discussion