Science Explorer Back to mapMap
Discussion
Topic · Neurology

Amyotrophic Lateral Sclerosis Research

Amyotrophic Lateral Sclerosis Research is a research topic within Neurology. Science Explorer counts 21k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the molecular mechanisms, genetics, and pathology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). It covers topics such as TDP-43, FUS/TLS, C9ORF72 mutations, neurodegeneration of motor neurons, RNA processing, progranulin deficiency, ubiquitin-positive inclusions, and the genetic underpinnings of these diseases.

  • TDP-43
  • FUS/TLS
  • C9ORF72
  • mutations
  • neurodegeneration
  • motor neurons
  • RNA processing
  • progranulin
  • ubiquitin-positive inclusions
  • genetics
Research works
21k
fractional, since 1950
In the world top 10%
2k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+18%
the tick is no change
Largest producer
United States
33% of the 10 largest, 2022-now
Amyotrophic Lateral Sclerosis Research

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Amyotrophic Lateral Sclerosis Research research?

By volume, the United States and China publish the most (1.4k and 699 works in 2022-now).

By volume, 2022-now

  1. 1 United States 1.4k works
  2. 2 China 699 works
  3. 3 Italy 433 works
  4. 4 United Kingdom 416 works
  5. 5 Japan 289 works
  6. 6 Germany 288 works
  7. 7 Canada 207 works
  8. 8 India 190 works
  9. 9 Australia 190 works
  10. 10 France 186 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 33.3%China: 16.1%Italy: 10.0%United Kingdom: 9.6%6 others listed: 31.1%33%largest
United States1,445 · 33.3%China699 · 16.1%Italy433 · 10.0%United Kingdom416 · 9.6%6 others listed1,350 · 31.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Amyotrophic Lateral Sclerosis Research research?

By volume in 2022-now, Harvard University publishes the most Amyotrophic Lateral Sclerosis Research research, followed by University College London and Mayo Clinic.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 73 works
  2. 2 University College LondonUnited Kingdom 58 works
  3. 3 Mayo ClinicUnited States 43 works
  4. 4 Johns Hopkins UniversityUnited States 41 works
  5. 5 Centre National de la Recherche ScientifiqueFrance 36 works
  6. 6 Sichuan UniversityChina 34 works
  7. 7 InsermFrance 34 works
  8. 8 McGill UniversityCanada 32 works
  9. 9 Helmholtz Association of German Research CentresGermany 32 works
  10. 10 The University of SydneyAustralia 32 works

Who are the leading researchers in Amyotrophic Lateral Sclerosis Research?

The most-cited researchers publishing on Amyotrophic Lateral Sclerosis Research include George Davey Smith, Mark J. Daly and Shizuo Akira.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 Shizuo Akira Japan 342k citations
  4. 4 Valery L. Feigin New Zealand 341k citations
  5. 5 Jun Wang China 340k citations
  6. 6 Mika Kivimäki United Kingdom 318k citations
  7. 7 Gregory Y.H. Lip United Kingdom 311k citations
  8. 8 Matthias Mann Germany 308k citations
  9. 9 Gonçalo R. Abecasis United States 300k citations
  10. 10 John Q. Trojanowski United States 286k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Amyotrophic Lateral Sclerosis Research?

The most cited paper in Amyotrophic Lateral Sclerosis Research is "Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis" (Daniel R. Rosen et al., 1993), with 7,116 citations. Next come "Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis" (6,756) and "El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis" (5,487).

Most cited papers
#PaperReleasedCitations
1 Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Daniel R. Rosen et al. · Nature Mar 1993 7,116
2 Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Manuela Neumann, Deepak M. Sampathu, Linda K. Kwong et al. · Science 5 Oct 2006 6,756
3 El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis Benjamin Rix Brooks, Robert G. Miller, Michael Swash et al. · Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 2000 5,487
4 Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia Katya Rascovsky et al. · Brain Open access 2 Aug 2011 5,386
5 Global prevalence of dementia: a Delphi consensus study Cleusa P. Ferri, Martin James Prince, Carol Brayne et al. · The Lancet Open access Dec 2005 5,347
All 100 most cited papers, with filters and sorting

Where is Amyotrophic Lateral Sclerosis Research research done?

The largest centres of Amyotrophic Lateral Sclerosis Research research in 2022-now are London (United Kingdom), Beijing (China), Paris (France) and Tokyo (Japan). Among places with at least 20 works in it, it is an unusually large share of all research in Ulm, Sheffield and Jacksonville.

Largest cities, 2022-now

  1. 1 LondonUnited Kingdom 157 works
  2. 2 BeijingChina 131 works
  3. 3 ParisFrance 88 works
  4. 4 TokyoJapan 86 works
  5. 5 MilanItaly 76 works
  6. 6 RomeItaly 76 works
  7. 7 New YorkUnited States 72 works
  8. 8 PhiladelphiaUnited States 61 works
  9. 9 SydneyAustralia 59 works
  10. 10 BostonUnited States 58 works

Where it is the local speciality

  1. UlmDE · 21.6 works14×
  2. SheffieldGB · 37.8 works9.5×
  3. JacksonvilleUS · 21.0 works7.7×
  4. BonnDE · 30.7 works7.2×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Amyotrophic Lateral Sclerosis Research than the world average.

See Amyotrophic Lateral Sclerosis Research on the map

Where is the best place to study Amyotrophic Lateral Sclerosis Research?

Among universities, judged by research, University College London, Johns Hopkins University and Harvard University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 16.15%fractional works in this field (log) →share of work in the world top 10% →KU LeuvenUniversity College L…Johns Hopkins Univer…Harvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1University College LondonUnited Kingdom 84.517.8%7.3×58 +11.9%
2Johns Hopkins UniversityUnited States 79.817.2%5.2×41 +25.1%
3Harvard UniversityUnited States 78.315.0%4.6×73 +5.7%
4KU LeuvenBelgium 69.521.8%4.4×21 -13.6%
5McGill UniversityCanada 66.710.6%6.4×32 +34.6%
6Karolinska InstitutetSweden 66.618.0%8.2×23 -0.2%
7University of SheffieldUnited Kingdom 66.19.0%11.7×31 +34.0%
8University of PennsylvaniaUnited States 64.313.1%5.7×30 +9.1%
9University of MichiganUnited States 63.519.1%2.7×21 +20.5%
10University of Massachusetts Chan Medical SchoolUnited States 61.319.9%14.8×12 +0.6%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Amyotrophic Lateral Sclerosis Research, country by country

Is Amyotrophic Lateral Sclerosis Research research growing?

Output in 2022-2025 was 18% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Amyotrophic Lateral Sclerosis Research.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Amyotrophic Lateral Sclerosis Research as a percentage of every work published that year, 0.020% in 2024.

still counting0.010%0.020%0.030%Amyotrophic Lateral Sclerosis Research0.025% in 202519801990200020102020

Fractional works of Amyotrophic Lateral Sclerosis Research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Amyotrophic Lateral Sclerosis Research9.8% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Questions people ask

Who is researching a cure for ALS?

By volume in 2022-now, Harvard University publishes the most Amyotrophic Lateral Sclerosis Research research, followed by University College London and Mayo Clinic. By volume, the United States and China publish the most (1.4k and 699 works in 2022-now).

How much research is there on ALS, and is it growing?

Output in 2022-2025 was 18% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Amyotrophic Lateral Sclerosis Research.

Is Amyotrophic Lateral Sclerosis Research research growing?

Which centres lead ALS research?

By volume in 2022-now, Harvard University publishes the most Amyotrophic Lateral Sclerosis Research research, followed by University College London and Mayo Clinic.

Which institutions lead Amyotrophic Lateral Sclerosis Research research?
All 1,273 questions in the Question Catalogue

Discussion

Ask a question or share a note about Amyotrophic Lateral Sclerosis Research. Posts are plain text and can be reported.