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Topic · Neurology

Cerebrovascular and genetic disorders

Cerebrovascular and genetic disorders is a research topic within Neurology. Science Explorer counts 7.7k research works in it since 1950. 10.2% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), a hereditary small vessel disease. It explores the genetics, clinical manifestations, diagnostic strategies, pathogenesis, and management aspects of CADASIL, with a particular emphasis on Notch3 receptor mutations, cerebrovascular dysfunction, white matter lesions, and cognitive impairment.

  • CADASIL
  • Notch3 receptor
  • small vessel disease
  • HtrA1 mutations
  • cerebrovascular dysfunction
  • white matter lesions
  • genetic model
  • MRI hyperintensities
  • cognitive impairment
  • microbleeds
Research works
7.7k
fractional, since 1950
In the world top 10%
784
per year above
Top-10% rate
10.2%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+28%
the tick is no change
Largest producer
United States
31% of the 10 largest, 2022-now
Cerebrovascular and genetic disorders

This ranks research output and citation impact. It says nothing about the quality of diagnosis, treatment or care.

Which countries lead Cerebrovascular and genetic disorders research?

By volume, the United States and China publish the most (376 and 301 works in 2022-now).

By volume, 2022-now

  1. 1 United States 376 works
  2. 2 China 301 works
  3. 3 France 94 works
  4. 4 Japan 89 works
  5. 5 United Kingdom 77 works
  6. 6 India 65 works
  7. 7 Germany 65 works
  8. 8 Italy 63 works
  9. 9 South Korea 50 works
  10. 10 Canada 37 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 30.9%China: 24.7%France: 7.7%Japan: 7.3%6 others listed: 29.4%31%largest
United States376 · 30.9%China301 · 24.7%France94 · 7.7%Japan89 · 7.3%6 others listed357 · 29.4%

Shares of the rows listed above, not of the whole node.

Which institutions lead Cerebrovascular and genetic disorders research?

By volume in 2022-now, Inserm publishes the most Cerebrovascular and genetic disorders research, followed by Harvard University and Capital Medical University.

By volume, 2022-now

  1. 1 InsermFrance 19 works
  2. 2 Harvard UniversityUnited States 19 works
  3. 3 Capital Medical UniversityChina 14 works
  4. 4 Mayo ClinicUnited States 14 works
  5. 5 University College LondonUnited Kingdom 11 works
  6. 6 Université Paris CitéFrance 11 works
  7. 7 Zhengzhou UniversityChina 10 works
  8. 8 Sun Yat-sen UniversityChina 9 works
  9. 9 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 9 works
  10. 10 Tsinghua UniversityChina 9 works

Who are the leading researchers in Cerebrovascular and genetic disorders?

The most-cited researchers publishing on Cerebrovascular and genetic disorders include George Davey Smith, Mark J. Daly and Emelia J. Benjamin.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 Emelia J. Benjamin United States 341k citations
  4. 4 Valery L. Feigin New Zealand 341k citations
  5. 5 Graeme J. Hankey Australia 316k citations
  6. 6 Gregory Y.H. Lip United Kingdom 311k citations
  7. 7 John Q. Trojanowski United States 286k citations
  8. 8 Luigi Ferrucci United States 281k citations
  9. 9 Josef Coresh United States 272k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Cerebrovascular and genetic disorders?

The most cited paper in Cerebrovascular and genetic disorders is "Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration" (Joanna Marguerite Wardlaw et al., 2013), with 5,550 citations. Next come "Vascular dementia" (4,937) and "Mild cognitive impairment" (3,903).

Most cited papers
#PaperReleasedCitations
1 Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration Joanna Marguerite Wardlaw et al. · The Lancet Neurology Open access 15 Jul 2013 5,550
2 Vascular dementia Gustavo C. Román et al. · Neurology Feb 1993 4,937
3 Mild cognitive impairment Serge G. Gauthier, ‌Barry Reisberg, Michael Zaudig et al. · The Lancet Apr 2006 3,903
4 Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges Leonardo Pantoni · The Lancet Neurology 17 Jun 2010 3,452
5 Paraneoplastic anti– N ‐methyl‐ D ‐aspartate receptor encephalitis associated with ovarian teratoma Josep O. Dalmau, Erdem Tüzün, Haiyan Wu et al. · Annals of Neurology Open access 2007 2,506
All 100 most cited papers, with filters and sorting

Where is Cerebrovascular and genetic disorders research done?

The largest centres of Cerebrovascular and genetic disorders research in 2022-now are Beijing (China), Paris (France), London (United Kingdom) and Seoul (South Korea). Among places with at least 20 works in it, it is an unusually large share of all research in Paris.

Largest cities, 2022-now

  1. 1 BeijingChina 61 works
  2. 2 ParisFrance 44 works
  3. 3 LondonUnited Kingdom 30 works
  4. 4 SeoulSouth Korea 24 works
  5. 5 TokyoJapan 24 works
  6. 6 BostonUnited States 20 works
  7. 7 ShanghaiChina 18 works
  8. 8 New YorkUnited States 18 works
  9. 9 GuangzhouChina 17 works
  10. 10 TaipeiTaiwan 16 works

Where it is the local speciality

  1. ParisFR · 44.4 works3.2×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Cerebrovascular and genetic disorders than the world average.

See Cerebrovascular and genetic disorders on the map

Where is the best place to study Cerebrovascular and genetic disorders?

Among universities, judged by research, Harvard University, University College London and Capital Medical University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 13.6125%fractional works in this field (log) →share of work in the world top 10% →Sun Yat-sen UniversityUniversity College L…Capital Medical Univ…Harvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 72.014.3%4.2×19 -8.4%
2University College LondonUnited Kingdom 61.817.1%4.8×11 +25.6%
3Capital Medical UniversityChina 57.816.0%9.4×14 +50.1%
4Sun Yat-sen UniversityChina 52.625.4%2.9×9 +50.8%
5Université Paris CitéFrance 42.810.1%9.9×11 +22.1%
6Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 27.19.8%5.7×9 +148.4%
7Zhengzhou UniversityChina 19.88.8%5.6×10 +108.7%
8Tsinghua UniversityChina 16.07.4%2.6×9 +88.6%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Cerebrovascular and genetic disorders, country by country

Is Cerebrovascular and genetic disorders research growing?

Output in 2022-2025 was 28% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Cerebrovascular and genetic disorders.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Cerebrovascular and genetic disorders as a percentage of every work published that year, 0.0070% in 2024.

still counting0.0050%0.010%0.015%Cerebrovascular and genetic disorders0.0079% in 202519801990200020102020

Fractional works of Cerebrovascular and genetic disorders over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Cerebrovascular and genetic disorders10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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