Science Explorer Back to mapMap
Discussion
Topic · Genetics

Virus-based gene therapy research

Virus-based gene therapy research is a research topic within Genetics. Science Explorer counts 72k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers covers a wide range of topics related to gene therapy, including the use of viral vectors such as AAV and adenovirus, advancements in oncolytic virus therapy, hematopoietic stem cell gene therapy, immunodeficiency treatments, lentiviral vector applications, transgene expression, and genomic integration. The research reflects the ongoing progress and challenges in the field of gene therapy.

  • Gene Therapy
  • Viral Vectors
  • AAV
  • Oncolytic Virus
  • Hematopoietic Stem Cell
  • Immunodeficiency
  • Lentiviral Vector
  • Adenovirus
  • Transgene Expression
  • Genomic Integration
Research works
72k
fractional, since 1950
In the world top 10%
7.1k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+14%
the tick is no change
Largest producer
United States
36% of the 10 largest, 2022-now
Virus-based gene therapy research

Which countries lead Virus-based gene therapy research research?

By volume, the United States and China publish the most (2.7k and 2.2k works in 2022-now).

By volume, 2022-now

  1. 1 United States 2.7k works
  2. 2 China 2.2k works
  3. 3 Germany 425 works
  4. 4 Japan 390 works
  5. 5 India 365 works
  6. 6 United Kingdom 340 works
  7. 7 Italy 260 works
  8. 8 France 234 works
  9. 9 South Korea 230 works
  10. 10 Canada 215 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 36.3%China: 30.0%Germany: 5.8%Japan: 5.3%6 others listed: 22.5%36%largest
United States2,653 · 36.3%China2,191 · 30.0%Germany425 · 5.8%Japan390 · 5.3%6 others listed1,644 · 22.5%

Shares of the rows listed above, not of the whole node.

Which institutions lead Virus-based gene therapy research research?

By volume in 2022-now, Chinese Academy of Agricultural Sciences publishes the most Virus-based gene therapy research research, followed by Harvard University and National Institutes of Health.

By volume, 2022-now

  1. 1 Chinese Academy of Agricultural SciencesChina 129 works
  2. 2 Harvard UniversityUnited States 123 works
  3. 3 National Institutes of HealthUnited States 80 works
  4. 4 Chinese Academy of SciencesChina 70 works
  5. 5 Russian Academy of SciencesRussia 55 works
  6. 6 University of PennsylvaniaUnited States 53 works
  7. 7 University of North Carolina at Chapel HillUnited States 52 works
  8. 8 Zhejiang UniversityChina 49 works
  9. 9 Sichuan UniversityChina 48 works
  10. 10 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 44 works

Who are the leading researchers in Virus-based gene therapy research?

The most-cited researchers publishing on Virus-based gene therapy research include Eric S. Lander, Zhong Lin Wang and Guido Kroemer.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Zhong Lin Wang United States 491k citations
  3. 3 Guido Kroemer France 386k citations
  4. 4 Bert Vogelstein United States 373k citations
  5. 5 Gad A. Getz United States 364k citations
  6. 6 Elaine R. Mardis United States 346k citations
  7. 7 Shizuo Akira Japan 342k citations
  8. 8 Jun Wang China 340k citations
  9. 9 Giuseppe Remuzzi Italy 328k citations
  10. 10 Róbert Langer United States 303k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Virus-based gene therapy research?

The most cited paper in Virus-based gene therapy research is "Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei" (John David Dignam, Russell M. Lebovitz, Robert G. Roeder, 1983), with 11,638 citations. Next come "Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine" (10,910) and "A new technique for the assay of infectivity of human adenovirus 5 DNA" (9,753).

Most cited papers
#PaperReleasedCitations
1 Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei John David Dignam, Russell M. Lebovitz, Robert G. Roeder · Nucleic Acids Research Open access 11 Mar 1983 11,638
2 Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine Lindsey R. Baden et al. · New England Journal of Medicine Open access 30 Dec 2020 10,910
3 A new technique for the assay of infectivity of human adenovirus 5 DNA Frank L. Graham, A.J. van der Eb · Virology Apr 1973 9,753
4 Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature May 2001 9,461
5 The serial cultivation of human diploid cell strains Leonard Hayflick, Paul S. Moorhead · Experimental Cell Research Dec 1961 8,548
All 100 most cited papers, with filters and sorting

Where is Virus-based gene therapy research research done?

The largest centres of Virus-based gene therapy research research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Wuhan (China).

Largest cities, 2022-now

  1. 1 BeijingChina 360 works
  2. 2 ShanghaiChina 161 works
  3. 3 GuangzhouChina 158 works
  4. 4 WuhanChina 130 works
  5. 5 LondonUnited Kingdom 124 works
  6. 6 New YorkUnited States 123 works
  7. 7 TokyoJapan 118 works
  8. 8 PhiladelphiaUnited States 105 works
  9. 9 ParisFrance 100 works
  10. 10 HangzhouChina 99 works
See Virus-based gene therapy research on the map

Where is the best place to study Virus-based gene therapy research?

Among universities, judged by research, Harvard University, Massachusetts Institute of Technology and Zhejiang University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 19.85%fractional works in this field (log) →share of work in the world top 10% →Massachusetts Instit…University of Pennsy…Zhejiang UniversityHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 76.318.5%4.6×123 +21.8%
2Massachusetts Institute of TechnologyUnited States 65.226.4%2.4×14 +47.4%
3Zhejiang UniversityChina 59.223.0%2.2×49 +24.0%
4University of PennsylvaniaUnited States 59.124.6%6.0×53 -20.0%
5University of Massachusetts Chan Medical SchoolUnited States 56.024.9%13.5×19 +6.3%
6Stanford UniversityUnited States 54.918.8%2.7×33 +6.0%
7Sichuan UniversityChina 52.817.0%2.5×48 +36.6%
8University of ZurichSwitzerland 52.110.8%4.6×27 +19.0%
9University College LondonUnited Kingdom 50.516.0%2.7×36 -3.3%
10Peking UniversityChina 50.418.5%1.9×33 +102.6%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Virus-based gene therapy research, country by country

Is Virus-based gene therapy research research growing?

Output in 2022-2025 was 14% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Virus-based gene therapy research.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Virus-based gene therapy research as a percentage of every work published that year, 0.040% in 2024.

still counting0.050%0.10%0.15%Virus-based gene therapy research0.041% in 202519801990200020102020

Fractional works of Virus-based gene therapy research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Virus-based gene therapy research10.2% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Questions people ask

Who leads gene therapy research?

By volume in 2022-now, Chinese Academy of Agricultural Sciences publishes the most Virus-based gene therapy research research, followed by Harvard University and National Institutes of Health. By volume, the United States and China publish the most (2.7k and 2.2k works in 2022-now).

All 1,273 questions in the Question Catalogue

Discussion

Ask a question or share a note about Virus-based gene therapy research. Posts are plain text and can be reported.