Most cited papers in Virus-based gene therapy research
What are the most cited papers in Virus-based gene therapy research?
The most cited paper in Virus-based gene therapy research is "Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei" (John David Dignam, Russell M. Lebovitz, Robert G. Roeder, 1983), with 11,638 citations. Next come "Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine" (10,910) and "A new technique for the assay of infectivity of human adenovirus 5 DNA" (9,753).
Showing 50 of 100 papers. Every paper with more than 1,726 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei John David Dignam, Russell M. Lebovitz, Robert G. Roeder · Nucleic Acids Research | 11 Mar 1983 | 11,638 |
| 2 | Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine Lindsey R. Baden et al. · New England Journal of Medicine | 30 Dec 2020 | 10,910 |
| 3 | A new technique for the assay of infectivity of human adenovirus 5 DNA Frank L. Graham, A.J. van der Eb · Virology | Apr 1973 | 9,753 |
| 4 | Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature | May 2001 | 9,461 |
| 5 | The serial cultivation of human diploid cell strains Leonard Hayflick, Paul S. Moorhead · Experimental Cell Research | Dec 1961 | 8,548 |
| 6 | Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia Shannon L. Maude et al. · New England Journal of Medicine | 31 Jan 2018 | 5,818 |
| 7 | Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia Shannon L. Maude, Noelle V. Frey, Pamela A. Shaw et al. · New England Journal of Medicine | 15 Oct 2014 | 5,489 |
| 8 | High-efficiency transformation of mammalian cells by plasmid DNA. C Chen, Hiroto Okayama · Molecular and Cellular Biology | Aug 1987 | 5,335 |
| 9 | Efficient selection for high-expression transfectants with a novel eukaryotic vector Hitoshi Niwa, Ken‐ichi Yamamura, Jun‐ichi Miyazaki · Gene | Dec 1991 | 5,233 |
| 10 | Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Manfred Gossen, Heidelberg Bujard · Proceedings of the National Academy of Sciences | 15 Jun 1992 | 5,005 |
| 11 | In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector Luigi Naldini, Ulrike Blömer, Philippe A. Gallay et al. · Science | 12 Apr 1996 | 4,952 |
| 12 | Generalized lacZ expression with the ROSA26 Cre reporter strain Philippe M. Soriano · Nature Genetics | 1999 | 4,935 |
| 13 | Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5 Frank L. Graham, W. C. Russell, James R. Smiley et al. · Journal of General Virology | Jul 1977 | 4,887 |
| 14 | Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma Stephen J. Schuster et al. · New England Journal of Medicine | Dec 2018 | 4,157 |
| 15 | The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 Martin Scheffner, Bruce A. Werness, Jon M. Huibregtse et al. · Cell | Dec 1990 | 4,034 |
| 16 | The p53 tumour suppressor gene Arnold J. Levine, Jamil Antonio Momand, Cathy A. Finlay · Nature | Jun 1991 | 3,842 |
| 17 | Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms David M. Malkin, Frederick P. Li, Louise C. Strong et al. · Science | 30 Nov 1990 | 3,809 |
| 18 | ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells Daniel W. Lee et al. · Transplantation and Cellular Therapy | 25 Dec 2018 | 3,663 |
| 19 | LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1 S. Hacein-Bey-Abina et al. · Science | 16 Oct 2003 | 3,582 |
| 20 | A Third-Generation Lentivirus Vector with a Conditional Packaging System Tom Dull, Romain Zufferey, Michael T. Kelly et al. · Journal of Virology | Nov 1998 | 3,409 |
| 21 | A simplified system for generating recombinant adenoviruses Tong‐Chuan He, Shibin Zhou, Luís Teixeira da Costa et al. · Proceedings of the National Academy of Sciences | 3 Mar 1998 | 3,244 |
| 22 | A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma Grazia Ambrosini, Colette Adida, Dario C. Altieri · Nature Medicine | Aug 1997 | 3,209 |
| 23 | Non-viral vectors for gene-based therapy Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy et al. · Nature Reviews Genetics | 15 Jul 2014 | 3,130 |
| 24 | Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5 Jeffrey M. Bergelson, Jennifer A. Cunningham, Gustavo Droguett et al. · Science | 28 Feb 1997 | 3,112 |
| 25 | The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product Nicholas J. Dyson, Peter M. Howley, Karl Münger et al. · Science | 17 Feb 1989 | 3,072 |
| 26 | The Immunobiology of Cancer Immunosurveillance and Immunoediting Gavin P. Dunn, Lloyd J. Old, Robert D. Schreiber · Immunity | Aug 2004 | 3,034 |
| 27 | Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids Arnold J. Berk, Phillip A. Sharp · Cell | Nov 1977 | 3,013 |
| 28 | p53-dependent apoptosis modulates the cytotoxicity of anticancer agents Scott W. Lowe, H. Earl Ruley, Tyler Jacks et al. · Cell | Sep 1993 | 2,949 |
| 29 | CAR-T cell therapy: current limitations and potential strategies Robert C. Sterner, Rosalie M. Sterner, Rosalie M. Sterner et al. · Blood Cancer Journal | 6 Apr 2021 | 2,920 |
| 30 | Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis Rie Watanabe‐Fukunaga, Camilynn I. Brannan, Neal G. Copeland et al. · Nature | Mar 1992 | 2,919 |
| 31 | Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes Hartmut Land, Luis F. Parada, Robert A. Weinberg · Nature | Aug 1983 | 2,873 |
| 32 | Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Glen Dranoff, Elizabeth M. Jaffee, Allison Lazenby et al. · Proceedings of the National Academy of Sciences | 15 Apr 1993 | 2,863 |
| 33 | Exploiting tumour hypoxia in cancer treatment J. Martin Brown, William Robert Wilson · Nature reviews. Cancer | Jun 2004 | 2,847 |
| 34 | Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes Mark E. Dudley, John R. Wunderlich, Paul F. Robbins et al. · Science | 24 Oct 2002 | 2,846 |
| 35 | Cellular uptake of the tat protein from human immunodeficiency virus Alan D. Frankel, Carl O. Pabo · Cell | Dec 1988 | 2,798 |
| 36 | In vivo genome editing using Staphylococcus aureus Cas9 F. Ann Ran, Le Dinh Công, Winston X. Yan et al. · Nature | 31 Mar 2015 | 2,785 |
| 37 | HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis Georgyi V. Los, Lance P. Encell, Mark G. McDougall et al. · ACS Chemical Biology | Jun 2008 | 2,688 |
| 38 | Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma Robert H.I. Andtbacka et al. · Journal of Clinical Oncology | 27 May 2015 | 2,662 |
| 39 | Easy quantitative assessment of genome editing by sequence trace decomposition Eva Karina Brinkman, Tao Chen, Mario Amendola et al. · Nucleic Acids Research | 9 Oct 2014 | 2,644 |
| 40 | Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease Marina Cavazzana, Salima Hacein‐Bey, Geneviève de Saint Basile et al. · Science | 28 Apr 2000 | 2,641 |
| 41 | Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19 JERALD C. SADOFF et al. · New England Journal of Medicine | 21 Apr 2021 | 2,625 |
| 42 | Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53 Bruce A. Werness, Arnold J. Levine, Peter M. Howley · Science | 6 Apr 1990 | 2,614 |
| 43 | Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes Richard A. Morgan, Mark E. Dudley, John R. Wunderlich et al. · Science | 31 Aug 2006 | 2,606 |
| 44 | Design and development of polymers for gene delivery Daniel W. Pack, Allan S. Hoffman, Suzie Hwang Pun et al. · Nature Reviews Drug Discovery | Jul 2005 | 2,563 |
| 45 | Cell Sensitivity Assays: The MTT Assay Johan van Meerloo, Gertjan J.L. Kaspers, Jacqueline J Cloos · Methods in molecular biology | 2011 | 2,549 |
| 46 | Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences Julian Downward, Yosef Yarden, E. L. V. Mayes et al. · Nature | Feb 1984 | 2,547 |
| 47 | Transcriptional Activation by Tetracyclines in Mammalian Cells Manfred Gossen, Sabine Freundlieb, Gabriele Bender et al. · Science | 23 Jun 1995 | 2,543 |
| 48 | Progress and problems with the use of viral vectors for gene therapy Clare E. Thomas, Anja Ehrhardt, Mark A. Kay · Nature Reviews Genetics | May 2003 | 2,518 |
| 49 | Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia Marco L. Davila et al. · Science Translational Medicine | 19 Feb 2014 | 2,514 |
| 50 | mRNA-based therapeutics — developing a new class of drugs Uğur Şahin, Katalin Karikó, Özlem Türeci · Nature Reviews Drug Discovery | 19 Sep 2014 | 2,505 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.