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Topic · Genetics

Connective tissue disorders research

Connective tissue disorders research is a research topic within Genetics. Science Explorer counts 28k research works in it since 1950. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores genetic and molecular aspects of various connective tissue disorders, including Marfan syndrome, Ehlers-Danlos syndrome, and Osteogenesis Imperfecta. It delves into mutations in genes encoding proteins like TGF-ß receptor, elastin, fibrillin-1, and collagen, as well as their implications in aortic aneurysms and skeletal abnormalities.

  • Marfan Syndrome
  • Ehlers-Danlos Syndrome
  • Osteogenesis Imperfecta
  • TGF-ß Receptor Mutations
  • Elastin
  • Fibrillin-1
  • Smooth Muscle Alpha-Actin Mutations
  • Collagen Disorders
  • Aortic Aneurysm
  • Genetic Skeletal Disorders
Research works
28k
fractional, since 1950
In the world top 10%
2.8k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+18%
the tick is no change
Largest producer
United States
33% of the 10 largest, 2022-now
Connective tissue disorders research

Which countries lead Connective tissue disorders research research?

By volume, the United States and China publish the most (1.3k and 963 works in 2022-now).

By volume, 2022-now

  1. 1 United States 1.3k works
  2. 2 China 963 works
  3. 3 Japan 295 works
  4. 4 India 255 works
  5. 5 United Kingdom 243 works
  6. 6 Germany 205 works
  7. 7 Italy 179 works
  8. 8 France 178 works
  9. 9 Spain 144 works
  10. 10 Canada 131 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 33.2%China: 24.8%Japan: 7.6%India: 6.6%6 others listed: 27.8%33%largest
United States1,287 · 33.2%China963 · 24.8%Japan295 · 7.6%India255 · 6.6%6 others listed1,081 · 27.8%

Shares of the rows listed above, not of the whole node.

Which institutions lead Connective tissue disorders research research?

By volume in 2022-now, Harvard University publishes the most Connective tissue disorders research research, followed by Shanghai Jiao Tong University and Inserm.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 41 works
  2. 2 Shanghai Jiao Tong UniversityChina 37 works
  3. 3 InsermFrance 33 works
  4. 4 Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 32 works
  5. 5 Capital Medical UniversityChina 30 works
  6. 6 All India Institute of Medical SciencesIndia 30 works
  7. 7 Sichuan UniversityChina 30 works
  8. 8 Johns Hopkins UniversityUnited States 29 works
  9. 9 McGill UniversityCanada 29 works
  10. 10 University of TorontoCanada 29 works

Who are the leading researchers in Connective tissue disorders research?

The most-cited researchers publishing on Connective tissue disorders research include Eric S. Lander, George Davey Smith and Mark J. Daly.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 George Davey Smith United Kingdom 435k citations
  3. 3 Mark J. Daly United States 403k citations
  4. 4 Jost Bruno Jonas Germany 350k citations
  5. 5 Cyrus Cooper United Kingdom 342k citations
  6. 6 Jun Wang China 340k citations
  7. 7 John P. A. Ioannidis United States 317k citations
  8. 8 Graeme J. Hankey Australia 316k citations
  9. 9 Gregory Y.H. Lip United Kingdom 311k citations
  10. 10 Róbert Langer United States 303k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Connective tissue disorders research?

The most cited paper in Connective tissue disorders research is "Bone: Formation by Autoinduction" (Marshall R. Urist, 1965), with 5,578 citations. Next come "Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts" (4,270) and "Matrix metalloproteinases and their inhibitors in connective tissue remodeling" (3,305).

Most cited papers
#PaperReleasedCitations
1 Bone: Formation by Autoinduction Marshall R. Urist · Science 12 Nov 1965 5,578
2 Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts Toshihisa Komori, Hideshi Yagi, Shogo Nomura et al. · Cell Open access May 1997 4,270
3 Matrix metalloproteinases and their inhibitors in connective tissue remodeling J. Frederick Woessner · The FASEB Journal Open access May 1991 3,305
4 de la Chapelle, A. Peter Beighton, Greta Beighton Book chapter 1997 3,167
5 Extracellular matrix structure Achilleas D. Theocharis, Spyros S. Skandalis, Chrysostomi Gialeli et al. · Advanced Drug Delivery Reviews Review 10 Nov 2015 2,609
All 100 most cited papers, with filters and sorting

Where is Connective tissue disorders research research done?

The largest centres of Connective tissue disorders research research in 2022-now are Beijing (China), Shanghai (China), London (United Kingdom) and Paris (France).

Largest cities, 2022-now

  1. 1 BeijingChina 150 works
  2. 2 ShanghaiChina 93 works
  3. 3 LondonUnited Kingdom 89 works
  4. 4 ParisFrance 76 works
  5. 5 GuangzhouChina 69 works
  6. 6 TokyoJapan 68 works
  7. 7 New YorkUnited States 57 works
  8. 8 PhiladelphiaUnited States 49 works
  9. 9 MadridSpain 47 works
  10. 10 BostonUnited States 45 works
See Connective tissue disorders research on the map

Where is the best place to study Connective tissue disorders research?

Among universities, judged by research, Harvard University, Washington University in St. Louis and Radboud University Nijmegen score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 16.24%fractional works in this field (log) →share of work in the world top 10% →Radboud University N…Washington Universit…University of TorontoHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 76.411.5%2.8×41 +12.0%
2Washington University in St. LouisUnited States 72.518.1%5.6×19 +11.8%
3Radboud University NijmegenNetherlands 72.524.3%4.4×12 +61.6%
4University of TorontoCanada 71.813.1%3.1×29 +32.2%
5Sichuan UniversityChina 71.421.1%2.8×30 +88.5%
6Shanghai Jiao Tong UniversityChina 70.417.8%2.8×37 +28.4%
7Stanford UniversityUnited States 68.715.3%3.5×24 +35.2%
8Baylor College of MedicineUnited States 68.419.7%8.8×20 +2.4%
9Johns Hopkins UniversityUnited States 66.58.5%4.2×30 +21.0%
10Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 65.613.0%6.7×32 +51.8%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Connective tissue disorders research, country by country

Is Connective tissue disorders research research growing?

Output in 2022-2025 was 18% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Connective tissue disorders research.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Connective tissue disorders research as a percentage of every work published that year, 0.021% in 2024.

still counting0.020%0.040%0.060%Connective tissue disorders research0.023% in 202519801990200020102020

Fractional works of Connective tissue disorders research over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Connective tissue disorders research9.9% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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