Most cited papers in Connective tissue disorders research
What are the most cited papers in Connective tissue disorders research?
The most cited paper in Connective tissue disorders research is "Bone: Formation by Autoinduction" (Marshall R. Urist, 1965), with 5,578 citations. Next come "Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts" (4,270) and "Matrix metalloproteinases and their inhibitors in connective tissue remodeling" (3,305).
Showing 50 of 100 papers. Every paper with more than 912 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Bone: Formation by Autoinduction Marshall R. Urist · Science | 12 Nov 1965 | 5,578 |
| 2 | Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts Toshihisa Komori, Hideshi Yagi, Shogo Nomura et al. · Cell | May 1997 | 4,270 |
| 3 | Matrix metalloproteinases and their inhibitors in connective tissue remodeling J. Frederick Woessner · The FASEB Journal | May 1991 | 3,305 |
| 4 | de la Chapelle, A. Peter Beighton, Greta Beighton | 1997 | 3,167 |
| 5 | Extracellular matrix structure Achilleas D. Theocharis, Spyros S. Skandalis, Chrysostomi Gialeli et al. · Advanced Drug Delivery Reviews | 10 Nov 2015 | 2,609 |
| 6 | Hyperelastic modelling of arterial layers with distributed collagen fibre orientations Thomas Christian Gasser, Ray W. Ogden, Gerhard A. Holzapfel · Journal of The Royal Society Interface | 28 Sep 2005 | 2,445 |
| 7 | TGF‐β signaling and the fibrotic response Andrew Leask, David Abraham · The FASEB Journal | 29 Apr 2004 | 2,304 |
| 8 | Effects of extracellular matrix viscoelasticity on cellular behaviour Ovijit Chaudhuri, Justin John Cooper-White, Paul A. Janmey et al. · Nature | 26 Aug 2020 | 2,287 |
| 9 | Genetic heterogeneity in osteogenesis imperfecta. David Owen Sillence, A Senn, D. M. Danks · Journal of Medical Genetics | Apr 1979 | 2,261 |
| 10 | The revised Ghent nosology for the Marfan syndrome: Table 1 Bart Loeys, Harry C. Dietz, Alan C. Braverman et al. · Journal of Medical Genetics | 30 Jun 2010 | 2,253 |
| 11 | Mechanotransduction and extracellular matrix homeostasis Jay D. Humphrey, Eric R. Dufresne, Martin Alexander Schwartz · Nature Reviews Molecular Cell Biology | 22 Oct 2014 | 2,218 |
| 12 | Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein Guangbin Luo, Patricia F. Ducy, Marc D. McKee et al. · Nature | Mar 1997 | 2,125 |
| 13 | WNT signaling in bone homeostasis and disease: from human mutations to treatments Roland Baron, Michaela Kneissel · Nature Medicine | Feb 2013 | 2,113 |
| 14 | Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene Harry C. Dietz, Carry R. Cutting, Reed Edwin Pyeritz et al. · Nature | Jul 1991 | 2,089 |
| 15 | Cellular signaling by fibroblast growth factor receptors Veraragavan P. Eswarakumar, Irit Lax, Joseph Schlessinger · Cytokine & Growth Factor Reviews | 2 Feb 2005 | 1,948 |
| 16 | The 2017 international classification of the Ehlers–Danlos syndromes Fransiska Malfait et al. · American Journal of Medical Genetics Part C Seminars in Medical Genetics | Mar 2017 | 1,940 |
| 17 | Fracture healing: mechanisms and interventions Thomas A. Einhorn, Louis C. Gerstenfeld · Nature Reviews Rheumatology | 30 Sep 2014 | 1,845 |
| 18 | Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta Edwin M. Horwitz, Darwin J. Prockop, Lorraine A. Fitzpatrick et al. · Nature Medicine | Mar 1999 | 1,832 |
| 19 | Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome Jennifer Pardo Habashi, Daniel Philip Judge, Tammy M. Holm et al. · Science | 6 Apr 2006 | 1,806 |
| 20 | A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2 Bart Loeys et al. · Nature Genetics | 30 Jan 2005 | 1,798 |
| 21 | Ehlers-Danlos syndromes: Revised nosology, Villefranche, 1997 Peter Beighton, Anne De Paepe, Beat Steinmann et al. · American Journal of Medical Genetics | 28 Apr 1998 | 1,753 |
| 22 | Nonlinear elasticity in biological gels Cornelis Storm, Jennifer J. Pastore, F. C. MacKintosh et al. · Nature | May 2005 | 1,723 |
| 23 | Aneurysm Syndromes Caused by Mutations in the TGF-β Receptor Bart Loeys et al. · New England Journal of Medicine | 23 Aug 2006 | 1,663 |
| 24 | Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone Edwin M. Horwitz, Patricia Gordon, Winston K. K. Koo et al. · Proceedings of the National Academy of Sciences | 25 Jun 2002 | 1,658 |
| 25 | Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis Timothy F. Day, Xizhi Guo, Lisa J. Garrett-Beal et al. · Developmental Cell | May 2005 | 1,623 |
| 26 | Reaching a Genetic and Molecular Understanding of Skeletal Development Gérard Karsenty, Erwin Friedrich Wagner · Developmental Cell | Apr 2002 | 1,620 |
| 27 | Revised diagnostic criteria for the Marfan syndrome Anne De Paepe, Richard B. Devereux, Harry C. Dietz et al. · American Journal of Medical Genetics | 24 Apr 1996 | 1,577 |
| 28 | An Overview of Epithelio-Mesenchymal Transformation Elizabeth D. Hay · Cells Tissues Organs | 1995 | 1,575 |
| 29 | Spontaneous Dissection of the Carotid and Vertebral Arteries Wouter I. Schievink · New England Journal of Medicine | 22 Mar 2001 | 1,574 |
| 30 | THE SMOOTH MUSCLE CELL Russell Ross · The Journal of Cell Biology | Jul 1971 | 1,572 |
| 31 | Bone's mechanostat: A 2003 update Harold M. Frost · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology | 3 Nov 2003 | 1,546 |
| 32 | Extracellular matrix assembly: a multiscale deconstruction Janna K. Mouw, Guanqing Ou, Valerie Marie Weaver · Nature Reviews Molecular Cell Biology | 5 Nov 2014 | 1,542 |
| 33 | Heritable Disorders of Connective Tissue Victor A. McKusick · Postgraduate Medical Journal | May 1960 | 1,534 |
| 34 | Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation Alan C. Rapraeger, Alison Krufka, Bradley B. Olwin · Science | 21 Jun 1991 | 1,507 |
| 35 | Targeting the TGFβ signalling pathway in disease Rosemary J. Akhurst, Akiko Hata · Nature Reviews Drug Discovery | 24 Sep 2012 | 1,496 |
| 36 | The extracellular matrix in development and morphogenesis: A dynamic view Tania Rozario, Douglas W. DeSimone · Developmental Biology | 24 Oct 2009 | 1,461 |
| 37 | Molecular Findings Among Patients Referred for Clinical Whole-Exome Sequencing Yaping Yang et al. · JAMA | 18 Oct 2014 | 1,427 |
| 38 | Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome Enid Neptune, Pamela A. Frischmeyer, Dan E. Arking et al. · Nature Genetics | 24 Feb 2003 | 1,422 |
| 39 | Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling Xiaofeng Li, Yazhou Zhang, Heeseog Kang et al. · Journal of Biological Chemistry | 19 Mar 2005 | 1,376 |
| 40 | Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin Alexander G. Robling, Paul Niziolek, Lee Ann Baldridge et al. · Journal of Biological Chemistry | 18 Dec 2007 | 1,356 |
| 41 | Clinical and Genetic Features of Ehlers–Danlos Syndrome Type IV, the Vascular Type Melanie G. Pepin, Ulrike Schwarze, Andrea Superti‐Furga et al. · New England Journal of Medicine | 9 Mar 2000 | 1,353 |
| 42 | Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia Rita Shiang, Leslie Michels Thompson, Yazhen Zhu et al. · Cell | Jul 1994 | 1,347 |
| 43 | LDL-receptor-related proteins in Wnt signal transduction Keiko Tamai, Mikhail A. Semenov, Yoichi Kato et al. · Nature | Sep 2000 | 1,347 |
| 44 | A completely biological tissue-engineered human blood vessel Nicolas L’Heureux, Stéphanie Pâquet, Raymond Labbé et al. · The FASEB Journal | 1998 | 1,346 |
| 45 | Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix Pierre‐Jean Wipff, Daniel B. Rifkin, Jean-Jacques Meister et al. · The Journal of Cell Biology | 17 Dec 2007 | 1,345 |
| 46 | Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin Elizabeth L George, Elisabeth Georges‐Labouesse, Ramila S. Patel‐King et al. · Development | Dec 1993 | 1,322 |
| 47 | MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover Kenn Holmbeck, Paolo Bianco, John J. Caterina et al. · Cell | Oct 1999 | 1,305 |
| 48 | Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity Boris Hinz, Giuseppe Celetta, James J. Tomasek et al. · Molecular Biology of the Cell | Sep 2001 | 1,301 |
| 49 | Endovascular Stent–Graft Placement for the Treatment of Acute Aortic Dissection Michael D. Dake, Noriyuki Kato, Robert Scott Mitchell et al. · New England Journal of Medicine | 20 May 1999 | 1,299 |
| 50 | A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait Randall D. Little et al. · The American Journal of Human Genetics | 2002 | 1,295 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.