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Topic · Molecular Biology

Protein Degradation and Inhibitors

Protein Degradation and Inhibitors is a research topic within Molecular Biology. Science Explorer counts 22k research works in it since 1952. 10.1% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the targeted degradation of specific proteins, particularly through the use of BET bromodomain inhibitors and PROTACs. The research explores the therapeutic potential of this approach, with a focus on histone recognition, small molecule inhibitors, and the role of epigenetic readers in transcriptional regulation. Additionally, it investigates the use of cereblon-dependent degradation and its implications for drug discovery.

  • BET Bromodomains
  • PROTACs
  • Therapeutic Strategy
  • Histone Recognition
  • Small Molecule Inhibitors
  • Cereblon-Dependent Degradation
  • Epigenetic Readers
  • Super-Enhancers
  • Transcriptional Regulation
  • Drug Discovery Paradigm
Research works
22k
fractional, since 1952
In the world top 10%
2.3k
per year above
Top-10% rate
10.1%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+31%
the tick is no change
Largest producer
United States
41% of the 10 largest, 2022-now
Protein Degradation and Inhibitors

Which countries lead Protein Degradation and Inhibitors research?

By volume, the United States and China publish the most (2.6k and 1.9k works in 2022-now).

By volume, 2022-now

  1. 1 United States 2.6k works
  2. 2 China 1.9k works
  3. 3 Germany 320 works
  4. 4 India 291 works
  5. 5 United Kingdom 277 works
  6. 6 Italy 237 works
  7. 7 Japan 229 works
  8. 8 Canada 166 works
  9. 9 France 161 works
  10. 10 South Korea 154 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States: 41.0%China: 29.7%Germany: 5.1%India: 4.6%6 others listed: 19.5%41%largest
United States2,580 · 41.0%China1,869 · 29.7%Germany320 · 5.1%India291 · 4.6%6 others listed1,224 · 19.5%

Shares of the rows listed above, not of the whole node.

Which institutions lead Protein Degradation and Inhibitors research?

By volume in 2022-now, Harvard University publishes the most Protein Degradation and Inhibitors research, followed by The University of Texas MD Anderson Cancer Center and Chinese Academy of Sciences.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 167 works
  2. 2 The University of Texas MD Anderson Cancer CenterUnited States 90 works
  3. 3 Chinese Academy of SciencesChina 75 works
  4. 4 National Institutes of HealthUnited States 62 works
  5. 5 Sun Yat-sen UniversityChina 55 works
  6. 6 Mayo ClinicUnited States 54 works
  7. 7 Sichuan UniversityChina 51 works
  8. 8 Zhejiang UniversityChina 51 works
  9. 9 University of North Carolina at Chapel HillUnited States 48 works
  10. 10 Shanghai Jiao Tong UniversityChina 46 works

Who are the leading researchers in Protein Degradation and Inhibitors?

The most-cited researchers publishing on Protein Degradation and Inhibitors include Eric S. Lander, Peer Bork and Guido Kroemer.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Peer Bork Germany 396k citations
  3. 3 Guido Kroemer France 386k citations
  4. 4 Bert Vogelstein United States 373k citations
  5. 5 Gad A. Getz United States 364k citations
  6. 6 Elaine R. Mardis United States 346k citations
  7. 7 Jun Wang China 340k citations
  8. 8 Matthias Mann Germany 308k citations
  9. 9 Róbert Langer United States 303k citations
  10. 10 Robert A. Weinberg United States 301k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Protein Degradation and Inhibitors?

The most cited paper in Protein Degradation and Inhibitors is "The language of covalent histone modifications" (Brian D. Strahl, C. David Allis, 2000), with 8,728 citations. Next come "International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma" (5,031) and "Histone H3K27ac separates active from poised enhancers and predicts developmental state" (4,654).

Most cited papers
#PaperReleasedCitations
1 The language of covalent histone modifications Brian D. Strahl, C. David Allis · Nature 2000 8,728
2 International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma S. Vincent Rajkumar et al. · The Lancet Oncology Open access 26 Oct 2014 5,031
3 Histone H3K27ac separates active from poised enhancers and predicts developmental state Menno P. Creyghton, Albert W. Cheng, G. Grant Welstead et al. · Proceedings of the National Academy of Sciences Open access 24 Nov 2010 4,654
4 Selective inhibition of BET bromodomains P. Filippakopoulos et al. · Nature Open access 24 Sep 2010 4,363
5 An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) Jürgen M. Lehmann, Linda B. Moore, Tracey A. Smith-Oliver et al. · Journal of Biological Chemistry Open access Jun 1995 3,648
All 100 most cited papers, with filters and sorting

Where is Protein Degradation and Inhibitors research done?

The largest centres of Protein Degradation and Inhibitors research in 2022-now are Beijing (China), Shanghai (China), New York (United States) and Guangzhou (China). Among places with at least 20 works in it, it is an unusually large share of all research in Dundee.

Largest cities, 2022-now

  1. 1 BeijingChina 233 works
  2. 2 ShanghaiChina 188 works
  3. 3 New YorkUnited States 165 works
  4. 4 GuangzhouChina 133 works
  5. 5 HoustonUnited States 130 works
  6. 6 BostonUnited States 130 works
  7. 7 HangzhouChina 102 works
  8. 8 NanjingChina 102 works
  9. 9 CambridgeUnited States 96 works
  10. 10 LondonUnited Kingdom 86 works

Where it is the local speciality

  1. DundeeGB · 20.8 works13×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Protein Degradation and Inhibitors than the world average.

See Protein Degradation and Inhibitors on the map

Where is the best place to study Protein Degradation and Inhibitors?

Among universities, judged by research, Kettering University, Harvard University and University of Dundee score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 20.8%fractional works in this field (log) →share of work in the world top 10% →Kettering UniversityUniversity of DundeeChina Pharmaceutical…Harvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Kettering UniversityUnited States 65.946.0%46.8×11 +381.1%
2Harvard UniversityUnited States 62.618.1%8.2×167 -7.9%
3University of DundeeUnited Kingdom 54.523.2%18.1×20 +40.1%
4China Pharmaceutical UniversityChina 53.420.6%31.4×45 +135.1%
5Sichuan UniversityChina 49.119.6%3.5×51 +85.5%
6University of MichiganUnited States 48.917.3%4.3×43 +33.8%
7University of California, San FranciscoUnited States 47.112.6%7.1×33 +22.8%
8Peking UniversityChina 46.516.6%3.1×42 +116.3%
9Zhejiang UniversityChina 45.814.8%2.9×50 +91.5%
10Stanford UniversityUnited States 45.519.2%2.8×27 +28.9%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Protein Degradation and Inhibitors, country by country

Is Protein Degradation and Inhibitors research growing?

Output in 2022-2025 was 31% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Protein Degradation and Inhibitors.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Protein Degradation and Inhibitors as a percentage of every work published that year, 0.026% in 2024.

still counting0.020%0.040%Protein Degradation and Inhibitors0.033% in 202519801990200020102020

Fractional works of Protein Degradation and Inhibitors over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Protein Degradation and Inhibitors9.8% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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