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Topic · Molecular Biology

DNA and Nucleic Acid Chemistry

DNA and Nucleic Acid Chemistry is a research topic within Molecular Biology. Science Explorer counts 69k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the structure, topology, and biological functions of G-quadruplex DNA, particularly in relation to telomeres, therapeutic targets, and antisense oligonucleotides. It explores the potential of G-quadruplexes as targets for cancer therapy and drug design, as well as their role in genomic stability and molecular recognition.

  • G-Quadruplexes
  • DNA Structure
  • Nucleic Acids
  • Therapeutic Targets
  • Telomeres
  • Antisense Oligonucleotides
  • Biological Functions
  • Molecular Recognition
  • Drug Design
  • Genomic Stability
Research works
69k
fractional, since 1950
In the world top 10%
6.8k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-12%
the tick is no change
Largest producer
China
28% of the 10 largest, 2022-now
DNA and Nucleic Acid Chemistry

Which countries lead DNA and Nucleic Acid Chemistry research?

By volume, China and the United States publish the most (1.1k and 1.1k works in 2022-now).

By volume, 2022-now

  1. 1 China 1.1k works
  2. 2 United States 1.1k works
  3. 3 Japan 350 works
  4. 4 India 348 works
  5. 5 Germany 217 works
  6. 6 France 193 works
  7. 7 United Kingdom 171 works
  8. 8 Russia 159 works
  9. 9 Italy 157 works
  10. 10 Canada 113 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 28.2%United States: 27.6%Japan: 9.1%India: 9.0%6 others listed: 26.1%28%largest
China1,089 · 28.2%United States1,067 · 27.6%Japan350 · 9.1%India348 · 9.0%6 others listed1,010 · 26.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead DNA and Nucleic Acid Chemistry research?

By volume in 2022-now, Centre National de la Recherche Scientifique publishes the most DNA and Nucleic Acid Chemistry research, followed by Russian Academy of Sciences and Chinese Academy of Sciences.

By volume, 2022-now

  1. 1 Centre National de la Recherche ScientifiqueFrance 90 works
  2. 2 Russian Academy of SciencesRussia 85 works
  3. 3 Chinese Academy of SciencesChina 70 works
  4. 4 Shanghai Jiao Tong UniversityChina 32 works
  5. 5 Hunan UniversityChina 25 works
  6. 6 Czech Academy of SciencesCzechia 25 works
  7. 7 Kyoto UniversityJapan 24 works
  8. 8 National Institutes of HealthUnited States 23 works
  9. 9 Sun Yat-sen UniversityChina 21 works
  10. 10 Sichuan UniversityChina 20 works

Who are the leading researchers in DNA and Nucleic Acid Chemistry?

The most-cited researchers publishing on DNA and Nucleic Acid Chemistry include Rob Knight, Michaël Grätzel and George Davey Smith.

  1. 1 Rob Knight United States 468k citations
  2. 2 Michaël Grätzel Switzerland 458k citations
  3. 3 George Davey Smith United Kingdom 435k citations
  4. 4 Ali H. Mokdad United States 429k citations
  5. 5 Guido Kroemer France 386k citations
  6. 6 Bert Vogelstein United States 373k citations
  7. 7 Jun Wang China 340k citations
  8. 8 Matthias Mann Germany 308k citations
  9. 9 Róbert Langer United States 303k citations
  10. 10 Robert A. Weinberg United States 301k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in DNA and Nucleic Acid Chemistry?

The most cited paper in DNA and Nucleic Acid Chemistry is "Detection of specific sequences among DNA fragments separated by gel electrophoresis" (E.M. Southern, 1975), with 32,849 citations. Next come "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity" (25,160) and "Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease" (22,217).

Most cited papers
#PaperReleasedCitations
1 Detection of specific sequences among DNA fragments separated by gel electrophoresis E.M. Southern · Journal of Molecular Biology Nov 1975 32,849
2 A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity Andrew P. Feinberg, Bert Vogelstein · Analytical Biochemistry Jul 1983 25,160
3 Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease John M. Chirgwin, Alan Przybyla, Raymond J. MacDonald et al. · Biochemistry Nov 1979 22,217
4 Development and testing of a general amber force field Junmei Wang, Romain M. Wolf, James W. Caldwell et al. · Journal of Computational Chemistry 13 Apr 2004 20,214
5 Mfold web server for nucleic acid folding and hybridization prediction Michael Zuker · Nucleic Acids Research Open access 24 Jun 2003 13,707
All 100 most cited papers, with filters and sorting

Where is DNA and Nucleic Acid Chemistry research done?

The largest centres of DNA and Nucleic Acid Chemistry research in 2022-now are Beijing (China), Tokyo (Japan), Shanghai (China) and Paris (France). Among places with at least 20 works in it, it is an unusually large share of all research in Kobe and Novosibirsk.

Largest cities, 2022-now

  1. 1 BeijingChina 146 works
  2. 2 TokyoJapan 96 works
  3. 3 ShanghaiChina 90 works
  4. 4 ParisFrance 85 works
  5. 5 MoscowRussia 74 works
  6. 6 GuangzhouChina 55 works
  7. 7 KolkataIndia 55 works
  8. 8 NanjingChina 54 works
  9. 9 WuhanChina 49 works
  10. 10 LondonUnited Kingdom 49 works

Where it is the local speciality

  1. KobeJP · 20.7 works8.1×
  2. NovosibirskRU · 37.7 works7.0×
← less than its size predicts1×more →

Location quotient: how much more of its research is in DNA and Nucleic Acid Chemistry than the world average.

See DNA and Nucleic Acid Chemistry on the map

Where is the best place to study DNA and Nucleic Acid Chemistry?

Among universities, judged by research, Hunan University, Southwest University and Wuhan University score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%20%40%mean 21.96%fractional works in this field (log) →share of work in the world top 10% →Wuhan UniversitySouthwest UniversityHunan UniversityShanghai Jiao Tong U…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Hunan UniversityChina 75.424.3%8.3×25 -7.6%
2Southwest UniversityChina 69.027.2%8.3×19 +6.2%
3Wuhan UniversityChina 68.029.0%3.3×19 +22.1%
4Shanghai Jiao Tong UniversityChina 67.816.6%2.6×32 +14.2%
5University of WaterlooCanada 61.424.6%5.5×13 -7.7%
6University College LondonUnited Kingdom 59.518.4%2.5×17 +38.1%
7Hebrew University of JerusalemIsrael 58.231.9%4.8×10 -24.1%
8Sun Yat-sen UniversityChina 57.716.2%2.5×21 +12.2%
9Harvard UniversityUnited States 55.818.5%1.2×16 -22.6%
10University of Naples Federico IIItaly 54.912.9%6.5×20 +26.6%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in DNA and Nucleic Acid Chemistry, country by country

Is DNA and Nucleic Acid Chemistry research growing?

Output in 2022-2025 was 12% lower than in 2018-2021, peaking in 2009.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is DNA and Nucleic Acid Chemistry as a percentage of every work published that year, 0.019% in 2024.

still counting0.10%0.20%0.30%DNA and Nucleic Acid Chemistry0.019% in 202519801990200020102020

Fractional works of DNA and Nucleic Acid Chemistry over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%DNA and Nucleic Acid Chemistry9.9% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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