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Topic · Molecular Biology

Chemical Synthesis and Analysis

Chemical Synthesis and Analysis is a research topic within Molecular Biology. Science Explorer counts 89k research works in it since 1950. 9.8% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on peptide synthesis, foldamers, amide bond formation, protein-protein interactions, diversity-oriented synthesis, and macrocycles in the context of drug discovery. It explores strategies for the design, synthesis, and application of peptides as therapeutic agents, as well as the development of novel methods for solid-phase peptide synthesis and chemical ligation.

  • Peptide Synthesis
  • Drug Discovery
  • Foldamers
  • Amide Bond Formation
  • Protein-Protein Interactions
  • Diversity-Oriented Synthesis
  • Macrocycles
  • Chemical Ligation
  • Therapeutic Peptides
  • Solid-Phase Synthesis
Research works
89k
fractional, since 1950
In the world top 10%
8.8k
per year above
Top-10% rate
9.8%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+0%
the tick is no change
Largest producer
China
33% of the 10 largest, 2022-now
Chemical Synthesis and Analysis

Which countries lead Chemical Synthesis and Analysis research?

By volume, China and the United States publish the most (1.9k and 1.2k works in 2022-now).

By volume, 2022-now

  1. 1 China 1.9k works
  2. 2 United States 1.2k works
  3. 3 India 671 works
  4. 4 Japan 480 works
  5. 5 Germany 361 works
  6. 6 United Kingdom 270 works
  7. 7 France 266 works
  8. 8 Russia 217 works
  9. 9 Italy 165 works
  10. 10 South Korea 147 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 33.1%United States: 21.6%India: 11.8%Japan: 8.4%6 others listed: 25.0%33%largest
China1,885 · 33.1%United States1,232 · 21.6%India671 · 11.8%Japan480 · 8.4%6 others listed1,425 · 25.0%

Shares of the rows listed above, not of the whole node.

Which institutions lead Chemical Synthesis and Analysis research?

By volume in 2022-now, Chinese Academy of Sciences publishes the most Chemical Synthesis and Analysis research, followed by Centre National de la Recherche Scientifique and Russian Academy of Sciences.

By volume, 2022-now

  1. 1 Chinese Academy of SciencesChina 153 works
  2. 2 Centre National de la Recherche ScientifiqueFrance 135 works
  3. 3 Russian Academy of SciencesRussia 107 works
  4. 4 Sichuan UniversityChina 43 works
  5. 5 Council of Scientific and Industrial ResearchIndia 41 works
  6. 6 University of Chinese Academy of SciencesChina 39 works
  7. 7 Shanghai Jiao Tong UniversityChina 39 works
  8. 8 University of North Carolina at Chapel HillUnited States 37 works
  9. 9 The University of TokyoJapan 37 works
  10. 10 Zhejiang UniversityChina 32 works

Who are the leading researchers in Chemical Synthesis and Analysis?

The most-cited researchers publishing on Chemical Synthesis and Analysis include George Davey Smith, Mark J. Daly and Peer Bork.

  1. 1 George Davey Smith United Kingdom 435k citations
  2. 2 Mark J. Daly United States 403k citations
  3. 3 Peer Bork Germany 396k citations
  4. 4 Shizuo Akira Japan 342k citations
  5. 5 Jun Wang China 340k citations
  6. 6 Matthias Mann Germany 308k citations
  7. 7 Róbert Langer United States 303k citations
  8. 8 Richard A. Gibbs United States 292k citations
  9. 9 Todd R. Golub United States 283k citations
  10. 10 Jeremy Grimshaw Canada 281k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Chemical Synthesis and Analysis?

The most cited paper in Chemical Synthesis and Analysis is "Click Chemistry: Diverse Chemical Function from a Few Good Reactions" (Hartmuth Christian Kolb, M. G. Finn, Karl Barry Sharpless, 2001), with 13,223 citations. Next come "A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes" (11,614) and "A procedure for the isolation of deoxyribonucleic acid from micro-organisms" (11,599).

Most cited papers
#PaperReleasedCitations
1 Click Chemistry: Diverse Chemical Function from a Few Good Reactions Hartmuth Christian Kolb, M. G. Finn, Karl Barry Sharpless · Angewandte Chemie International Edition Jun 2001 13,223
2 A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition 15 Jul 2002 11,614
3 A procedure for the isolation of deoxyribonucleic acid from micro-organisms Julius Marmur · Journal of Molecular Biology Apr 1961 11,599
4 A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases Stanley Reitman, Sam Frankel · American Journal of Clinical Pathology Jul 1957 10,038
5 Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides Christian Wenzel Tornøe, Caspar Elo Christensen, Morten Meldal · The Journal of Organic Chemistry 2 Apr 2002 8,627
All 98 most cited papers, with filters and sorting

Where is Chemical Synthesis and Analysis research done?

The largest centres of Chemical Synthesis and Analysis research in 2022-now are Beijing (China), Shanghai (China), Tokyo (Japan) and Paris (France). Among places with at least 20 works in it, it is an unusually large share of all research in Rahway and Ghaziabad.

Largest cities, 2022-now

  1. 1 BeijingChina 277 works
  2. 2 ShanghaiChina 200 works
  3. 3 TokyoJapan 139 works
  4. 4 ParisFrance 97 works
  5. 5 HangzhouChina 97 works
  6. 6 NanjingChina 93 works
  7. 7 MoscowRussia 90 works
  8. 8 GuangzhouChina 78 works
  9. 9 TianjinChina 69 works
  10. 10 New YorkUnited States 68 works

Where it is the local speciality

  1. RahwayUS · 23.6 works39×
  2. GhaziabadIN · 27.6 works7.7×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Chemical Synthesis and Analysis than the world average.

See Chemical Synthesis and Analysis on the map

Where is the best place to study Chemical Synthesis and Analysis?

Among universities, judged by research, ETH Zurich, University of Chinese Academy of Sciences and Sichuan University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 20.55%fractional works in this field (log) →share of work in the world top 10% →ETH ZurichMassachusetts Instit…Sichuan UniversityUniversity of Chines…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1ETH ZurichSwitzerland 70.822.0%7.2×31 -20.5%
2University of Chinese Academy of SciencesChina 70.617.9%3.8×39 +26.7%
3Sichuan UniversityChina 68.020.2%3.0×43 +38.0%
4Massachusetts Institute of TechnologyUnited States 67.021.3%4.6×20 -5.1%
5Shanghai Jiao Tong UniversityChina 66.017.8%2.1×39 +64.3%
6University of Illinois Urbana-ChampaignUnited States 65.721.2%3.1×17 +31.6%
7Harvard UniversityUnited States 64.723.6%1.2×24 -11.4%
8École Polytechnique Fédérale de LausanneSwitzerland 64.118.3%5.7×15 +40.2%
9Southern University of Science and TechnologyChina 62.123.0%3.5×12 +19.8%
10Lanzhou UniversityChina 61.720.2%6.5×28 +89.1%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Chemical Synthesis and Analysis, country by country

Is Chemical Synthesis and Analysis research growing?

Output in 2022-2025 was 0% higher than in 2018-2021, peaking in 2011. The fastest-growing topics are Chemical Synthesis and Analysis.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Chemical Synthesis and Analysis as a percentage of every work published that year, 0.034% in 2024.

still counting0.10%0.20%0.30%Chemical Synthesis and Analysis0.032% in 202519801990200020102020

Fractional works of Chemical Synthesis and Analysis over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Chemical Synthesis and Analysis9.8% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Discussion

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