DNA Repair Mechanisms

DNA Repair Mechanisms is a research topic within Molecular Biology. Science Explorer counts 56k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the molecular mechanisms of the DNA damage response, including DNA repair pathways, genomic instability, the role of ATM and ATR kinases, homologous recombination, cell cycle checkpoints, and their implications in cancer biology. It also explores the involvement of histone H2AX and chromatin in maintaining genome stability.

DNA Damage
Repair
Genomic Instability
ATM and ATR Kinases
Homologous Recombination
Cell Cycle Checkpoints
Cancer
Histone H2AX
Chromatin
Genome Stability

Research works: 56k
In the world top 10%: 5.5k
Top-10% rate: 9.9%
Growth, 2018-21 → 2022-25: -14%
Largest producer: United States

DNA Repair Mechanisms

Which countries lead DNA Repair Mechanisms research?

By volume, the United States and China publish the most (1.7k and 977 works in 2022-now).

By volume, 2022-now

1 United States 1.7k works
2 China 977 works
3 Japan 302 works
4 United Kingdom 290 works
5 France 242 works
6 Germany 238 works
7 India 215 works
8 Italy 153 works
9 Russia 145 works
10 Canada 132 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States1,663 · 38.2%China977 · 22.4%Japan302 · 6.9%United Kingdom290 · 6.7%6 others listed1,124 · 25.8%

Shares of the rows listed above, not of the whole node.

Which institutions lead DNA Repair Mechanisms research?

By volume in 2022-now, Centre National de la Recherche Scientifique publishes the most DNA Repair Mechanisms research, followed by Russian Academy of Sciences and National Institutes of Health.

By volume, 2022-now

1 Centre National de la Recherche ScientifiqueFrance 81 works
2 Russian Academy of SciencesRussia 70 works
3 National Institutes of HealthUnited States 68 works
4 Harvard UniversityUnited States 64 works
5 University of North Carolina at Chapel HillUnited States 48 works
6 Chinese Academy of SciencesChina 44 works
7 The University of Texas MD Anderson Cancer CenterUnited States 36 works
8 Peking UniversityChina 30 works
9 Sun Yat-sen UniversityChina 28 works
10 InsermFrance 28 works

Who are the leading researchers in DNA Repair Mechanisms?

The most-cited researchers publishing on DNA Repair Mechanisms include Eric S. Lander, Richard M. Durbin and Mark J. Daly.

1 Eric S. Lander United States 524k citations
2 Richard M. Durbin United Kingdom 410k citations
3 Mark J. Daly United States 403k citations
4 Stacey L. Gabriel United States 402k citations
5 Peer Bork Germany 396k citations
6 Guido Kroemer France 386k citations
7 Bert Vogelstein United States 373k citations
8 Gad A. Getz United States 364k citations
9 Elaine R. Mardis United States 346k citations
10 Hermann Brenner Germany 343k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in DNA Repair Mechanisms?

The most cited paper in DNA Repair Mechanisms is "The Hallmarks of Cancer" (Douglas Hanahan, Robert A. Weinberg, 2000), with 28,893 citations. Next come "A simple salting out procedure for extracting DNA from human nucleated cells" (20,633) and "Signatures of mutational processes in human cancer" (10,284).

Most cited papers
#	Paper	Released	Citations
1	The Hallmarks of Cancer Douglas Hanahan, Robert A. Weinberg · Cell Open access	2000	28,893
2	A simple salting out procedure for extracting DNA from human nucleated cells S.A. Miller, Dale D. Dykes, Herbert F. Polesky · Nucleic Acids Research Open access	1988	20,633
3	Signatures of mutational processes in human cancer Australian Pancreatic Cancer Genome Initiative et al. · Nature Open access	14 Aug 2013	10,284
4	Crystal structure of the nucleosome core particle at 2.8 Å resolution Karolin Luger, Armin W. Mäder, Robin K. Richmond et al. · Nature	Sep 1997	9,627
5	A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide Gels William M. Bonner, Ronald Alfred Laskey · European Journal of Biochemistry Open access	Jul 1974	8,651

All 100 most cited papers, with filters and sorting

Where is DNA Repair Mechanisms research done?

The largest centres of DNA Repair Mechanisms research in 2022-now are Beijing (China), Paris (France), New York (United States) and Shanghai (China). Among places with at least 20 works in it, it is an unusually large share of all research in Bethesda and Novosibirsk.

Largest cities, 2022-now

1 BeijingChina 143 works
2 ParisFrance 110 works
3 New YorkUnited States 110 works
4 ShanghaiChina 85 works
5 TokyoJapan 83 works
6 LondonUnited Kingdom 78 works
7 GuangzhouChina 68 works
8 MoscowRussia 65 works
9 HoustonUnited States 61 works
10 HangzhouChina 53 works

Where it is the local speciality

BethesdaUS · 52.5 works8.0×
NovosibirskRU · 37.8 works6.2×

← less than its size predicts1×more →

Location quotient: how much more of its research is in DNA Repair Mechanisms than the world average.

See DNA Repair Mechanisms on the map

Where is the best place to study DNA Repair Mechanisms?

Among universities, judged by research, Harvard University, Rockefeller University and Institute of Cancer Research score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged

40%

Specialisationhow much of its work is in this field, counted up to 10× the world share

10%

Sizeits output in this field, on a log scale

30%

Growthoutput growth, counted from -20% to +20%

10%

Internationalshare of its work with a co-author abroad

10%

Each slider sets a weight; the share it gets of the score is beside it.

#	University	Score	Top 10%	Specialisation	Works	Growth
1	Harvard UniversityUnited States	74.4	19.1%	4.2×	64	-23.3%
2	Rockefeller UniversityUnited States	67.1	21.9%	55.7×	16	+3.1%
3	Institute of Cancer ResearchUnited Kingdom	63.9	29.7%	53.9×	8	+4.6%
4	University of CambridgeUnited Kingdom	59.7	23.0%	3.3×	19	-15.6%
5	University of OxfordUnited Kingdom	57.9	17.7%	3.6×	24	-40.4%
6	Oncode InstituteNetherlands	53.7	20.3%	62.3×	8	-26.5%
7	University of BirminghamUnited Kingdom	53.0	18.7%	3.9×	12	+10.3%
8	University of SussexUnited Kingdom	51.0	23.8%	8.4×	10	-40.0%
9	Cornell UniversityUnited States	50.8	11.5%	4.3×	27	-13.7%
10	Stanford UniversityUnited States	50.6	16.3%	2.4×	17	-4.4%
11	University of CopenhagenDenmark	50.1	16.7%	4.0×	18	-27.5%
12	Peking UniversityChina	49.5	14.5%	3.1×	30	-4.8%
13	University of Massachusetts Chan Medical SchoolUnited States	49.0	19.9%	11.0×	9	+57.6%
14	Pennsylvania State UniversityUnited States	48.6	21.7%	2.9×	15	+9.3%
15	University of TorontoCanada	48.3	16.6%	2.0×	19	-11.7%
16	University of PennsylvaniaUnited States	47.0	17.0%	3.4×	17	-7.1%
17	Sichuan UniversityChina	45.9	16.5%	2.0×	22	+29.9%
18	Massachusetts Institute of TechnologyUnited States	45.4	13.9%	3.1×	10	-0.8%
19	Johns Hopkins UniversityUnited States	45.2	11.9%	3.2×	24	-26.0%
20	Ludwig-Maximilians-Universität MünchenGermany	45.1	26.2%	2.4×	10	-41.5%
21	University of PittsburghUnited States	44.5	11.8%	5.8×	22	-9.6%
22	Columbia UniversityUnited States	44.5	13.1%	4.1×	21	-26.5%
23	Zhejiang UniversityChina	43.6	12.9%	2.2×	28	-6.0%
24	The University of Texas at San AntonioUnited States	43.5	16.3%	8.6×	13	-29.4%
25	China Pharmaceutical UniversityChina	43.4	17.3%	7.7×	8	+58.0%
26	Washington University in St. LouisUnited States	42.8	10.8%	5.7×	20	-18.8%
27	Sun Yat-sen UniversityChina	42.7	13.1%	2.8×	28	-0.5%
28	Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina	42.3	10.3%	4.2×	21	+91.2%
29	University of North Carolina at Chapel HillUnited States	41.8	3.9%	5.6×	48	-63.9%
30	Leiden UniversityNetherlands	41.4	17.1%	4.5×	12	-3.8%
31	University of ZurichSwitzerland	41.2	15.8%	3.2×	11	-42.4%
32	Vanderbilt UniversityUnited States	41.0	14.6%	5.9×	20	-29.2%
33	University of California, San FranciscoUnited States	40.8	12.9%	3.5×	12	-3.3%
34	Southern Medical UniversityChina	39.0	15.7%	3.7×	11	+34.4%
35	Heidelberg UniversityGermany	38.8	14.6%	4.3×	16	-19.6%
36	Yale UniversityUnited States	38.5	8.3%	3.7×	19	-36.8%
37	University of EdinburghUnited Kingdom	38.5	9.8%	3.6×	15	-10.6%
38	New York UniversityUnited States	37.3	16.9%	2.7×	15	-38.1%
39	Central South UniversityChina	36.4	10.2%	1.9×	18	+27.2%
40	Karolinska InstitutetSweden	36.2	10.4%	4.6×	12	-38.3%
41	University of GroningenNetherlands	35.4	16.2%	2.5×	8	+3.5%
42	Shanghai Jiao Tong UniversityChina	33.3	7.1%	1.8×	25	+0.5%
43	Guiyang Medical UniversityChina	32.5	9.3%	9.5×	9	+114.7%
44	Brown UniversityUnited States	32.2	8.0%	4.5×	10	+57.2%
45	University College LondonUnited Kingdom	31.7	14.1%	1.3×	10	-5.5%
46	Wuhan UniversityChina	30.9	10.1%	1.9×	13	+21.6%
47	Oregon Health & Science UniversityUnited States	30.5	4.1%	6.3×	10	+47.3%
48	Imperial College LondonUnited Kingdom	30.5	15.6%	1.9×	9	-27.1%
49	University of California, RiversideUnited States	30.1	8.3%	8.0×	11	+5.0%
50	The University of Texas Medical Branch at GalvestonUnited States	29.0	4.9%	10.1×	9	+7.9%
51	University of Hong KongChina	23.6	9.9%	1.8×	8	-26.3%
52	Novosibirsk State UniversityRussia	13.3	2.9%	13.4×	9	-15.7%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in DNA Repair Mechanisms, country by country

Is DNA Repair Mechanisms research growing?

Output in 2022-2025 was 14% lower than in 2018-2021, peaking in 2013.

grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is DNA Repair Mechanisms as a percentage of every work published that year, 0.022% in 2024.

Fractional works of DNA Repair Mechanisms over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Discussion

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Which countries lead DNA Repair Mechanisms research?

By volume, 2022-now

How concentrated that is

Which institutions lead DNA Repair Mechanisms research?

By volume, 2022-now

Who are the leading researchers in DNA Repair Mechanisms?

What are the most cited papers in DNA Repair Mechanisms?

Where is DNA Repair Mechanisms research done?

Largest cities, 2022-now

Where it is the local speciality

Where is the best place to study DNA Repair Mechanisms?

Is DNA Repair Mechanisms research growing?

Its share of all research

How much of it reaches the world top 10%

Which topics inside it are moving

Related research

Discussion