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Topic · Molecular Biology

Epigenetics and DNA Methylation

Epigenetics and DNA Methylation is a research topic within Molecular Biology. Science Explorer counts 72k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers explores the diverse mechanisms and functional implications of epigenetic modifications, including DNA methylation, histone modification, and chromatin remodeling. It delves into the role of these modifications in various biological processes such as cancer development, transgenerational inheritance, and environmental responses. Additionally, it discusses the potential applications of epigenetic therapy.

  • DNA Methylation
  • Histone Modification
  • Epigenetic Reprogramming
  • Cancer Epigenetics
  • Transgenerational Inheritance
  • Chromatin Structure
  • TET Proteins
  • Polycomb Complexes
  • Environmental Epigenomics
  • Epigenetic Therapy
Research works
72k
fractional, since 1950
In the world top 10%
7.1k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
+4%
the tick is no change
Largest producer
China
42% of the 10 largest, 2022-now
Epigenetics and DNA Methylation

Which countries lead Epigenetics and DNA Methylation research?

By volume, China and the United States publish the most (5.5k and 4k works in 2022-now).

By volume, 2022-now

  1. 1 China 5.5k works
  2. 2 United States 4k works
  3. 3 Germany 608 works
  4. 4 Japan 574 works
  5. 5 India 561 works
  6. 6 United Kingdom 547 works
  7. 7 Italy 417 works
  8. 8 Canada 363 works
  9. 9 France 336 works
  10. 10 South Korea 311 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 41.6%United States: 30.4%Germany: 4.6%Japan: 4.3%6 others listed: 19.1%42%largest
China5,523 · 41.6%United States4,044 · 30.4%Germany608 · 4.6%Japan574 · 4.3%6 others listed2,536 · 19.1%

Shares of the rows listed above, not of the whole node.

Which institutions lead Epigenetics and DNA Methylation research?

By volume in 2022-now, Harvard University publishes the most Epigenetics and DNA Methylation research, followed by Sun Yat-sen University and Shanghai Jiao Tong University.

By volume, 2022-now

  1. 1 Harvard UniversityUnited States 192 works
  2. 2 Sun Yat-sen UniversityChina 158 works
  3. 3 Shanghai Jiao Tong UniversityChina 148 works
  4. 4 Chinese Academy of SciencesChina 142 works
  5. 5 National Institutes of HealthUnited States 127 works
  6. 6 Nanjing Medical UniversityChina 120 works
  7. 7 Zhejiang UniversityChina 120 works
  8. 8 Sichuan UniversityChina 119 works
  9. 9 Central South UniversityChina 116 works
  10. 10 University of North Carolina at Chapel HillUnited States 115 works

Who are the leading researchers in Epigenetics and DNA Methylation?

The most-cited researchers publishing on Epigenetics and DNA Methylation include Eric S. Lander, Rob Knight and George Davey Smith.

  1. 1 Eric S. Lander United States 524k citations
  2. 2 Rob Knight United States 468k citations
  3. 3 George Davey Smith United Kingdom 435k citations
  4. 4 Walter Churchill Willett United States 411k citations
  5. 5 Richard M. Durbin United Kingdom 410k citations
  6. 6 Mark J. Daly United States 403k citations
  7. 7 Stacey L. Gabriel United States 402k citations
  8. 8 Peer Bork Germany 396k citations
  9. 9 Julian P. T. Higgins United Kingdom 390k citations
  10. 10 Guido Kroemer France 386k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Epigenetics and DNA Methylation?

The most cited paper in Epigenetics and DNA Methylation is "Model-based Analysis of ChIP-Seq (MACS)" (Yong Zhang, Tao Liu, Clifford A. Meyer et al., 2008), with 20,527 citations. Next come "Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities" (14,980) and "A human gut microbial gene catalogue established by metagenomic sequencing" (11,892).

Most cited papers
#PaperReleasedCitations
1 Model-based Analysis of ChIP-Seq (MACS) Yong Zhang, Tao Liu, Clifford A. Meyer et al. · Genome biology Open access 17 Sep 2008 20,527
2 Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities Sven Heinz, Christopher W. Benner, Nathanael J. Spann et al. · Molecular Cell Open access May 2010 14,980
3 A human gut microbial gene catalogue established by metagenomic sequencing Junjie Qin et al. · Nature Open access Mar 2010 11,892
4 Developing and evaluating complex interventions: the new Medical Research Council guidance Peter Craig, Paul A Dieppe, Sally MacIntyre et al. · BMJ Open access 29 Sep 2008 11,477
5 Chromatin Modifications and Their Function Tony Kouzarides · Cell Open access Feb 2007 10,979
All 100 most cited papers, with filters and sorting

Where is Epigenetics and DNA Methylation research done?

The largest centres of Epigenetics and DNA Methylation research in 2022-now are Beijing (China), Shanghai (China), Guangzhou (China) and Wuhan (China). Among places with at least 20 works in it, it is an unusually large share of all research in Zunyi.

Largest cities, 2022-now

  1. 1 BeijingChina 602 works
  2. 2 ShanghaiChina 482 works
  3. 3 GuangzhouChina 407 works
  4. 4 WuhanChina 256 works
  5. 5 NanjingChina 234 works
  6. 6 HangzhouChina 225 works
  7. 7 New YorkUnited States 216 works
  8. 8 ChangshaChina 182 works
  9. 9 ChengduChina 172 works
  10. 10 LondonUnited Kingdom 169 works

Where it is the local speciality

  1. ZunyiCN · 22.0 works6.6×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Epigenetics and DNA Methylation than the world average.

See Epigenetics and DNA Methylation on the map

Where is the best place to study Epigenetics and DNA Methylation?

Among universities, judged by research, Harvard University, Sun Yat-sen University and Sichuan University score highest, combining citation excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%mean 15.05%fractional works in this field (log) →share of work in the world top 10% →Sun Yat-sen UniversitySichuan UniversityPeking UniversityHarvard University
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Citation excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Harvard UniversityUnited States 76.615.7%4.3×192 -12.3%
2Sun Yat-sen UniversityChina 73.216.9%5.4×158 +27.5%
3Sichuan UniversityChina 67.216.1%3.7×119 +82.5%
4Peking UniversityChina 66.316.1%3.5×100 +15.8%
5Shanghai Jiao Tong UniversityChina 63.912.6%3.6×148 +25.1%
6Macau University of Science and TechnologyChina 63.221.4%3.0×9 +172.5%
7Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina 63.114.5%6.1×91 +56.1%
8Central South UniversityChina 62.312.7%4.3×116 +30.2%
9Zhejiang UniversityChina 61.811.7%3.2×120 +26.9%
10Wuhan UniversityChina 60.912.8%4.8×96 +30.6%

Universities only. The score blends citation excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Epigenetics and DNA Methylation, country by country

Is Epigenetics and DNA Methylation research growing?

Output in 2022-2025 was 4% higher than in 2018-2021, peaking in 2022. The fastest-growing topics are Epigenetics and DNA Methylation.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Epigenetics and DNA Methylation as a percentage of every work published that year, 0.067% in 2024.

still counting0.050%0.10%Epigenetics and DNA Methylation0.063% in 202519801990200020102020

Fractional works of Epigenetics and DNA Methylation over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Epigenetics and DNA Methylation9.7% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Questions people ask

Who leads epigenetics research?

By volume in 2022-now, Harvard University publishes the most Epigenetics and DNA Methylation research, followed by Sun Yat-sen University and Shanghai Jiao Tong University. By volume, China and the United States publish the most (5.5k and 4k works in 2022-now).

All 1,273 questions in the Question Catalogue

Discussion

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