Topic · Epigenetics and DNA Methylation
Most cited papers in Epigenetics and DNA Methylation
What are the most cited papers in Epigenetics and DNA Methylation?
The most cited paper in Epigenetics and DNA Methylation is "Model-based Analysis of ChIP-Seq (MACS)" (Yong Zhang, Tao Liu, Clifford A. Meyer et al., 2008), with 20,527 citations. Next come "Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities" (14,980) and "A human gut microbial gene catalogue established by metagenomic sequencing" (11,892).
Showing 50 of 100 papers. Every paper with more than 3,177 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Model-based Analysis of ChIP-Seq (MACS) Yong Zhang, Tao Liu, Clifford A. Meyer et al. · Genome biology | 17 Sep 2008 | 20,527 |
| 2 | Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities Sven Heinz, Christopher W. Benner, Nathanael J. Spann et al. · Molecular Cell | May 2010 | 14,980 |
| 3 | A human gut microbial gene catalogue established by metagenomic sequencing Junjie Qin et al. · Nature | Mar 2010 | 11,892 |
| 4 | Developing and evaluating complex interventions: the new Medical Research Council guidance Peter Craig, Paul A Dieppe, Sally MacIntyre et al. · BMJ | 29 Sep 2008 | 11,477 |
| 5 | Chromatin Modifications and Their Function Tony Kouzarides · Cell | Feb 2007 | 10,979 |
| 6 | Translating the Histone Code Thomas Jenuwein, C. David Allis · Science | 10 Aug 2001 | 9,803 |
| 7 | Stem cells, cancer, and cancer stem cells Tannishtha Reya, Sean J. Morrison, Michael F. Clarke et al. · Nature | Nov 2001 | 9,797 |
| 8 | Hallmarks of Cancer: New Dimensions Douglas Hanahan · Cancer Discovery | 2022 | 9,794 |
| 9 | Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy Shikshya Shrestha, Steven M. Offer · Medical Epigenetics | 23 Mar 2016 | 8,958 |
| 10 | WAF1, a potential mediator of p53 tumor suppression Wafik S. El‐Deiry, Takashi Tokino, Victor E. Velculescu et al. · Cell | Nov 1993 | 8,417 |
| 11 | Cancer Genome Landscapes Bert Vogelstein, Nickolas Papadopoulos, Victor E. Velculescu et al. · Science | 28 Mar 2013 | 8,204 |
| 12 | Comprehensive genomic characterization defines human glioblastoma genes and core pathways Roger E. McLendon et al. · Nature | 4 Sep 2008 | 7,893 |
| 13 | p53, the Cellular Gatekeeper for Growth and Division Arnold J. Levine · Cell | Feb 1997 | 7,766 |
| 14 | DNA methylation age of human tissues and cell types Steve Horvath · Genome biology | 20 Oct 2013 | 7,572 |
| 15 | Identification of human brain tumour initiating cells Sheila Kumari Singh, Cynthia E Hawkins, Ian D. Clarke et al. · Nature | Nov 2004 | 7,487 |
| 16 | MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma Monika E. Hegi, Annie‐Claire Diserens, Thierry Gorlia et al. · New England Journal of Medicine | 9 Mar 2005 | 7,397 |
| 17 | Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position Jason Daniel Buenrostro, Paul G. Giresi, Lisa C. Zaba et al. · Nature Methods | 6 Oct 2013 | 7,255 |
| 18 | Integrative analysis of 111 reference human epigenomes Anshul Kundaje et al. · Nature | 17 Feb 2015 | 7,245 |
| 19 | DNA methylation patterns and epigenetic memory Adrian Peter Bird · Genes & Development | 2002 | 7,213 |
| 20 | A metagenome-wide association study of gut microbiota in type 2 diabetes Junjie Qin et al. · Nature | 25 Sep 2012 | 7,088 |
| 21 | High-Resolution Profiling of Histone Methylations in the Human Genome Artem Barski, Suresh Cuddapah, Kairong Cui et al. · Cell | May 2007 | 7,037 |
| 22 | Surfing the p53 network Bert Vogelstein, David Philip Lane, Arnold J. Levine · Nature | Nov 2000 | 6,649 |
| 23 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals Rudolf Jaenisch, Adrian Peter Bird · Nature Genetics | 27 Feb 2003 | 6,397 |
| 24 | Functions of DNA methylation: islands, start sites, gene bodies and beyond Peter Anthony Jones · Nature Reviews Genetics | 29 May 2012 | 6,369 |
| 25 | Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences | 6 Jun 1995 | 6,278 |
| 26 | Epigenetic programming by maternal behavior Ian C.G. Weaver, Nadia Cervoni, Frances A. Champagne et al. · Nature Neuroscience | 27 Jun 2004 | 6,205 |
| 27 | The Emerging Hallmarks of Cancer Metabolism Natalya N. Pavlova, Craig B. Thompson · Cell Metabolism | 2016 | 6,192 |
| 28 | DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development Masaki Okano, Daphne W. Bell, Daniel A. Haber et al. · Cell | Oct 1999 | 6,189 |
| 29 | Regulation of chromatin by histone modifications Andrew J. Bannister, Tony Kouzarides · Cell Research | 15 Feb 2011 | 6,138 |
| 30 | Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications Felix Krueger, Simon Andrews · Bioinformatics | 14 Apr 2011 | 6,026 |
| 31 | Notch Signaling: Cell Fate Control and Signal Integration in Development Spyros Artavanis‐Tsakonas, Matthew D. Rand, Robert J. Lake · Science | 30 Apr 1999 | 5,977 |
| 32 | Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1 Mamta Tahiliani, Kian Peng Koh, Yinghua Shen et al. · Science | 16 Apr 2009 | 5,936 |
| 33 | The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases J. Wade Harper · Cell | 19 Nov 1993 | 5,700 |
| 34 | The fundamental role of epigenetic events in cancer Peter Anthony Jones, Stephen B. Baylin · Nature Reviews Genetics | Jun 2002 | 5,697 |
| 35 | Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. James Gordon Herman, Jeremy Richard Graff, Sanna Myöhänen et al. · Proceedings of the National Academy of Sciences | 3 Sep 1996 | 5,687 |
| 36 | Maftools: efficient and comprehensive analysis of somatic variants in cancer Anand Mayakonda, De‐Chen Lin, Yassen Assenov et al. · Genome Research | 19 Oct 2018 | 5,587 |
| 37 | Cerebral organoids model human brain development and microcephaly Madeline A. Lancaster, Magdalena Renner, Carol-Anne Martin et al. · Nature | 27 Aug 2013 | 5,545 |
| 38 | A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells B Bernstein, Tarjei S. Mikkelsen, Xiaohui S. Xie et al. · Cell | Apr 2006 | 5,522 |
| 39 | Cancer Cell Cycles Charles J. Sherr · Science | 6 Dec 1996 | 5,411 |
| 40 | THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE Catriona Y. Logan, Roel Nusse · Annual Review of Cell and Developmental Biology | 8 Oct 2004 | 5,350 |
| 41 | Macrophage Diversity Enhances Tumor Progression and Metastasis Bin‐Zhi Qian, Jeffrey W. Pollard · Cell | Apr 2010 | 5,286 |
| 42 | p53, guardian of the genome David Philip Lane · Nature | Jul 1992 | 5,171 |
| 43 | DNA Methylation and Its Basic Function Lisa Dorothy Moore, Thuc T. Le, Guoping Fan · Neuropsychopharmacology | 11 Jul 2012 | 5,095 |
| 44 | Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 Ruthie E. Amir, Ignatia B. Van den Veyver, Mimi Wan et al. · Nature Genetics | Oct 1999 | 5,086 |
| 45 | Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays Martin J. Aryee, Andrew E. Jaffe, Héctor Corrada Bravo et al. · Bioinformatics | 28 Jan 2014 | 4,956 |
| 46 | Human DNA methylomes at base resolution show widespread epigenomic differences Ryan Lister, Mattia Pelizzola, Robert H. Dowen et al. · Nature | 14 Oct 2009 | 4,857 |
| 47 | Gut microbiota in human metabolic health and disease Yong Fan, Oluf Borbye Pedersen · Nature Reviews Microbiology | 4 Sep 2020 | 4,818 |
| 48 | TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data Antonio Colaprico, Tiago C. Silva, Catharina Olsen et al. · Nucleic Acids Research | 23 Dec 2015 | 4,660 |
| 49 | Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates Gregory Hannum, Justin Guinney, Ling Zhao et al. · Molecular Cell | 21 Nov 2012 | 4,654 |
| 50 | Histone H3K27ac separates active from poised enhancers and predicts developmental state Menno P. Creyghton, Albert W. Cheng, G. Grant Welstead et al. · Proceedings of the National Academy of Sciences | 24 Nov 2010 | 4,654 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.