Mitochondrial Function and Pathology

Mitochondrial Function and Pathology is a research topic within Molecular Biology. Science Explorer counts 84k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the dynamics of mitochondria, the production and regulation of reactive oxygen species (ROS), and their implications in various biological processes such as aging, neurodegenerative diseases, and metabolic regulation. The papers cover topics including mitochondrial fusion and fission, oxidative stress, mitochondrial dysfunction, and the role of mitochondria in cell death.

Mitochondria
Reactive Oxygen Species
Oxidative Stress
Mitochondrial Dysfunction
Cell Death
Mitochondrial Fusion
Mitochondrial Fission
Aging
Neurodegenerative Diseases
Metabolic Regulation

Research works: 84k
In the world top 10%: 8.3k
Top-10% rate: 9.9%
Growth, 2018-21 → 2022-25: +8%
Largest producer: United States

Mitochondrial Function and Pathology

Which countries lead Mitochondrial Function and Pathology research?

By volume, the United States and China publish the most (3.3k and 2.8k works in 2022-now).

By volume, 2022-now

1 United States 3.3k works
2 China 2.8k works
3 India 552 works
4 Germany 548 works
5 Japan 498 works
6 United Kingdom 498 works
7 Italy 480 works
8 France 359 works
9 Canada 334 works
10 Russia 300 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

United States3,329 · 34.2%China2,830 · 29.1%India552 · 5.7%Germany548 · 5.6%6 others listed2,469 · 25.4%

Shares of the rows listed above, not of the whole node.

Which institutions lead Mitochondrial Function and Pathology research?

By volume in 2022-now, Harvard University publishes the most Mitochondrial Function and Pathology research, followed by Russian Academy of Sciences and Centre National de la Recherche Scientifique.

By volume, 2022-now

1 Harvard UniversityUnited States 110 works
2 Russian Academy of SciencesRussia 109 works
3 Centre National de la Recherche ScientifiqueFrance 104 works
4 National Institutes of HealthUnited States 91 works
5 Chinese Academy of SciencesChina 75 works
6 Zhejiang UniversityChina 68 works
7 InsermFrance 66 works
8 Shanghai Jiao Tong UniversityChina 64 works
9 University College LondonUnited Kingdom 63 works
10 Johns Hopkins UniversityUnited States 58 works

Who are the leading researchers in Mitochondrial Function and Pathology?

The most-cited researchers publishing on Mitochondrial Function and Pathology include Eric S. Lander, George Davey Smith and Richard M. Durbin.

1 Eric S. Lander United States 524k citations
2 George Davey Smith United Kingdom 435k citations
3 Richard M. Durbin United Kingdom 410k citations
4 Mark J. Daly United States 403k citations
5 Stacey L. Gabriel United States 402k citations
6 Peer Bork Germany 396k citations
7 Guido Kroemer France 386k citations
8 Bert Vogelstein United States 373k citations
9 Gad A. Getz United States 364k citations
10 Elaine R. Mardis United States 346k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Mitochondrial Function and Pathology?

The most cited paper in Mitochondrial Function and Pathology is "The Hallmarks of Aging" (Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al., 2013), with 15,388 citations. Next come "Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees." (11,497) and "Tandem repeats finder: a program to analyze DNA sequences" (10,129).

Most cited papers
#	Paper	Released	Citations
1	The Hallmarks of Aging Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al. · Cell Open access	Jun 2013	15,388
2	Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. Koichiro Tamura, M Nei · Molecular Biology and Evolution Open access	May 1993	11,497
3	Tandem repeats finder: a program to analyze DNA sequences Gary Benson · Nucleic Acids Research Open access	1999	10,129
4	Sequence and organization of the human mitochondrial genome Stephen K. Anderson, Alan T. Bankier, B. G. Barrell et al. · Nature	Apr 1981	9,759
5	Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Yael Gavrieli, Yoav Sherman, Shmuel A. Ben‐Sasson · The Journal of Cell Biology Open access	Nov 1992	9,552

All 99 most cited papers, with filters and sorting

Where is Mitochondrial Function and Pathology research done?

The largest centres of Mitochondrial Function and Pathology research in 2022-now are Beijing (China), Shanghai (China), Paris (France) and Guangzhou (China). Among places with at least 20 works in it, it is an unusually large share of all research in Pushchino, Oklahoma City and Luzhou.

Largest cities, 2022-now

1 BeijingChina 373 works
2 ShanghaiChina 211 works
3 ParisFrance 176 works
4 GuangzhouChina 168 works
5 LondonUnited Kingdom 161 works
6 MoscowRussia 158 works
7 TokyoJapan 137 works
8 HangzhouChina 132 works
9 New YorkUnited States 130 works
10 WuhanChina 121 works

Where it is the local speciality

PushchinoRU · 24.5 works28×
Oklahoma CityUS · 23.6 works7.4×
LuzhouCN · 20.8 works6.7×

← less than its size predicts1×more →

Location quotient: how much more of its research is in Mitochondrial Function and Pathology than the world average.

See Mitochondrial Function and Pathology on the map

Where is the best place to study Mitochondrial Function and Pathology?

Among universities, judged by research, Harvard University, Wuhan University and University of Cambridge score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged

40%

Specialisationhow much of its work is in this field, counted up to 10× the world share

10%

Sizeits output in this field, on a log scale

30%

Growthoutput growth, counted from -20% to +20%

10%

Internationalshare of its work with a co-author abroad

10%

Each slider sets a weight; the share it gets of the score is beside it.

#	University	Score	Top 10%	Specialisation	Works	Growth
1	Harvard UniversityUnited States	78.8	15.9%	3.2×	110	+1.7%
2	Wuhan UniversityChina	74.8	25.5%	3.2×	49	+58.9%
3	University of CambridgeUnited Kingdom	68.8	20.2%	4.4×	57	-31.1%
4	Sichuan UniversityChina	68.6	22.1%	2.3×	56	+55.7%
5	University of California, BerkeleyUnited States	68.5	23.2%	2.2×	23	+52.8%
6	McGill UniversityCanada	67.0	16.3%	3.4×	37	+17.9%
7	Washington University in St. LouisUnited States	66.0	18.0%	4.0×	32	+30.9%
8	University of CologneGermany	65.6	16.1%	7.2×	34	+40.5%
9	Northwestern UniversityUnited States	65.3	15.7%	3.2×	30	+17.4%
10	University of BaselSwitzerland	64.2	16.3%	3.1×	13	+26.8%
11	Zhejiang UniversityChina	64.1	14.3%	2.3×	68	+34.1%
12	Stanford UniversityUnited States	64.1	12.8%	2.3×	37	+37.5%
13	Nanjing Medical UniversityChina	63.9	18.7%	5.0×	49	+44.1%
14	Johns Hopkins UniversityUnited States	62.4	10.0%	3.5×	58	-3.1%
15	Beijing University of Chinese MedicineChina	61.5	26.4%	5.9×	15	+66.7%
16	University College LondonUnited Kingdom	61.3	12.5%	3.6×	63	-8.1%
17	Sun Yat-sen UniversityChina	60.9	14.7%	2.2×	50	+24.5%
18	Central South UniversityChina	60.7	15.7%	2.7×	56	+27.2%
19	Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina	60.3	14.6%	4.4×	51	+92.8%
20	Albert Einstein College of MedicineUnited States	59.7	19.3%	4.0×	15	+39.8%
21	Peking UniversityChina	59.3	14.2%	2.2×	50	+24.7%
22	Hunan University of Traditional Chinese MedicineChina	59.3	22.5%	12.5×	10	+234.1%
23	University of PennsylvaniaUnited States	59.0	11.5%	4.0×	46	+10.8%
24	Southeast UniversityChina	58.9	28.0%	0.8×	14	+50.8%
25	Shanghai University of Traditional Chinese MedicineChina	58.8	24.1%	4.3×	13	+190.1%
26	University of South ChinaChina	58.4	20.7%	5.2×	15	+99.8%
27	Shanghai Jiao Tong UniversityChina	57.6	12.7%	2.0×	64	+33.3%
28	Massachusetts Institute of TechnologyUnited States	57.5	17.7%	1.4×	11	+25.5%
29	Soochow UniversityChina	57.0	13.0%	3.9×	42	+169.2%
30	University of OxfordUnited Kingdom	56.6	12.3%	1.9×	28	+16.6%
31	University of RochesterUnited States	56.5	11.5%	5.3×	26	+24.3%
32	Cornell UniversityUnited States	56.4	9.8%	2.5×	36	+3.5%
33	Fudan UniversityChina	56.2	14.4%	2.7×	46	+13.9%
34	Capital Medical UniversityChina	55.7	12.7%	4.5×	52	+27.1%
35	University of MichiganUnited States	54.9	9.3%	2.6×	44	+52.6%
36	University of California San DiegoUnited States	54.5	9.1%	4.5×	48	-3.3%
37	University of California, San FranciscoUnited States	54.4	12.5%	3.3×	26	+11.2%
38	Chongqing Medical UniversityChina	54.0	15.2%	5.1×	32	+82.3%
39	California Institute of TechnologyUnited States	54.0	7.2%	2.9×	11	+46.0%
40	Air Force Medical UniversityChina	53.9	16.1%	12.2×	22	+23.1%
41	Jiangsu UniversityChina	52.1	26.4%	1.1×	10	+283.9%
42	École Polytechnique Fédérale de LausanneSwitzerland	51.9	16.6%	2.4×	11	-9.9%
43	University of KaiserslauternGermany	50.4	17.9%	7.5×	8	+47.4%
44	Karolinska InstitutetSweden	48.5	10.4%	3.7×	23	-25.7%
45	University of Hong KongChina	47.9	13.5%	1.8×	18	+16.5%
46	Moscow State UniversityTajikistan	45.0	7.8%	3.6×	10	+101.7%
47	Heilongjiang University of Chinese MedicineChina	44.7	18.5%	8.9×	9	-
48	University of GenevaSwitzerland	42.1	7.7%	2.1×	9	+14.6%
49	University of Arkansas for Medical SciencesUnited States	41.8	9.0%	8.7×	14	+48.0%
50	SUNY Upstate Medical UniversityUnited States	41.1	8.9%	10.3×	14	+71.2%
51	University of South AlabamaUnited States	40.4	8.8%	9.4×	9	+61.5%
52	Gdańsk Medical UniversityPoland	35.4	11.6%	7.4×	10	+27.6%
53	National University of SingaporeSingapore	33.5	10.2%	1.1×	14	-25.7%
54	Medical College of WisconsinUnited States	33.1	3.3%	7.8×	24	-16.1%
55	Imperial College LondonUnited Kingdom	30.9	14.0%	1.1×	11	-27.9%
56	Maastricht UniversityNetherlands	25.9	7.3%	2.1×	9	-27.7%
57	Chinese University of Hong KongChina	25.2	9.1%	1.2×	10	-22.6%
58	University of BernSwitzerland	23.6	8.9%	1.6×	9	-21.6%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Mitochondrial Function and Pathology, country by country

Is Mitochondrial Function and Pathology research growing?

Output in 2022-2025 was 8% higher than in 2018-2021, peaking in 2025. The fastest-growing topics are Mitochondrial Function and Pathology.

grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Mitochondrial Function and Pathology as a percentage of every work published that year, 0.055% in 2024.

Fractional works of Mitochondrial Function and Pathology over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

Discussion

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Which countries lead Mitochondrial Function and Pathology research?

By volume, 2022-now

How concentrated that is

Which institutions lead Mitochondrial Function and Pathology research?

By volume, 2022-now

Who are the leading researchers in Mitochondrial Function and Pathology?

What are the most cited papers in Mitochondrial Function and Pathology?

Where is Mitochondrial Function and Pathology research done?

Largest cities, 2022-now

Where it is the local speciality

Where is the best place to study Mitochondrial Function and Pathology?

Is Mitochondrial Function and Pathology research growing?

Its share of all research

How much of it reaches the world top 10%

Which topics inside it are moving

Related research

Discussion