Most cited papers in Mitochondrial Function and Pathology
What are the most cited papers in Mitochondrial Function and Pathology?
The most cited paper in Mitochondrial Function and Pathology is "The Hallmarks of Aging" (Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al., 2013), with 15,388 citations. Next come "Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees." (11,497) and "Tandem repeats finder: a program to analyze DNA sequences" (10,129).
Showing 50 of 99 papers. Every paper with more than 2,373 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | The Hallmarks of Aging Carlos López-Otı́n, Marı́a A. Blasco, Linda Partridge et al. · Cell | Jun 2013 | 15,388 |
| 2 | Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. Koichiro Tamura, M Nei · Molecular Biology and Evolution | May 1993 | 11,497 |
| 3 | Tandem repeats finder: a program to analyze DNA sequences Gary Benson · Nucleic Acids Research | 1999 | 10,129 |
| 4 | Sequence and organization of the human mitochondrial genome Stephen K. Anderson, Alan T. Bankier, B. G. Barrell et al. · Nature | Apr 1981 | 9,759 |
| 5 | Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Yael Gavrieli, Yoav Sherman, Shmuel A. Ben‐Sasson · The Journal of Cell Biology | Nov 1992 | 9,552 |
| 6 | Biochemistry and molecular cell biology of diabetic complications Michael Brownlee · Nature | 13 Dec 2001 | 9,153 |
| 7 | Mitochondria and Apoptosis Douglas R. Green, John C. Reed · Science | 28 Aug 1998 | 9,050 |
| 8 | How mitochondria produce reactive oxygen species Michael P. Murphy · Biochemical Journal | 12 Dec 2008 | 8,245 |
| 9 | Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Charles E. Murry, Robert B. Jennings, K A Reimer · Circulation | Nov 1986 | 7,857 |
| 10 | Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade Peng Li, Deepak Nijhawan, I. Imawati Budihardjo et al. · Cell | Nov 1997 | 7,307 |
| 11 | Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Daniel R. Rosen et al. · Nature | Mar 1993 | 7,116 |
| 12 | Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Michael T. S. Lin, M. Flint Beal · Nature | Oct 2006 | 6,522 |
| 13 | Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences | 6 Jun 1995 | 6,278 |
| 14 | Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release Dmitry B. Zorov, Magdalena Juhaszova, Steven J. Sollott · Physiological Reviews | Jul 2014 | 5,423 |
| 15 | Distantly related sequences in the alpha‐ and beta‐subunits of ATP synthase, myosin, kinases and other ATP‐requiring enzymes and a common nucleotide binding fold. John E. Walker, M Saraste, M J Runswick et al. · The EMBO Journal | Aug 1982 | 5,355 |
| 16 | THE HEAT-SHOCK PROTEINS S Lindquist, Elizabeth A. Craig · Annual Review of Genetics | Dec 1988 | 5,335 |
| 17 | Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers. Thomas D. Kocher, W. Kelley Thomas, Axel Meyer et al. · Proceedings of the National Academy of Sciences | Aug 1989 | 5,071 |
| 18 | Copper induces cell death by targeting lipoylated TCA cycle proteins Peter Tsvetkov, Shannon Coy, Boryana Petrova et al. · Science | 17 Mar 2022 | 5,017 |
| 19 | Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked Jie Yang, Xuesong Liu, Kapil N. Bhalla et al. · Science | 21 Feb 1997 | 4,964 |
| 20 | Why do cancers have high aerobic glycolysis? Robert A. Gatenby, Robert J. Gillies · Nature reviews. Cancer | Nov 2004 | 4,841 |
| 21 | The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis Ruth M. Kluck, Ella Bossy‐Wetzel, Douglas R. Green et al. · Science | 21 Feb 1997 | 4,758 |
| 22 | Caspases: the executioners of apoptosis Gerald M. Cohen · Biochemical Journal | 15 Aug 1997 | 4,755 |
| 23 | Cell Death Nika N. Danial, Stanley J. Korsmeyer · Cell | 2004 | 4,675 |
| 24 | Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis Honglin Li, Hong Zhu, Chi-jie Xu et al. · Cell | Aug 1998 | 4,466 |
| 25 | Mitochondria, Oxidants, and Aging Robert S. Balaban, Shino Nemoto, Toren Finkel · Cell | Feb 2005 | 4,416 |
| 26 | Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005–2009 Anne T. Berg, Samuel Frank Berkovic, Martin J. Brodie et al. · Epilepsia | 26 Feb 2010 | 4,391 |
| 27 | Mitochondrial formation of reactive oxygen species Julio F. Turrens · The Journal of Physiology | 25 Aug 2003 | 4,379 |
| 28 | The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation Ralph J. DeBerardinis, Julian J. Lum, Georgia Hatzivassiliou et al. · Cell Metabolism | 2008 | 4,188 |
| 29 | Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 Zhidan Wu, Pere Puigserver, Ulf Andersson et al. · Cell | Jul 1999 | 4,156 |
| 30 | THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons Kozi Asada · Annual Review of Plant Physiology and Plant Molecular Biology | Jun 1999 | 4,091 |
| 31 | Parkin is recruited selectively to impaired mitochondria and promotes their autophagy Derek P. Narendra, Atsushi Tanaka, Der‐Fen Suen et al. · The Journal of Cell Biology | 24 Nov 2008 | 4,074 |
| 32 | The Bcl2 family: regulators of the cellular life-or-death switch Suzanne Cory, Jerry M. Adams · Nature reviews. Cancer | Sep 2002 | 4,029 |
| 33 | Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death Michael C. Wei, Wei‐Xing Zong, Emily H. Cheng et al. · Science | 27 Apr 2001 | 3,999 |
| 34 | Animal mitochondrial genomes Jeffrey L. Boore · Nucleic Acids Research | Apr 1999 | 3,850 |
| 35 | Oxidative Stress, Glutamate, and Neurodegenerative Disorders Joseph T. Coyle, Pamela S. Puttfarcken · Science | 29 Oct 1993 | 3,800 |
| 36 | Activation of apoptosis signalling pathways by reactive oxygen species Maureen Redza-Dutordoir, Diana A. Averill‐Bates · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | 17 Sep 2016 | 3,794 |
| 37 | Mitochondrial Fission, Fusion, and Stress Richard J. Youle, Alexander M. van der Bliek · Science | 30 Aug 2012 | 3,720 |
| 38 | Hypoxia-Inducible Factors in Physiology and Medicine Gregg L. Semenza · Cell | Feb 2012 | 3,632 |
| 39 | Mitochondrial Membrane Permeabilization in Cell Death Guido Kroemer, Lorenzo Galluzzi, Catherine Brenner · Physiological Reviews | 2007 | 3,622 |
| 40 | Mitochondria: In Sickness and in Health Jodi M. Nunnari, Anu Suomalainen · Cell | Mar 2012 | 3,549 |
| 41 | Otto Warburg's contributions to current concepts of cancer metabolism Willem Hendrik Koppenol, Patricia L. Bounds, Chi V. Dang · Nature reviews. Cancer | 14 Apr 2011 | 3,514 |
| 42 | Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition Chunying Du, Min Hui Fang, Yucheng Li et al. · Cell | Jul 2000 | 3,499 |
| 43 | Rapid evolution of animal mitochondrial DNA. Wesley M. Brown, M George, Alex C. C. Wilson · Proceedings of the National Academy of Sciences | Apr 1979 | 3,492 |
| 44 | Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA Richard M. Andrews, Iwona Kubacka, Patrick Francis Chinnery et al. · Nature Genetics | Oct 1999 | 3,434 |
| 45 | The Pathophysiology of Mitochondrial Cell Death Douglas R. Green, Guido Kroemer · Science | 30 Jul 2004 | 3,411 |
| 46 | C. elegans : des neurones et des gènes Christelle Gally, Jean‐Louis Bessereau · médecine/sciences | Jun 2003 | 3,405 |
| 47 | Robbins and Cotran Pathologic Basis of Disease Syed A. Hoda, Raza S. Hoda · American Journal of Clinical Pathology | 13 Aug 2020 | 3,387 |
| 48 | C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation Andrew C.R. Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell | Oct 2001 | 3,373 |
| 49 | Architecture of the Photosynthetic Oxygen-Evolving Center Kristina N. Ferreira, T.M. Iverson, Karim Maghlaoui et al. · Science | 9 Feb 2004 | 3,351 |
| 50 | Protein Oxidation in Aging, Disease, and Oxidative Stress Barbara S. Berlett, Earl R. Stadtman · Journal of Biological Chemistry | Aug 1997 | 3,338 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for a field when OpenAlex files it under one of the field's topics; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.