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Topic · Molecular Biology

Microbial Metabolic Engineering and Bioproduction

Microbial Metabolic Engineering and Bioproduction is a research topic within Molecular Biology. Science Explorer counts 63k research works in it since 1950. 9.9% of them reached the world's top 10% most cited for their field and year.

This cluster of papers focuses on the field of metabolic engineering and synthetic biology, with an emphasis on genome-scale models, constraint-based models, and their application in biofuel production, microbial metabolism, pathway reconstruction, and biorefineries. The papers cover topics such as flux balance analysis, high-quality genome-scale metabolic reconstructions, programming cells for accelerated evolution, and the use of synthetic protein scaffolds to control metabolic flux.

  • Metabolic Engineering
  • Genome-Scale Models
  • Constraint-Based Models
  • Biofuel Production
  • Microbial Metabolism
  • Pathway Reconstruction
  • Flux Balance Analysis
  • Biorefineries
  • Synthetic Biology
  • Enzyme Database
Research works
63k
fractional, since 1950
In the world top 10%
6.3k
per year above
Top-10% rate
9.9%
share of its works in the world top 10%
Growth, 2018-21 → 2022-25
-3%
the tick is no change
Largest producer
China
38% of the 10 largest, 2022-now
Microbial Metabolic Engineering and Bioproduction

Which countries lead Microbial Metabolic Engineering and Bioproduction research?

By volume, China and the United States publish the most (2.6k and 1.1k works in 2022-now).

By volume, 2022-now

  1. 1 China 2.6k works
  2. 2 United States 1.1k works
  3. 3 India 912 works
  4. 4 Germany 534 works
  5. 5 Brazil 315 works
  6. 6 Japan 298 works
  7. 7 South Korea 290 works
  8. 8 United Kingdom 280 works
  9. 9 France 269 works
  10. 10 Spain 230 works

How concentrated that is

The same countries as shares of everything the list above accounts for. A node where two countries do two thirds of the work and one spread evenly across twelve read alike as a ranking and not at all alike here.

China: 37.5%United States: 16.8%India: 13.3%Germany: 7.8%6 others listed: 24.6%38%largest
China2,570 · 37.5%United States1,148 · 16.8%India912 · 13.3%Germany534 · 7.8%6 others listed1,683 · 24.6%

Shares of the rows listed above, not of the whole node.

Which institutions lead Microbial Metabolic Engineering and Bioproduction research?

By volume in 2022-now, Chinese Academy of Sciences publishes the most Microbial Metabolic Engineering and Bioproduction research, followed by Jiangnan University and Centre National de la Recherche Scientifique.

By volume, 2022-now

  1. 1 Chinese Academy of SciencesChina 218 works
  2. 2 Jiangnan UniversityChina 195 works
  3. 3 Centre National de la Recherche ScientifiqueFrance 77 works
  4. 4 Russian Academy of SciencesRussia 67 works
  5. 5 East China University of Science and TechnologyChina 64 works
  6. 6 Technical University of DenmarkDenmark 59 works
  7. 7 Chinese Academy of Agricultural SciencesChina 56 works
  8. 8 Helmholtz Association of German Research CentresGermany 54 works
  9. 9 Nanjing Tech UniversityChina 53 works
  10. 10 Beijing University of Chemical TechnologyChina 52 works

Who are the leading researchers in Microbial Metabolic Engineering and Bioproduction?

The most-cited researchers publishing on Microbial Metabolic Engineering and Bioproduction include Rob Knight, George Davey Smith and Richard M. Durbin.

  1. 1 Rob Knight United States 468k citations
  2. 2 George Davey Smith United Kingdom 435k citations
  3. 3 Richard M. Durbin United Kingdom 410k citations
  4. 4 Peer Bork Germany 396k citations
  5. 5 Steven L. Salzberg United States 372k citations
  6. 6 Jun Wang China 340k citations
  7. 7 Matthias Mann Germany 308k citations
  8. 8 Sudhir Kumar United States 295k citations
  9. 9 Chris Sander United States 276k citations
  10. 10 Heng Li United States 270k citations

Ranked by citations received across their whole record, among researchers with at least three works on this topic.

What are the most cited papers in Microbial Metabolic Engineering and Bioproduction?

The most cited paper in Microbial Metabolic Engineering and Bioproduction is "Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks" (Paul T. Shannon, Andrew Markiel, Owen W. Ozier et al., 2003), with 55,788 citations. Next come "Gene Ontology: tool for the unification of biology" (45,425) and "KEGG: Kyoto Encyclopedia of Genes and Genomes" (40,289).

Most cited papers
#PaperReleasedCitations
1 Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks Paul T. Shannon, Andrew Markiel, Owen W. Ozier et al. · Genome Research Open access Nov 2003 55,788
2 Gene Ontology: tool for the unification of biology Michael Ashburner, Catherine A. Ball, Judith A. Blake et al. · Nature Genetics Open access May 2000 45,425
3 KEGG: Kyoto Encyclopedia of Genes and Genomes Minoru I. Kanehisa · Nucleic Acids Research Open access 2000 40,289
4 KEGG: Kyoto Encyclopedia of Genes and Genomes Hiroyuki Ogata, Susumu Goto, Kazushige Sato et al. · Nucleic Acids Research Open access 1999 32,529
5 Coot : model-building tools for molecular graphics Paul Emsley, Kevin D. Cowtan · Acta Crystallographica Section D Biological Crystallography Open access 26 Nov 2004 31,846
All 98 most cited papers, with filters and sorting

Where is Microbial Metabolic Engineering and Bioproduction research done?

The largest centres of Microbial Metabolic Engineering and Bioproduction research in 2022-now are Beijing (China), Wuxi (China), Nanjing (China) and Shanghai (China). Among places with at least 20 works in it, it is an unusually large share of all research in Wuxi, Kongens Lyngby and Jülich.

Largest cities, 2022-now

  1. 1 BeijingChina 409 works
  2. 2 WuxiChina 228 works
  3. 3 NanjingChina 187 works
  4. 4 ShanghaiChina 184 works
  5. 5 TianjinChina 157 works
  6. 6 HangzhouChina 129 works
  7. 7 SeoulSouth Korea 117 works
  8. 8 GuangzhouChina 100 works
  9. 9 ParisFrance 97 works
  10. 10 WuhanChina 97 works

Where it is the local speciality

  1. WuxiCN · 227.8 works25×
  2. Kongens LyngbyDK · 59.1 works12×
  3. JülichDE · 26.0 works11×
  4. WageningenNL · 29.1 works7.8×
  5. BielefeldDE · 20.7 works7.5×
← less than its size predicts1×more →

Location quotient: how much more of its research is in Microbial Metabolic Engineering and Bioproduction than the world average.

See Microbial Metabolic Engineering and Bioproduction on the map

Where is the best place to study Microbial Metabolic Engineering and Bioproduction?

Among universities, judged by research, Jiangnan University, Korea Advanced Institute of Science and Technology and Chalmers University of Technology score highest, combining excellence, specialisation, size, growth and international reach. Research strength is one signal when choosing where to study; it does not measure teaching.

0%10%20%30%mean 17.44%fractional works in this field (log) →share of work in the world top 10% →Korea Advanced Insti…Jiangnan UniversityChalmers University …Technical University…
above the meannear itbelow it

One dot per university in the first ten of the table below, at the default weights. The upper left is the interesting corner: small places doing unusually strong work.

Excellenceshare of its work in the world top 10%, 2022-now and all time averaged
40%
Specialisationhow much of its work is in this field, counted up to 10× the world share
10%
Sizeits output in this field, on a log scale
30%
Growthoutput growth, counted from -20% to +20%
10%
Internationalshare of its work with a co-author abroad
10%
Each slider sets a weight; the share it gets of the score is beside it.
#UniversityScoreTop 10%SpecialisationWorksGrowth
1Jiangnan UniversityChina 73.817.4%39.0×195 +42.6%
2Korea Advanced Institute of Science and TechnologySouth Korea 71.227.4%8.6×34 -1.0%
3Chalmers University of TechnologySweden 63.814.7%11.9×26 +3.8%
4Technical University of DenmarkDenmark 59.713.6%13.7×59 -29.7%
5University of Illinois Urbana-ChampaignUnited States 58.713.5%5.0×37 +7.8%
6Shandong UniversityChina 57.917.4%3.9×43 +28.8%
7Nanjing Tech UniversityChina 57.815.3%12.7×53 +42.8%
8Nanjing Normal UniversityChina 57.815.9%10.7×33 +225.7%
9Jiangsu UniversityChina 57.821.5%3.6×24 +62.8%
10ETH ZurichSwitzerland 57.817.7%3.3×19 -9.9%

Universities only. The score blends excellence (40%), size (30%), specialisation (10%), growth (10%), international reach (10%), 2022-now; growth compares 2018-21 with 2022-25 and counts up to +20%, since a jump from a small base is mostly noise.

Every institution in Microbial Metabolic Engineering and Bioproduction, country by country

Is Microbial Metabolic Engineering and Bioproduction research growing?

Output in 2022-2025 was 3% lower than in 2018-2021, peaking in 2013.

still counting19801990200020102020
grewheldshrank

The same series as a ribbon: one cell per year, darker for more. The line above answers how much; this answers when.

Its share of all research

Growing output can still be a shrinking share: all of science grows. This is Microbial Metabolic Engineering and Bioproduction as a percentage of every work published that year, 0.040% in 2024.

still counting0.050%0.10%Microbial Metabolic Engineering and Bioproduction0.040% in 202519801990200020102020

Fractional works of Microbial Metabolic Engineering and Bioproduction over all fractional works that year. How the balance of science has shifted.

How much of it reaches the world top 10%

Year by year.

still counting5%10%15%Microbial Metabolic Engineering and Bioproduction10.0% in 2025200020102020

Of each year's works in it, the share that reached the world's 10% most cited for their field and year. A field is the world for its own topics, so there is no other line to hold it against.

Which topics inside it are moving

Growth and decline on one axis around a shared zero. Two lists side by side hide the thing that matters: whether the growth dwarfs the decline, or the other way round.

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